{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:40:47Z","timestamp":1791726047876,"version":"4.3.4"},"reference-count":97,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T00:00:00Z","timestamp":1724457600000},"content-version":"am","delay-in-days":358,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100015691","name":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"NHLBI Division of Intramural Research","doi-asserted-by":"publisher","award":["R01AI111914"],"award-info":[{"award-number":["R01AI111914"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"NHLBI Division of Intramural Research","doi-asserted-by":"publisher","award":["R01AI150043"],"award-info":[{"award-number":["R01AI150043"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"NHLBI Division of Intramural Research","doi-asserted-by":"publisher","award":["R01AI155024"],"award-info":[{"award-number":["R01AI155024"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"NHLBI Division of Intramural Research","doi-asserted-by":"publisher","award":["T32 HL007317-44"],"award-info":[{"award-number":["T32 HL007317-44"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Immunology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.it.2023.07.003","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T02:56:22Z","timestamp":1691031382000},"page":"712-723","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Rifampicin drug resistance and host immunity in tuberculosis: more than meets the eye"],"prefix":"10.1016","volume":"44","author":[{"given":"Suhas","family":"Bobba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9545-4982","authenticated-orcid":false,"given":"Shabaana A.","family":"Khader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.it.2023.07.003_bb0005","series-title":"Global Tuberculosis Report 2022","author":"WHO","year":"2022"},{"key":"10.1016\/j.it.2023.07.003_bb0010","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/ja.2014.107","article-title":"Resistance to rifampicin: a review","volume":"67","author":"Goldstein","year":"2014","journal-title":"J. Antibiot. (Tokyo)"},{"key":"10.1016\/j.it.2023.07.003_bb0015","doi-asserted-by":"crossref","first-page":"14248","DOI":"10.1074\/jbc.M116.716704","article-title":"Rifampin resistance mutations are associated with broad chemical remodeling of Mycobacterium tuberculosis","volume":"291","author":"Lahiri","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.it.2023.07.003_bb0020","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/s41564-018-0245-0","article-title":"Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes","volume":"3","author":"Howard","year":"2018","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.it.2023.07.003_bb0025","doi-asserted-by":"crossref","first-page":"5025","DOI":"10.1128\/IAI.00224-09","article-title":"Patients with multidrug-resistant tuberculosis display impaired Th1 responses and enhanced regulatory T-cell levels in response to an outbreak of multidrug-resistant Mycobacterium tuberculosis M and Ra strains","volume":"77","author":"Geffner","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.it.2023.07.003_bb0030","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/cei.12873","article-title":"Mycobacterium tuberculosis multi-drug-resistant strain M induces IL-17+IFN\u03b3\u2013 CD4+ T cell expansion through an IL-23 and TGF-\u03b2-dependent mechanism in patients with MDR-TB tuberculosis","volume":"187","author":"Basile","year":"2017","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.it.2023.07.003_bb0035","doi-asserted-by":"crossref","first-page":"492","DOI":"10.4049\/jimmunol.158.1.492","article-title":"Patients with multidrug-resistant tuberculosis with low CD4+ T cell counts have impaired Th1 responses","volume":"158","author":"McDyer","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.it.2023.07.003_bb0040","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s10096-011-1434-4","article-title":"Characterization of Th1- and Th2-type immune response in human multidrug-resistant tuberculosis","volume":"31","author":"Tan","year":"2012","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.it.2023.07.003_bb0045","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/0140-6736(93)90417-F","article-title":"Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis","volume":"341","author":"Telenti","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.it.2023.07.003_bb0050","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jbiotec.2014.11.024","article-title":"Rifampicin-resistance, rpoB polymorphism and RNA polymerase genetic engineering","volume":"202","author":"Alifano","year":"2015","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.it.2023.07.003_bb0055","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1574-6968.2007.00905.x","article-title":"Specific mutations in the Mycobacterium tuberculosis rpoB gene are associated with increased dnaE2 expression","volume":"275","author":"Bergval","year":"2007","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.it.2023.07.003_bb0060","first-page":"3036","article-title":"Genome-wide DNA methylation and transcriptome changes in Mycobacterium tuberculosis with rifampicin and isoniazid resistance","volume":"11","author":"Chen","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.it.2023.07.003_bb0065","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1534\/genetics.105.045526","article-title":"Intermediate mutation frequencies