{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:49:34Z","timestamp":1791989374230,"version":"4.4.0"},"reference-count":100,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T00:00:00Z","timestamp":1508198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"NIDCR","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council (BBSRC","doi-asserted-by":"publisher","award":["BB\/M025977\/1"],"award-info":[{"award-number":["BB\/M025977\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Manchester Collaborative Centre for Inflammation Research"}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Immunology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.it.2017.08.005","type":"journal-article","created":{"date-parts":[[2017,9,8]],"date-time":"2017-09-08T18:00:25Z","timestamp":1504893625000},"page":"276-287","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":393,"title":["Tissue-Specific Immunity at the Oral Mucosal Barrier"],"prefix":"10.1016","volume":"39","author":[{"given":"Niki M.","family":"Moutsopoulos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne E.","family":"Konkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.it.2017.08.005_bib0005","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.immuni.2017.04.008","article-title":"Homeostatic immunity and the microbiota","volume":"46","author":"Belkaid","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.it.2017.08.005_bib0010","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1126\/science.1177486","article-title":"Bacterial community variation in human body habitats across space and time","volume":"326","author":"Costello","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.it.2017.08.005_bib0015","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature11234","article-title":"Structure, function and diversity of the healthy human microbiome","volume":"486","author":"Human Microbiome Project Consortium","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.it.2017.08.005_bib0020","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.chom.2017.03.011","article-title":"The landscape ecology and microbiota of the human nose, mouth, and throat","volume":"21","author":"Proctor","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.it.2017.08.005_bib0025","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1128\/JB.00542-10","article-title":"The human oral microbiome","volume":"192","author":"Dewhirst","year":"2010","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.it.2017.08.005_bib0030","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ismej.2012.174","article-title":"The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation","volume":"7","author":"Abusleme","year":"2013","journal-title":"ISME J."},{"key":"10.1016\/j.it.2017.08.005_bib0035","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/ismej.2011.191","article-title":"Distinct and complex bacterial profiles in human periodontitis and health revealed by 16S pyrosequencing","volume":"6","author":"Griffen","year":"2012","journal-title":"ISME J."},{"key":"10.1016\/j.it.2017.08.005_bib0040","doi-asserted-by":"crossref","first-page":"E791","DOI":"10.1073\/pnas.1522149113","article-title":"Biogeography of a human oral microbiome at the micron scale","volume":"113","author":"Mark Welch","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2017.08.005_bib0045","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1126\/science.1223490","article-title":"Interactions between the microbiota and the immune system","volume":"336","author":"Hooper","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.it.2017.08.005_bib0050","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1126\/science.1225152","article-title":"Compartmentalized control of skin immunity by resident commensals","volume":"337","author":"Naik","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.it.2017.08.005_bib0055","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.cell.2009.09.033","article-title":"Induction of intestinal Th17 cells by segmented filamentous bacteria","volume":"139","author":"Ivanov","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.it.2017.08.005_bib0060","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.immuni.2016.12.010","article-title":"On-going mechanical damage from mastication drives homeostatic Th17 cell responses at the oral barrier","volume":"46","author":"Dutzan","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.it.2017.08.005_bib0065","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1111\/cmi.12127","article-title":"Commensal bacteria-dependent select expression of CXCL2 contributes to periodontal tissue homeostasis","volume":"15","author":"Zenobia","year":"2013","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.it.2017.08.005_bib0070","doi-asserted-by":"crossref","first-page":"E337","DOI":"10.1073\/pnas.1614926114","article-title":"GAS6 is a key homeostatic immunological regulator of host-commensal interactions in the oral mucosa","volume":"114","author":"Nassar","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2017.08.005_bib0075","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1126\/science.1200439","article-title":"Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity","volume":"332","author":"Puel","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.it.2017.08.005_bib0080","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a019638","article-title":"Mendelian genetics of human susceptibility to fungal infection","volume":"4","author":"Lionakis","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.it.2017.08.005_bib0085","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1084\/jem.20130877","article-title":"Oral-resident natural Th17 cells and gammadelta T cells control opportunistic Candida albicans infections","volume":"211","author":"Conti","year":"2014","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.it.2017.08.005_bib0090","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1084\/jem.20081463","article-title":"Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis","volume":"206","author":"Conti","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.it.2017.08.005_bib0095","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.chom.2016.10.001","article-title":"IL-17 receptor signaling in oral epithelial cells is critical for protection against oropharyngeal candidiasis","volume":"20","author":"Conti","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.it.2017.08.005_bib0100","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/mi.2011.5","article-title":"New mechanism of oral immunity to mucosal candidiasis in hyper-IgE syndrome","volume":"4","author":"Conti","year":"2011","journal-title":"Mucosal. Immunol."