{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:09:02Z","timestamp":1787162942510,"version":"build-2736575974"},"reference-count":112,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","bmn.com","cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Immunology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.it.2024.08.004","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T16:10:47Z","timestamp":1726935047000},"page":"799-813","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Novel human iPSC models of neuroinflammation in neurodegenerative disease and regenerative medicine"],"prefix":"10.1016","volume":"45","author":[{"given":"Rose Ana","family":"Summers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Fagiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Rowitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Absinta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2628-4334","authenticated-orcid":false,"given":"Daniel S.","family":"Reich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.it.2024.08.004_bb0005","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/glia.23571","article-title":"Neuroinflammation in the central nervous system: symphony of glial cells","volume":"67","author":"Yang","year":"2019","journal-title":"Glia"},{"key":"10.1016\/j.it.2024.08.004_bb0010","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2024.1396520","article-title":"The complement system in neurodegenerative and inflammatory diseases of the central nervous system","volume":"15","author":"Negro-Demontel","year":"2024","journal-title":"Front. Neurol."},{"key":"10.1016\/j.it.2024.08.004_bb0015","doi-asserted-by":"crossref","first-page":"5816","DOI":"10.1038\/s41467-019-13812-z","article-title":"Dual microglia effects on blood brain barrier permeability induced by systemic inflammation","volume":"10","author":"Haruwaka","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2024.08.004_bb0020","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41392-023-01486-5","article-title":"Role of neuroinflammation in neurodegeneration development","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.it.2024.08.004_bb0025","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1038\/s41380-022-01511-z","article-title":"The blood-brain barrier in aging and neurodegeneration","volume":"27","author":"Knox","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.it.2024.08.004_bb0030","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.it.2024.08.004_bb0035","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.scr.2013.11.010","article-title":"Comparison of the molecular profiles of human embryonic and induced pluripotent stem cells of isogenic origin","volume":"12","author":"Mallon","year":"2014","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.it.2024.08.004_bb0040","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41392-024-01809-0","article-title":"Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications","volume":"9","author":"Cerneckis","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.it.2024.08.004_bb0045","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/s41593-018-0242-x","article-title":"Microglia in neurodegeneration","volume":"21","author":"Hickman","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.it.2024.08.004_bb0050","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1016\/j.neuron.2022.10.020","article-title":"Microglia states and nomenclature: a field at its crossroads","volume":"110","author":"Paolicelli","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.it.2024.08.004_bb0055","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41392-023-01588-0","article-title":"Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets","volume":"8","author":"Gao","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.it.2024.08.004_bb0060","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.neuron.2017.03.042","article-title":"iPSC-Derived human microglia-like cells to study neurological diseases","volume":"94","author":"Abud","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.it.2024.08.004_bb0065","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/j.stemcr.2017.05.017","article-title":"A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response","volume":"8","author":"Haenseler","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.it.2024.08.004_bb0070","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1038\/s41590-023-01558-2","article-title":"Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro","volume":"24","author":"Dolan","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2024.08.004_bb0075","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/s41593-022-01131-4","article-title":"A CRISPRi\/a platform in human iPSC-derived microglia uncovers regulators of disease states","volume":"25","author":"Dr\u00e4ger","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.it.2024.08.004_bb0080","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.it.2024.08.004_bb0085","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1038\/s41386-021-01139-7","article-title":"Astrocyte-derived TNF and glutamate critically modulate microglia activation by methamphetamine","volume":"46","author":"Canedo","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.it.2024.08.004_bb0090","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41583-022-00641-1","article-title":"Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders","volume":"24","author":"Brandebura","year":"2023","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.it.2024.08.004_bb0095","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41587-019-0035-0","article-title":"NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells","volume":"37","author":"Tchieu","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.it.2024.08.004_bb0100","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12575-023-00218-x","article-title":"Comparison of two protocols for the generation of iPSC-derived human astrocytes","volume":"25","author":"Mulica","year":"2023","journal-title":"Biol. Proced. Online"},{"key":"10.1016\/j.it.2024.08.004_bb0105","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1007\/s12015-022-10376-2","article-title":"Generation of human iPSC-derived astrocytes with a mature star-shaped phenotype for CNS modeling","volume":"18","author":"Voulgaris","year":"2022","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.it.2024.08.004_bb0110","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.stemcr.2017.06.018","article-title":"An efficient platform for astrocyte differentiation from human