{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:04:06Z","timestamp":1790964246929,"version":"4.1.0"},"reference-count":115,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Immunology"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.it.2019.09.008","type":"journal-article","created":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T03:15:55Z","timestamp":1572750955000},"page":"984-997","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"title":["Immune Networks and Therapeutic Targeting of\u00a0iNKT Cells in Cancer"],"prefix":"10.1016","volume":"40","author":[{"given":"Shin-Ichiro","family":"Fujii","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.it.2019.09.008_bib1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/s41577-018-0034-2","article-title":"Tissue-specific functions of invariant natural killer T\u00a0cells","volume":"18","author":"Crosby","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib2","doi-asserted-by":"crossref","first-page":"886","DOI":"10.3389\/fimmu.2017.00886","article-title":"Exploiting antitumor immunotherapeutic novel strategies by deciphering the cross talk between invariant NKT\u00a0cells and dendritic cells","volume":"8","author":"Fujii","year":"2017","journal-title":"Front Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1600-065X.2007.00561.x","article-title":"Innate Valpha14+ natural killer T\u00a0cells mature dendritic cells, leading to strong adaptive immunity","volume":"220","author":"Fujii","year":"2007","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.it.2019.09.008_bib4","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1084\/jem.180.3.1097","article-title":"An invariant T\u00a0cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4\u22128\u2212 T\u00a0cells in mice and humans","volume":"180","author":"Lantz","year":"1994","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.it.2019.09.008_bib5","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1084\/jem.180.3.1171","article-title":"An invariant Va24-JaQ\/Vb11 T\u00a0cell receptor is expressed in all individuals by clonally expanded CD4\u22128\u2212 T\u00a0cells","volume":"180","author":"Dellabona","year":"1994","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.it.2019.09.008_bib6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1084\/jem.20041379","article-title":"High frequency of antitumor T\u00a0cells in the blood of melanoma patients before and after vaccination with tumor antigens","volume":"201","author":"Germeau","year":"2005","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.it.2019.09.008_bib7","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.4049\/jimmunol.177.5.3484","article-title":"Evaluation of the function of human invariant NKT cells from cancer patients using \u03b1-galactosylceramide-loaded murine dendritic cells","volume":"177","author":"Shimizu","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib8","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3389\/fimmu.2018.00314","article-title":"Possible therapeutic application of targeting type II natural killer T\u00a0cell-mediated suppression of tumor immunity","volume":"9","author":"Kato","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib9","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2015.06.025","article-title":"Tissue-specific distribution of iNKT cells impacts their cytokine response","volume":"43","author":"Lee","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.it.2019.09.008_bib10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.coi.2013.01.003","article-title":"Transcriptional regulation of the NKT cell lineage","volume":"25","author":"Constantinides","year":"2013","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib11","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.molimm.2018.09.023","article-title":"The ins and outs of type I iNKT cell development","volume":"105","author":"Shissler","year":"2019","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib12","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/ni827","article-title":"Prolonged interferon-\u03b3 producing NKT response induced with \u03b1-galactosylceramide-loaded dendritic cells","volume":"3","author":"Fujii","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib13","doi-asserted-by":"crossref","first-page":"12474","DOI":"10.1073\/pnas.1406240111","article-title":"KLRG+ invariant natural killer T\u00a0cells are long-lived effectors","volume":"111","author":"Shimizu","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2019.09.008_bib14","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S1074-7613(04)00076-7","article-title":"T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells","volume":"20","author":"Townsend","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.it.2019.09.008_bib15","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ni.1641","article-title":"The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T\u00a0cell effector functions","volume":"9","author":"Kovalovsky","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib16","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.immuni.2008.07.011","article-title":"The transcription factor PLZF directs the effector program of the NKT cell lineage","volume":"29","author":"Savage","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.it.2019.09.008_bib17","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/ni.1696","article-title":"The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T\u00a0cells","volume":"10","author":"Lazarevic","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib18","doi-asserted-by":"crossref","first-page":"e1001255","DOI":"10.1371\/journal.pbio.1001255","article-title":"Development and function of invariant natural killer T\u00a0cells producing Th2- and Th17-cytokines","volume":"10","author":"Watarai","year":"2012","journal-title":"PLoS Biol."