},{"key":"10.1016\/j.it.2017.08.005_bib0105","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.micinf.2016.03.008","article-title":"Autonomous immunity in mucosal epithelial cells: fortifying the barrier against infection","volume":"18","author":"Ross","year":"2016","journal-title":"Microbes Infect."},{"key":"10.1016\/j.it.2017.08.005_bib0110","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1067\/mpr.2001.113778","article-title":"A review of saliva: normal composition, flow, and function","volume":"85","author":"Humphrey","year":"2001","journal-title":"J. Prosthet. Dent."},{"key":"10.1016\/j.it.2017.08.005_bib0115","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/odi.12626","article-title":"Elucidating the role of hyposalivation and autoimmunity in oral candidiasis","volume":"23","author":"Billings","year":"2017","journal-title":"Oral Dis."},{"key":"10.1016\/j.it.2017.08.005_bib0120","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/154405910808700411","article-title":"Oral manifestations of Sjogren's syndrome","volume":"87","author":"Mathews","year":"2008","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.it.2017.08.005_bib0125","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4110\/in.2013.13.3.81","article-title":"Sublingual delivery of vaccines for the induction of mucosal immunity","volume":"13","author":"Shim","year":"2013","journal-title":"Immune Netw."},{"key":"10.1016\/j.it.2017.08.005_bib0130","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/mi.2015.136","article-title":"Characterization of the human immune cell network at the gingival barrier","volume":"9","author":"Dutzan","year":"2016","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.it.2017.08.005_bib0135","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1128\/MMBR.62.1.71-109.1998","article-title":"Oral microbial ecology and the role of salivary immunoglobulin A","volume":"62","author":"Marcotte","year":"1998","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.it.2017.08.005_bib0140","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.cell.2014.08.006","article-title":"Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease","volume":"158","author":"Palm","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.it.2017.08.005_bib0145","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.tim.2016.02.010","article-title":"Dancing with the stars: how choreographed bacterial interactions dictate nososymbiocity and give rise to keystone pathogens, accessory pathogens, and pathobionts","volume":"24","author":"Hajishengallis","year":"2016","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.it.2017.08.005_bib0150","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jaut.2012.03.003","article-title":"Porphyromonas gingivalis promotes Th17 inducing pathways in chronic periodontitis","volume":"39","author":"Moutsopoulos","year":"2012","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.it.2017.08.005_bib0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004698","article-title":"Subgingival microbial communities in leukocyte adhesion deficiency and their relationship with local immunopathology","volume":"11","author":"Moutsopoulos","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.it.2017.08.005_bib0160","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: from microbial immune subversion to systemic inflammation","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.it.2017.08.005_bib0165","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaj1921","article-title":"Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis","volume":"8","author":"Konig","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.it.2017.08.005_bib0170","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1600-051X.2006.00924.x","article-title":"Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation","volume":"33","author":"Forner","year":"2006","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.it.2017.08.005_bib0175","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1902\/jop.2002.73.1.73","article-title":"Systemic release of endotoxins induced by gentle mastication: association with periodontitis severity","volume":"73","author":"Geerts","year":"2002","journal-title":"J. Periodontol."},{"key":"10.1016\/j.it.2017.08.005_bib0180","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1902\/jop.2014.140115","article-title":"Commentary: changing paradigms in the oral disease-systemic disease relationship","volume":"85","author":"Offenbacher","year":"2014","journal-title":"J. Periodontol."},{"key":"10.1016\/j.it.2017.08.005_bib0185","series-title":"Ten Cate\u2019s Oral Histology: Development, Structure, and Function","author":"Nanci","year":"2013"},{"key":"10.1016\/j.it.2017.08.005_bib0190","series-title":"Carranza\u2019s Clinical Periodontology","article-title":"Defense mechanisms of the gingiva","author":"Bulkacz","year":"2014"},{"key":"10.1016\/j.it.2017.08.005_bib0195","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1902\/annals.1997.2.1.123","article-title":"Evaluation of components of gingival crevicular fluid as diagnostic tests","volume":"2","author":"Lamster","year":"1997","journal-title":"Ann. Periodontol."