favor evolution of multidrug resistance in Escherichia coli","volume":"171","author":"Denamur","year":"2005","journal-title":"Genetics"},{"key":"10.1016\/j.it.2023.07.003_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2021.126709","article-title":"DNA adenine methylation is involved in persister formation in E. coli","volume":"246","author":"Xu","year":"2021","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.it.2023.07.003_bb0075","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1084\/jem.123.3.445","article-title":"Microbial persistence","volume":"123","author":"McCune","year":"1966","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.it.2023.07.003_bb0080","doi-asserted-by":"crossref","first-page":"S134","DOI":"10.1016\/j.ijmyco.2016.10.011","article-title":"Proteome-scale MDR-TB-antibody responses for identification of putative biomarkers for the diagnosis of drug-resistant Mycobacterium tuberculosis","volume":"5","author":"Yari","year":"2016","journal-title":"Int. J. Mycobacteriol."},{"key":"10.1016\/j.it.2023.07.003_bb0085","article-title":"Comparing mRNA expression and protein abundance in MDR Mycobacterium tuberculosis: novel protein candidates, Rv0443, Rv0379 and Rv0147 as TB potential diagnostic or therapeutic targets","volume":"30","author":"Hadizadeh Tasbiti","year":"2021","journal-title":"Biotechnol. Rep."},{"key":"10.1016\/j.it.2023.07.003_bb0090","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0971-5916.154492","article-title":"Comparative proteomic analysis of sequential isolates of Mycobacterium tuberculosis from a patient with pulmonary tuberculosis turning from drug sensitive to multidrug resistant","volume":"141","author":"Singh","year":"2015","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.it.2023.07.003_bb0095","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1126\/science.aav5912","article-title":"PE\/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis","volume":"367","author":"Wang","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.it.2023.07.003_bb0100","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01766-21","article-title":"Transcriptomic characterization of tuberculous sputum reveals a host Warburg effect and microbial cholesterol catabolism","volume":"12","author":"Lai","year":"2021","journal-title":"mBio"},{"key":"10.1016\/j.it.2023.07.003_bb0105","doi-asserted-by":"crossref","DOI":"10.1172\/JCI152509","article-title":"Macrophage global metabolomics identifies cholestenone as host\/pathogen cometabolite present in human Mycobacterium tuberculosis infection","volume":"132","author":"Chandra","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.it.2023.07.003_bb0110","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2201632119","article-title":"Chemical\u2013genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy","volume":"119","author":"Koh","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2023.07.003_bb0115","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev-micro-091014-104121","article-title":"Assembly of the mycobacterial cell wall","volume":"69","author":"Jankute","year":"2015","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.it.2023.07.003_bb0120","doi-asserted-by":"crossref","first-page":"12807","DOI":"10.1038\/s41598-017-12718-4","article-title":"Dissecting the mycobacterial cell envelope and defining the composition of the native mycomembrane","volume":"7","author":"Chiaradia","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.it.2023.07.003_bb0125","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00148-17","article-title":"The cell wall lipid PDIM contributes to phagosomal escape and host cell exit of Mycobacterium tuberculosis","volume":"8","author":"Quigley","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.it.2023.07.003_bb0130","doi-asserted-by":"crossref","first-page":"6441","DOI":"10.1128\/JB.01013-12","article-title":"Upregulation of the phthiocerol dimycocerosate biosynthetic pathway by rifampin-resistant, rpoB mutant Mycobacterium tuberculosis","volume":"194","author":"Bisson","year":"2012","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.it.2023.07.003_bb0135","doi-asserted-by":"crossref","first-page":"494","DOI":"10.3389\/fmicb.2018.00494","article-title":"Altered Mycobacterium tuberculosis cell wall metabolism and physiology associated with RpoB mutation H526D","volume":"9","author":"Campod\u00f3nico","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.it.2023.07.003_bb0140","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.2147\/IDR.S405987","article-title":"Metabolic profiles of clinical isolates of drug-susceptible and multidrug-resistant Mycobacterium tuberculosis: a metabolomics-based study","volume":"16","author":"Wang","year":"2023","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.it.2023.07.003_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0259348","article-title":"In silico repurposing of a Novobiocin derivative for activity against latency associated Mycobacterium tuberculosis drug target nicotinate-nucleotide adenylyl transferase (Rv2421c)","volume":"16","author":"Cloete","year":"2021","journal-title":"PLoS ONE"},{"key":"10.1016\/j.it.2023.07.003_bb0150","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1080\/22221751.2018.1559706","article-title":"Housecleaning of pyrimidine nucleotide pool coordinates metabolic adaptation of nongrowing Mycobacterium