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Immunol."},{"key":"10.1016\/j.it.2026.02.005_bb0350","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1016\/j.immuni.2024.11.004","article-title":"Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis","volume":"57","author":"MacDonald","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.it.2026.02.005_bb0355","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0140-6736(92)90399-N","article-title":"Detection of Chlamydia trachomatis DNA in joints of reactive arthritis patients by polymerase chain reaction","volume":"340","author":"Taylor-Robinson","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.it.2026.02.005_bb0360","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/1529-0131(200003)43:3<593::AID-ANR16>3.0.CO;2-1","article-title":"Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritides","volume":"43","author":"van der Heijden","year":"2000","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.it.2026.02.005_bb0365","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1093\/rheumatology\/40.8.920","article-title":"Bacterial DNA in synovial fluid cells of patients with juvenile onset spondyloarthropathies","volume":"40","author":"Pacheco-Tena","year":"2001","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.it.2026.02.005_bb0370","doi-asserted-by":"crossref","first-page":"20526","DOI":"10.1038\/s41598-022-24872-5","article-title":"The causal relationship between psoriasis, psoriatic arthritis, and inflammatory bowel diseases","volume":"12","author":"Sun","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.it.2026.02.005_bb0375","doi-asserted-by":"crossref","DOI":"10.1038\/cti.2016.17","article-title":"Regulation of immune cell function by short-chain fatty acids","volume":"5","author":"Corr\u00eaa-Oliveira","year":"2016","journal-title":"Clin. Transl. Immunol."},{"key":"10.1016\/j.it.2026.02.005_bb0380","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/nrrheum.2016.85","article-title":"How the microbiota shapes rheumatic diseases","volume":"12","author":"Van de Wiele","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.it.2026.02.005_bb0385","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/s41579-025-01211-9","article-title":"The human skin microbiome: from metagenomes to therapeutics","volume":"23","author":"Oh","year":"2025","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.it.2026.02.005_bb0390","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/path.1954","article-title":"Peptidoglycan and peptidoglycan-specific Th1 cells in psoriatic skin lesions","volume":"209","author":"Baker","year":"2006","journal-title":"J. Pathol."},{"key":"10.1016\/j.it.2026.02.005_bb0395","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/MOG.0b013e328333d751","article-title":"Obesity and the human microbiome","volume":"26","author":"Ley","year":"2010","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.it.2026.02.005_bb0400","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0173032","article-title":"The dual role of short fatty acid chains in the pathogenesis of autoimmune disease models","volume":"12","author":"Mizuno","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.it.2026.02.005_bb0405","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1136\/ard.2005.050963","article-title":"Detailed analysis of the cell infiltrate and the expression of mediators of synovial inflammation and joint destruction in the synovium of patients with psoriatic arthritis: implications for treatment","volume":"65","author":"van Kuijk","year":"2006","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.it.2026.02.005_bb0410","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s11926-011-0181-y","article-title":"Synovitis in psoriatic arthritis: immunohistochemistry, comparisons with rheumatoid arthritis, and effects of therapy","volume":"13","author":"van Kuijk","year":"2011","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.it.2026.02.005_bb0415","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/s13075-019-2088-3","article-title":"Enhanced angiogenic function in response to fibroblasts from psoriatic arthritis synovium compared to rheumatoid arthritis","volume":"21","author":"Fromm","year":"2019","journal-title":"Arthritis Res. 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Dis."},{"key":"10.1016\/j.it.2026.02.005_bb0440","article-title":"Clinical significance of gut microbiota community types for long-term response to fecal microbiota transplantation in patients with psoriatic arthritis","author":"Qin","year":"2025","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.it.2026.02.005_bb0445","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-019231","article-title":"Efficacy and safety of faecal microbiota transplantation in patients with psoriatic arthritis: protocol for a 6-month, double-blind, randomised, placebo-controlled trial","volume":"8","author":"Kragsnaes","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.it.2026.02.005_bb0450","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1134\/S1607672925700140","article-title":"The efficacy and safety of BCD-180, an anti-TRBV9+ T cell monoclonal antibody, in patients with active radiographic axial spondyloarthritis: 36-week results from the randomized, double-blind, placebo-controlled phase 2 clinical study ELEFTA","volume":"522","author":"Nasonov","year":"2025","journal-title":"Dokl. Biochem. Biophys."},{"key":"10.1016\/j.it.2026.02.005_bb0455","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1056\/NEJMoa1905725","article-title":"Vedolizumab versus adalimumab for moderate-to-severe ulcerative colitis","volume":"381","author":"Sands","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.it.2026.02.005_bb0460","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1136\/annrheumdis-2021-221664","article-title":"Efficacy and safety of selective TYK2 inhibitor, deucravacitinib, in a phase II trial in psoriatic arthritis","volume":"81","author":"Mease","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.it.2026.02.005_bb0465","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.ard.2025.04.018","article-title":"CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in spondyloarthritis synovial tissue","volume":"84","author":"Liu","year":"2025","journal-title":"Ann. Rheum. 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Rev. Rheumatol."