},{"key":"10.1016\/j.it.2019.09.008_bib19","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1084\/jem.20141499","article-title":"Coupling of T\u00a0cell receptor specificity to natural killer T\u00a0cell development by bivalent histone H3 methylation","volume":"212","author":"Dobenecker","year":"2015","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.it.2019.09.008_bib20","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/ni.3644","article-title":"The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T\u00a0cells","volume":"18","author":"Beyaz","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib21","first-page":"E1204","article-title":"Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T\u00a0cell development and function","volume":"115","author":"Sundararaj","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.\u00a0S. A."},{"key":"10.1016\/j.it.2019.09.008_bib22","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1126\/science.1069017","article-title":"A thymic precursor to the NK T\u00a0cell lineage","volume":"296","author":"Benlagha","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.it.2019.09.008_bib23","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1084\/jem.20011544","article-title":"A natural killer T (NKT) cell developmental pathway involving a thymus-dependent NK1.1\u2212CD4+ CD1d-dependent precursor stage","volume":"195","author":"Pellicci","year":"2002","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.it.2019.09.008_bib24","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/ni.2731","article-title":"Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells","volume":"14","author":"Lee","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib25","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/ni.2230","article-title":"Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling","volume":"13","author":"Seiler","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib26","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1038\/s41467-018-05026-6","article-title":"TCR signal strength controls thymic differentiation of iNKT cell subsets","volume":"9","author":"Tuttle","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2019.09.008_bib27","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1038\/s41467-018-05095-7","article-title":"Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70","volume":"9","author":"Zhao","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2019.09.008_bib28","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/ni.3668","article-title":"Alternative pathway for the development of Valpha14+ NKT cells directly from CD4\u2212CD8\u2212 thymocytes that bypasses the CD4+CD8+ stage","volume":"18","author":"Dashtsoodol","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib29","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/s41590-019-0334-0","article-title":"SLAM receptors foster iNKT cell development by reducing TCR signal strength after positive selection","volume":"20","author":"Lu","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib30","doi-asserted-by":"crossref","first-page":"13116","DOI":"10.1038\/ncomms13116","article-title":"Distinct gene expression patterns correlate with developmental and functional traits of iNKT subsets","volume":"7","author":"Georgiev","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2019.09.008_bib31","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.coi.2018.01.006","article-title":"Transcriptional and epigenetic regulation of innate-like T lymphocyte development","volume":"51","author":"Verykokakis","year":"2018","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib32","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s42003-019-0389-3","article-title":"Eomes transcription factor is required for the development and differentiation of invariant NKT cells","volume":"2","author":"Shimizu","year":"2019","journal-title":"Commun. Biol."