tuberculosis","volume":"8","author":"Shi","year":"2019","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.it.2023.07.003_bb0155","doi-asserted-by":"crossref","first-page":"9779","DOI":"10.1073\/pnas.1808874115","article-title":"Arginine-deprivation-induced oxidative damage sterilizes Mycobacterium tuberculosis","volume":"115","author":"Tiwari","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2023.07.003_bb0160","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3390\/metabo12060493","article-title":"Rifampicin-mediated metabolic changes in Mycobacterium tuberculosis","volume":"12","author":"Yelamanchi","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.it.2023.07.003_bb0165","doi-asserted-by":"crossref","first-page":"D1045","DOI":"10.1093\/nar\/gkv1072","article-title":"BindingDB in 2015: a public database for medicinal chemistry, computational chemistry and systems pharmacology","volume":"44","author":"Gilson","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.it.2023.07.003_bb0170","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.chom.2020.11.013","article-title":"The immune landscape in tuberculosis reveals populations linked to disease and latency","volume":"29","author":"Esaulova","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.it.2023.07.003_bb0175","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay0233","article-title":"Immune correlates of tuberculosis disease and risk translate across species","volume":"12","author":"Ahmed","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.it.2023.07.003_bb0180","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.74419","article-title":"Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice","volume":"11","author":"Smith","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.it.2023.07.003_bb0185","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-pathol-031920-101429","article-title":"Lethal infectious diseases as inborn errors of immunity: toward a synthesis of the germ and genetic theories","volume":"16","author":"Casanova","year":"2021","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.it.2023.07.003_bb0190","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1084\/jem.193.3.271","article-title":"The relative importance of T cell subsets in immunity and immunopathology of airborne Mycobacterium tuberculosis infection in mice","volume":"193","author":"Mogues","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.it.2023.07.003_bb0195","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4049\/jimmunol.1200061","article-title":"(2013) IFN-\u03b3 from CD4 T cells is essential for host survival and enhances CD8 T cell function during Mycobacterium tuberculosis infection","volume":"190","author":"Green","year":"1950","journal-title":"J. Immunol."},{"key":"10.1016\/j.it.2023.07.003_bb0200","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.cell.2022.12.038","article-title":"Human IRF1 governs macrophagic IFN-\u03b3 immunity to mycobacteria","volume":"186","author":"Rosain","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.it.2023.07.003_bb0205","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1172\/JCI135460","article-title":"Inherited human IFN-\u03b3 deficiency underlies mycobacterial disease","volume":"130","author":"Kerner","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.it.2023.07.003_bb0210","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ni1449","article-title":"IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge","volume":"8","author":"Khader","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2023.07.003_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004099","article-title":"Unexpected role for IL-17 in protective immunity against hypervirulent Mycobacterium tuberculosis HN878 infection","volume":"10","author":"Gopal","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.it.2023.07.003_bb0220","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/mi.2017.15","article-title":"Novel role for IL-22 in protection during chronic Mycobacterium tuberculosis HN878 infection","volume":"10","author":"Treerat","year":"2017","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.it.2023.07.003_bb0225","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.1128\/IAI.00415-09","article-title":"Cytotoxicity and secretion of gamma interferon are carried out by distinct CD8 T cells during Mycobacterium tuberculosis infection","volume":"77","author":"Einarsdottir","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.it.2023.07.003_bb0230","doi-asserted-by":"crossref","first-page":"12210","DOI":"10.1073\/pnas.210391497","article-title":"Antimicrobial activity of MHC class I-restricted CD8+ T cells in human tuberculosis","volume":"97","author":"Cho","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2023.07.003_bb0235","doi-asserted-by":"crossref","first-page":"967","DOI":"10.3389\/fimmu.2017.00967","article-title":"Memory of natural killer cells: a new chance against Mycobacterium tuberculosis?","volume":"8","author":"Chore\u00f1o Parra","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.it.2023.07.003_bb0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000204","article-title":"Foamy macrophages from tuberculous patients\u2019 granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence","volume":"4","author":"Peyron","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.it.2023.07.003_bb0245","doi-asserted-by":"crossref","first-page":"773","DOI":"10.4049\/jimmunol.1300113","article-title":"Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms","volume":"191","author":"Mattila","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.it.2023.07.003_bb0250","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.4049\/jimmunol.160.9.4490","article-title":"Induction of in vitro human macrophage anti-Mycobacterium tuberculosis activity: requirement for IFN-\u03b3 and primed lymphocytes","volume":"160","author":"Bonecini-Almeida","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.it.2023.07.003_bb0255","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1159\/000050577","article-title":"Natural killer cell activity in multidrug-resistant pulmonary tuberculosis","volume":"68","author":"Yildiz","year":"2001","journal-title":"Respiration"},{"key":"10.1016\/j.it.2023.07.003_bb0260","doi-asserted-by":"crossref","first-page":"77","DOI":"10.5114\/aoms.2010.13511","article-title":"Can immune parameters be used as predictors to distinguish between pulmonary multidrug-resistant and drug-sensitive tuberculosis?","volume":"6","author":"Kiran","year":"2010","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.it.2023.07.003_bb0265","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/cei.12007","article-title":"Different immunosuppressive mechanisms in multi-drug-resistant tuberculosis and non-tuberculous mycobacteria patients","volume":"171","author":"Pinheiro","year":"2013","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.it.2023.07.003_bb0270","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1365-2249.2005.02872.x","article-title":"Detection of in vitro interferon-\u03b3 and serum tumour necrosis factor-\u03b1 in multidrug-resistant tuberculosis patients","volume":"141","author":"Fortes","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.it.2023.07.003_bb0275","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1093\/infdis\/jir460","article-title":"Outbreaks of Mycobacterium tuberculosis MDR strains induce high IL-17 T-cell response in patients with MDR tuberculosis that is closely associated with high antigen load","volume":"204","author":"Basile","year":"2011","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.it.2023.07.003_bb0280","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1136\/thoraxjnl-2019-214238","article-title":"Tuberculosis bacillary load, an early marker of disease severity: the utility of tuberculosis molecular bacterial load assay","volume":"75","author":"Sabiiti","year":"2020","journal-title":"Thorax"},{"key":"10.1016\/j.it.2023.07.003_bb0285","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/cei.13544","article-title":"Th22 response induced by Mycobacterium tuberculosis strains is closely related to severity of pulmonary lesions and bacillary load in patients with multi-drug-resistant tuberculosis","volume":"203","author":"Imperiale","year":"2021","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.it.2023.07.003_bb0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097837","article-title":"Mycobacterium tuberculosis multidrug resistant strain M induces an altered activation of cytotoxic CD8+ T cells","volume":"9","author":"Geffner","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.it.2023.07.003_bb0295","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/j.1440-1843.2008.01478.x","article-title":"In vitro cytotoxicity of CD8+ T cells in multi-drug-resistant tuberculosis. A preliminary report","volume":"14","author":"Sada-Ovalle","year":"2009","journal-title":"Respirology"},{"key":"10.1016\/j.it.2023.07.003_bb0300","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.tube.2016.02.001","article-title":"Impaired NK cells\u2019 activity and increased numbers of CD4 + CD25+ regulatory T cells in multidrug-resistant Mycobacterium tuberculosis patients","volume":"98","author":"Fan","year":"2016","journal-title":"Tuberculosis"},{"key":"10.1016\/j.it.2023.07.003_bb0305","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-2249.1994.tb06097.x","article-title":"Reduced NK activity correlates with active disease in HIV- patients with multidrug-resistant pulmonary tuberculosis","volume":"97","author":"Ratcliffe","year":"1994","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.it.2023.07.003_bb0310","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12879-020-4802-9","article-title":"Different macrophage polarization between drug-susceptible and multidrug-resistant pulmonary tuberculosis","volume":"20","author":"Cho","year":"2020","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.it.2023.07.003_bb0315","article-title":"Interferon-gamma improves macrophages function against M. tuberculosis in multidrug-resistant tuberculosis patients","volume":"2016","author":"Khan","year":"2016","journal-title":"Chemother. Res. Pract."