{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:13:27Z","timestamp":1784013207407,"version":"3.55.0"},"reference-count":93,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"am","delay-in-days":374,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","bmn.com","cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Immunology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.it.2024.08.007","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T20:10:55Z","timestamp":1726949455000},"page":"783-798","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Setting the tone: nociceptors as conductors of immune responses"],"prefix":"10.1016","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0511-5566","authenticated-orcid":false,"given":"Pavel","family":"Han\u010d","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3553-0971","authenticated-orcid":false,"given":"Marie-Ang\u00e8le","family":"Messou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8695-1637","authenticated-orcid":false,"given":"Jainu","family":"Ajit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4231-2283","authenticated-orcid":false,"given":"Ulrich H.","family":"von Andrian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.it.2024.08.007_bb0005","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3389\/fimmu.2020.00308","article-title":"Neuro-immune circuits regulate immune responses in tissues and organ homeostasis","volume":"11","author":"Jakob","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.it.2024.08.007_bb0010","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/nri2566","article-title":"Reflex control of immunity","volume":"9","author":"Tracey","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.it.2024.08.007_bb0015","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.immuni.2024.03.008","article-title":"Sensory neurons: an integrated component of innate immunity","volume":"57","author":"Deng","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.it.2024.08.007_bb0020","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neuron.2007.07.016","article-title":"Nociceptors--noxious stimulus detectors","volume":"55","author":"Woolf","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.it.2024.08.007_bb0025","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.cell.2024.02.006","article-title":"A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes","volume":"187","author":"Qi","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.it.2024.08.007_bb0030","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1038\/s41467-020-16859-5","article-title":"Central circuit mechanisms of itch","volume":"11","author":"Chen","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2024.08.007_bb0035","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cell.2020.02.026","article-title":"Mycobacterium tuberculosis sulfolipid-1 activates nociceptive neurons and induces cough","volume":"181","author":"Ruhl","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.it.2024.08.007_bb0040","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.1016\/j.cell.2021.05.017","article-title":"Sneezing reflex is mediated by a peptidergic pathway from nose to brainstem","volume":"184","author":"Li","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.it.2024.08.007_bb0045","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.tips.2010.06.006","article-title":"Regulation of signal transduction by calcitonin gene-related peptide receptors","volume":"31","author":"Walker","year":"2010","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.it.2024.08.007_bb0050","doi-asserted-by":"crossref","first-page":"607","DOI":"10.4049\/jimmunol.179.1.607","article-title":"Negative regulation of TLR responses by the neuropeptide CGRP is mediated by the transcriptional repressor ICER","volume":"179","author":"Harzenetter","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.it.2024.08.007_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009557","article-title":"Pseudomonas aeruginosa-induced nociceptor activation increases susceptibility to infection","volume":"17","author":"Lin","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.it.2024.08.007_bb0060","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.2147\/JIR.S356960","article-title":"Nociceptor neurons are involved in the host response to Escherichia coli urinary tract infections","volume":"15","author":"Gao","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.it.2024.08.007_bb0065","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nm.4501","article-title":"Nociceptor sensory neurons suppress neutrophil and gammadelta T cell responses in bacterial lung infections and lethal pneumonia","volume":"24","author":"Baral","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.it.2024.08.007_bb0070","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.cell.2018.04.006","article-title":"Blocking neuronal signaling to immune cells treats streptococcal invasive infection","volume":"173","author":"Pinho-Ribeiro","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.it.2024.08.007_bb0075","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/s41586-023-05753-x","article-title":"Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion","volume":"615","author":"Pinho-Ribeiro","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.it.2024.08.007_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0086367","article-title":"Calcitonin gene-related peptide regulates type IV hypersensitivity through dendritic cell functions","volume":"9","author":"Mikami","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.it.2024.08.007_bb0085","doi-asserted-by":"crossref","first-page":"16702","DOI":"10.1073\/pnas.0705974104","article-title":"Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice","volume":"104","author":"Tsujikawa","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2024.08.007_bb0090","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.immuni.2015.05.018","article-title":"GM-CSF mouse bone marrow cultures comprise a heterogeneous population of CD11c(+)MHCII(+) macrophages and dendritic cells","volume":"42","author":"Helft","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.it.2024.08.007_bb0095","doi-asserted-by":"crossref","DOI":"10.1126\/science.abm5658","article-title":"Multimodal control of dendritic cell functions by nociceptors","volume":"379","author":"Han\u010d","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.it.2024.08.007_bb0100","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.immuni.2015.08.016","article-title":"Nociceptive sensory fibers drive interleukin-23 production from CD301b+ dermal dendritic cells and drive protective cutaneous immunity","volume":"43","author":"Kashem","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.it.2024.08.007_bb0105","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.immuni.2019.06.009","article-title":"Neuropeptide CGRP limits group 2 innate lymphoid cell responses and constrains type 2 