{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:46:48Z","timestamp":1790862408901,"version":"4.1.0"},"reference-count":190,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"am","delay-in-days":359,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaacap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Child &amp; Adolescent Psychiatry"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.jaac.2022.06.020","type":"journal-article","created":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T20:58:49Z","timestamp":1661115529000},"page":"518-557","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Systematic Review: Emotion Dysregulation in Syndromic Causes of Intellectual and Developmental Disabilities"],"prefix":"10.1016","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6935-4403","authenticated-orcid":false,"given":"Rebecca C.","family":"Shaffer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6498-0808","authenticated-orcid":false,"given":"Debra L.","family":"Reisinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2864-3767","authenticated-orcid":false,"given":"Lauren M.","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5873-0813","authenticated-orcid":false,"given":"Martine","family":"Lamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3775-2479","authenticated-orcid":false,"given":"Kelli C.","family":"Dominick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth G.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6715-7016","authenticated-orcid":false,"given":"Marika C.","family":"Coffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2649-7791","authenticated-orcid":false,"given":"Anna J.","family":"Esbensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaac.2022.06.020_bib1","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1467-8624.2004.00674.x","article-title":"Emotion-related regulation: Sharpening the definition","volume":"75","author":"Eisenberg","year":"2004","journal-title":"Child Dev"},{"key":"10.1016\/j.jaac.2022.06.020_bib2","series-title":"Handbook of Emotion Regulation","first-page":"3","article-title":"Emotion regulation: Conceptual foundations","author":"Gross","year":"2007"},{"key":"10.1016\/j.jaac.2022.06.020_bib3","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1080\/02699931.2010.544160","article-title":"Explicit and implicit emotion regulation: A dual-process framework","volume":"25","author":"Gyurak","year":"2011","journal-title":"Cogn Emot"},{"key":"10.1016\/j.jaac.2022.06.020_bib4","doi-asserted-by":"crossref","unstructured":"Gross JJ. Emotion regulation: Current status and future prospects. Psychol Inq. 26:1-26. https:\/\/doi.org\/10.1080\/1047840X.2014.940781","DOI":"10.1080\/1047840X.2014.940781"},{"key":"10.1016\/j.jaac.2022.06.020_bib5","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1007\/s10803-020-04370-1","article-title":"A\u00a0comparative study of suicidality and its association with emotion regulation impairment in large ASD and US census-matched samples","volume":"50","author":"Conner","year":"2020","journal-title":"J\u00a0Autism Dev Disord"},{"key":"10.1016\/j.jaac.2022.06.020_bib6","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/aur.2450","article-title":"Emotion dysregulation is substantially elevated in autism compared to the general population: Impact on psychiatric services","volume":"14","author":"Conner","year":"2021","journal-title":"Autism Res"},{"key":"10.1016\/j.jaac.2022.06.020_bib7","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1177\/1362361310366571","article-title":"Emotion regulation and internalizing symptoms in children with autism spectrum disorders","volume":"15","author":"Rieffe","year":"2011","journal-title":"Autism"},{"key":"10.1016\/j.jaac.2022.06.020_bib8","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cpr.2009.11.004","article-title":"Emotion-regulation strategies across psychopathology: A meta-analytic review","volume":"30","author":"Aldao","year":"2010","journal-title":"Clin Psychol Rev"},{"key":"10.1016\/j.jaac.2022.06.020_bib9","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s10862-009-9161-1","article-title":"Emotion regulation and the anxiety disorders: An integrative review","volume":"32","author":"Cisler","year":"2010","journal-title":"J\u00a0Psychopathol Behav Assess"},{"key":"10.1016\/j.jaac.2022.06.020_bib10","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s10578-011-0274-x","article-title":"Emotion regulation and depressive symptoms in preadolescence","volume":"43","author":"Siener","year":"2012","journal-title":"Child Psychiatry Hum