},{"key":"10.1016\/j.it.2019.09.008_bib33","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1182\/blood-2010-03-277103","article-title":"Thymic and peripheral microenvironments differentially mediate development and maturation of iNKT cells by IL-15 transpresentation","volume":"116","author":"Castillo","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.it.2019.09.008_bib34","doi-asserted-by":"crossref","first-page":"6335","DOI":"10.4049\/jimmunol.1003965","article-title":"IL-15 regulates homeostasis and terminal maturation of NKT cells","volume":"187","author":"Gordy","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib35","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.4049\/jimmunol.1400993","article-title":"Differential requirement for CCR4 and CCR7 during the development of innate and adaptive alphabetaT cells in the adult thymus","volume":"193","author":"Cowan","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib36","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.4049\/jimmunol.1303057","article-title":"An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells","volume":"192","author":"White","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib37","doi-asserted-by":"crossref","first-page":"e34793","DOI":"10.7554\/eLife.34793","article-title":"CCR7 defines a precursor for murine iNKT cells in thymus and periphery","volume":"7","author":"Wang","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.it.2019.09.008_bib38","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.4049\/jimmunol.167.7.4046","article-title":"Loss of IFN-\u03b3 production by invariant NK T\u00a0cells in advanced cancer","volume":"167","author":"Tahir","year":"2001","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib39","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1084\/jem.20021650","article-title":"A reversible defect in natural killer T\u00a0cell function characterizes the progression of premalignant to malignant multiple myeloma","volume":"197","author":"Dhodapkar","year":"2003","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.it.2019.09.008_bib40","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1046\/j.1365-2141.2003.04465.x","article-title":"Severe and selective deficiency of interferon-gamma-producing invariant natural killer T\u00a0cells in patients with myelodysplastic syndromes","volume":"122","author":"Fujii","year":"2003","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.it.2019.09.008_bib41","doi-asserted-by":"crossref","first-page":"6494","DOI":"10.4049\/jimmunol.168.12.6494","article-title":"Impaired proliferative response of V alpha 24 NKT cells from cancer patients against alpha-galactosylceramide","volume":"168","author":"Yanagisawa","year":"2002","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib42","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1084\/jem.20031462","article-title":"Natural killer T\u00a0cells infiltrate neuroblastomas expressing the chemokine CCL2","volume":"199","author":"Metelitsa","year":"2004","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.it.2019.09.008_bib43","doi-asserted-by":"crossref","first-page":"7322","DOI":"10.1158\/1078-0432.CCR-05-0877","article-title":"Increased intratumor Valpha24-positive natural killer T\u00a0cells: a prognostic factor for primary colorectal carcinomas","volume":"11","author":"Tachibana","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.it.2019.09.008_bib44","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.clim.2011.01.009","article-title":"Anti-tumor immune responses induced by iNKT cell-based immunotherapy for lung cancer and head and neck cancer","volume":"140","author":"Motohashi","year":"2011","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib45","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1200\/JCO.2011.38.8819","article-title":"Circulating invariant natural killer T-cell numbers predict outcome in head and neck squamous cell carcinoma: updated analysis with 10-year follow-up","volume":"30","author":"Schneiders","year":"2012","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.it.2019.09.008_bib46","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.clim.2013.06.005","article-title":"Medulloblastoma expresses CD1d and can be targeted for immunotherapy with NKT cells","volume":"149","author":"Liu","year":"2013","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib47","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1084\/jem.191.4.661","article-title":"Differential tumor surveillance by natural killer (NK) and NKT cells","volume":"191","author":"Smyth","year":"2000","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.it.2019.09.008_bib48","doi-asserted-by":"crossref","first-page":"e8646","DOI":"10.1371\/journal.pone.0008646","article-title":"iNKT cells control mouse spontaneous carcinoma independently of tumor-specific cytotoxic T\u00a0cells","volume":"5","author":"Bellone","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.it.2019.09.008_bib49","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/imm.12746","article-title":"Loss of natural killer T\u00a0cells promotes pancreatic cancer in LSL-Kras(G12D\/+) mice","volume":"152","author":"Janakiram","year":"2017","journal-title":"Immunology"},{"key":"10.1016\/j.it.2019.09.008_bib50","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1172\/JCI37869","article-title":"Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages","volume":"119","author":"Song","year":"2009","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.it.2019.09.008_bib51","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.4049\/jimmunol.0802430","article-title":"Immunosuppressive myeloid-derived suppressor cells can be converted into immunogenic APCs with the help of activated NKT cells: an alternative cell-based antitumor vaccine","volume":"182","author":"Ko","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib52","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/ni.1942","article-title":"Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A","volume":"11","author":"De Santo","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib53","doi-asserted-by":"crossref","first-page":"eaan5931","DOI":"10.1126\/science.aan5931","article-title":"Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells","volume":"360","author":"Ma","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.it.2019.09.008_bib54","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/mi.2013.75","article-title":"Oxidative stress-mediated iNKT-cell activation is involved in COPD pathogenesis","volume":"7","author":"Pichavant","year":"2014","journal-title":"Mucosal. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib55","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.4049\/jimmunol.0901017","article-title":"Protumor vs antitumor functions of IL-17","volume":"183","author":"Murugaiyan","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib56","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1016\/S0040-4020(01)86991-X","article-title":"Agelasphins, novel antitumor and immunostimulatory cerebrosides from the sponge Agelas mauritanus","volume":"50","author":"Natori","year":"1994","journal-title":"Tetrahedron"},{"key":"10.1016\/j.it.2019.09.008_bib57","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1126\/science.278.5343.1626","article-title":"CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides","volume":"278","author":"Kawano","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.it.2019.09.008_bib58","doi-asserted-by":"crossref","first-page":"5498","DOI":"10.1073\/pnas.040566697","article-title":"Critical contribution of liver natural killer T\u00a0cells to a murine model of hepatitis","volume":"97","author":"Takeda","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2019.09.008_bib59","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.4049\/jimmunol.178.5.2853","article-title":"Tumor cells loaded with \u03b1-galactosylceramide Induce innate NKT and NK cell-dependent resistance to tumor implantation in mice","volume":"178","author":"Shimizu","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib60","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1172\/JCI24762","article-title":"Glycolipid antigen induces long-term natural killer T\u00a0cell anergy in mice","volume":"115","author":"Parekh","year":"2005","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.it.2019.09.008_bib61","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.4049\/jimmunol.0803648","article-title":"PD-1\/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells","volume":"182","author":"Parekh","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib62","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1172\/JCI72308","article-title":"IL-10-producing NKT10 cells are a distinct regulatory invariant NKT cell subset","volume":"124","author":"Sag","year":"2014","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.it.2019.09.008_bib63","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1084\/jem.20031192","article-title":"Superior protection against\u00a0malaria and melanoma metastases by a C-glycoside analogue of the natural killer T\u00a0cell ligand alpha-galactosylceramide","volume":"198","author":"Schmieg","year":"2003","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.it.2019.09.008_bib64","doi-asserted-by":"crossref","first-page":"13010","DOI":"10.1073\/pnas.1006662107","article-title":"Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant","volume":"107","author":"Li","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2019.09.008_bib65","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.coi.2018.05.013","article-title":"The widening spectrum of immunological memory","volume":"54","author":"Lau","year":"2018","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib66","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1172\/JCI83476","article-title":"CD62L+ NKT cells have prolonged persistence and antitumor activity in vivo","volume":"126","author":"Tian","year":"2016","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.it.2019.09.008_bib67","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.4049\/jimmunol.1701026","article-title":"Memory follicular helper invariant NKT cells recognize lipid antigens on memory B cells and elicit antibody recall responses","volume":"200","author":"Chen","year":"2018","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib68","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1002\/eji.201445209","article-title":"Activated NKT cells imprint NK-cell differentiation, functionality and education","volume":"45","author":"Riese","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib69","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.clim.2017.10.007","article-title":"Amelioration of NK cell function driven by Valpha24+ invariant NKT cell activation in multiple myeloma","volume":"187","author":"Iyoda","year":"2018","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib70","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/cas.12882","article-title":"Antibody-dependent cellular cytotoxicity toward neuroblastoma enhanced by activated invariant natural killer T\u00a0cells","volume":"107","author":"Mise","year":"2016","journal-title":"Cancer Sci."