inflammation","volume":"51","author":"Nagashima","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.it.2024.08.007_bb0110","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.immuni.2019.09.005","article-title":"Calcitonin gene-related peptide negatively regulates alarmin-driven Type 2 innate lymphoid cell responses","volume":"51","author":"Wallrapp","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.it.2024.08.007_bb0115","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.1016\/j.cell.2023.10.019","article-title":"S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis","volume":"186","author":"Deng","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.it.2024.08.007_bb0120","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41467-017-02448-6","article-title":"Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314","volume":"9","author":"Blake","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2024.08.007_bb0125","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/j.cell.2024.03.001","article-title":"Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection","volume":"187","author":"Granton","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.it.2024.08.007_bb0130","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/s41586-022-05374-w","article-title":"Nociceptor neurons affect cancer immunosurveillance","volume":"611","author":"Balood","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.it.2024.08.007_bb0135","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2322574121","article-title":"The neuroimmune CGRP-RAMP1 axis tunes cutaneous adaptive immunity to the microbiota","volume":"121","author":"Kulalert","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2024.08.007_bb0140","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.cell.2022.12.037","article-title":"Immunity to the microbiota promotes sensory neuron regeneration","volume":"186","author":"Enamorado","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.it.2024.08.007_bb0145","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1016\/j.cell.2022.09.024","article-title":"Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection","volume":"185","author":"Yang","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.it.2024.08.007_bb0150","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cell.2019.11.014","article-title":"Gut-innervating nociceptor neurons regulate peyer's patch microfold cells and SFB levels to mediate Salmonella host defense","volume":"180","author":"Lai","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.it.2024.08.007_bb0155","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1016\/j.cell.2022.09.008","article-title":"Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection","volume":"185","author":"Zhang","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.it.2024.08.007_bb0160","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cell.2023.11.027","article-title":"Sensory neurons promote immune homeostasis in the lung","volume":"187","author":"Tamari","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.it.2024.08.007_bb0165","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/s41586-024-07237-y","article-title":"CGRP sensory neurons promote tissue healing via neutrophils and macrophages","volume":"628","author":"Lu","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.it.2024.08.007_bb0170","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1038\/s41590-024-01857-2","article-title":"Nociceptor-immune interactomes reveal insult-specific immune signatures of pain","volume":"25","author":"Jain","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2024.08.007_bb0175","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41586-021-03563-7","article-title":"Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions","volume":"594","author":"Hoeffel","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.it.2024.08.007_bb0180","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aba5683","article-title":"Activation of TRPA1 nociceptor promotes systemic adult mammalian skin regeneration","volume":"5","author":"Wei","year":"2020","journal-title":"Sci Immunol."},{"key":"10.1016\/j.it.2024.08.007_bb0185","doi-asserted-by":"crossref","first-page":"4685","DOI":"10.4049\/jimmunol.162.8.4685","article-title":"Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide prevent inducible nitric oxide synthase transcription in macrophages by inhibiting NF-kappa B and IFN regulatory factor 1 activation","volume":"162","author":"Delgado","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.it.2024.08.007_bb0190","doi-asserted-by":"crossref","first-page":"31427","DOI":"10.1074\/jbc.273.47.31427","article-title":"Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit tumor necrosis factor alpha transcriptional activation by regulating nuclear factor-kB and cAMP response element-binding protein\/c-Jun","volume":"273","author":"Delgado","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.it.2024.08.007_bb0195","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41586-020-2039-9","article-title":"Feeding-dependent VIP neuron-ILC3 circuit regulates the intestinal barrier","volume":"579","author":"Talbot","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.it.2024.08.007_bb0200","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41590-019-0567-y","article-title":"The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity","volume":"21","author":"Seillet","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2024.08.007_bb0205","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41385-022-00516-9","article-title":"The neuropeptide VIP potentiates intestinal innate type 2 and type 3 immunity in response to feeding","volume":"15","author":"Pascal","year":"2022","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.it.2024.08.007_bb0210","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1016\/j.jid.2021.11.041","article-title":"Skin injury activates a rapid TRPV1-dependent antiviral protein response","volume":"142","author":"Lei","year":"2022","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.it.2024.08.007_bb0215","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/nn.3144","article-title":"Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology","volume":"15","author":"Chiu","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.it.2024.08.007_bb0220","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.cell.2019.06.022","article-title":"Cutaneous TRPV1(+) neurons trigger protective innate type 17 anticipatory immunity","volume":"178","author":"Cohen","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.it.2024.08.007_bb0225","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/s41587-020-0673-2","article-title":"Epineural optogenetic activation of nociceptors initiates and amplifies inflammation","volume":"39","author":"Michoud","year":"2021","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.it.2024.08.007_bb0230","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nature13199","article-title":"Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation","volume":"510","author":"Riol-Blanco","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.it.2024.08.007_bb0235","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.jaci.2021.02.005","article-title":"Pituitary