{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T10:34:31Z","timestamp":1794479671226,"version":"4.9.1"},"reference-count":52,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001116","name":"Foundation Fighting Blindness Inc","doi-asserted-by":"publisher","award":["TA-RM-0522-0824-TUD-TRAP"],"award-info":[{"award-number":["TA-RM-0522-0824-TUD-TRAP"]}],"id":[{"id":"10.13039\/100001116","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","award":["01EK1613C"],"award-info":[{"award-number":["01EK1613C"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","award":["01EK1613A"],"award-info":[{"award-number":["01EK1613A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.isci.2026.117750","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:02:22Z","timestamp":1791406942000},"page":"117750","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extensive monolayer formation after transplantation depends on an RPE subpopulation derived from human iPSCs"],"prefix":"10.1016","volume":"29","author":[{"given":"Karen","family":"Tessmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia J.","family":"Gasparini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klara","family":"Schmidtke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trishla","family":"Adhikari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Michalke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Sch\u00f6n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Sulaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana R.","family":"Loureiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Last","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Chelius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annett","family":"Kurtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Johannsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madalena","family":"Carido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Petzold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike A.","family":"Friedrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kurth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Feldmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seba","family":"Almedawar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Kn\u00f6bel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9467-7677","authenticated-orcid":false,"given":"Marius","family":"Ader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.117750_bib1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41572-021-00265-2","article-title":"Age-related macular degeneration","volume":"7","author":"Fleckenstein","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.isci.2026.117750_bib2","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.3390\/biom15081167","article-title":"Retinal Pigment Epithelium Transplantation in Retinal Disease: Clinical Trial Development, Challenges, and Future Directions","volume":"15","author":"Chen","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.isci.2026.117750_bib3","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1093\/stcltm\/szad039","article-title":"Progress in Stem Cells-Based Replacement Therapy for Retinal Pigment Epithelium: In Vitro Differentiation to In Vivo Delivery","volume":"12","author":"Gupta","year":"2023","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.isci.2026.117750_bib4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.exer.2004.09.006","article-title":"Impaired RPE survival on aged submacular human Bruch\u2019s membrane","volume":"80","author":"Gullapalli","year":"2005","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.isci.2026.117750_bib5","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1167\/iovs.10-6112","article-title":"Cell-Deposited Matrix Improves Retinal Pigment Epithelium Survival on Aged Submacular Human Bruch\u2019s Membrane","volume":"52","author":"Sugino","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.isci.2026.117750_bib6","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aat5580","article-title":"Clinical-grade stem cell\u2013derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs","volume":"11","author":"Sharma","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.isci.2026.117750_bib7","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1073\/pnas.1119416110","article-title":"Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation","volume":"110","author":"Singh","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.117750_bib8","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20230913","article-title":"Identifying biomarkers of heterogeneity and transplantation efficacy in retinal pigment epithelial cells","volume":"220","author":"Farjood","year":"2023","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.isci.2026.117750_bib9","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.stemcr.2022.05.005","article-title":"Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation","volume":"17","author":"Petrus-Reurer","year":"2022","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.isci.2026.117750_bib10","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.stemcr.2017.05.016","article-title":"The Developmental Stage of Adult Human Stem Cell-Derived Retinal Pigment Epithelium Cells Influences Transplant Efficacy for Vision Rescue","volume":"9","author":"Davis","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.isci.2026.117750_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2023.109772","article-title":"Optimizing the sodium iodate model: Effects of dose, gender, and age","volume":"239","author":"Anderson","year":"2024","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.isci.2026.117750_bib12","doi-asserted-by":"crossref","first-page":"5431","DOI":"10.1167\/iovs.14-14325","article-title":"Characterization of a Mouse Model With Complete RPE Loss