{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:54:04Z","timestamp":1790751244795,"version":"4.1.0"},"reference-count":92,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["FP\/2007-2013\/ERC"],"award-info":[{"award-number":["FP\/2007-2013\/ERC"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["2012-322698"],"award-info":[{"award-number":["2012-322698"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Rosalind Franklin Fellowship (University of Groningen)","award":["715772"],"award-info":[{"award-number":["715772"]}]},{"name":"CardioVasculair Onderzoek Nederland","award":["2012-03"],"award-info":[{"award-number":["2012-03"]}]},{"name":"NWO Vidi grant","award":["NWO-VIDI 864.13.013"],"award-info":[{"award-number":["NWO-VIDI 864.13.013"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","cell.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","bmn.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Immunology"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.it.2017.06.003","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T09:01:31Z","timestamp":1498726891000},"page":"633-647","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":292,"title":["Host Genetics and Gut Microbiome: Challenges and Perspectives"],"prefix":"10.1016","volume":"38","author":[{"given":"Alexander","family":"Kurilshikov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cisca","family":"Wijmenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4574-0841","authenticated-orcid":false,"given":"Alexandra","family":"Zhernakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.it.2017.06.003_bib0005","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4161\/gmic.19320","article-title":"The role of gut microbiota in immune homeostasis and autoimmunity","volume":"3","author":"Wu","year":"2012","journal-title":"Gut Microbes"},{"key":"10.1016\/j.it.2017.06.003_bib0010","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.it.2017.06.003_bib0015","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1126\/science.aad3369","article-title":"Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity","volume":"352","author":"Zhernakova","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.it.2017.06.003_bib0020","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1126\/science.aad3503","article-title":"Population-level analysis of gut microbiome variation","volume":"352","author":"Falony","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.it.2017.06.003_bib0025","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nature18848","article-title":"The microbiota in adaptive immune homeostasis and disease","volume":"535","author":"Honda","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.it.2017.06.003_bib0030","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nature18847","article-title":"The microbiome and innate immunity","volume":"535","author":"Thaiss","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.it.2017.06.003_bib0035","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1182\/blood-2015-10-675173","article-title":"Peptidoglycan from the gut microbiota governs the lifespan of circulating phagocytes at homeostasis","volume":"127","author":"Hergott","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.it.2017.06.003_bib0040","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature07540","article-title":"A core gut microbiome in obese and lean twins","volume":"457","author":"Turnbaugh","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.it.2017.06.003_bib0045","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cell.2014.09.053","article-title":"Human genetics shape the gut microbiome","volume":"159","author":"Goodrich","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.it.2017.06.003_bib0050","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.chom.2016.04.017","article-title":"Genetic determinants of the gut microbiome in UK twins","volume":"19","author":"Goodrich","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.it.2017.06.003_bib0055","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.cels.2016.10.004","article-title":"Shotgun metagenomics of 250 adult twins reveals genetic and environmental impacts on the gut microbiome","volume":"3","author":"Xie","year":"2016","journal-title":"Cell Syst."},{"key":"10.1016\/j.it.2017.06.003_bib0060","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/ng.3693","article-title":"Association of host genome with intestinal microbial composition in a large healthy cohort","volume":"48","author":"Turpin","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.it.2017.06.003_bib0065","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.chom.2014.08.014","article-title":"The Integrative Human Microbiome Project: dynamic analysis of microbiome-host omics profiles during periods of human health and disease","volume":"16","author":"Integrative HMP (iHMP) Research Network Consortium","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.it.2017.06.003_bib0070","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nature06244","article-title":"The human microbiome project","volume":"449","author":"Turnbaugh","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.it.2017.06.003_bib0075","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nature11319","article-title":"Gut microbiota composition correlates with diet and health in the elderly","volume":"488","author":"Claesson","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.it.2017.06.003_bib0080","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1126\/science.1229000","article-title":"Gut microbiomes of Malawian twin pairs discordant for Kwashiorkor","volume":"339","author":"Smith","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.it.2017.06.003_bib0085","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.chom.2014.02.005","article-title":"The treatment-naive microbiome in new-onset Crohn\u2019s disease","volume":"15","author":"Gevers","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.it.2017.06.003_bib0090","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature11450","article-title":"A metagenome-wide association study of gut microbiota in type 2 diabetes","volume":"490","author":"Qin","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.it.2017.06.003_bib0095","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1038\/ng.3695","article-title":"Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota","volume":"48","author":"Wang","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.it.2017.06.003_bib0100","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nature11550","article-title":"Diversity, stability and resilience of the human gut microbiota","volume":"489","author":"Lozupone","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.it.2017.06.003_bib0105","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cell.2015.08.059","article-title":"Regulators