},{"key":"10.1016\/j.it.2023.07.003_bb0320","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.0818-9641.2004.01245.x","article-title":"Mycobacterium tuberculosis induces high production of nitric oxide in coordination with production of tumour necrosis factor-\u03b1 in patients with fresh active tuberculosis but not in MDR tuberculosis","volume":"82","author":"Sharma","year":"2004","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.it.2023.07.003_bb0325","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1080\/21505594.2022.2135268","article-title":"Host cell transcriptomic response to the multidrug-resistant Mycobacterium tuberculosis clonal outbreak Beijing strain reveals its pathogenic features","volume":"13","author":"Prombutara","year":"2022","journal-title":"Virulence"},{"key":"10.1016\/j.it.2023.07.003_bb0330","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/s41598-018-19476-x","article-title":"IL-36\/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis","volume":"8","author":"Ahsan","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.it.2023.07.003_bb0335","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1365-2249.2004.02577.x","article-title":"IL-10 down-regulates costimulatory molecules on Mycobacterium tuberculosis-pulsed macrophages and impairs the lytic activity of CD4 and CD8 CTL in tuberculosis patients","volume":"138","author":"de la Barrera","year":"2004","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.it.2023.07.003_bb0340","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.clim.2006.11.009","article-title":"CD4+CD25+FoxP3+ regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active disease","volume":"123","author":"Chen","year":"2007","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.it.2023.07.003_bb0345","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1084\/jem.20060772","article-title":"CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells","volume":"203","author":"Liu","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.it.2023.07.003_bb0350","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009605","article-title":"Increase of CD4+CD25highFoxP3+ cells impairs in vitro human microbicidal activity against Mycobacterium tuberculosis during latent and acute pulmonary tuberculosis","volume":"15","author":"Stringari","year":"2021","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.it.2023.07.003_bb0355","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.5588\/ijtld.15.0148","article-title":"Enrichment of regulatory T-cells in blood of patients with multidrug-resistant tuberculosis","volume":"19","author":"Li","year":"2015","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"10.1016\/j.it.2023.07.003_bb0360","first-page":"57","article-title":"IL-10 and IL-12 production in response to Mycobacterium tuberculosis total lipid antigens in multidrug resistant tuberculosis","volume":"7","author":"Shams Shahemabadi","year":"2010","journal-title":"Iran. J. Immunol."},{"key":"10.1016\/j.it.2023.07.003_bb0365","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.666293","article-title":"Mycobacterium tuberculosis Rv2145c promotes intracellular survival by STAT3 and IL-10 receptor signaling","volume":"12","author":"Park","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.it.2023.07.003_bb0370","doi-asserted-by":"crossref","first-page":"17854","DOI":"10.1038\/s41598-017-18200-5","article-title":"Clinical and immunological effects of rhIL-2 therapy in eastern Chinese patients with multidrug-resistant tuberculosis","volume":"7","author":"Tan","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.it.2023.07.003_bb0375","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a018572","article-title":"Animal models of tuberculosis: guinea pigs","volume":"5","author":"Clark","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.it.2023.07.003_bb0380","doi-asserted-by":"crossref","first-page":"4.4.08","DOI":"10.1128\/microbiolspec.TBTB2-0002-2015","article-title":"Mouse and guinea pig models of tuberculosis","volume":"4","author":"Orme","year":"2016","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.it.2023.07.003_bb0385","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.tube.2009.01.005","article-title":"Clinical strains of Mycobacterium tuberculosis display a wide range of virulence in guinea pigs","volume":"89","author":"Palanisamy","year":"2009","journal-title":"Tuberculosis"},{"key":"10.1016\/j.it.2023.07.003_bb0390","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.tube.2011.03.002","article-title":"Natural infection of guinea pigs exposed to patients with highly drug-resistant tuberculosis","volume":"91","author":"Dharmadhikari","year":"2011","journal-title":"Tuberculosis"},{"key":"10.1016\/j.it.2023.07.003_bb0395","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a018556","article-title":"Mouse model of tuberculosis","volume":"5","author":"Cooper","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.it.2023.07.003_bb0400","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1128\/iai.63.2.741-743.1995","article-title":"Drug-resistant strains of Mycobacterium tuberculosis exhibit a range of virulence for mice","volume":"63","author":"Ordway","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.it.2023.07.003_bb0405","first-page":"58","article-title":"Comparative growth pattern of multi drug resistance versus susceptible isolates of Mycobacterium tuberculosis in mice lungs","volume":"130","author":"Dave","year":"2009","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.it.2023.07.003_bb0410","article-title":"Reduced virulence of an extensively drug-resistant outbreak strain of Mycobacterium tuberculosis in a murine model","volume":"9","author":"Smith","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.it.2023.07.003_bb0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109195","article-title":"Type I interferon decreases macrophage energy metabolism during mycobacterial infection","volume":"35","author":"Olson","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.it.2023.07.003_bb0420","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.03168-22","article-title":"Mutations