{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T08:35:18Z","timestamp":1792917318083,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["Next Gen Clinician Scientist 2024 -ID. 30144"],"award-info":[{"award-number":["Next Gen Clinician Scientist 2024 -ID. 30144"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["IG-2019 -ID. 23088"],"award-info":[{"award-number":["IG-2019 -ID. 23088"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["IG 2022 -ID. 27566"],"award-info":[{"award-number":["IG 2022 -ID. 27566"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.isci.2026.117828","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:42:00Z","timestamp":1791808920000},"page":"117828","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["I\u03baB\u03b6 target genes in chronic lymphocytic leukemia"],"prefix":"10.1016","volume":"29","author":[{"given":"Ilenia","family":"Sana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0837-8946","authenticated-orcid":false,"given":"Miriam","family":"Meloni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7470-6386","authenticated-orcid":false,"given":"Francesca","family":"Genova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1203-2515","authenticated-orcid":false,"given":"Maria Elena","family":"Mantione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Sofia","family":"Tascini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ettore","family":"Zapparoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8758-1445","authenticated-orcid":false,"given":"Greta","family":"Carbone Faccin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Paschaloudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Del Nero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Lenzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Ranghetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Perotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Scarf\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Ghia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7761-759X","authenticated-orcid":false,"given":"Marta","family":"Muzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.117828_bib1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1101\/gad.351630.124","article-title":"Selective regulation of a defined subset of inflammatory and immunoregulatory genes by an NF-\u03baB p50-I\u03baB\u03b6 pathway","volume":"38","author":"Daly","year":"2024","journal-title":"Genes Dev."},{"key":"10.1016\/j.isci.2026.117828_bib2","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1101\/gad.351892.124","article-title":"Structural and biochemical analyses of the nuclear I\u03baB\u03b6 protein in complex with the NF-\u03baB p50 homodimer","volume":"38","author":"Zhu","year":"2024","journal-title":"Genes Dev."},{"key":"10.1016\/j.isci.2026.117828_bib3","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.3390\/cells13171467","article-title":"The Nuclear NF-\u03baB Regulator I\u03baB\u03b6: Updates on Its Molecular Functions and Pathophysiological Roles","volume":"13","author":"Yamazaki","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.isci.2026.117828_bib4","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.molcel.2024.01.007","article-title":"I\u03baB\u03b6 is a dual-use coactivator of NF-\u03baB and POU transcription factors","volume":"84","author":"Alpsoy","year":"2024","journal-title":"Mol. Cell"},{"key":"10.1016\/j.isci.2026.117828_bib5","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.immuni.2024.05.006","article-title":"Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2-dependent transcription of Ifng","volume":"57","author":"Sun","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2026.117828_bib6","doi-asserted-by":"crossref","first-page":"5387","DOI":"10.1038\/s41467-025-60929-5","article-title":"Constitutive expression of the transcriptional co-activator I\u03baB\u03b6 promotes melanoma growth and immunotherapy resistance","volume":"16","author":"Kolb","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.117828_bib7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0014-5793(00)02185-2","article-title":"MAIL, a novel nuclear I\u03baB protein that potentiates LPS-induced IL-6 production","volume":"485","author":"Kitamura","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.isci.2026.117828_bib8","doi-asserted-by":"crossref","first-page":"12485","DOI":"10.1074\/jbc.C100075200","article-title":"Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs","volume":"276","author":"Haruta","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.117828_bib9","doi-asserted-by":"crossref","first-page":"27657","DOI":"10.1074\/jbc.M103426200","article-title":"A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei","volume":"276","author":"Yamazaki","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.117828_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202451273","article-title":"Regulation and Function of the Atypical I\u03baBs-Bcl-3, I\u03baBNS, and I\u03baB\u03b6-in Lymphocytes and Autoimmunity","volume":"55","author":"K\u00fcbelbeck","year":"2025","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.isci.2026.117828_bib11","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.130835","article-title":"Keratinocyte-derived I\u03baB\u03b6 drives psoriasis and associated systemic inflammation","volume":"4","author":"Lorscheid","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.isci.2026.117828_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1032","article-title":"Emerging role of I\u03baB\u03b6 in inflammation: Emphasis on psoriasis","volume":"12","author":"Gautam","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.isci.2026.117828_bib13","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/art.42990","article-title":"I\u0138B\u03b6 as a Central Modulator of Inflammatory Arthritis Pathogenesis","volume":"77","author":"Swarnkar","year":"2025","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.isci.2026.117828_bib14","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2012.11.016","article-title":"Enhanced apoptosis by disruption of the STAT3-IkappaB-zeta signaling pathway in epithelial cells induces Sjogren's syndrome-like autoimmune disease","volume":"38","author":"Okuma","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.isci.2026.117828_bib15","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1038\/s41467-018-06354-3","article-title":"Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma","volume":"9","author":"Arthur","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.117828_bib16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41568-024-00763-x","article-title":"The present and future of the Cancer Dependency Map","volume":"25","author":"Arafeh","year":"2025","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.isci.2026.117828_bib17","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/leu.2017.177","article-title":"Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHVmut and IgHVunmut