of gut motility revealed by a gnotobiotic model of diet-microbiome interactions related to travel","volume":"163","author":"Dey","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.it.2017.06.003_bib0110","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.chom.2008.02.015","article-title":"Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome","volume":"3","author":"Turnbaugh","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.it.2017.06.003_bib0115","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet rapidly and reproducibly alters the human gut microbiome","volume":"505","author":"David","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.it.2017.06.003_bib0120","doi-asserted-by":"crossref","first-page":"1241214","DOI":"10.1126\/science.1241214","article-title":"Gut microbiota from twins discordant for obesity modulate metabolism in mice","volume":"341","author":"Ridaura","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.it.2017.06.003_bib0125","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nm.3145","article-title":"Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis","volume":"19","author":"Koeth","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.it.2017.06.003_bib0130","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1136\/gutjnl-2015-310376","article-title":"Proton pump inhibitors affect the gut microbiome","volume":"65","author":"Imhann","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.it.2017.06.003_bib0135","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nature11400","article-title":"Antibiotics in early life alter the murine colonic microbiome and adiposity","volume":"488","author":"Cho","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.it.2017.06.003_bib0140","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature14177","article-title":"Genetic studies of body mass index yield new insights for obesity biology","volume":"518","author":"Locke","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.it.2017.06.003_bib0145","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature15766","article-title":"Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota","volume":"528","author":"Forslund","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.it.2017.06.003_bib0150","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.cell.2016.04.007","article-title":"Variation in microbiome LPS immunogenicity contributes to autoimmunity in humans","volume":"165","author":"Vatanen","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.it.2017.06.003_bib0155","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1161\/CIRCRESAHA.115.306807","article-title":"The gut microbiome contributes to a substantial proportion of the variation in blood lipids","volume":"117","author":"Fu","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.it.2017.06.003_bib0160","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1017\/S0007114515000793","article-title":"Effects of two whole-grain barley varieties on caecal SCFA, gut microbiota and plasma inflammatory markers in rats consuming low- and high-fat diets","volume":"113","author":"Zhong","year":"2015","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.it.2017.06.003_bib0165","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature18646","article-title":"Human gut microbes impact host serum metabolome and insulin sensitivity","volume":"535","author":"Pedersen","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.it.2017.06.003_bib0170","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1053\/j.gastro.2012.06.031","article-title":"Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome","volume":"143","author":"Vrieze","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.it.2017.06.003_bib0175","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.chom.2008.09.009","article-title":"Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine","volume":"4","author":"Ivanov","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.it.2017.06.003_bib0180","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/ng.2756","article-title":"Systematic identification of trans eQTLs as putative drivers of known disease associations","volume":"45","author":"Westra","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.it.2017.06.003_bib0185","doi-asserted-by":"crossref","first-page":"1046S","DOI":"10.1093\/ajcn\/69.5.1046s","article-title":"Influences of microbiota on intestinal immune system development","volume":"69","author":"Cebra","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.it.2017.06.003_bib0190","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.tem.2016.08.003","article-title":"Linking the microbiota, chronic disease, and the immune system","volume":"27","author":"Hand","year":"2016","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.it.2017.06.003_bib0195","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1038\/cti.2016.17","article-title":"Regulation of immune cell function by short-chain fatty acids","volume":"5","author":"Corr\u00eaa-Oliveira","year":"2016","journal-title":"Clin. Transl. Immunol."},{"key":"10.1016\/j.it.2017.06.003_bib0200","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.cell.2011.04.022","article-title":"NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis","volume":"145","author":"Elinav","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.it.2017.06.003_bib0205","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/mi.2012.23","article-title":"Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2, and antibacterial peptides","volume":"5","author":"Frantz","year":"2012","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.it.2017.06.003_bib0210","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1126\/science.1179721","article-title":"Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5","volume":"328","author":"Vijay-Kumar","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.it.2017.06.003_bib0215","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1126\/science.1222551","article-title":"Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria","volume":"336","author":"Sonnenberg","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.it.2017.06.003_bib0220","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3389\/fmicb.2016.00459","article-title":"Characterization of the gut microbiome using 16S or shotgun metagenomics","volume":"7","author":"Jovel","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.it.2017.06.003_bib0225","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/nmeth.3589","article-title":"MetaPhlAn2 for enhanced metagenomic taxonomic profiling","volume":"12","author":"Truong","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.it.2017.06.003_bib0230","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature11053","article-title":"Human