{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:55:44Z","timestamp":1791093344562,"version":"4.1.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American Academy of Child &amp; Adolescent Psychiatry"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.jaac.2010.07.001","type":"journal-article","created":{"date-parts":[[2011,1,19]],"date-time":"2011-01-19T10:13:41Z","timestamp":1295432021000},"page":"921-933","source":"Crossref","is-referenced-by-count":144,"title":["Autism in Fragile X Syndrome: A Category Mistake?"],"prefix":"10.1016","volume":"49","author":[{"given":"Scott S.","family":"Hall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy A.","family":"Lightbody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Hirt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ava","family":"Rezvani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan L.","family":"Reiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaac.2010.07.001_bib1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/CHI.0b013e318195bd15","article-title":"Physiological correlates of social avoidance behavior in children and adolescents with fragile X syndrome","volume":"48","author":"Hall","year":"2009","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.jaac.2010.07.001_bib2","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/j.1469-7610.1989.tb00286.x","article-title":"Parent-child dyadic gaze patterns in fragile X males and in non-fragile X males with autistic disorder","volume":"30","author":"Cohen","year":"1989","journal-title":"J Child Psychol Psychiatry"},{"key":"10.1016\/j.jaac.2010.07.001_bib3","first-page":"431","article-title":"Conversational analyses of males with fragile X, Down syndrome, and autism: comparison of the emergence of deviant language","volume":"94","author":"Sudhalter","year":"1990","journal-title":"Am J Ment Retard"},{"key":"10.1016\/j.jaac.2010.07.001_bib4","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1023\/A:1010747131386","article-title":"Autistic behavior, FMR1 protein, and developmental trajectories in young males with fragile X syndrome","volume":"31","author":"Bailey","year":"2001","journal-title":"J Autism Dev Disord"},{"key":"10.1016\/j.jaac.2010.07.001_bib5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/BF01531375","article-title":"Autism is associated with the fragile-X syndrome","volume":"12","author":"Brown","year":"1982","journal-title":"J Autism Dev Disord"},{"key":"10.1016\/j.jaac.2010.07.001_bib6","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1469-7610.2008.01988.x","article-title":"Behavioural and cognitive phenotypes in idiopathic autism versus autism associated with fragile X syndrome","volume":"50","author":"Dissanayake","year":"2009","journal-title":"J Child Psychol Psychiatry"},{"key":"10.1016\/j.jaac.2010.07.001_bib7","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/ajmg.1320230128","article-title":"An analysis of autism in fifty males with the fragile X syndrome","volume":"23","author":"Hagerman","year":"1986","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jaac.2010.07.001_bib8","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1002\/ajmg.a.31286","article-title":"Autistic behavior in children with fragile X syndrome: prevalence, stability, and the impact of FMRP","volume":"140A","author":"Hatton","year":"2006","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jaac.2010.07.001_bib9","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1352\/0895-8017(2004)109<208:LACFAA>2.0.CO;2","article-title":"Linguistic and cognitive functioning and autism symptoms in young children with fragile X syndrome","volume":"109","author":"Philofsky","year":"2004","journal-title":"Am J Ment Retard"},{"key":"10.1016\/j.jaac.2010.07.001_bib10","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/ajmg.a.32848","article-title":"Autism spectrum disorder in fragile X syndrome: a longitudinal evaluation","volume":"149A","author":"Hernandez","year":"2009","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jaac.2010.07.001_bib11","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/ajmg.a.30229","article-title":"Autism spectrum disorder in fragile X syndrome: communication, social interaction, and specific behaviors","volume":"129A","author":"Kaufmann","year":"2004","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jaac.2010.07.001_bib12","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1002\/ajmg.a.31405","article-title":"Autism spectrum disorder in fragile X syndrome: differential contribution of adaptive socialization and social withdrawal","volume":"140A","author":"Budimirovic","year":"2006","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jaac.2010.07.001_bib13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/ajmg.a.20218","article-title":"Social behavior profile in young males with fragile X syndrome: characteristics and specificity","volume":"126A","author":"Kau","year":"2004","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jaac.2010.07.001_bib14","series-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"1994"},{"key":"10.1016\/j.jaac.2010.07.001_bib15","series-title":"Autism Diagnostic Interview\u2013Revised","author":"Rutter","year":"2003"},{"key":"10.1016\/j.jaac.2010.07.001_bib16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/BF02211841","article-title":"Autism diagnostic observation schedule: a standardized observation of communicative and social behavior","volume":"19","author":"Lord","year":"1989","journal-title":"J Autism Dev Disord"},{"key":"10.1016\/j.jaac.2010.07.001_bib17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/00004703-200112000-00008","article-title":"The behavioral phenotype in fragile X: symptoms of autism in very young children with fragile X syndrome, idiopathic autism, and other developmental disorders","volume":"22","author":"Rogers","year":"2001","journal-title":"J