{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T17:31:04Z","timestamp":1785259864944,"version":"3.55.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["390874280"],"award-info":[{"award-number":["390874280"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Immunology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.it.2025.02.013","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T01:38:56Z","timestamp":1742261936000},"page":"284-294","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Using structure-function information from IFN-\u03b3-binding proteins and biased agonists to uncouple immunostimulatory and immunosuppressive activities"],"prefix":"10.1016","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1111-2027","authenticated-orcid":false,"given":"Lucas","family":"Mendes-Monteiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6395-4010","authenticated-orcid":false,"given":"Abel","family":"Viejo-Borbolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.it.2025.02.013_bb0005","doi-asserted-by":"crossref","first-page":"8355","DOI":"10.1038\/s41467-024-52689-5","article-title":"SARS-CoV-2 spike-specific nasal-resident CD49a+CD8+ memory T cells exert immediate effector functions with enhanced IFN-gamma production","volume":"15","author":"Rha","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2025.02.013_bb0010","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-77969-4","article-title":"IFN-gamma derived from activated human CD4+ T cells inhibits the replication of SARS-CoV-2 depending on cell-type and viral strain","volume":"14","author":"Shimizu","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.it.2025.02.013_bb0015","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00430-024-00808-w","article-title":"MPXV infection impairs IFN response but is partially sensitive to IFN-gamma antiviral effect","volume":"213","author":"Bordi","year":"2024","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.it.2025.02.013_bb0020","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1126\/science.149.3681.310","article-title":"Interferon-like virus-inhibitor induced in human leukocytes by phytohemagglutinin","volume":"149","author":"Wheelock","year":"1965","journal-title":"Science"},{"key":"10.1016\/j.it.2025.02.013_bb0025","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1051673","article-title":"Pathogen spectrum and immunotherapy in patients with anti-IFN-gamma autoantibodies: A multicenter retrospective study and systematic review","volume":"13","author":"Qiu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.it.2025.02.013_bb0030","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1186\/s12879-024-10217-2","article-title":"Multiple pathogen infections accompanied with ocular pathologies in a patient with high-titer anti-IFN-gamma autoantibodies: a case report","volume":"24","author":"Wu","year":"2024","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.it.2025.02.013_bb0035","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.67","article-title":"Interferon-gamma derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity","volume":"8","author":"Bhat","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.it.2025.02.013_bb0040","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.7618088","article-title":"Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in TH1 cells","volume":"269","author":"Pernis","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.it.2025.02.013_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104037","article-title":"Interferon-gamma inhibits influenza A virus cellular attachment by reducing sialic acid cluster size","volume":"25","author":"Fong","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.it.2025.02.013_bb0050","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1128\/JVI.78.5.2591-2596.2004","article-title":"Inflammatory cytokines inhibit Kaposi\u2019s sarcoma-associated herpesvirus lytic gene transcription in in vitro-infected endothelial cells","volume":"78","author":"Milligan","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.it.2025.02.013_bb0055","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.coi.2020.04.008","article-title":"Virus-encoded cytokine and chemokine decoy receptors","volume":"66","author":"Hernaez","year":"2020","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.it.2025.02.013_bb0060","doi-asserted-by":"crossref","first-page":"5318","DOI":"10.1038\/s41467-024-49657-4","article-title":"Viral modulation of type II interferon increases T cell adhesion and virus spread","volume":"15","author":"Jacobsen","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2025.02.013_bb0065","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1515\/bmc-2018-0007","article-title":"Interferon-gamma (IFN-gamma): exploring its implications in infectious diseases","volume":"9","author":"Kak","year":"2018","journal-title":"Biomol. Concepts"},{"key":"10.1016\/j.it.2025.02.013_bb0070","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41586-019-0988-7","article-title":"Structure of the IFNgamma receptor complex guides design of biased agonists","volume":"567","author":"Mendoza","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.it.2025.02.013_bb0075","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41590-023-01420-5","article-title":"IFNgamma binding to extracellular matrix prevents fatal systemic toxicity","volume":"24","author":"Kemna","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2025.02.013_bb0080","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.2353\/ajpath.2010.090855","article-title":"Antigen-specific