subgroups","volume":"32","author":"Burns","year":"2018","journal-title":"Leukemia"},{"key":"10.1016\/j.isci.2026.117828_bib18","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1038\/s41588-022-01211-y","article-title":"Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features","volume":"54","author":"Robbe","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2026.117828_bib19","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1084\/jem.20142009","article-title":"Functional loss of I\u03baB\u03b5 leads to NF-\u03baB deregulation in aggressive chronic lymphocytic leukemia","volume":"212","author":"Mansouri","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.isci.2026.117828_bib20","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.3324\/haematol.2017.165878","article-title":"Toll-like receptor 9 stimulation can induce I\u03baB\u03b6 expression and IgM secretion in chronic lymphocytic leukemia cells","volume":"102","author":"Fonte","year":"2017","journal-title":"Haematologica"},{"key":"10.1016\/j.isci.2026.117828_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202350418","article-title":"Dimethyl itaconate selectively targets inflammatory and metabolic pathways in chronic lymphocytic leukemia","volume":"53","author":"Sana","year":"2023","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.isci.2026.117828_bib22","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41419-024-06602-z","article-title":"Disrupting pro-survival and inflammatory pathways with dimethyl fumarate sensitizes chronic lymphocytic leukemia to cell death","volume":"15","author":"Mantione","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.isci.2026.117828_bib23","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1038\/sj.onc.1201643","article-title":"Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia","volume":"15","author":"Liu","year":"1997","journal-title":"Oncogene"},{"key":"10.1016\/j.isci.2026.117828_bib24","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1182\/blood.V97.7.2098","article-title":"Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia","volume":"97","author":"Migliazza","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.isci.2026.117828_bib25","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ccr.2009.11.019","article-title":"The DLEU2\/miR-15a\/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia","volume":"17","author":"Klein","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.isci.2026.117828_bib26","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1038\/leu.2016.383","article-title":"Mutations in NOTCH1 PEST domain orchestrate CCL19-driven homing of chronic lymphocytic leukemia cells by modulating the tumor suppressor gene DUSP22","volume":"31","author":"Arruga","year":"2017","journal-title":"Leukemia"},{"key":"10.1016\/j.isci.2026.117828_bib27","doi-asserted-by":"crossref","first-page":"30925","DOI":"10.1074\/jbc.M114.553230","article-title":"Control of Toll-like receptor-mediated T cell-independent type 1 antibody responses by the inducible nuclear protein IkappaB-zeta","volume":"289","author":"Hanihara-Tatsuzawa","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.117828_bib28","doi-asserted-by":"crossref","first-page":"12851","DOI":"10.1074\/jbc.M116.718825","article-title":"The Atypical Inhibitor of NF-kappaB, IkappaBzeta, Controls Macrophage Interleukin-10 Expression","volume":"291","author":"H\u00f6rber","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.isci.2026.117828_bib29","article-title":"NF-kB and the CLL microenvironment","volume":"13","author":"O'Donnell","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.isci.2026.117828_bib30","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3109\/10428199609054868","article-title":"Nuclear NF-ATp is a hallmark of unstimulated B cells from B-CLL patients","volume":"23","author":"Schuh","year":"1996","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.isci.2026.117828_bib31","first-page":"675","article-title":"B-chronic lymphocytic leukemia cells contain both endogenous kappa immunoglobulin mRNA and critical immunoglobulin gene activation transcription factors","volume":"6","author":"Zaknoen","year":"1992","journal-title":"Leukemia"},{"key":"10.1016\/j.isci.2026.117828_bib32","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1182\/blood-2014-01-553412","article-title":"FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-\u03baB to promote survival of human B cells","volume":"124","author":"van Keimpema","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.isci.2026.117828_bib33","article-title":"FOXP1 is associated with oncogenesis and clinical outcomes in hematologic malignancies","volume":"16","author":"Wen","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.isci.2026.117828_bib34","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1182\/blood-2013-09-527234","article-title":"miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1","volume":"124","author":"Mraz","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.isci.2026.117828_bib35","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/s41375-018-0230-x","article-title":"MicroRNA miR-34a downregulates FOXP1 during DNA damage response to limit BCR signalling in chronic lymphocytic leukaemia B cells","volume":"33","author":"Cerna","year":"2019","journal-title":"Leukemia"},{"key":"10.1016\/j.isci.2026.117828_bib36","first-page":"7695","article-title":"Transcriptional regulation of NF-kappa B2: evidence for kappa B-mediated positive and negative autoregulation","volume":"14","author":"Liptay","year":"1994","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.isci.2026.117828_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0228674","article-title":"CpG stimulation of chronic lymphocytic leukemia cells induces a polarized cell shape and promotes migration in vitro and in vivo","volume":"15","author":"Dampmann","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.isci.2026.117828_bib38","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1182\/blood.2020005964","article-title":"TLR9 expression in chronic lymphocytic leukemia identifies a promigratory subpopulation and novel therapeutic target","volume":"137","author":"Kennedy","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.isci.2026.117828_bib39","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1182\/blood-2007-05-089409","article-title":"Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia","volume":"110","author":"B\u00fcrkle","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.isci.2026.117828_bib40","doi-asserted-by":"crossref","first-page":"13789","DOI":"10.1073\/pnas.0605944103","article-title":"Testing gene function early in the B cell lineage in mb1-cre mice","volume":"103","author":"Hobeika","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226032098?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226032098?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T07:42:43Z","timestamp":1792914163000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226032098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S2589004226032098"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.117828","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"I\u03baB\u03b6 target genes in chronic lymphocytic leukemia","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.117828","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117828"}}