Dev Behav Pediatr"},{"key":"10.1016\/j.jaac.2010.07.001_bib18","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1007\/s10803-006-0205-z","article-title":"Autism spectrum phenotype in males and females with fragile X full mutation and premutation","volume":"37","author":"Clifford","year":"2007","journal-title":"J Autism Dev Disord"},{"key":"10.1016\/j.jaac.2010.07.001_bib19","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1352\/2008.113:427-438","article-title":"Autism profiles of males with fragile X syndrome","volume":"113","author":"Harris","year":"2008","journal-title":"Am J Ment Retard"},{"key":"10.1016\/j.jaac.2010.07.001_bib20","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0092-8674(91)90397-H","article-title":"Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome","volume":"65","author":"Verkerk","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.jaac.2010.07.001_bib21","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/nn1770","article-title":"Time to give up on a single explanation for autism","volume":"9","author":"Happe","year":"2006","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jaac.2010.07.001_bib22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/mrdd.10029","article-title":"The epidemiology of autistic spectrum disorders: is the prevalence rising?","volume":"8","author":"Wing","year":"2002","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"10.1016\/j.jaac.2010.07.001_bib23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1352\/2008.46:243-246","article-title":"Detrimental effects of overestimating the occurrence of autism","volume":"46","author":"Holburn","year":"2008","journal-title":"Intellect Dev Disabil"},{"key":"10.1016\/j.jaac.2010.07.001_bib24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1469-7610.2008.02046.x","article-title":"Childhood developmental disorders: an academic and clinical convergence point for psychiatry, neurology, psychology and pediatrics","volume":"50","author":"Reiss","year":"2009","journal-title":"J Child Psychol Psychiatry"},{"key":"10.1016\/j.jaac.2010.07.001_bib25","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1440-1754.2005.00634.x","article-title":"From complexity to category: responding to diagnostic uncertainties of autistic spectrum disorders","volume":"41","author":"Skellern","year":"2005","journal-title":"J Paediatr Child Health"},{"key":"10.1016\/j.jaac.2010.07.001_bib26","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/j.1365-2788.2009.01197.x","article-title":"Autism spectrum disorders in genetic syndromes: implications for diagnosis, intervention and understanding the wider autism spectrum disorder population","volume":"53","author":"Moss","year":"2009","journal-title":"J Intellect Disabil Res"},{"key":"10.1016\/j.jaac.2010.07.001_bib27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/ajmg.1320340211","article-title":"Autism is not associated with the fragile X syndrome","volume":"34","author":"Einfeld","year":"1989","journal-title":"Am J Med Genet"},{"issue":"1-2","key":"10.1016\/j.jaac.2010.07.001_bib28","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/ajmg.1320430107","article-title":"Is autism associated with the fragile X syndrome?","volume":"43","author":"Fisch","year":"1992","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jaac.2010.07.001_bib29","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/ajmg.1320480210","article-title":"What is associated with the fragile X syndrome?","volume":"48","author":"Fisch","year":"1993","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jaac.2010.07.001_bib30","first-page":"217","article-title":"Autistic disturbances of affective contact","volume":"2","author":"Kanner","year":"1943","journal-title":"Nervous Child"},{"key":"10.1016\/j.jaac.2010.07.001_bib31","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/ajmg.1320380271","article-title":"Effects of age and communication level on eye contact in fragile X males and non-fragile X autistic males","volume":"38","author":"Cohen","year":"1991","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jaac.2010.07.001_bib32","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1023\/A:1026048027397","article-title":"Autistic behavior in young boys with fragile X syndrome","volume":"28","author":"Bailey","year":"1998","journal-title":"J Autism Dev Disord"},{"key":"10.1016\/j.jaac.2010.07.001_bib33","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1023\/A:1022999712639","article-title":"Autism and phenylketonuria","volume":"33","author":"Baieli","year":"2003","journal-title":"J Autism Dev Disord"},{"key":"10.1016\/j.jaac.2010.07.001_bib34","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s10803-005-0010-0","article-title":"Brief report: autism in individuals with Down syndrome","volume":"35","author":"Starr","year":"2005","journal-title":"J Autism Dev Disord"},{"key":"10.1016\/j.jaac.2010.07.001_bib35","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/ajmg.a.31294","article-title":"The near universal presence of autism spectrum disorders in children with Smith-Lemli-Opitz syndrome","volume":"140","author":"Sikora","year":"2006","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jaac.2010.07.001_bib36","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1399-0004.2004.00362.x","article-title":"Autism in Angelman syndrome: implications for autism research","volume":"66","author":"Peters","year":"2004","journal-title":"Clin Genet"},{"key":"10.1016\/j.jaac.2010.07.001_bib37","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1017\/S0012162206000090","article-title":"Autism spectrum disorders and underlying brain pathology in CHARGE association","volume":"48","author":"Johansson","year":"2006","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.jaac.2010.07.001_bib38","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/ajmg.a.30545","article-title":"Autistic-like