{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:25:47Z","timestamp":1786991147038,"version":"build-2736575974"},"reference-count":23,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American Academy of Child &amp; Adolescent Psychiatry"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.jaac.2013.06.006","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T13:31:48Z","timestamp":1375363908000},"page":"921-930","source":"Crossref","is-referenced-by-count":47,"title":["Randomized, Double-Blind Trial of Guanfacine Extended Release in Children With Attention-Deficit\/Hyperactivity Disorder: Morning or Evening Administration"],"prefix":"10.1016","volume":"52","author":[{"given":"Jeffrey H.","family":"Newcorn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann C.","family":"Childress","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Youcha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Enright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaac.2013.06.006_bib1","first-page":"1439","article-title":"Increasing prevalence of parent-reported attention-deficit\/hyperactivity disorder among children\u2014United States, 2003 and 2007","volume":"59","year":"2010","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.jaac.2013.06.006_bib2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/DBP.0b013e31811ff87d","article-title":"Long-term school outcomes for children with attention-deficit\/hyperactivity disorder: a population-based perspective","volume":"28","author":"Barbaresi","year":"2007","journal-title":"J\u00a0Dev Behav Pediatr"},{"key":"10.1016\/j.jaac.2013.06.006_bib3","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1093\/jpepsy\/jsl054","article-title":"Academic and educational outcomes of children with ADHD","volume":"32","author":"Loe","year":"2007","journal-title":"J\u00a0Pediatr Psychol"},{"key":"10.1016\/j.jaac.2013.06.006_bib4","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1001\/archpsyc.56.12.1073","article-title":"A\u00a014-month randomized clinical trial of treatment strategies for attention-deficit\/hyperactivity disorder","volume":"56","year":"1999","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.jaac.2013.06.006_bib5","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S1056-4993(18)30108-1","article-title":"The stimulants revisited","volume":"9","author":"Wilens","year":"2000","journal-title":"Child Adolesc Psychiatr Clin N Am"},{"issue":"Suppl 1","key":"10.1016\/j.jaac.2013.06.006_bib6","first-page":"I102","article-title":"Non-stimulant medications in the treatment of ADHD","volume":"13","author":"Banaschewski","year":"2004","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"10.1016\/j.jaac.2013.06.006_bib7","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1471-244X-11-70","article-title":"Relation between therapeutic response and side effects induced by methylphenidate as observed by parents and teachers of children with ADHD","volume":"11","author":"Lee","year":"2011","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.jaac.2013.06.006_bib8","unstructured":"INTUNIV\u00ae (guanfacine) extended-release tablets [package insert]. Wayne, PA: Shire Pharmaceuticals LLC."},{"key":"10.1016\/j.jaac.2013.06.006_bib9","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1542\/peds.2006-3695","article-title":"A\u00a0randomized, double-blind, placebo-controlled study of guanfacine extended release in children and adolescents with attention-deficit\/hyperactivity disorder","volume":"121","author":"Biederman","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaac.2013.06.006_bib10","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/CHI.0b013e318191769e","article-title":"Guanfacine extended release in children and adolescents with attention-deficit\/hyperactivity disorder: a placebo-controlled trial","volume":"48","author":"Sallee","year":"2009","journal-title":"J\u00a0Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.jaac.2013.06.006_bib11","doi-asserted-by":"crossref","first-page":"e1406","DOI":"10.1542\/peds.2010-1260","article-title":"Clonidine extended-release tablets as add-on therapy to psychostimulants in children and adolescents with ADHD","volume":"127","author":"Kollins","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaac.2013.06.006_bib12","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0002-7138(09)60065-0","article-title":"Clonidine benefits children with attention deficit disorder and hyperactivity: report of a double-blind placebo-crossover therapeutic trial","volume":"24","author":"Hunt","year":"1985","journal-title":"J\u00a0Am Acad Child Psychiatry"},{"key":"10.1016\/j.jaac.2013.06.006_bib13","first-page":"229","article-title":"The therapeutic effect of clonidine in attention deficit disorder with hyperactivity: a comparison with placebo and methylphenidate","volume":"22","author":"Hunt","year":"1986","journal-title":"Psychopharmacol Bull."},{"key":"10.1016\/j.jaac.2013.06.006_bib14","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1097\/00004583-199912000-00017","article-title":"A\u00a0meta-analysis of clonidine for symptoms of attention-deficit hyperactivity disorder","volume":"38","author":"Connor","year":"1999","journal-title":"J\u00a0Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.jaac.2013.06.006_bib15","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/00004583-199501000-00013","article-title":"An open trial of guanfacine in the treatment of attention-deficit hyperactivity disorder","volume":"34","author":"Hunt","year":"1995","journal-title":"J\u00a0Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.jaac.2013.06.006_bib16","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jaac.2010.11.005","article-title":"Clonidine extended-release tablets for pediatric patients with attention-deficit\/hyperactivity disorder","volume":"50","author":"Jain","year":"2011","journal-title":"J\u00a0Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.jaac.2013.06.006_bib17","doi-asserted-by":"crossref","unstructured":"Rubin J, Lopez FA, Youcha S. Impact of guanfacine extended release on cognitive problems and inattention. Poster presented at: 2010 Annual Meeting of the Society for Developmental and Behavioral Pediatrics Annual Meeting; September 11-14, 2010; Boston, MA.","DOI":"10.1097\/01.DBP.0000390306.94001.58"},{"key":"10.1016\/j.jaac.2013.06.006_bib18","unstructured":"Lopez FA, White C, Rubin J. Effects of guanfacine extended release on parent-reported behaviors in a randomized double-blind study of subjects with attention-deficit\/hyperactivity disorder. Poster presented at: American Professional Society of ADHD and Related Disorders; November 5-6, 2010; Washington, DC."},{"key":"10.1016\/j.jaac.2013.06.006_bib19","series-title":"Textbook of Child and Adolescent Psychopharmacology","first-page":"263","article-title":"Adrenergic agonists: Clonidine and guanfacine","author":"Newcorn","year":"2011"},{"key":"10.1016\/j.jaac.2013.06.006_bib20","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jaac.2011.10.012","article-title":"A\u00a0controlled trial of extended-release guanfacine and psychostimulants for attention-deficit\/hyperactivity disorder","volume":"51","author":"Wilens","year":"2012","journal-title":"J\u00a0Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.jaac.2013.06.006_bib21","series-title":"Attention-deficit and disruptive behavior disorders. Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision (DSM-IV-TR)","first-page":"85","year":"2000"},{"key":"10.1016\/j.jaac.2013.06.006_bib22","series-title":"ADHD Rating Scale\u2013IV: Checklists, Norms, and Clinical Interpretation","author":"DuPaul","year":"1998"},{"key":"10.1016\/j.jaac.2013.06.006_bib23","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1177\/0009922809335321","article-title":"Once-daily atomoxetine for treating pediatric attention-deficit\/hyperactivity disorder: comparison of morning and evening dosing","volume":"48","author":"Block","year":"2009","journal-title":"Clin Pediatr (Phila )"}],"container-title":["Journal of the American Academy of Child &amp; Adolescent Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890856713004048?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890856713004048?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,20]],"date-time":"2019-07-20T02:21:32Z","timestamp":1563589292000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890856713004048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S0890856713004048"],"URL":"https:\/\/doi.org\/10.1016\/j.jaac.2013.06.006","relation":{},"ISSN":["0890-8567"],"issn-type":[{"value":"0890-8567","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}