in rpoB that confer rifampicin resistance can alter levels of peptidoglycan precursors and affect \u03b2-lactam susceptibility","volume":"14","author":"Patel","year":"2023","journal-title":"mBio"},{"key":"10.1016\/j.it.2023.07.003_bb0425","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1128\/jb.125.2.416-422.1976","article-title":"Altered nutritional requirements associated with mutations affecting the structures of ribonucleic acid polymerase in Lactobacillus casei","volume":"125","author":"Morishita","year":"1976","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.it.2023.07.003_bb0430","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1128\/jb.120.1.253-265.1974","article-title":"Isolation and characterization of rifampin-resistant and streptolydigin-resistant mutants of Bacillus subtilis with altered sporulation properties","volume":"120","author":"Sonenshein","year":"1974","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.it.2023.07.003_bb0435","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/infdis\/jis772","article-title":"The RpoB H481Y rifampicin resistance mutation and an active stringent response reduce virulence and increase resistance to innate immune responses in Staphylococcus aureus","volume":"207","author":"Gao","year":"2013","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.it.2023.07.003_bb0440","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1089\/jir.2005.25.694","article-title":"Hypervirulent M. tuberculosis W\/Beijing strains upregulate type I IFNs and increase expression of negative regulators of the Jak-Stat pathway","volume":"25","author":"Manca","year":"2005","journal-title":"J. Interf. Cytokine Res."},{"key":"10.1016\/j.it.2023.07.003_bb0445","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1128\/JCM.42.9.4040-4049.2004","article-title":"Definition of the Beijing\/W lineage of Mycobacterium tuberculosis on the basis of genetic markers","volume":"42","author":"Kremer","year":"2004","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.it.2023.07.003_bb0450","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005809","article-title":"The mechanism for type i interferon induction by Mycobacterium tuberculosis is bacterial strain-dependent","volume":"12","author":"Wiens","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.it.2023.07.003_bb0455","doi-asserted-by":"crossref","first-page":"5752","DOI":"10.1073\/pnas.091096998","article-title":"Virulence of a Mycobacterium tuberculosis clinical isolate in mice is determined by failure to induce Th1 type immunity and is associated with induction of IFN-\u03b1\/\u03b2","volume":"98","author":"Manca","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2023.07.003_bb0460","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13073-020-00817-3","article-title":"Robust barcoding and identification of Mycobacterium tuberculosis lineages for epidemiological and clinical studies","volume":"12","author":"Napier","year":"2020","journal-title":"Genome Med."},{"key":"10.1016\/j.it.2023.07.003_bb0465","article-title":"Mycobacterium tuberculosis lineages associated with mutations and drug resistance in isolates from India","volume":"10","author":"Shanmugam","year":"2020","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.it.2023.07.003_bb0470","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/s41564-023-01335-9","article-title":"ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages","volume":"8","author":"Aylan","year":"2023","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.it.2023.07.003_bb0475","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/s41564-023-01354-6","article-title":"Autophagy restricts Mycobacterium tuberculosis during acute infection in mice","volume":"8","author":"Golovkine","year":"2023","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.it.2023.07.003_bb0480","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.3390\/pharmaceutics12111071","article-title":"Antimicrobial peptide against Mycobacterium tuberculosis that activates autophagy is an effective treatment for tuberculosis","volume":"12","author":"Pel\u00e1ez Coyotl","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.it.2023.07.003_bb0485","doi-asserted-by":"crossref","DOI":"10.1093\/infdis\/jiad214","article-title":"Co-treatment with clofazimine and rapamycin eliminates drug-resistant tuberculosis by inducing polyfunctional central memory T cell responses","author":"Singh","year":"2023","journal-title":"J. Infect. Dis."}],"container-title":["Trends in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471490623001370?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471490623001370?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T07:12:32Z","timestamp":1761462752000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471490623001370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":97,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S1471490623001370"],"URL":"https:\/\/doi.org\/10.1016\/j.it.2023.07.003","relation":{},"ISSN":["1471-4906"],"issn-type":[{"value":"1471-4906","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rifampicin drug resistance and host immunity in tuberculosis: more than meets the eye","name":"articletitle","label":"Article Title"},{"value":"Trends in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.it.2023.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}