},{"key":"10.1016\/j.it.2026.02.005_bb0510","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/s41590-024-01774-4","article-title":"CD200+ fibroblasts form a pro-resolving mesenchymal network in arthritis","volume":"25","author":"Rauber","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.it.2026.02.005_bb0515","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1136\/annrheumdis-2016-209709","volume":"76","author":"Mease","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.it.2026.02.005_bb0520","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0140-6736(22)02302-9","article-title":"Bimekizumab in patients with psoriatic arthritis, naive to biologic treatment: a randomised, double-blind, placebo-controlled, phase 3 trial (BE OPTIMAL)","volume":"401","author":"McInnes","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.it.2026.02.005_bb0525","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0140-6736(20)30265-8","article-title":"Guselkumab in patients with active psoriatic arthritis who were biologic-naive or had previously received TNF\u03b1 inhibitor treatment (DISCOVER-1): a double-blind, randomised, placebo-controlled phase 3 trial","volume":"395","author":"Deodhar","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.it.2026.02.005_bb0530","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/S0140-6736(13)60594-2","article-title":"Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial","volume":"382","author":"McInnes","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.it.2026.02.005_bb0535","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1136\/annrheumdis-2021-221422","article-title":"No efficacy of anti-IL-23 therapy for axial spondyloarthritis in randomised controlled trials but in post-hoc analyses of psoriatic arthritis-related \u2018physician-reported spondylitis\u2019?","volume":"81","author":"Braun","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.it.2026.02.005_bb0540","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.immuni.2015.08.019","article-title":"Differential roles for interleukin-23 and interleukin-17 in intestinal immunoregulation","volume":"43","author":"Maxwell","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.it.2026.02.005_bb0545","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/ng.3528","article-title":"Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci","volume":"48","author":"Ellinghaus","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.it.2026.02.005_bb0550","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000011185","article-title":"Association between psoriasis and vitamin D: duration of disease correlates with decreased vitamin D serum levels: an observational case-control study","volume":"97","author":"Filoni","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.it.2026.02.005_bb0555","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.3945\/jn.113.180794","article-title":"Vitamin D regulates the gut microbiome and protects mice from dextran sodium sulfate-induced colitis","volume":"143","author":"Ooi","year":"2013","journal-title":"J. Nutr."},{"key":"10.1016\/j.it.2026.02.005_bb0560","doi-asserted-by":"crossref","first-page":"G208","DOI":"10.1152\/ajpgi.00398.2007","article-title":"Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier","volume":"294","author":"Kong","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.it.2026.02.005_bb0565","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1172\/JCI65842","article-title":"Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis","volume":"123","author":"Liu","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.it.2026.02.005_bb0570","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1080\/15548627.2015.1072670","article-title":"VDR\/vitamin D receptor regulates autophagic activity through ATG16L1","volume":"12","author":"Sun","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.it.2026.02.005_bb0575","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1177\/1535370214523890","article-title":"Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease","volume":"239","author":"Cantorna","year":"2014","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.it.2026.02.005_bb0580","doi-asserted-by":"crossref","first-page":"S210","DOI":"10.1038\/d41586-020-03524-6","article-title":"The skin microbiome and its relationship with the human body explained","volume":"588","author":"Eisenstein","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.it.2026.02.005_bb0585","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1016\/j.cell.2023.03.011","article-title":"Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment","volume":"186","author":"Bender","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.it.2026.02.005_bb0590","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.immuni.2016.09.008","article-title":"Bile acids control inflammation and metabolic disorder through inhibition of NLRP3 inflammasome","volume":"45","author":"Guo","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.it.2026.02.005_bb0595","article-title":"Vitamin D decreases plasma trimethylamine-N-oxide level in mice by regulating gut microbiota","volume":"2020","author":"Wang","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.it.2026.02.005_bb0600","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1002\/art.20518","article-title":"Reduction of synovial sublining layer inflammation and proinflammatory cytokine expression in psoriatic arthritis treated with methotrexate","volume":"50","author":"Kane","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.it.2026.02.005_bb0605","doi-asserted-by":"crossref","first-page":"R326","DOI":"10.1186\/ar1182","article-title":"Deactivation of endothelium and reduction in angiogenesis in psoriatic skin and synovium by low dose infliximab therapy in combination with stable methotrexate therapy: a prospective single-centre study","volume":"6","author":"Goedkoop","year":"2004","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.it.2026.02.005_bb0610","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/art.21914","article-title":"Identification of synovial biomarkers of response to experimental treatment in early-phase clinical trials in spondylarthritis","volume":"54","author":"Kruithof","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.it.2026.02.005_bb0615","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1136\/ard.2008.091389","article-title":"A prospective, randomised, placebo-controlled study to identify biomarkers associated with active treatment in psoriatic arthritis: effects of Adalimumab treatment on synovial tissue","volume":"68","author":"van Kuijk","year":"2009","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.it.2026.02.005_bb0620","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1136\/annrheumdis-2014-206323","article-title":"Type 3 innate lymphoid cells producing IL-17 and IL-22 are expanded in the gut, in the peripheral blood, synovial fluid and bone marrow of patients with ankylosing spondylitis","volume":"74","author":"Ciccia","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.it.2026.02.005_bb0625","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1084\/jem.20070906","article-title":"Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases","volume":"205","author":"Armaka","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.it.2026.02.005_bb0630","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1136\/ard-2024-226284","article-title":"Shared lung and joint T cell repertoire in early rheumatoid arthritis driven by cigarette smoking","volume":"84","author":"Venken","year":"2024","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.it.2026.02.005_bb0635","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/s41586-022-05501-7","article-title":"Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides","volume":"612","author":"Yang","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.it.2026.02.005_bb0640","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1136\/ard-2022-222852","article-title":"EULAR study group on \u2018MHC-I-opathy\u2019: identifying disease-overarching mechanisms across disciplines and borders","volume":"82","author":"Kuiper","year":"2023","journal-title":"Ann. Rheum. 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