CD25\u2212 Foxp3\u2212 IFN-gammahigh CD4+ T cells restrain the development of experimental allergic encephalomyelitis by suppressing Th17","volume":"176","author":"Wildbaum","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.it.2025.02.013_bb0085","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2412120121","article-title":"Augmenting antitumor efficacy of Th17-derived Th1 cells through IFN-gamma-induced type I interferon response network via IRF7","volume":"121","author":"Lei","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2025.02.013_bb0090","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.ado4856","article-title":"IFN-gamma-producing TH1 cells and dysfunctional regulatory T cells contribute to the pathogenesis of Sjogren\u2019s disease","volume":"16","author":"Wang","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.it.2025.02.013_bb0095","doi-asserted-by":"crossref","first-page":"6118","DOI":"10.1158\/1078-0432.CCR-11-0482","article-title":"The two faces of interferon-gamma in cancer","volume":"17","author":"Zaidi","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.it.2025.02.013_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019105","article-title":"Interferon gamma activated macrophages kill mycobacteria by nitric oxide induced apoptosis","volume":"6","author":"Herbst","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.it.2025.02.013_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.cytox.2021.100057","article-title":"Interferon-gamma impairs phagocytosis of Escherichia coli by primary murine peritoneal macrophages stimulated with LPS and differentially modulates proinflammatory cytokine release","volume":"3","author":"Schutze","year":"2021","journal-title":"Cytokine X"},{"key":"10.1016\/j.it.2025.02.013_bb0110","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1038\/s41467-018-04717-4","article-title":"C-terminal truncation of IFN-gamma inhibits proinflammatory macrophage responses and is deficient in autoimmune disease","volume":"9","author":"Dufour","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2025.02.013_bb0115","doi-asserted-by":"crossref","first-page":"20918","DOI":"10.1073\/pnas.0911509106","article-title":"Acute in vivo exposure to interferon-gamma enables resident brain dendritic cells to become effective antigen presenting cells","volume":"106","author":"Gottfried-Blackmore","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.it.2025.02.013_bb0120","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3390\/ijms19010089","article-title":"The dark side of IFN-gamma: its role in promoting cancer immunoevasion","volume":"19","author":"Mojic","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.it.2025.02.013_bb0125","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1749-6632.2009.05069.x","article-title":"Clinical use of interferon-gamma","volume":"1182","author":"Miller","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.it.2025.02.013_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2019.05.002","article-title":"IFN-gamma: a cytokine at the right time, is in the right place","volume":"43","author":"Burke","year":"2019","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.it.2025.02.013_bb0135","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/ni.3205","article-title":"Interferon-gamma regulates cellular metabolism and mRNA translation to potentiate macrophage activation","volume":"16","author":"Su","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2025.02.013_bb0140","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1084\/jem.192.7.977","article-title":"Interferon gamma signaling alters the function of T helper type 1 cells","volume":"192","author":"Tau","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.it.2025.02.013_bb0145","doi-asserted-by":"crossref","first-page":"6727","DOI":"10.1038\/s41467-023-42455-4","article-title":"Interferon-gamma couples CD8+ T cell avidity and differentiation during infection","volume":"14","author":"Uhl","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2025.02.013_bb0150","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1007\/s10875-022-01391-6","article-title":"Efficacy and safety of interferon-gamma in chronic granulomatous disease: a systematic review and meta-analysis","volume":"43","author":"Lugo Reyes","year":"2023","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.it.2025.02.013_bb0155","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jaut.2014.02.003","article-title":"IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice","volume":"53","author":"Hodge","year":"2014","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.it.2025.02.013_bb0160","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/hep.28641","article-title":"Chronic expression of interferon-gamma leads to murine autoimmune cholangitis with a female predominance","volume":"64","author":"Bae","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.it.2025.02.013_bb0165","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00134-021-06377-3","article-title":"Potential role for interferon gamma in the treatment of recurrent ventilator-acquired pneumonia in patients with COVID-19: a hypothesis","volume":"47","author":"Nguyen","year":"2021","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.it.2025.02.013_bb0170","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1185\/03007995.2014.899209","article-title":"A short 2 week dose titration regimen reduces the severity of flu-like symptoms with initial interferon gamma-1b treatment","volume":"30","author":"Devane","year":"2014","journal-title":"Curr. Med. Res. Opin."