and Its Use for RPE Cell Transplantation","volume":"55","author":"Carido","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.isci.2026.117750_bib13","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.stemcr.2020.02.004","article-title":"MERTK-Dependent Ensheathment of Photoreceptor Outer Segments by Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium","volume":"14","author":"Almedawar","year":"2020","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.isci.2026.117750_bib14","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.stemcr.2020.10.013","article-title":"A Human Retinal Pigment Epithelium-Based Screening Platform Reveals Inducers of Photoreceptor Outer Segments Phagocytosis","volume":"15","author":"Schreiter","year":"2020","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.isci.2026.117750_bib15","article-title":"Three-Dimensional Neuroepithelial Culture from Human Embryonic Stem Cells and Its Use for Quantitative Conversion to Retinal Pigment Epithelium","volume":"8","author":"Zhu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.117750_bib16","doi-asserted-by":"crossref","first-page":"9109","DOI":"10.1073\/pnas.0403149101","article-title":"Knock-in human rhodopsin-GFP fusions as mouse models for human disease and targets for gene therapy","volume":"101","author":"Chan","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.117750_bib17","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2117553119","article-title":"Single-cell\u2013resolution map of human retinal pigment epithelium helps discover subpopulations with differential disease sensitivity","volume":"119","author":"Ortolan","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.isci.2026.117750_bib18","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.iy.09.040191.001543","article-title":"The SCID mouse mutant: Definition, Characterization, and potential uses","volume":"9","author":"Bosma","year":"1991","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.isci.2026.117750_bib19","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/stcltm\/szae004","article-title":"Recent Progress in Retinal Pigment Epithelium Cell-Based Therapy for Retinal Disease","volume":"13","author":"Klymenko","year":"2024","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.isci.2026.117750_bib20","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1152\/physrev.00021.2004","article-title":"The Retinal Pigment Epithelium in Visual Function","volume":"85","author":"Strauss","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.isci.2026.117750_bib21","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/s41467-020-15326-5","article-title":"Identification of cell surface markers and establishment of monolayer differentiation to retinal pigment epithelial cells","volume":"11","author":"Plaza Reyes","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.117750_bib22","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.exer.2019.05.001","article-title":"Molecular characterization of foveal versus peripheral human retina by single-cell RNA sequencing","volume":"184","author":"Voigt","year":"2019","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.isci.2026.117750_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.802457","article-title":"A Single-Cell Transcriptome Atlas of the Human Retinal Pigment Epithelium","volume":"9","author":"Xu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.isci.2026.117750_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2022.101582","article-title":"Triphasic developmentally guided protocol to generate retinal pigment epithelium from induced pluripotent stem cells","volume":"3","author":"Sharma","year":"2022","journal-title":"STAR Protoc."},{"key":"10.1016\/j.isci.2026.117750_bib25","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.92510.3","article-title":"Pigmentation level of human iPSC-derived RPE does not indicate a specific gene expression profile","volume":"12","author":"Nakai-Futatsugi","year":"2024","journal-title":"eLife"},{"key":"10.1016\/j.isci.2026.117750_bib26","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.2174\/0929867033456774","article-title":"Untangling the Functional Potential of PSA-NCAM-Expressing Cells in CNS Development and Brain Repair Strategies","volume":"10","author":"Nguyen","year":"2003","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.isci.2026.117750_bib27","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.scr.2012.10.005","article-title":"Efficient neuronal in vitro and in vivo differentiation after immunomagnetic purification of mESC derived neuronal precursors","volume":"10","author":"Barral","year":"2013","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.isci.2026.117750_bib28","article-title":"Highly Pure and Expandable PSA-NCAM-Positive Neural Precursors from Human ESC and iPSC-Derived Neural Rosettes","volume":"7","author":"Kim","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.117750_bib29","first-page":"518","article-title":"Schwann Cell Grafting into the Retina of the Dystrophic RCS Rat Limits Functional Deterioration","volume":"41","author":"Lawrence","year":"2000","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.isci.2026.117750_bib30","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1167\/iovs.07-0992","article-title":"Morphological and Functional Rescue in RCS Rats after RPE Cell Line Transplantation at a Later Stage of Degeneration","volume":"49","author":"Wang","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.isci.2026.117750_bib31","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1167\/iovs.16-20738","article-title":"Integration of Subretinal Suspension Transplants of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in a Large-Eyed Model of Geographic