adenylate cyclase-activating polypeptide promotes cutaneous dendritic cell functions in contact hypersensitivity","volume":"148","author":"Yamamoto","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.it.2024.08.007_bb0240","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jdermsci.2021.10.001","article-title":"Type 2 immunity plays an essential role for murine model of allergic contact dermatitis with mixed type 1\/type 2 immune response","volume":"104","author":"Park","year":"2021","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.it.2024.08.007_bb0245","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1189\/jlb.1203626","article-title":"VIP\/PACAP oppositely affects immature and mature dendritic cell expression of CD80\/CD86 and the stimulatory activity for CD4(+) T cells","volume":"75","author":"Delgado","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.it.2024.08.007_bb0250","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1084\/jem.20122006","article-title":"IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cells","volume":"210","author":"Ben-Sasson","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.it.2024.08.007_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108381","article-title":"Inflammasomes within hyperactive murine dendritic cells stimulate long-lived T cell-mediated anti-tumor immunity","volume":"33","author":"Zhivaki","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.it.2024.08.007_bb0260","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1038\/s41467-021-22841-6","article-title":"Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection","volume":"12","author":"Filtjens","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2024.08.007_bb0265","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.cell.2020.11.028","article-title":"Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential","volume":"184","author":"Huang","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.it.2024.08.007_bb0270","doi-asserted-by":"crossref","first-page":"18","DOI":"10.15424\/bioelectronmed.2016.00001","article-title":"Neuronal circuits modulate antigen flow through lymph nodes","volume":"3","author":"Hanes","year":"2016","journal-title":"Bioelectron. Med."},{"key":"10.1016\/j.it.2024.08.007_bb0275","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1016\/j.cell.2024.04.027","article-title":"Innervation of nociceptor neurons in the spleen promotes germinal center responses and humoral immunity","volume":"187","author":"Wu","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.it.2024.08.007_bb0280","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s42234-024-00145-6","article-title":"TRPV1 nociceptors are required to optimize antigen-specific primary antibody responses to novel antigens","volume":"10","author":"Tynan","year":"2024","journal-title":"Bioelectron. Med."},{"key":"10.1016\/j.it.2024.08.007_bb0285","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/nn.3289","article-title":"A subpopulation of nociceptors specifically linked to itch","volume":"16","author":"Han","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.it.2024.08.007_bb0290","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature23469","article-title":"Neuronal regulation of type 2 innate lymphoid cells via neuromedin U","volume":"549","author":"Cardoso","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.it.2024.08.007_bb0295","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nature23676","article-title":"The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation","volume":"549","author":"Klose","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.it.2024.08.007_bb0300","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/nature24029","article-title":"The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation","volume":"549","author":"Wallrapp","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.it.2024.08.007_bb0305","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/s41385-022-00543-6","article-title":"Neuromedin U promotes human type 2 immune responses","volume":"15","author":"Ye","year":"2022","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.it.2024.08.007_bb0310","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/s41586-022-05297-6","article-title":"Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces","volume":"611","author":"Tsou","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.it.2024.08.007_bb0315","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20201637","article-title":"A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment","volume":"218","author":"Balestrini","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.it.2024.08.007_bb0320","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuron.2015.06.007","article-title":"Silencing nociceptor neurons reduces allergic airway inflammation","volume":"87","author":"Talbot","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.it.2024.08.007_bb0325","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.148510","article-title":"Nociceptor neurons promote IgE class switch in B cells","volume":"6","author":"Mathur","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.it.2024.08.007_bb0330","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1016\/j.jaci.2020.12.644","article-title":"FcepsilonR1-expressing nociceptors trigger allergic airway inflammation","volume":"147","author":"Crosson","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.it.2024.08.007_bb0335","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1038\/s41590-019-0493-z","article-title":"House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation","volume":"20","author":"Serhan","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2024.08.007_bb0340","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.neuron.2019.01.012","article-title":"A mast-cell-specific receptor mediates neurogenic inflammation and pain","volume":"101","author":"Green","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.it.2024.08.007_bb0345","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.immuni.2020.10.001","article-title":"Substance P release by sensory neurons triggers dendritic cell migration and initiates the Type-2 immune response to allergens","volume":"53","author":"Perner","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.it.2024.08.007_bb0350","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0304-3940(90)90450-N","article-title":"Histamine acts directly on calcitonin gene-related peptide- and substance P-containing trigeminal ganglion neurons as assessed by calcium influx and immunocytochemistry","volume":"115","author":"Tani","year":"1990","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.it.2024.08.007_bb0355","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.immuni.2019.03.013","article-title":"Activation of