{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:45:38Z","timestamp":1787838338263,"version":"build-2784847793"},"reference-count":10,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trends in Immunology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.it.2017.02.006","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T01:23:34Z","timestamp":1488331414000},"page":"229-231","source":"Crossref","is-referenced-by-count":13,"title":["Small-Molecule ROR\u03b3t Antagonists: One Stone Kills Two Birds"],"prefix":"10.1016","volume":"38","author":[{"given":"Chao","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.it.2017.02.006_bib0005","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nri3707","article-title":"The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing","volume":"14","author":"Gaffen","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.it.2017.02.006_bib0010","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","article-title":"The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells","volume":"126","author":"Ivanov","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.it.2017.02.006_bib0015","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrd4100","article-title":"REV-ERB and ROR nuclear receptors as drug targets","volume":"13","author":"Kojetin","year":"2014","journal-title":"Nat. Rev. Drug Discovery"},{"key":"10.1016\/j.it.2017.02.006_bib0020","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nature09978","article-title":"Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORgammat activity","volume":"472","author":"Huh","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.it.2017.02.006_bib0025","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nature10075","article-title":"Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand","volume":"472","author":"Solt","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.it.2017.02.006_bib0030","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.immuni.2014.04.004","article-title":"Small-molecule RORgammat antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms","volume":"40","author":"Xiao","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.it.2017.02.006_bib0035","doi-asserted-by":"crossref","first-page":"8833","DOI":"10.1038\/ncomms9833","article-title":"Identification of an allosteric binding site for RORgammat inhibition","volume":"6","author":"Scheepstra","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2017.02.006_bib0040","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1016\/j.celrep.2016.11.073","article-title":"Inhibition of RORgammaT skews TCRalpha gene rearrangement and limits T cell repertoire diversity","volume":"17","author":"Guo","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.it.2017.02.006_bib0045","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/ni791","article-title":"Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes","volume":"3","author":"Guo","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2017.02.006_bib0050","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nm.4046","article-title":"Transient inhibition of ROR-gammat therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells","volume":"22","author":"Withers","year":"2016","journal-title":"Nat. Med."}],"container-title":["Trends in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471490617300297?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471490617300297?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T23:59:07Z","timestamp":1536019147000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471490617300297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S1471490617300297"],"URL":"https:\/\/doi.org\/10.1016\/j.it.2017.02.006","relation":{},"ISSN":["1471-4906"],"issn-type":[{"value":"1471-4906","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}