behavior in CHARGE syndrome","volume":"133A","author":"Hartshorne","year":"2005","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jaac.2010.07.001_bib39","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1080\/09297040601033680","article-title":"Socio-communicative deficits in young children with Williams syndrome: performance on the Autism Diagnostic Observation Schedule","volume":"13","author":"Klein-Tasman","year":"2007","journal-title":"Child Neuropsychol"},{"key":"10.1016\/j.jaac.2010.07.001_bib40","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1192\/bjp.175.5.444","article-title":"Autism screening questionnaire: diagnostic validity","volume":"175","author":"Berument","year":"1999","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.jaac.2010.07.001_bib41","series-title":"Autism Diagnostic Observation Schedule","author":"Lord","year":"2002"},{"key":"10.1016\/j.jaac.2010.07.001_bib42","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1352\/0895-8017(2008)113[44:CSAABI]2.0.CO;2","article-title":"Compulsive, self-injurious, and autistic behavior in children and adolescents with fragile X syndrome","volume":"113","author":"Hall","year":"2008","journal-title":"Am J Ment Retard"},{"key":"10.1016\/j.jaac.2010.07.001_bib43","series-title":"The Social Communication Questionaire. Manual","author":"Rutter","year":"2003"},{"key":"10.1016\/j.jaac.2010.07.001_bib44","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s004390050363","article-title":"Rapid antibody test for diagnosing fragile X syndrome: a validation of the technique","volume":"99","author":"Willemsen","year":"1997","journal-title":"Hum Genet"},{"key":"10.1016\/j.jaac.2010.07.001_bib45","series-title":"Wechsler Intelligence Scale for Children\u2014Third Edition","author":"Wechsler","year":"1991"},{"key":"10.1016\/j.jaac.2010.07.001_bib46","series-title":"Wechsler Adult Intelligence Scale\u2014Third Edition","author":"Wechsler","year":"1997"},{"key":"10.1016\/j.jaac.2010.07.001_bib47","doi-asserted-by":"crossref","first-page":"E88","DOI":"10.1542\/peds.108.5.e88","article-title":"The influence of environmental and genetic factors on behavior problems and autistic symptoms in boys and girls with fragile X syndrome","volume":"108","author":"Hessl","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaac.2010.07.001_bib48","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1093\/brain\/124.8.1610","article-title":"Brain anatomy, gender and IQ in children and adolescents with fragile X syndrome","volume":"124","author":"Eliez","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.jaac.2010.07.001_bib49","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/ana.21243","article-title":"Neuroanatomy of fragile X syndrome is associated with aberrant behavior and the fragile X mental retardation protein (FMRP)","volume":"63","author":"Gothelf","year":"2008","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jaac.2010.07.001_bib50","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.biopsych.2006.09.040","article-title":"Caudate nucleus is enlarged in high-functioning medication-naive subjects with autism","volume":"62","author":"Langen","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jaac.2010.07.001_bib51","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1001\/archgenpsychiatry.2009.19","article-title":"Longitudinal study of amygdala volume and joint attention in 2- to 4-year-old children with autism","volume":"66","author":"Mosconi","year":"2009","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.jaac.2010.07.001_bib52","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11689-009-9009-8","article-title":"Teasing apart the heterogeneity of autism: Same behavior, different brains in toddlers with fragile X syndrome and autism","volume":"1","author":"Hazlett","year":"2009","journal-title":"J Neurodev Disord"},{"key":"10.1016\/j.jaac.2010.07.001_bib53","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/ddrr.78","article-title":"Treatments for fragile X syndrome: a closer look at the data","volume":"15","author":"Hall","year":"2009","journal-title":"Dev Disabil Res Rev"},{"key":"10.1016\/j.jaac.2010.07.001_bib54","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.chc.2007.03.001","article-title":"Fragile X syndrome: assessment and treatment implications","volume":"16","author":"Reiss","year":"2007","journal-title":"Child Adolesc Psychiatr Clin North Am"},{"key":"10.1016\/j.jaac.2010.07.001_bib55","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1901\/jaba.2009.42-171","article-title":"Using percentile schedules to increase eye contact in children with fragile X syndrome","volume":"42","author":"Hall","year":"2009","journal-title":"J Appl Behav Anal"},{"key":"10.1016\/j.jaac.2010.07.001_bib56","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1365-2788.2006.00814.x","article-title":"The acquisition of stimulus equivalence in individuals with fragile X syndrome","volume":"50","author":"Hall","year":"2006","journal-title":"J Intellect Disabil Res"},{"key":"10.1016\/j.jaac.2010.07.001_bib57","series-title":"The Concept of Mind","author":"Ryle","year":"1949"}],"container-title":["Journal of the American Academy of Child &amp; Adolescent Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890856710005265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890856710005265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T12:25:04Z","timestamp":1544012704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890856710005265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":57,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0890856710005265"],"URL":"https:\/\/doi.org\/10.1016\/j.jaac.2010.07.001","relation":{},"ISSN":["0890-8567"],"issn-type":[{"value":"0890-8567","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}