Atrophy","volume":"58","author":"Petrus-Reurer","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.isci.2026.117750_bib32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1167\/iovs.61.8.9","article-title":"Combined Transplantation With Human Mesenchymal Stem Cells Improves Retinal Rescue Effect of Human Fetal RPE Cells in Retinal Degeneration Mouse Model","volume":"61","author":"Pan","year":"2020","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.isci.2026.117750_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/sciadv.adr6211","article-title":"Female sex hormones exacerbate retinal neurodegeneration","volume":"11","author":"Rowe","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.isci.2026.117750_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2019.107773","article-title":"Sex-related differences in the progressive retinal degeneration of the rd10 mouse","volume":"187","author":"Li","year":"2019","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.isci.2026.117750_bib35","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.isci.2026.117750_bib36","article-title":"Visual Function is Gradually Restored During Retina Regeneration in Adult Zebrafish","volume":"9","author":"Hammer","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.isci.2026.117750_bib37","author":"Tanaka"},{"key":"10.1016\/j.isci.2026.117750_bib38","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/7651_2013_56","article-title":"Accelerated Three-Dimensional Neuroepithelium Formation from Human Embryonic Stem Cells and Its Use for Quantitative Differentiation to Human Retinal Pigment Epithelium","volume":"1307","author":"Zhu","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.isci.2026.117750_bib39","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/bioinformatics\/btq057","article-title":"Fast and SNP-tolerant detection of complex variants and splicing in short reads","volume":"26","author":"Wu","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2026.117750_bib40","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.isci.2026.117750_bib41","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.isci.2026.117750_bib42","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.117750_bib43","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.24956.2","article-title":"gprofiler2 -- an R package for gene list functional enrichment analysis and namespace conversion toolset g:Profiler","volume":"9","author":"Kolberg","year":"2020","journal-title":"F1000Res."},{"key":"10.1016\/j.isci.2026.117750_bib44","doi-asserted-by":"crossref","first-page":"W207","DOI":"10.1093\/nar\/gkad347","article-title":"g:Profiler\u2014interoperable web service for functional enrichment analysis and gene identifier mapping (2023 update)","volume":"51","author":"Kolberg","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.117750_bib45","doi-asserted-by":"crossref","first-page":"W191","DOI":"10.1093\/nar\/gkz369","article-title":"g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)","volume":"47","author":"Raudvere","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.isci.2026.117750_bib46","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/978-1-0716-2720-4_5","article-title":"Micromanipulator-Assisted Subretinal Transplantation of Human Photoreceptor Reporter Cell Suspensions into Mice","author":"Tessmer","year":"2023","journal-title":"Neuromethods"},{"key":"10.1016\/j.isci.2026.117750_bib47","doi-asserted-by":"crossref","DOI":"10.1172\/JCI154619","article-title":"Transplanted human cones incorporate into the retina and function in a murine cone degeneration model","volume":"132","author":"Gasparini","year":"2022","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.isci.2026.117750_bib48","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1083\/jcb.25.2.407","article-title":"A SIMPLIFIED LEAD CITRATE STAIN FOR USE IN ELECTRON MICROSCOPY","volume":"25","author":"Venable","year":"1965","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.isci.2026.117750_bib49","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2818.1982.tb00362.x","article-title":"Resin development for electron microscopy and an analysis of embedding at low temperature","volume":"126","author":"Carlemalm","year":"1982","journal-title":"J. Microsc."},{"key":"10.1016\/j.isci.2026.117750_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046305","article-title":"Outer Segment Formation of Transplanted Photoreceptor Precursor Cells","volume":"7","author":"Eberle","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.117750_bib51","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/B978-0-12-416026-2.00005-4","article-title":"Chapter 5 - Labeling of Ultrathin Resin Sections for Correlative Light and Electron Microscopy","volume":"111","author":"Fabig","year":"2012","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.isci.2026.117750_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.mcb.2024.02.030","article-title":"Chapter One - How to apply the broad toolbox of correlative light and electron microscopy to address a specific biological question","volume":"187","author":"Tranfield","year":"2024","journal-title":"Methods Cell Biol."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226031317?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226031317?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T10:15:52Z","timestamp":1794478552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226031317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":52,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S2589004226031317"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.117750","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extensive monolayer formation after transplantation depends on an RPE subpopulation derived from human iPSCs","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.117750","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117750"}}