},{"key":"10.1016\/j.it.2017.08.005_bib0200","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1600-051X.1991.tb00086.x","article-title":"Histologic studies on the extension of the inflammatory infiltrate in human periodontitis","volume":"18","author":"Moskow","year":"1991","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.it.2017.08.005_bib0205","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/prd.12075","article-title":"Systemic antibiotics in the treatment of periodontitis","volume":"67","author":"Feres","year":"2015","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.it.2017.08.005_bib0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0765.1966.tb01842.x","article-title":"Experimental gingivitis in man. II. A longitudinal clinical and bacteriological investigation","volume":"1","author":"Theilade","year":"1966","journal-title":"J. Periodontal. Res."},{"key":"10.1016\/j.it.2017.08.005_bib0215","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1902\/jop.1965.36.3.177","article-title":"Experimental gingivitis in man","volume":"36","author":"Loe","year":"1965","journal-title":"J. Periodontol."},{"key":"10.1016\/j.it.2017.08.005_bib0220","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1128\/CMR.00028-08","article-title":"Microbiology of odontogenic bacteremia: beyond endocarditis","volume":"22","author":"Parahitiyawa","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.it.2017.08.005_bib0225","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.molmed.2014.11.004","article-title":"Polymicrobial synergy and dysbiosis in inflammatory disease","volume":"21","author":"Lamont","year":"2015","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.it.2017.08.005_bib0230","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrmicro2337","article-title":"Periodontitis: a polymicrobial disruption of host homeostasis","volume":"8","author":"Darveau","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.it.2017.08.005_bib0235","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.it.2013.09.001","article-title":"Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response","volume":"35","author":"Hajishengallis","year":"2014","journal-title":"Trends Immunol."},{"key":"10.1016\/j.it.2017.08.005_bib0240","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1177\/0022034512457373","article-title":"Prevalence of periodontitis in adults in the United States: 2009 and 2010","volume":"91","author":"Eke","year":"2012","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.it.2017.08.005_bib0245","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1177\/0022034512458692","article-title":"The prevalence of periodontitis in the US: forget what you were told","volume":"91","author":"Papapanou","year":"2012","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.it.2017.08.005_bib0250","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1034\/j.1600-0757.2003.03105.x","article-title":"Origin and function of the cellular components in gingival crevice fluid","volume":"31","author":"Delima","year":"2003","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.it.2017.08.005_bib0255","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/ijos.2016.23","article-title":"Oral polymorphonuclear neutrophil characteristics in relation to oral health: a cross-sectional, observational clinical study","volume":"8","author":"Rijkschroeff","year":"2016","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.it.2017.08.005_bib0260","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1600-0765.1970.tb01835.x","article-title":"The origin and variation in number of leukocytes in the human saliva","volume":"5","author":"Schiott","year":"1970","journal-title":"J. Periodontal. Res."},{"key":"10.1016\/j.it.2017.08.005_bib0265","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1177\/0022034516645564","article-title":"Distinct oral neutrophil aubsets define health and periodontal disease states","volume":"95","author":"Fine","year":"2016","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.it.2017.08.005_bib0270","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1177\/0022034513507956","article-title":"Neutrophil homeostasis and periodontal health in children and adults","volume":"93","author":"Hajishengallis","year":"2014","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.it.2017.08.005_bib0275","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev-immunol-020711-074942","article-title":"Neutrophil function: from mechanisms to disease","volume":"30","author":"Amulic","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.it.2017.08.005_bib0280","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1177\/0022034515583533","article-title":"Inborn errors in immunity: unique natural models to dissect oral immunity","volume":"94","author":"Moutsopoulos","year":"2015","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.it.2017.08.005_bib0285","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004651","article-title":"Neutrophils: Between host defence, immune modulation, and tissue injury","volume":"11","author":"Kruger","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.it.2017.08.005_bib0290","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nri2294","article-title":"Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators","volume":"8","author":"Serhan","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.it.2017.08.005_bib0295","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1056\/NEJMe1615654","article-title":"Breaking a vicious cycle","volume":"376","author":"Ley","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.it.2017.08.005_bib0300","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.immuni.2005.01.011","article-title":"Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17","volume":"22","author":"Stark","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.it.2017.08.005_bib0305","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3007696","article-title":"Defective neutrophil recruitment in leukocyte adhesion deficiency type I disease causes local IL-17-driven