{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T16:31:43Z","timestamp":1755793903509,"version":"3.44.0"},"reference-count":11,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["bmn.com","cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Trends in Immunology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.it.2025.07.006","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T14:42:19Z","timestamp":1752849739000},"page":"554-555","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primed to be primed: a new, second phase"],"prefix":"10.1016","volume":"46","author":[{"given":"Benjamin M.","family":"Kahn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0410-4037","authenticated-orcid":false,"given":"Ben Z.","family":"Stanger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.it.2025.07.006_bb0005","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1146\/annurev-immunol-030409-101308","article-title":"Functional anatomy of T cell activation and synapse formation","volume":"28","author":"Fooksman","year":"2010","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.it.2025.07.006_bb0010","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.4049\/jimmunol.162.6.3256","article-title":"Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells","volume":"162","author":"Curtsinger","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.it.2025.07.006_bb0015","doi-asserted-by":"crossref","DOI":"10.1126\/science.adq1405","article-title":"A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals","volume":"388","author":"Jobin","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.it.2025.07.006_bb0020","doi-asserted-by":"crossref","first-page":"7445","DOI":"10.4049\/jimmunol.181.11.7445","article-title":"Cutting edge: CD4+ T cell-derived IL-2 is essential for help-dependent primary CD8+ T cell responses","volume":"181","author":"Wilson","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.it.2025.07.006_bb0025","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.4049\/jimmunol.1101649","article-title":"Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction","volume":"187","author":"Kastenmuller","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.it.2025.07.006_bb0030","doi-asserted-by":"crossref","first-page":"4936","DOI":"10.4049\/jimmunol.1000173","article-title":"Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function","volume":"184","author":"Schmid","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.it.2025.07.006_bb0035","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.4049\/jimmunol.162.9.5212","article-title":"Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity","volume":"162","author":"Gudmundsdottir","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.it.2025.07.006_bb0040","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nri778","article-title":"Effector and memory T-cell differentiation: implications for vaccine development","volume":"2","author":"Kaech","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.it.2025.07.006_bb0045","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1056\/NEJM198512053132327","article-title":"Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer","volume":"313","author":"Rosenberg","year":"1985","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.it.2025.07.006_bb0050","doi-asserted-by":"crossref","DOI":"10.1158\/2159-8290.CD-24-1847","article-title":"Intrinsic properties of the lymph node render it immunologically susceptible to metastasis","author":"Kahn","year":"2025","journal-title":"Cancer Discov."},{"key":"10.1016\/j.it.2025.07.006_bb0055","doi-asserted-by":"crossref","DOI":"10.1126\/science.adk3248","article-title":"Regulatory T cells constrain T cells of shared specificity to enforce tolerance during infection","volume":"387","author":"Klawon","year":"2025","journal-title":"Science"}],"container-title":["Trends in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471490625001735?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1471490625001735?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T07:16:53Z","timestamp":1755242213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1471490625001735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S1471490625001735"],"URL":"https:\/\/doi.org\/10.1016\/j.it.2025.07.006","relation":{},"ISSN":["1471-4906"],"issn-type":[{"type":"print","value":"1471-4906"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Primed to be primed: a new, second phase","name":"articletitle","label":"Article Title"},{"value":"Trends in Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.it.2025.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}