{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T10:34:40Z","timestamp":1794479680591,"version":"4.9.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3602501"],"award-info":[{"award-number":["2022YFC3602501"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["iScience"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.isci.2026.117864","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:08:00Z","timestamp":1791907680000},"page":"117864","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potential role of platelet-derived growth factor D in atherosclerotic cardiovascular disease risk"],"prefix":"10.1016","volume":"29","author":[{"given":"Xuan","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuju","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchen","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhen","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueting","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3311-0818","authenticated-orcid":false,"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.isci.2026.117864_bib1","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1016\/j.jacc.2023.11.007","article-title":"Global Burden of Cardiovascular Diseases and Risks, 1990-2022","volume":"82","author":"Mensah","year":"2023","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.isci.2026.117864_bib2","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/S0140-6736(25)00055-8","article-title":"The lancet commission on rethinking coronary artery disease: Moving from ischaemia to atheroma","volume":"405","author":"Zaman","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2026.117864_bib3","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/ATVBAHA.118.311999","article-title":"Highlighting Residual Atherosclerotic Cardiovascular Disease Risk","volume":"39","author":"Matsuura","year":"2019","journal-title":"ATVB"},{"key":"10.1016\/j.isci.2026.117864_bib4","first-page":"70","article-title":"Chinese guideline on the primary prevention of cardiovascular diseases","volume":"1","year":"2021","journal-title":"Cardiol. Discov."},{"key":"10.1016\/j.isci.2026.117864_bib5","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41392-025-02198-8","article-title":"Platelets and diseases: signal transduction and advances in targeted therapy","volume":"10","author":"Tian","year":"2025","journal-title":"Sig. Transduct Target Ther."},{"key":"10.1016\/j.isci.2026.117864_bib6","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.ajpath.2024.05.010","article-title":"Platelets in Thrombosis and Atherosclerosis","volume":"194","author":"Martinez Bravo","year":"2024","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.isci.2026.117864_bib7","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s40364-024-00700-y","article-title":"Platelet signaling in immune landscape: comprehensive mechanism and clinical therapy","volume":"12","author":"Yan","year":"2024","journal-title":"Biomark. Res."},{"key":"10.1016\/j.isci.2026.117864_bib8","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/s41467-023-36518-9","article-title":"Molecular mechanisms of coronary artery disease risk at the PDGFD locus","volume":"14","author":"Kim","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.117864_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12092","article-title":"Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci","volume":"7","author":"Miller","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.117864_bib10","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/ng.782","article-title":"A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease","volume":"43","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2026.117864_bib11","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mam.2017.09.005","article-title":"Platelet-derived growth factor-C and -D in the cardiovascular system and diseases","volume":"62","author":"Lee","year":"2018","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.isci.2026.117864_bib12","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.yjmcc.2011.06.023","article-title":"Platelet-derived growth factor involvement in myocardial remodeling following infarction","volume":"51","author":"Zhao","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.isci.2026.117864_bib13","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1365-2362.2009.02095.x","article-title":"PDGF-C and -D and their receptors PDGFR-alpha and PDGFR-beta in atherosclerotic human arteries","volume":"39","author":"Karvinen","year":"2009","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.isci.2026.117864_bib14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cytogfr.2004.03.004","article-title":"PDGF and cardiovascular disease","volume":"15","author":"Raines","year":"2004","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.isci.2026.117864_bib15","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1093\/aje\/kwae318","article-title":"Disentangling the inverse LDL-C-hemorrhagic stroke association in Chinese adults with hypertension: findings from the Chinese Multi-provincial Cohort Study","volume":"194","author":"Yang","year":"2025","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.isci.2026.117864_bib16","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1002\/sim.8471","article-title":"A causal framework for classical statistical estimands in failure-time settings with competing events","volume":"39","author":"Young","year":"2020","journal-title":"Stat. Med."},{"key":"10.1016\/j.isci.2026.117864_bib17","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1038\/s41591-022-01891-3","article-title":"Large-scale genome-wide association study of coronary artery disease in genetically diverse populations","volume":"28","author":"Tcheandjieu","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.isci.2026.117864_bib18","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.031012","article-title":"Effector genes at the coronary artery disease risk locus harboring PDGFD and LncRNA AP002989.1","volume":"12","author":"Solomon","year":"2023","journal-title":"JAHA"},{"key":"10.1016\/j.isci.2026.117864_bib19","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ijcard.2021.08.022","article-title":"Platelet-derived growth factor (PDGF) therapy in myocardial infarction: Challenges and opportunities","volume":"341","author":"Frangogiannis","year":"2021","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.isci.2026.117864_bib20","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1161\/CIRCRESAHA.122.321566","article-title":"Platelets at the vessel wall in non-thrombotic disease","volume":"132","author":"Aggarwal","year":"2023","journal-title":"Circ. Res."