},{"key":"10.1016\/j.it.2019.09.008_bib71","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.immuni.2016.10.010","article-title":"Functions of murine dendritic cells","volume":"45","author":"Durai","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.it.2019.09.008_bib72","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1084\/jem.20030324","article-title":"Activation of natural killer T\u00a0cells by alpha-galactosylceramide rapidly induces the full maturation of dendritic cells in vivo and thereby acts as an adjuvant for combined CD4 and CD8 T\u00a0cell immunity to a coadministered protein","volume":"198","author":"Fujii","year":"2003","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.it.2019.09.008_bib73","doi-asserted-by":"crossref","first-page":"5140","DOI":"10.4049\/jimmunol.171.10.5140","article-title":"NKT cells enhance CD4+ and CD8+ T\u00a0cell responses to soluble antigen in vivo through direct interaction with dendritic cells","volume":"171","author":"Hermans","year":"2003","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib74","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.4049\/jimmunol.180.7.4615","article-title":"Invariant NKT cells promote CD8+ cytotoxic T\u00a0cell responses by inducing CD70 expression on dendritic cells","volume":"180","author":"Taraban","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib75","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1158\/0008-5472.CAN-15-3219","article-title":"Systemic DC activation modulates the tumor microenvironment and shapes the long-lived tumor-specific memory mediated by CD8+ T\u00a0cells","volume":"76","author":"Shimizu","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.it.2019.09.008_bib76","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/ni.1848","article-title":"Alternative cross-priming through CCL17\u2013CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs","volume":"11","author":"Semmling","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib77","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1084\/jem.20040317","article-title":"The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80\/86 costimulation","volume":"199","author":"Fujii","year":"2004","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.it.2019.09.008_bib78","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.immuni.2011.05.006","article-title":"Toll-like receptors and\u00a0their crosstalk with other innate receptors in infection and immunity","volume":"34","author":"Kawai","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.it.2019.09.008_bib79","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nri3193","article-title":"Fine-tuning of dendritic cell biology by the TNF\u00a0superfamily","volume":"12","author":"Summers deLuca","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib80","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3389\/fimmu.2015.00529","article-title":"The contribution of CD40\/CD40L axis in inflammatory bowel disease: an update","volume":"6","author":"Senhaji","year":"2015","journal-title":"Front Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib81","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1172\/JCI200422046","article-title":"Utilizing the adjuvant properties of CD1d-dependent NK T\u00a0cells in T\u00a0cell-mediated immunotherapy","volume":"114","author":"Silk","year":"2004","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.it.2019.09.008_bib82","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3389\/fimmu.2018.00384","article-title":"Novel approaches to exploiting invariant NKT cells in cancer immunotherapy","volume":"9","author":"Wolf","year":"2018","journal-title":"Front Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib83","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1084\/jem.20102630","article-title":"PLZF induces an intravascular surveillance program mediated by long-lived LFA-1\u2013ICAM-1 interactions","volume":"208","author":"Thomas","year":"2011","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.it.2019.09.008_bib84","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1084\/jem.20042592","article-title":"Sustained expansion of NKT cells and antigen-specific T\u00a0cells after injection of alpha-galactosyl-ceramide loaded mature dendritic cells in cancer patients","volume":"201","author":"Chang","year":"2005","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.it.2019.09.008_bib85","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1182\/blood-2012-06-435503","article-title":"Clinical regressions and broad immune activation following combination therapy targeting human NKT cells in myeloma","volume":"121","author":"Richter","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.it.2019.09.008_bib86","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.4049\/jimmunol.0800126","article-title":"A phase I\u2013II study of \u03b1-galactosylceramide-pulsed IL-2\/GM-CSF-cultured peripheral blood mononuclear cells in patients with advanced and recurrent non-small cell lung