gut microbiome viewed across age and geography","volume":"486","author":"Yatsunenko","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.it.2017.06.003_bib0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0140301","article-title":"Genome-wide association studies of the human gut microbiota","volume":"10","author":"Davenport","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.it.2017.06.003_bib0240","doi-asserted-by":"crossref","first-page":"18933","DOI":"10.1073\/pnas.1007028107","article-title":"Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors","volume":"107","author":"Benson","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2017.06.003_bib0245","doi-asserted-by":"crossref","first-page":"e39191","DOI":"10.1371\/journal.pone.0039191","article-title":"Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits","volume":"7","author":"McKnite","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.it.2017.06.003_bib0250","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1101\/gr.194118.115","article-title":"Genetic and environmental control of host-gut microbiota interactions","volume":"25","author":"Org","year":"2015","journal-title":"Genome Res."},{"key":"10.1016\/j.it.2017.06.003_bib0255","doi-asserted-by":"crossref","first-page":"6440","DOI":"10.1038\/ncomms7440","article-title":"Analysis of intestinal microbiota in hybrid house mice reveals evolutionary divergence in a vertebrate hologenome","volume":"6","author":"Wang","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2017.06.003_bib0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ismej.2014.64","article-title":"Reprograming of gut microbiome energy metabolism by the FUT2 Crohn\u2019s disease risk polymorphism","volume":"8","author":"Tong","year":"2014","journal-title":"ISME J."},{"key":"10.1016\/j.it.2017.06.003_bib0265","doi-asserted-by":"crossref","first-page":"e3064","DOI":"10.1371\/journal.pone.0003064","article-title":"Predominant role of host genetics in controlling the composition of gut microbiota","volume":"3","author":"Khachatryan","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.it.2017.06.003_bib0270","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13073-014-0107-1","article-title":"Complex host genetics influence the microbiome in inflammatory bowel disease","volume":"6","author":"Knights","year":"2014","journal-title":"Genome Med."},{"key":"10.1016\/j.it.2017.06.003_bib0275","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s13059-015-0759-1","article-title":"Host genetic variation impacts microbiome composition across human body sites","volume":"16","author":"Blekhman","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.it.2017.06.003_bib0280","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/ng.3663","article-title":"The effect of host genetics on the gut microbiome","volume":"48","author":"Bonder","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.it.2017.06.003_bib0285","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.clinthera.2015.04.004","article-title":"Lack of vitamin D receptor causes dysbiosis and changes the functions of the murine intestinal microbiome","volume":"37","author":"Jin","year":"2015","journal-title":"Clin. Ther."},{"key":"10.1016\/j.it.2017.06.003_bib0290","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1053\/j.gastro.2016.06.051","article-title":"A pleiotropic missense variant in SLC39A8 is associated with Crohn\u2019s disease and human gut microbiome composition","volume":"151","author":"Li","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.it.2017.06.003_bib0295","article-title":"Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease","author":"Imhann","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.it.2017.06.003_bib0300","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.chom.2014.02.006","article-title":"Gut microbiota promote hematopoiesis to control bacterial infection","volume":"15","author":"Khosravi","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.it.2017.06.003_bib0305","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.immuni.2008.11.001","article-title":"Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense","volume":"29","author":"Satoh-Takayama","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.it.2017.06.003_bib0310","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/ni.1684","article-title":"ROR\u03b3t and commensal microflora are required for the differentiation of mucosal interleukin 22\u2013producing NKp46+ cells","volume":"10","author":"Sanos","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2017.06.003_bib0315","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1096\/fj.10-172205","article-title":"Colonic mucosal DNA methylation, immune response, and microbiome patterns in Toll-like receptor 2-knockout mice","volume":"25","author":"Kellermayer","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.it.2017.06.003_bib0320","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4161\/gmic.22430","article-title":"Cystic fibrosis transmembrane conductance regulator knockout mice exhibit aberrant gastrointestinal microbiota","volume":"4","author":"Lynch","year":"2013","journal-title":"Gut Microbes"},{"key":"10.1016\/j.it.2017.06.003_bib0325","doi-asserted-by":"crossref","first-page":"e220","DOI":"10.1038\/cddis.2011.101","article-title":"Caspase deficiency alters the murine gut microbiome","volume":"2","author":"Brinkman","year":"2011","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.it.2017.06.003_bib0330","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cimid.2015.10.005","article-title":"Dysbiotic gut microbiome: a key element of Crohn\u2019s disease","volume":"43","author":"\u00d8yri","year":"2015","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"10.1016\/j.it.2017.06.003_bib0335","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.clim.2016.07.026","article-title":"The human microbiome in rheumatic autoimmune diseases: a comprehensive review","volume":"170","author":"Coit","year":"2016","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.it.2017.06.003_bib0340","doi-asserted-by":"crossref","first-page":"12015","DOI":"10.1038\/ncomms12015","article-title":"Alterations of the human gut microbiome in multiple sclerosis","volume":"7","author":"Jangi","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2017.06.003_bib0345","doi-asserted-by":"crossref","first-page":"15813","DOI":"10.1073\/pnas.0907722106","article-title":"Nod2 is required for the regulation of commensal microbiota in the intestine","volume":"106","author":"Petnicki-Ocwieja","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2017.06.003_bib0350","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1136\/gut.2010.216259","article-title":"Nod2 is essential for temporal