induced pluripotent stem cells","volume":"9","author":"Tcw","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.it.2024.08.004_bb0115","doi-asserted-by":"crossref","first-page":"E2243","DOI":"10.1073\/pnas.1614412114","article-title":"Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors","volume":"114","author":"Ehrlich","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2024.08.004_bb0120","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.stem.2012.12.002","article-title":"Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination","volume":"12","author":"Wang","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.it.2024.08.004_bb0125","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1038\/nprot.2015.075","article-title":"Generation and isolation of oligodendrocyte progenitor cells from human pluripotent stem cells","volume":"10","author":"Douvaras","year":"2015","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.it.2024.08.004_bb0130","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1038\/nprot.2009.186","article-title":"Differentiation of human oligodendrocytes from pluripotent stem cells","volume":"4","author":"Hu","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.it.2024.08.004_bb0135","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41586-022-05219-6","article-title":"A nomenclature consensus for nervous system organoids and assembloids","volume":"609","author":"Pa\u0219ca","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.it.2024.08.004_bb0140","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature12517","article-title":"Cerebral organoids model human brain development and microcephaly","volume":"501","author":"Lancaster","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.it.2024.08.004_bb0145","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s41582-022-00723-9","article-title":"Human cerebral organoids \u2014 a new tool for clinical neurology research","volume":"18","author":"Eichm\u00fcller","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.it.2024.08.004_bb0150","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.stemcr.2019.04.011","article-title":"Pluripotent stem cell-derived cerebral organoids reveal human oligodendrogenesis with dorsal and ventral origins","volume":"12","author":"Kim","year":"2019","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.it.2024.08.004_bb0155","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/s41593-018-0316-9","article-title":"Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures","volume":"22","author":"Marton","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.it.2024.08.004_bb0160","article-title":"A glia-enriched stem cell 3D model of the human brain mimics the glial-immune neurodegenerative phenotypes of multiple sclerosis","volume":"5","author":"Fagiani","year":"2024","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.it.2024.08.004_bb0165","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1818348116","article-title":"Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis","volume":"116","author":"Nicaise","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2024.08.004_bb0170","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/s41592-018-0081-4","article-title":"Induction of myelinating oligodendrocytes in human cortical spheroids","volume":"15","author":"Madhavan","year":"2018","journal-title":"Nat. Methods"},{"key":"10.1016\/j.it.2024.08.004_bb0175","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41586-023-06713-1","article-title":"iPS-cell-derived microglia promote brain organoid maturation via cholesterol transfer","volume":"623","author":"Park","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.it.2024.08.004_bb0180","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1038\/nm.4189","article-title":"Efficient derivation of microglia-like cells from human pluripotent stem cells","volume":"22","author":"Muffat","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.it.2024.08.004_bb0185","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1038\/s41467-018-06684-2","article-title":"Microglia innately develop within cerebral organoids","volume":"9","author":"Ormel","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2024.08.004_bb0190","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202107135","article-title":"Assessing Gq-GPCR-induced human astrocyte reactivity using bioengineered neural organoids","volume":"221","author":"Cvetkovic","year":"2022","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.it.2024.08.004_bb0195","doi-asserted-by":"crossref","first-page":"11055","DOI":"10.1038\/s41598-019-47444-6","article-title":"Functionalization of brain region-specific spheroids with isogenic microglia-like cells","volume":"9","author":"Song","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.it.2024.08.004_bb0200","doi-asserted-by":"crossref","first-page":"5733","DOI":"10.1038\/s41380-020-0807-4","article-title":"Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer\u2019s disease-like pathology in human cerebral organoids","volume":"26","author":"P\u00e9rez","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.it.2024.08.004_bb0205","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/s41586-021-03892-7","article-title":"A lymphocyte\u2013microglia\u2013astrocyte axis in chronic active multiple sclerosis","volume":"597","author":"Absinta","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.it.2024.08.004_bb0210","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/j.stemcr.2021.06.011","article-title":"Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology","volume":"16","author":"Xu","year":"2021","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.it.2024.08.004_bb0215","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1038\/s41467-019-11866-7","article-title":"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice","volume":"10","author":"Figueiredo","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2024.08.004_bb0220","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.cell.2016.04.032","article-title":"Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure","volume":"165","author":"Qian","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.it.2024.08.004_bb0225","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00018-023-05073-3","article-title":"Imaging of brain barrier inflammation and brain fluid drainage in human neurological diseases","volume":"81","author":"Okar","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.it.2024.08.004_bb0230","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.tibtech.2016.01.001","article-title":"Stem cell-based human blood\u2013brain barrier models for drug discovery and delivery","volume":"34","author":"Aday","year":"2016","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.it.2024.08.004_bb0235","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/s41592-019-0586-5","article-title":"Engineering of human brain organoids with a functional vascular-like system","volume":"16","author":"Cakir","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.it.2024.08.004_bb0240","doi-asserted-by":"crossref","DOI":"10.1002\/adbi.201800335","article-title":"A microfluidic human model of blood\u2013brain barrier employing primary human astrocytes","volume":"3","author":"Lauranzano","year":"2019","journal-title":"Adv. Biosyst."