mast-cell-expressed Mas-related G-protein-coupled receptors drives non-histaminergic itch","volume":"50","author":"Meixiong","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.it.2024.08.007_bb0360","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.cell.2020.12.033","article-title":"A basophil-neuronal axis promotes itch","volume":"184","author":"Wang","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.it.2024.08.007_bb0365","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adi5578","article-title":"Recurrent infections drive persistent bladder dysfunction and pain via sensory nerve sprouting and mast cell activity","volume":"9","author":"Hayes","year":"2024","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.it.2024.08.007_bb0370","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1016\/j.cell.2021.03.002","article-title":"Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis","volume":"184","author":"Zhang","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.it.2024.08.007_bb0375","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/imcb.12253","article-title":"The role of Langerhans cells in pathologies of the skin","volume":"97","author":"Rajesh","year":"2019","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.it.2024.08.007_bb0380","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.123947","article-title":"Cutaneous immune responses mediated by dendritic cells and mast cells","volume":"4","author":"Sumpter","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.it.2024.08.007_bb0385","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s41593-023-01561-8","article-title":"Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen","volume":"27","author":"Zhu","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.it.2024.08.007_bb0390","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1161\/ATVBAHA.110.207449","article-title":"Prostaglandins and inflammation","volume":"31","author":"Ricciotti","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.it.2024.08.007_bb0395","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.it.2017.12.003","article-title":"Immune cytokines and their receptors in inflammatory pain","volume":"39","author":"Cook","year":"2018","journal-title":"Trends Immunol."},{"key":"10.1016\/j.it.2024.08.007_bb0400","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.immuni.2020.06.023","article-title":"The cytokine TGF-beta induces interleukin-31 expression from dermal dendritic cells to activate sensory neurons and stimulate wound itching","volume":"53","author":"Xu","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.it.2024.08.007_bb0405","article-title":"Skin-resident dendritic cells mediate postoperative pain via CCR4 on sensory neurons","volume":"119","author":"Silva","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2024.08.007_bb0410","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1038\/s41467-024-47640-7","article-title":"CXCL5 activates CXCR2 in nociceptive sensory neurons to drive joint pain and inflammation in experimental gouty arthritis","volume":"15","author":"Yin","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2024.08.007_bb0415","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2023.1144614","article-title":"Peripheral CCL2 induces inflammatory pain via regulation of I(h) currents in small diameter DRG neurons","volume":"16","author":"Li","year":"2023","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.it.2024.08.007_bb0420","doi-asserted-by":"crossref","DOI":"10.1177\/17448069241252384","article-title":"The regulation of the PD-1\/PD-L1 pathway in imiquimod-induced chronic psoriasis itch and itch sensitization in mouse","volume":"20","author":"Xu","year":"2024","journal-title":"Mol. Pain"},{"key":"10.1016\/j.it.2024.08.007_bb0425","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nn.4571","article-title":"PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1","volume":"20","author":"Chen","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.it.2024.08.007_bb0430","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1097\/j.pain.0000000000001921","article-title":"Interleukin-10 resolves pain hypersensitivity induced by cisplatin by reversing sensory neuron hyperexcitability","volume":"161","author":"Laumet","year":"2020","journal-title":"Pain"},{"key":"10.1016\/j.it.2024.08.007_bb0435","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bbi.2023.12.013","article-title":"Interleukin-10 signaling in somatosensory neurons controls CCL2 release and inflammatory response","volume":"116","author":"de Souza","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.it.2024.08.007_bb0440","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/S1474-4422(14)70102-4","article-title":"Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms","volume":"13","author":"Jensen","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.it.2024.08.007_bb0445","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nn.3881","article-title":"Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing","volume":"18","author":"Usoskin","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.it.2024.08.007_bb0450","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1038\/s41467-017-01841-5","article-title":"Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma","volume":"8","author":"Simeoli","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2024.08.007_bb0455","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2102034118","article-title":"HMGB1 released from nociceptors mediates inflammation","volume":"118","author":"Yang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2024.08.007_bb0460","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature12479","article-title":"Bacteria activate sensory neurons that modulate pain and inflammation","volume":"501","author":"Chiu","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.it.2024.08.007_bb0465","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1016\/j.celrep.2017.06.002","article-title":"Nociceptors boost the resolution of fungal osteoinflammation via the TRP channel-CGRP-Jdp2 axis","volume":"19","author":"Maruyama","year":"2017","journal-title":"Cell Rep."}],"container-title":["Trends in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471490624001935?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471490624001935?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T00:14:47Z","timestamp":1730506487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471490624001935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":93,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S1471490624001935"],"URL":"https:\/\/doi.org\/10.1016\/j.it.2024.08.007","relation":{},"ISSN":["1471-4906"],"issn-type":[{"value":"1471-4906","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Setting the tone: nociceptors as conductors of immune responses","name":"articletitle","label":"Article Title"},{"value":"Trends in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.it.2024.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}