cancer","volume":"182","author":"Motohashi","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib87","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00262-017-2085-9","article-title":"A phase I vaccination study with dendritic cells loaded with NY-ESO-1 and alpha-galactosylceramide: induction of polyfunctional T\u00a0cells in high-risk melanoma patients","volume":"67","author":"Gasser","year":"2018","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.it.2019.09.008_bib88","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.it.2019.02.002","article-title":"The cellular immunotherapy revolution: arming the immune system for precision therapy","volume":"40","author":"Paucek","year":"2019","journal-title":"Trends Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib89","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1182\/blood-2013-11-541235","article-title":"Invariant NKT cells with chimeric antigen receptor provide a novel platform for safe and effective cancer immunotherapy","volume":"124","author":"Heczey","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.it.2019.09.008_bib90","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.ccell.2018.08.017","article-title":"Enhanced anti-lymphoma activity of CAR19-iNKT cells inderpinned by dual CD19 and CD1d targeting","volume":"34","author":"Rotolo","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.it.2019.09.008_bib91","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1002\/stem.2465","article-title":"Efficient regeneration of human Valpha24+ invariant natural killer T\u00a0cells and their anti-tumor activity in vivo","volume":"34","author":"Yamada","year":"2016","journal-title":"Stem Cells"},{"key":"10.1016\/j.it.2019.09.008_bib92","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.immuni.2018.03.009","article-title":"Unconventional T\u00a0cell targets for cancer immunotherapy","volume":"48","author":"Godfrey","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.it.2019.09.008_bib93","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1084\/jem.20070458","article-title":"Cross-presentation of glycolipid from tumor cells loaded with \u03b1-galactosylceramide leads to potent and long-lived T\u00a0cell mediated immunity via dendritic cells","volume":"204","author":"Shimizu","year":"2007","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.it.2019.09.008_bib94","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1182\/blood-2008-08-176446","article-title":"Antigen mRNA-transfected, allogeneic fibroblasts loaded with NKT-cell ligand confer antitumor immunity","volume":"113","author":"Fujii","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.it.2019.09.008_bib95","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1158\/0008-5472.CAN-12-0759","article-title":"Vaccination with antigen-transfected, NKT cell ligand-loaded, human cells elicits robust in situ immune responses by dendritic cells","volume":"73","author":"Shimizu","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.it.2019.09.008_bib96","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1016\/j.celrep.2016.07.052","article-title":"iNKT cell emigration out of the lung vasculature requires neutrophils and monocyte-derived dendritic cells in inflammation","volume":"16","author":"Thanabalasuriar","year":"2016","journal-title":"Cell. Rep."},{"key":"10.1016\/j.it.2019.09.008_bib97","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.lungcan.2015.08.017","article-title":"The relationship between COPD and lung cancer","volume":"90","author":"Durham","year":"2015","journal-title":"Lung Cancer"},{"key":"10.1016\/j.it.2019.09.008_bib98","doi-asserted-by":"crossref","first-page":"5664","DOI":"10.1073\/pnas.1319051111","article-title":"T helper 17 cells play a critical pathogenic role in lung cancer","volume":"111","author":"Chang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"10.1016\/j.it.2019.09.008_bib99","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s10875-014-0090-8","article-title":"Mycobacterium tuberculosis-specific memory NKT cells in patients with tuberculous pleurisy","volume":"34","author":"Li","year":"2014","journal-title":"J.\u00a0Clin. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib100","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.clim.2016.04.014","article-title":"Co-administration of alpha-GalCer analog and TLR4 agonist induces robust CD8+ T-cell responses to PyCS protein and WT-1 antigen and activates memory-like effector NKT cells","volume":"168","author":"Coelho-Dos-Reis","year":"2016","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib101","doi-asserted-by":"crossref","first-page":"8339","DOI":"10.1073\/pnas.0801375105","article-title":"NK T\u00a0cells provide lipid antigen-specific cognate help for B cells","volume":"105","author":"Leadbetter","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2019.09.008_bib102","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/ni.2172","article-title":"Invariant natural killer T\u00a0cells\u00a0direct B cell responses to cognate lipid antigen in an IL-21-dependent manner","volume":"13","author":"King","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib103","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/ni.2166","article-title":"Identification