inflammatory bone loss","volume":"6","author":"Moutsopoulos","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.it.2017.08.005_bib0310","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1056\/NEJMoa1612197","article-title":"Interleukin-12 and interleukin-23 blockade in leukocyte adhesion deficiency type 1","volume":"376","author":"Moutsopoulos","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.it.2017.08.005_bib0315","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/ni.2260","article-title":"The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss","volume":"13","author":"Eskan","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2017.08.005_bib0320","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1902\/jop.2003.74.1.66","article-title":"Neutrophil-mediated tissue injury in periodontal disease pathogenesis: findings from localized aggressive periodontitis","volume":"74","author":"Kantarci","year":"2003","journal-title":"J. Periodontol."},{"key":"10.1016\/j.it.2017.08.005_bib0325","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1365-2249.2006.03276.x","article-title":"Hyperactivity and reactivity of peripheral blood neutrophils in chronic periodontitis","volume":"147","author":"Matthews","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.it.2017.08.005_bib0330","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1600-051X.2004.00516.x","article-title":"Mast cells \u2013 a role in periodontal diseases?","volume":"31","author":"Steinsvoll","year":"2004","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.it.2017.08.005_bib0335","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002619","article-title":"The role of mast cells in the defence against pathogens","volume":"8","author":"Urb","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.it.2017.08.005_bib0340","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/mi.2013.42","article-title":"Dendritic cells of the oral mucosa","volume":"7","author":"Hovav","year":"2014","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.it.2017.08.005_bib0345","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1093\/infdis\/jiv763","article-title":"CX3CR1hi monocyte\/macrophages support bacterial survival and experimental infection-driven bone resorption","volume":"213","author":"Steinmetz","year":"2016","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.it.2017.08.005_bib0350","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00424-017-1958-2","article-title":"Macrophages in gastrointestinal homeostasis and inflammation","volume":"469","author":"Grainger","year":"2017","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.it.2017.08.005_bib0355","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.cell.2014.11.018","article-title":"Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment","volume":"159","author":"Lavin","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.it.2017.08.005_bib0360","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1600-0714.1978.tb01596.x","article-title":"A fine structural comparison of the healing of incisional wounds of mucosa and skin","volume":"7","author":"Sciubba","year":"1978","journal-title":"J. Oral Pathol."},{"key":"10.1016\/j.it.2017.08.005_bib0365","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.immuni.2015.06.017","article-title":"Distinct murine mucosal Langerhans cell subsets develop from pre-dendritic cells and monocytes","volume":"43","author":"Capucha","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.it.2017.08.005_bib0370","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1177\/154405910308200915","article-title":"Multiple dendritic cell (DC) subpopulations in human gingiva and association of mature DCs with CD4+ T-cells in situ","volume":"82","author":"Jotwani","year":"2003","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.it.2017.08.005_bib0375","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.4049\/jimmunol.167.8.4693","article-title":"Mature dendritic cells infiltrate the T cell-rich region of oral mucosa in chronic periodontitis: in situ, in vivo, and in vitro studies","volume":"167","author":"Jotwani","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.it.2017.08.005_bib0380","doi-asserted-by":"crossref","first-page":"7043","DOI":"10.1073\/pnas.1116770109","article-title":"Langerhans cells down-regulate inflammation-driven alveolar bone loss","volume":"109","author":"Arizon","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2017.08.005_bib0385","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.immuni.2012.04.012","article-title":"Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells","volume":"37","author":"Haniffa","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.it.2017.08.005_bib0390","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/mi.2012.89","article-title":"Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors","volume":"6","author":"Bain","year":"2013","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.it.2017.08.005_bib0395","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.immuni.2013.04.011","article-title":"IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses","volume":"38","author":"Schlitzer","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.it.2017.08.005_bib0400","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature14052","article-title":"Commensal-dendritic-cell interaction specifies a unique protective skin immune signature","volume":"520","author":"Naik","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.it.2017.08.005_bib0405","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1126\/science.1164206","article-title":"Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity","volume":"322","author":"Hildner","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.it.2017.08.005_bib0410","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/omi.12082","article-title":"Periodontitis in the absence of B cells and specific anti-bacterial antibody","volume":"30","author":"Oliver-Bell","year":"2015","journal-title":"Mol. Oral Microbiol."