},{"key":"10.1016\/j.it.2025.02.013_bb0175","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/bs.aivir.2018.01.003","article-title":"How does vaccinia virus interfere with interferon?","volume":"100","author":"Smith","year":"2018","journal-title":"Adv. Virus Res."},{"key":"10.1016\/j.it.2025.02.013_bb0180","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1128\/jvi.69.8.4633-4639.1995","article-title":"Vaccinia, cowpox, and camelpox viruses encode soluble gamma interferon receptors with novel broad species specificity","volume":"69","author":"Alcami","year":"1995","journal-title":"J. Virol."},{"key":"10.1016\/j.it.2025.02.013_bb0185","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1074\/jbc.270.7.3031","article-title":"The myxoma virus-soluble interferon-gamma receptor homolog, M-T7, inhibits interferon-gamma in a species-specific manner","volume":"270","author":"Mossman","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.it.2025.02.013_bb0190","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1126\/science.1455233","article-title":"Encoding of a homolog of the IFN-gamma receptor by myxoma virus","volume":"258","author":"Upton","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.it.2025.02.013_bb0195","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.3390\/pharmaceutics12111003","article-title":"Recombinant myxoma virus-derived immune modulator M-T7 accelerates cutaneous wound healing and improves tissue remodeling","volume":"12","author":"Yaron","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.it.2025.02.013_bb0200","doi-asserted-by":"crossref","first-page":"588","DOI":"10.3390\/pathogens11050588","article-title":"Virus-derived chemokine modulating protein pre-treatment blocks chemokine-glycosaminoglycan interactions and significantly reduces transplant immune damage","volume":"11","author":"Zanetti","year":"2022","journal-title":"Pathogens"},{"key":"10.1016\/j.it.2025.02.013_bb0205","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1128\/jvi.71.6.4356-4363.1997","article-title":"The purified myxoma virus gamma interferon receptor homolog M-T7 interacts with the heparin-binding domains of chemokines","volume":"71","author":"Lalani","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.it.2025.02.013_bb0210","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1006\/viro.1995.1208","article-title":"Species specificity of ectromelia virus and vaccinia virus interferon-gamma binding proteins","volume":"208","author":"Mossman","year":"1995","journal-title":"Virology"},{"key":"10.1016\/j.it.2025.02.013_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006346","article-title":"Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration","volume":"13","author":"Gonzalez-Motos","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.it.2025.02.013_bb0220","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/JLB.2MR0220-549R","article-title":"ICAM-1: a master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis","volume":"108","author":"Bui","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.it.2025.02.013_bb0225","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/eji.201646769","article-title":"IL4-induced gene 1 is secreted at the immune synapse and modulates TCR activation independently of its enzymatic activity","volume":"48","author":"Aubatin","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.it.2025.02.013_bb0230","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1038\/s41598-018-21344-7","article-title":"IL-2 inducible kinase ITK is critical for HIV-1 infection of Jurkat T-cells","volume":"8","author":"Hain","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.it.2025.02.013_bb0235","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrmicro3215","article-title":"Molecular mechanisms of varicella zoster virus pathogenesis","volume":"12","author":"Zerboni","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.it.2025.02.013_bb0240","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1128\/JVI.79.5.2651-2658.2005","article-title":"Varicella-zoster virus pathogenesis and immunobiology: new concepts emerging from investigations with the SCIDhu mouse model","volume":"79","author":"Ku","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.it.2025.02.013_bb0245","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1084\/jem.20040634","article-title":"Varicella-zoster virus transfer to skin by T cells and modulation of viral replication by epidermal cell interferon-alpha","volume":"200","author":"Ku","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.it.2025.02.013_bb0250","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.celrep.2014.06.024","article-title":"Single-cell mass cytometry analysis of human tonsil T cell remodeling by varicella zoster virus","volume":"8","author":"Sen","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.it.2025.02.013_bb0255","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-004400","article-title":"PD-L1 blockade restores CAR T cell activity through IFN-gamma-regulation of CD163+ M2 macrophages","volume":"10","author":"Yamaguchi","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.it.2025.02.013_bb0260","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20221721","article-title":"PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I IFN pathway","volume":"221","author":"Hodgins","year":"2024","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.it.2025.02.013_bb0265","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/s41586-021-03861-0","article-title":"An engineered IL-2 partial agonist promotes CD8+ T cell stemness","volume":"597","author":"Mo","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.it.2025.02.013_bb0270","doi-asserted-by":"crossref","DOI":"10.1126\/science.abc8433","article-title":"Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10","volume":"371","author":"Saxton","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.it.2025.02.013_bb0275","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/s41586-023-06415-8","article-title":"De novo design of protein structure and function with RFdiffusion","volume":"620","author":"Watson","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.it.2025.02.013_bb0280","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1038\/s41467-023-38328-5","article-title":"Improving de novo protein binder design with deep learning","volume":"14","author":"Bennett","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.it.2025.02.013_bb0285","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41586-022-04654-9","article-title":"Design of protein-binding proteins from the target structure alone","volume":"605","author":"Cao","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.it.2025.02.013_bb0290","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41586-023-06953-1","article-title":"De novo design of high-affinity binders of bioactive helical peptides","volume":"626","author":"Vazquez Torres","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.it.2025.02.013_bb0295","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/ni.2449","article-title":"Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15","volume":"13","author":"Ring","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2025.02.013_bb0300","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/s41586-018-0830-7","article-title":"De novo design of potent and selective mimics of IL-2 and IL-15","volume":"565","author":"Silva","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.it.2025.02.013_bb0305","doi-asserted-by":"crossref","first-page":"13925","DOI":"10.1074\/jbc.R116.774745","article-title":"Current prospects of type II interferon gamma signaling and autoimmunity","volume":"292","author":"Green","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.it.2025.02.013_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107464","article-title":"Designing monomeric IFNgamma: the significance of domain-swapped dimer structure in IFNgamma immune responses","volume":"300","author":"Goto","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.it.2025.02.013_bb0315","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nri1604","article-title":"Mechanisms of type-I- and type-II-interferon-mediated signalling","volume":"5","author":"Platanias","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.it.2025.02.013_bb0320","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.3389\/fimmu.2019.01425","article-title":"An NFkappaB activity calculator to delineate signaling crosstalk: type I and II interferons enhance NFkappaB via distinct mechanisms","volume":"10","author":"Mitchell","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.it.2025.02.013_bb0325","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.4049\/jimmunol.180.7.4523","article-title":"Selective roles of MAPKs during the macrophage response to IFN-gamma","volume":"180","author":"Valledor","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.it.2025.02.013_bb0330","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1096\/fj.08-106831","article-title":"Suppressor of cytokine signaling 1 inhibits IFN-gamma inflammatory signaling in human keratinocytes by sustaining ERK1\/2 activation","volume":"22","author":"Madonna","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.it.2025.02.013_bb0335","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/jmcb\/mjw042","article-title":"SENP1 regulates IFN-gamma-STAT1 signaling through STAT3-SOCS3 negative feedback loop","volume":"9","author":"Yu","year":"2017","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.it.2025.02.013_bb0340","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.3389\/fimmu.2017.01139","article-title":"Deciphering of the human interferon-regulated proteome by mass spectrometry-based quantitative analysis reveals extent and dynamics of protein induction and repression","volume":"8","author":"Megger","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.it.2025.02.013_bb0345","doi-asserted-by":"crossref","first-page":"10316","DOI":"10.1073\/pnas.1119273109","article-title":"An IFN-gamma-stimulated ATF6-C\/EBP-beta-signaling pathway critical for the expression of death associated protein kinase 1 and induction of autophagy","volume":"109","author":"Gade","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Trends in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471490625000560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471490625000560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T20:19:04Z","timestamp":1762546744000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471490625000560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S1471490625000560"],"URL":"https:\/\/doi.org\/10.1016\/j.it.2025.02.013","relation":{},"ISSN":["1471-4906"],"issn-type":[{"value":"1471-4906","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Using structure-function information from IFN-\u03b3-binding proteins and biased agonists to uncouple immunostimulatory and immunosuppressive activities","name":"articletitle","label":"Article Title"},{"value":"Trends in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.it.2025.02.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}