development of intestinal microbial communities","volume":"60","author":"Rehman","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.it.2017.06.003_bib0355","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1126\/science.1104911","article-title":"Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract","volume":"307","author":"Kobayashi","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.it.2017.06.003_bib0360","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/mi.2013.95","article-title":"NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen","volume":"7","author":"Nordlander","year":"2014","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.it.2017.06.003_bib0365","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10809","article-title":"Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity","volume":"482","author":"Henao-Mejia","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.it.2017.06.003_bib0370","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nm.4102","article-title":"CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands","volume":"22","author":"Lamas","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.it.2017.06.003_bib0375","doi-asserted-by":"crossref","first-page":"16731","DOI":"10.1073\/pnas.0804812105","article-title":"Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients","volume":"105","author":"Sokol","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2017.06.003_bib0380","doi-asserted-by":"crossref","first-page":"7113","DOI":"10.1038\/ncomms8113","article-title":"Interplay between enterobactin, myeloperoxidase and lipocalin 2 regulates E. coli survival in the inflamed gut","volume":"6","author":"Singh","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2017.06.003_bib0385","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.cyto.2009.07.010","article-title":"The dectin-2 family of C-type lectins in immunity and homeostasis","volume":"48","author":"Graham","year":"2009","journal-title":"Cytokine"},{"key":"10.1016\/j.it.2017.06.003_bib0390","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.coi.2014.12.002","article-title":"C-type lectins in immunity: recent developments","volume":"32","author":"Dambuza","year":"2015","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.it.2017.06.003_bib0395","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1126\/science.1237910","article-title":"Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals","volume":"342","author":"Shan","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.it.2017.06.003_bib0400","doi-asserted-by":"crossref","first-page":"11779","DOI":"10.1074\/jbc.M114.552307","article-title":"A shrimp C-type lectin inhibits proliferation of the hemolymph microbiota by maintaining the expression of antimicrobial peptides","volume":"289","author":"Wang","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.it.2017.06.003_bib0405","doi-asserted-by":"crossref","first-page":"16023","DOI":"10.1038\/nmicrobiol.2016.23","article-title":"Mosquito C-type lectins maintain gut microbiome homeostasis","volume":"1","author":"Pang","year":"2016","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.it.2017.06.003_bib0410","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1126\/science.1221789","article-title":"Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis","volume":"336","author":"Iliev","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.it.2017.06.003_bib0415","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1758-2229.2012.00393.x","article-title":"Temporal stability of the mouse gut microbiota in relation to innate and adaptive immunity","volume":"5","author":"Dimitriu","year":"2013","journal-title":"Environ. Microbiol. Rep."},{"key":"10.1016\/j.it.2017.06.003_bib0420","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.immuni.2010.06.001","article-title":"Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells","volume":"32","author":"Wu","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.it.2017.06.003_bib0425","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1126\/science.aac4255","article-title":"Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy","volume":"350","author":"Sivan","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.it.2017.06.003_bib0430","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature12331","article-title":"Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota","volume":"500","author":"Atarashi","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.it.2017.06.003_bib0435","doi-asserted-by":"crossref","first-page":"28484","DOI":"10.1038\/srep28484","article-title":"Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.it.2017.06.003_bib0440","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/nm.3914","article-title":"The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment","volume":"21","author":"Zhang","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.it.2017.06.003_bib0445","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.cell.2014.08.006","article-title":"Immunoglobulin a coating identifies colitogenic bacteria in inflammatory bowel disease","volume":"158","author":"Palm","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.it.2017.06.003_bib0450","article-title":"MicrobiomeGWAS: a tool for identifying host genetic variants associated with microbiome composition","author":"Hua","year":"2015","journal-title":"bioRxiv"},{"key":"10.1016\/j.it.2017.06.003_bib0455","doi-asserted-by":"crossref","first-page":"e0129606","DOI":"10.1371\/journal.pone.0129606","article-title":"Assessment and selection of competing models for zero-inflated microbiome data","volume":"10","author":"Xu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.it.2017.06.003_bib0460","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nature13595","article-title":"Biological insights from 108 schizophrenia-associated genetic loci","volume":"511","author":"Ripke","year":"2014","journal-title":"Nature"}],"container-title":["Trends in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471490617301060?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471490617301060?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T12:46:07Z","timestamp":1538657167000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471490617301060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":92,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S1471490617301060"],"URL":"https:\/\/doi.org\/10.1016\/j.it.2017.06.003","relation":{},"ISSN":["1471-4906"],"issn-type":[{"value":"1471-4906","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Host Genetics and Gut Microbiome: Challenges and Perspectives","name":"articletitle","label":"Article Title"},{"value":"Trends in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.it.2017.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}