},{"key":"10.1016\/j.it.2024.08.004_bb0245","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.stem.2019.05.011","article-title":"Human iPSC-derived blood-brain barrier chips enable disease modeling and personalized medicine applications","volume":"24","author":"Vatine","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.it.2024.08.004_bb0250","doi-asserted-by":"crossref","first-page":"15623","DOI":"10.1038\/ncomms15623","article-title":"Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents","volume":"8","author":"Cho","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2024.08.004_bb0255","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nbt.2247","article-title":"Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells","volume":"30","author":"Lippmann","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.it.2024.08.004_bb0260","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.76707","article-title":"Generation of vascularized brain organoids to study neurovascular interactions","volume":"11","author":"Sun","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.it.2024.08.004_bb0265","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.stem.2024.04.019","article-title":"Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids","volume":"31","author":"Dao","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.it.2024.08.004_bb0270","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1093\/brain\/awac019","article-title":"Intrinsic blood\u2013brain barrier dysfunction contributes to multiple sclerosis pathogenesis","volume":"145","author":"Nishihara","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.it.2024.08.004_bb0275","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/s41586-022-05439-w","article-title":"APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes","volume":"611","author":"Blanchard","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.it.2024.08.004_bb0280","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1146\/annurev-immunol-102319-103410","article-title":"Meningeal immunity and its function in maintenance of the central nervous system in health and disease","volume":"38","author":"Alves de Lima","year":"2020","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.it.2024.08.004_bb0285","doi-asserted-by":"crossref","first-page":"7809","DOI":"10.1038\/s41598-023-35077-9","article-title":"Novel model of cortical\u2013meningeal organoid co-culture system improves human cortical brain organoid cytoarchitecture","volume":"13","author":"Jalilian","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.it.2024.08.004_bb0290","article-title":"Leptomeningeal neural organoid (LMNO) fusions as models to study meninges-brain signaling","author":"Jones","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.it.2024.08.004_bb0295","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/ana.22230","article-title":"A gradient of neuronal loss and meningeal inflammation in multiple sclerosis","volume":"68","author":"Magliozzi","year":"2010","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.it.2024.08.004_bb0300","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/ana.26448","article-title":"\u2018Ependymal-in\u2019 gradient of thalamic damage in progressive multiple sclerosis","volume":"92","author":"Magliozzi","year":"2022","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.it.2024.08.004_bb0305","doi-asserted-by":"crossref","DOI":"10.4137\/BBI.S33124","article-title":"Cross-species transcriptomic comparison of in vitro and in vivo mammalian neural cells","volume":"9","author":"LoVerso","year":"2015","journal-title":"Bioinform. Biol. Insights"},{"key":"10.1016\/j.it.2024.08.004_bb0310","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.neuron.2019.07.002","article-title":"Development of a chimeric model to study and manipulate human microglia in vivo","volume":"103","author":"Hasselmann","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.it.2024.08.004_bb0315","doi-asserted-by":"crossref","first-page":"25293","DOI":"10.1073\/pnas.1913541116","article-title":"Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain","volume":"116","author":"Svoboda","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2024.08.004_bb0320","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/978-1-4939-9072-6_18","article-title":"Human glial chimeric mice to define the role of glial pathology in human disease","volume":"1936","author":"Mariani","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.it.2024.08.004_bb0325","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/j.cell.2023.04.022","article-title":"An in vivo neuroimmune organoid model to study human microglia phenotypes","volume":"186","author":"Schafer","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.it.2024.08.004_bb0330","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/glia.24485","article-title":"iPSC-derived microglia carrying the TREM2 R47H\/+ mutation are proinflammatory and promote synapse loss","volume":"72","author":"Penney","year":"2024","journal-title":"Glia"},{"key":"10.1016\/j.it.2024.08.004_bb0335","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/s41593-024-01600-y","article-title":"Xenografted human microglia display diverse transcriptomic states in response to Alzheimer\u2019s disease-related amyloid-\u03b2 pathology","volume":"27","author":"Mancuso","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.it.2024.08.004_bb0340","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13024-021-00487-8","article-title":"Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-\u03b2 plaques","volume":"16","author":"Preman","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.it.2024.08.004_bb0345","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1038\/s41467-020-15411-9","article-title":"Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain","volume":"11","author":"Xu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2024.08.004_bb0350","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2023.1322451","article-title":"Single-cell