of Bcl-6-dependent follicular helper NKT cells that provide cognate help for B cell responses","volume":"13","author":"Chang","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib104","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1365-2567.2006.02413.x","article-title":"The CD1d-binding glycolipid alpha-galactosylceramide enhances humoral immunity to T-dependent and T-independent antigen in a CD1d-dependent manner","volume":"119","author":"Lang","year":"2006","journal-title":"Immunology"},{"key":"10.1016\/j.it.2019.09.008_bib105","doi-asserted-by":"crossref","first-page":"35173","DOI":"10.1038\/srep35173","article-title":"In vivo dendritic cell targeting cellular vaccine induces CD4+ Tfh cell-dependent antibody against influenza virus","volume":"6","author":"Yamasaki","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.it.2019.09.008_bib106","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.4049\/jimmunol.1300263","article-title":"BAFF- and APRIL-dependent maintenance of antibody titers after immunization with T-dependent antigen and CD1d-binding ligand","volume":"191","author":"Shah","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib107","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1158\/1078-0432.CCR-04-1453","article-title":"A phase I study of \u03b1-galactosylceramide (KRN7000)-pulsed dendritic cells in patients with advanced and recurrent non-small cell lung cancer","volume":"11","author":"Ishikawa","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.it.2019.09.008_bib108","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s10875-012-9697-9","article-title":"Accumulation of activated invariant natural killer T\u00a0cells in the tumor microenvironment after alpha-galactosylceramide-pulsed antigen presenting cells","volume":"32","author":"Nagato","year":"2012","journal-title":"J.\u00a0Clin. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib109","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00262-007-0373-5","article-title":"Phase I study of alpha-galactosylceramide-pulsed antigen presenting cells administration to the nasal submucosa in unresectable or recurrent head and neck cancer","volume":"57","author":"Uchida","year":"2008","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.it.2019.09.008_bib110","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/j.1349-7006.2009.01135.x","article-title":"Combination therapy of in vitro-expanded natural killer T\u00a0cells and alpha-galactosylceramide-pulsed antigen-presenting cells in patients with recurrent head and neck carcinoma","volume":"100","author":"Kunii","year":"2009","journal-title":"Cancer Sci."},{"key":"10.1016\/j.it.2019.09.008_bib111","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.clim.2010.11.014","article-title":"Induction of NKT cell-specific immune responses in cancer tissues after NKT cell-targeted adoptive immunotherapy","volume":"138","author":"Yamasaki","year":"2011","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.it.2019.09.008_bib112","first-page":"3702","article-title":"A phase I study of the natural killer T-cell ligand \u03b1-galactosylceramide (KRN7000) in patients with solid tumors","volume":"8","author":"Giaccone","year":"2002","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.it.2019.09.008_bib113","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1182\/blood-2003-04-1155","article-title":"Therapeutic activation of Valpha24+Vbeta11+ NKT cells in human subjects results in highly coordinated secondary activation of\u00a0acquired and innate immunity","volume":"103","author":"Nieda","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.it.2019.09.008_bib114","doi-asserted-by":"crossref","first-page":"5140","DOI":"10.1158\/1078-0432.CCR-10-3105","article-title":"Comparison of clinical and immunological effects of intravenous and intradermal administration of alpha-galactosylceramide (KRN7000)-pulsed dendritic cells","volume":"17","author":"Nicol","year":"2011","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.it.2019.09.008_bib115","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.it.2018.12.003","article-title":"The emergence of natural killer cells as a major target in cancer immunotherapy","volume":"40","author":"Souza-Fonseca-Guimaraes","year":"2019","journal-title":"Trends Immunol."}],"container-title":["Trends in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471490619301966?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471490619301966?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T07:03:58Z","timestamp":1761462238000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471490619301966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":115,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S1471490619301966"],"URL":"https:\/\/doi.org\/10.1016\/j.it.2019.09.008","relation":{},"ISSN":["1471-4906"],"issn-type":[{"value":"1471-4906","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immune Networks and Therapeutic Targeting of\u00a0iNKT Cells in Cancer","name":"articletitle","label":"Article Title"},{"value":"Trends in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.it.2019.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}