},{"key":"10.1016\/j.it.2017.08.005_bib0415","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.4049\/jimmunol.1500496","article-title":"The B cell-stimulatory cytokines BLyS and APRIL are elevated in human periodontitis and are required for B cell-dependent bone loss in experimental murine periodontitis","volume":"195","author":"Abe","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.it.2017.08.005_bib0420","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1128\/IAI.67.6.2804-2809.1999","article-title":"CD4+ T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice","volume":"67","author":"Baker","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.it.2017.08.005_bib0425","doi-asserted-by":"crossref","first-page":"R59","DOI":"10.1172\/JCI10763","article-title":"Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection","volume":"106","author":"Teng","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.it.2017.08.005_bib0430","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3389\/fimmu.2017.00250","article-title":"Phenotype and tissue residency of lymphocytes in the murine oral mucosa","volume":"8","author":"Park","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.it.2017.08.005_bib0435","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/ni.2029","article-title":"Regional and mucosal memory T cells","volume":"12","author":"Sheridan","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2017.08.005_bib0440","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3389\/fimmu.2014.00333","article-title":"Organ-specific and memory treg cells: specificity, development, function, and maintenance","volume":"5","author":"Gratz","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.it.2017.08.005_bib0445","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.immuni.2017.03.015","article-title":"Transforming growth factor-beta signaling in regulatory T cells controls T helper-17 cells and tissue-specific immune responses","volume":"46","author":"Konkel","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.it.2017.08.005_bib0450","doi-asserted-by":"crossref","first-page":"18525","DOI":"10.1073\/pnas.1302829110","article-title":"Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes","volume":"110","author":"Glowacki","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2017.08.005_bib0455","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/imr.12167","article-title":"Contextual functions of antigen-presenting cells in the gastrointestinal tract","volume":"259","author":"Grainger","year":"2014","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.it.2017.08.005_bib0460","first-page":"53736","article-title":"Isolation, Characterization and functional examination of the gingival immune cell network","author":"Dutzan","year":"2016","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.it.2017.08.005_bib0465","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1084\/jem.20070602","article-title":"Small intestine lamina propria dendritic cells promote de novo generation of Foxp3T reg cells via retinoic acid","volume":"204","author":"Sun","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.it.2017.08.005_bib0470","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.it.2008.08.003","article-title":"T-cell recruitment to the intestinal mucosa","volume":"29","author":"Agace","year":"2008","journal-title":"Trends Immunol."},{"key":"10.1016\/j.it.2017.08.005_bib0475","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/mi.2014.46","article-title":"A role for CCL28\u2013CCR3 in T-cell homing to the human upper airway mucosa","volume":"8","author":"Danilova","year":"2015","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.it.2017.08.005_bib0480","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/jbmr.2376","article-title":"IL-4\/CCL22\/CCR4 axis controls regulatory T-cell migration that suppresses inflammatory bone loss in murine experimental periodontitis","volume":"30","author":"Araujo-Pires","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.it.2017.08.005_bib0485","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jcv.2014.12.003","article-title":"A 17-year old patient with DOCK8 deficiency, severe oral HSV-1 and aggressive periodontitis \u2013 a case of virally induced periodontitis?","volume":"63","author":"Betts","year":"2015","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.it.2017.08.005_bib0490","article-title":"IL-17: overview and role in oral immunity and microbiome","author":"Abusleme","year":"2016","journal-title":"Oral Dis."},{"key":"10.1016\/j.it.2017.08.005_bib0495","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/jcpe.12238","article-title":"The presence, function and regulation of IL-17 and Th17 cells in periodontitis","volume":"41","author":"Cheng","year":"2014","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.it.2017.08.005_bib0500","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.immuni.2016.12.016","article-title":"Th17 cells require you to chew before you swallow","volume":"46","author":"Veldhoen","year":"2017","journal-title":"Immunity"}],"container-title":["Trends in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471490617301692?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471490617301692?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T07:01:51Z","timestamp":1761462111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471490617301692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":100,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S1471490617301692"],"URL":"https:\/\/doi.org\/10.1016\/j.it.2017.08.005","relation":{},"ISSN":["1471-4906"],"issn-type":[{"value":"1471-4906","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tissue-Specific Immunity at the Oral Mucosal Barrier","name":"articletitle","label":"Article Title"},{"value":"Trends in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.it.2017.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}