sequencing reveals an important role of SPP1 and microglial activation in age-related macular degeneration","volume":"17","author":"Lei","year":"2024","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.it.2024.08.004_bb0355","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1016\/j.neuron.2024.05.023","article-title":"Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy","volume":"112","author":"Chadarevian","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.it.2024.08.004_bb0360","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1016\/j.neuron.2024.05.018","article-title":"Microglia protect against age-associated brain pathologies","volume":"112","author":"Munro","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.it.2024.08.004_bb0365","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/s41591-022-02097-3","article-title":"Neural stem cell transplantation in patients with progressive multiple sclerosis: an open-label, phase 1 study","volume":"29","author":"Genchi","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.it.2024.08.004_bb0370","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.stem.2023.11.001","article-title":"Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis","volume":"30","author":"Leone","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.it.2024.08.004_bb0375","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1038\/s41591-022-01956-3","article-title":"Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1\/2a trial","volume":"28","author":"Baloh","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.it.2024.08.004_bb0380","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41586-022-05277-w","article-title":"Maturation and circuit integration of transplanted human cortical organoids","volume":"610","author":"Revah","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.it.2024.08.004_bb0385","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.stem.2023.01.004","article-title":"Structural and functional integration of human forebrain organoids with the injured adult rat visual system","volume":"30","author":"Jgamadze","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.it.2024.08.004_bb0390","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.stemcr.2020.06.016","article-title":"Axonal extensions along corticospinal tracts from transplanted human cerebral organoids","volume":"15","author":"Kitahara","year":"2020","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.it.2024.08.004_bb0395","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1038\/s41380-020-00910-4","article-title":"Human cerebral organoids establish subcortical projections in the mouse brain after transplantation","volume":"26","author":"Dong","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.it.2024.08.004_bb0400","doi-asserted-by":"crossref","first-page":"9094","DOI":"10.1073\/pnas.2000690117","article-title":"Activity in grafted human iPS cell-derived cortical neurons integrated in stroke-injured rat brain regulates motor behavior","volume":"117","author":"Palma-Tortosa","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2024.08.004_bb0405","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1016\/j.neuron.2021.08.003","article-title":"Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors","volume":"109","author":"Lagomarsino","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.it.2024.08.004_bb0410","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nbt.4042","article-title":"Multiplexed droplet single-cell RNA-sequencing using natural genetic variation","volume":"36","author":"Kang","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.it.2024.08.004_bb0415","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41586-024-07578-8","article-title":"Brain chimeroids reveal individual susceptibility to neurotoxic triggers","volume":"631","author":"Ant\u00f3n-Bola\u00f1os","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.it.2024.08.004_bb0420","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/j.cell.2016.11.038","article-title":"Perturb-Seq: dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screens","volume":"167","author":"Dixit","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.it.2024.08.004_bb0425","article-title":"Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis","author":"Ionescu","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.it.2024.08.004_bb0430","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1038\/s41593-022-01185-4","article-title":"Age-related Huntington\u2019s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy","volume":"25","author":"Oh","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.it.2024.08.004_bb0435","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.stem.2015.09.001","article-title":"Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects","volume":"17","author":"Mertens","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.it.2024.08.004_bb0440","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41588-022-01024-z","article-title":"New insights into the genetic etiology of Alzheimer\u2019s disease and related dementias","volume":"54","author":"Bellenguez","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.it.2024.08.004_bb0445","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00401-023-02568-y","article-title":"Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation","volume":"145","author":"Filipello","year":"2023","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.it.2024.08.004_bb0450","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1002\/glia.24345","article-title":"The role of FUT8-catalyzed core fucosylation in Alzheimer\u2019s amyloid-\u03b2 oligomer-induced activation of human microglia","volume":"71","author":"Jin","year":"2023","journal-title":"Glia"},{"key":"10.1016\/j.it.2024.08.004_bb0455","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12974-021-02158-3","article-title":"Crosstalk between astrocytes and microglia results in increased degradation of \u03b1-synuclein and amyloid-\u03b2 aggregates","volume":"18","author":"Rostami","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.it.2024.08.004_bb0460","doi-asserted-by":"crossref","first-page":"5220","DOI":"10.1038\/s41467-021-25344-6","article-title":"Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia","volume":"12","author":"Bassil","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2024.08.004_bb0465","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/s41593-020-00796-z","article-title":"Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer\u2019s disease","volume":"24","author":"Guttikonda","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.it.2024.08.004_bb0470","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41531-024-00640-2","article-title":"Microglial inhibition alleviates alpha-synuclein propagation and neurodegeneration in Parkinson\u2019s disease mouse model","volume":"10","author":"Lai","year":"2024","journal-title":"NPJ Parkinsons Dis."