},{"key":"10.1016\/j.isci.2026.117864_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2018.01.005","article-title":"PDGF-C and PDGF-D signaling in vascular diseases and animal models","volume":"62","author":"Folestad","year":"2018","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.isci.2026.117864_bib22","doi-asserted-by":"crossref","first-page":"H442","DOI":"10.1152\/ajpheart.00165.2008","article-title":"PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns","volume":"296","author":"Thomas","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.isci.2026.117864_bib23","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12881-016-0325-z","article-title":"PDGF-D gene polymorphism is associated with increased cardiovascular mortality in elderly men","volume":"17","author":"Alehagen","year":"2016","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.isci.2026.117864_bib24","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20210252","article-title":"PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice","volume":"218","author":"Cheng","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.isci.2026.117864_bib25","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1038\/s41440-023-01455-z","article-title":"Smoking cessation and vascular endothelial function","volume":"46","author":"Higashi","year":"2023","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.isci.2026.117864_bib26","doi-asserted-by":"crossref","first-page":"482","DOI":"10.7150\/ijms.79889","article-title":"Smoking and Unstable Plaque in Acute Coronary Syndrome: A Systematic Review of The Role of Matrix Metalloproteinases","volume":"20","author":"Aminuddin","year":"2023","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.isci.2026.117864_bib27","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1161\/ATVBAHA.113.300156","article-title":"Smoking and Cardiovascular Disease: Mechanisms of Endothelial Dysfunction and Early Atherogenesis","volume":"34","author":"Messner","year":"2014","journal-title":"ATVB"},{"key":"10.1016\/j.isci.2026.117864_bib28","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.1093\/eurheartj\/ehaa034","article-title":"Application of the 2019 ESC\/EAS dyslipidaemia guidelines to nationwide data of patients with a recent myocardial infarction: A simulation study","volume":"41","author":"Allahyari","year":"2020","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.isci.2026.117864_bib29","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1161\/CIRCULATIONAHA.118.034309","article-title":"Clinical Benefit of Evolocumab by Severity and Extent of Coronary Artery Disease: Analysis From FOURIER","volume":"138","author":"Sabatine","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2026.117864_bib30","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0140-6736(12)60367-5","article-title":"The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: Meta-analysis of individual data from 27 randomised trials","volume":"380","author":"Mihaylova","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.isci.2026.117864_bib31","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1001\/jama.291.21.2591","article-title":"Predictive value for the Chinese population of the framingham CHD risk assessment tool compared with the chinese multi-provincial cohort study","volume":"291","author":"Liu","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.isci.2026.117864_bib32","doi-asserted-by":"crossref","first-page":"217","DOI":"10.26599\/1671-5411.2026.04.001","article-title":"Association of apolipoprotein C-III with atherosclerotic cardiovascular disease and the effectiveness of simulated interventions","volume":"23","author":"Deng","year":"2026","journal-title":"J. Geriatr. Cardiol."},{"key":"10.1016\/j.isci.2026.117864_bib33","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1161\/01.CIR.103.3.462","article-title":"Sino-MONICA project: A collaborative study on trends and determinants in cardiovascular diseases in China, part I: morbidity and mortality monitoring","volume":"103","author":"Wu","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.isci.2026.117864_bib34","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.jacc.2018.06.056","article-title":"Long-term cardiovascular risk associated with stage 1 hypertension defined by the 2017 ACC\/AHA hypertension guideline","volume":"72","author":"Qi","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.isci.2026.117864_bib35","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s41588-022-01036-9","article-title":"Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores","volume":"54","author":"Weissbrod","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.isci.2026.117864_bib36","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/sim.8757","article-title":"Analysis of time-to-event for observational studies: Guidance to the use of intensity models","volume":"40","author":"Kragh Andersen","year":"2021","journal-title":"Stat. Med."},{"key":"10.1016\/j.isci.2026.117864_bib37","doi-asserted-by":"crossref","first-page":"9922","DOI":"10.1038\/s41467-024-54078-4","article-title":"Effectiveness of treat-to-target cholesterol-lowering interventions on cardiovascular disease and all-cause mortality risk in the community-dwelling population: a target trial emulation","volume":"15","author":"Yang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.isci.2026.117864_bib38","article-title":"Targeted Maximum Likelihood Based Causal Inference: Part I","volume":"6","author":"Van Der Laan","year":"2010","journal-title":"Int. J. Biostat."},{"key":"10.1016\/j.isci.2026.117864_bib39","doi-asserted-by":"crossref","DOI":"10.2202\/1544-6115.1309","article-title":"Super Learner","volume":"6","author":"Van der Laan","year":"2007","journal-title":"Stat. Appl. Genet. Mol. Biol."}],"container-title":["iScience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226032475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589004226032475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T10:19:08Z","timestamp":1794478748000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589004226032475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":39,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S2589004226032475"],"URL":"https:\/\/doi.org\/10.1016\/j.isci.2026.117864","relation":{},"ISSN":["2589-0042"],"issn-type":[{"value":"2589-0042","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential role of platelet-derived growth factor D in atherosclerotic cardiovascular disease risk","name":"articletitle","label":"Article Title"},{"value":"iScience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2026.117864","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117864"}}