},{"key":"10.1016\/j.it.2024.08.004_bb0475","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1038\/s41467-020-15626-w","article-title":"\u03b1-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson\u2019s disease","volume":"11","author":"Lindestam Arlehamn","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2024.08.004_bb0480","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.740758","article-title":"iPSC-Derived microglia as a model to study inflammation in idiopathic Parkinson\u2019s disease","volume":"9","author":"Badanjak","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.it.2024.08.004_bb0485","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1159\/000445751","article-title":"The incidence of Parkinson\u2019s disease: a systematic review and meta-analysis","volume":"46","author":"Hirsch","year":"2016","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.it.2024.08.004_bb0490","doi-asserted-by":"crossref","first-page":"14474","DOI":"10.1038\/s41598-020-71329-8","article-title":"Metabolic alterations in Parkinson\u2019s disease astrocytes","volume":"10","author":"Sonninen","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.it.2024.08.004_bb0495","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.stemcr.2018.12.011","article-title":"Patient-specific iPSC-derived astrocytes contribute to non-cell-autonomous neurodegeneration in Parkinson\u2019s disease","volume":"12","author":"di Domenico","year":"2019","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.it.2024.08.004_bb0500","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1038\/s41418-023-01195-0","article-title":"Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression","volume":"30","author":"Van San","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.it.2024.08.004_bb0505","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/jon.12957","article-title":"Quantitative evaluation of brain iron accumulation in different stages of Parkinson\u2019s disease","volume":"32","author":"Li","year":"2022","journal-title":"J. Neuroimaging"},{"key":"10.1016\/j.it.2024.08.004_bb0510","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41593-022-01221-3","article-title":"Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration","volume":"26","author":"Ryan","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.it.2024.08.004_bb0515","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1056\/NEJMra1401483","article-title":"Multiple sclerosis","volume":"378","author":"Reich","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.it.2024.08.004_bb0520","doi-asserted-by":"crossref","DOI":"10.1126\/science.aav7188","article-title":"Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility","volume":"365","author":"International Multiple Sclerosis Genetics Consortium","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.it.2024.08.004_bb0525","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41586-023-06250-x","article-title":"Locus for severity implicates CNS resilience in progression of multiple sclerosis","volume":"619","author":"International Multiple Sclerosis Genetics Consortium","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.it.2024.08.004_bb0530","doi-asserted-by":"crossref","DOI":"10.1172\/JCI164637","article-title":"iPSC-derived reactive astrocytes from patients with multiple-sclerosis protect cocultured neurons in inflammatory conditions","volume":"133","author":"Kerkering","year":"2023","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.it.2024.08.004_bb0535","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1002\/ana.26336","article-title":"MS-driven metabolic alterations are recapitulated in iPSC-derived astrocytes","volume":"91","author":"Ghirotto","year":"2022","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.it.2024.08.004_bb0540","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.1038\/s41467-018-07785-8","article-title":"Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis","volume":"9","author":"Ponath","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2024.08.004_bb0545","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2024.08.002","article-title":"Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis","author":"Clayton","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.it.2024.08.004_bb0550","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0233980","article-title":"iPSCs from people with MS can differentiate into oligodendrocytes in a homeostatic but not an inflammatory milieu","volume":"15","author":"Morales Pantoja","year":"2020","journal-title":"PLoS ONE"},{"key":"10.1016\/j.it.2024.08.004_bb0555","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1038\/s41467-024-46068-3","article-title":"Profiling of microglia nodules in multiple sclerosis reveals propensity for lesion formation","volume":"15","author":"van den Bosch","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2024.08.004_bb0560","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/6a917a2e-df4a-4ad9-99bb-6aa7218b833e","article-title":"Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling","volume":"8","author":"Reinhardt","year":"2013","journal-title":"PLoS ONE"}],"container-title":["Trends in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147149062400190X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147149062400190X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T20:14:44Z","timestamp":1730492084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S147149062400190X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":112,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S147149062400190X"],"URL":"https:\/\/doi.org\/10.1016\/j.it.2024.08.004","relation":{},"ISSN":["1471-4906"],"issn-type":[{"value":"1471-4906","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel human iPSC models of neuroinflammation in neurodegenerative disease and regenerative medicine","name":"articletitle","label":"Article Title"},{"value":"Trends in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.it.2024.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}