Dev"},{"key":"10.1016\/j.jaac.2022.06.020_bib11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.chc.2013.07.002","article-title":"Emotion regulation: Concepts and practice in autism spectrum disorder","volume":"23","author":"Mazefsky","year":"2014","journal-title":"Child Adolesc Psychiatr Clin N Am"},{"key":"10.1016\/j.jaac.2022.06.020_bib12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s10803-005-0051-4","article-title":"Affect regulation and temperament in children with autism spectrum disorder","volume":"36","author":"Konstantareas","year":"2006","journal-title":"J\u00a0Autism Dev Disord"},{"key":"10.1016\/j.jaac.2022.06.020_bib13","series-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2013"},{"key":"10.1016\/j.jaac.2022.06.020_bib14","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ijdevneu.2014.05.012","article-title":"Social-cognitive, physiological, and neural mechanisms underlying emotion regulation impairments: Understanding anxiety in autism spectrum disorder","volume":"39","author":"White","year":"2014","journal-title":"Int J Dev Neurosci"},{"key":"10.1016\/j.jaac.2022.06.020_bib15","first-page":"867","article-title":"The spectrum of autism\u2014from neuronal connections to behavioral expression","volume":"12","author":"Mazefsky","year":"2010","journal-title":"Virtual Mentor"},{"key":"10.1016\/j.jaac.2022.06.020_bib16","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1017\/S095457940800059X","article-title":"The development of emotion-related neural circuitry in health and psychopathology","volume":"20","author":"Monk","year":"2008","journal-title":"Dev Psychopathol"},{"key":"10.1016\/j.jaac.2022.06.020_bib17","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1177\/1745691611419672","article-title":"A\u00a0heuristic for developing transdiagnostic models of psychopathology: Explaining multifinality and divergent trajectories","volume":"6","author":"Nolen-Hoeksema","year":"2011","journal-title":"Perspect Psychol Sci"},{"key":"10.1016\/j.jaac.2022.06.020_bib18","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.copsyc.2014.12.014","article-title":"Recent advances in the genetics of emotion regulation: A review","volume":"3","author":"Hawn","year":"2015","journal-title":"Curr Opin Psychol"},{"key":"10.1016\/j.jaac.2022.06.020_bib19","series-title":"The Oxford handbook of emotion dysregulation","first-page":"203","article-title":"Behavioral and molecular genetics of emotion dysregulation","author":"Rappaport","year":"2020"},{"key":"10.1016\/j.jaac.2022.06.020_bib20","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/nn.4420","article-title":"Lessons learned from studying syndromic autism spectrum disorders","volume":"19","author":"Sztainberg","year":"2016","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.jaac.2022.06.020_bib21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.neubiorev.2014.02.015","article-title":"Intellectual disability and autism spectrum disorders: Causal genes and molecular mechanisms","volume":"46","author":"Srivastava","year":"2014","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.jaac.2022.06.020_bib22","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1002\/bdra.20735","article-title":"Updated national birth prevalence estimates for selected birth defects in the United States, 2004-2006","volume":"88","author":"Parker","year":"2010","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.jaac.2022.06.020_bib23","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/1098-2779(2000)6:2<84::AID-MRDD2>3.0.CO;2-P","article-title":"Behavioral phenotype of individuals with Down syndrome","volume":"6","author":"Chapman","year":"2000","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"10.1016\/j.jaac.2022.06.020_bib24","series-title":"A\u00a0Comprehensive Guide to Intellectual and Developmental Disabilities","first-page":"195","article-title":"Down syndrome","author":"Esbensen","year":"2017"},{"key":"10.1016\/j.jaac.2022.06.020_bib25","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.nicl.2013.05.006","article-title":"Abnormal brain synchrony in Down syndrome","volume":"2","author":"Anderson","year":"2013","journal-title":"Neuroimage Clin"},{"key":"10.1016\/j.jaac.2022.06.020_bib26","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/19315864.2018.1481473","article-title":"Behavioral characteristics of individuals with Down syndrome","volume":"11","author":"Patel","year":"2018","journal-title":"J\u00a0Ment Health Res Intellect Disabil"},{"key":"10.1016\/j.jaac.2022.06.020_bib27","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1352\/0895-8017(1997)102<0228:MBICWP>2.0.CO;2","article-title":"Maladaptive behavior in children with Prader-Willi syndrome, Down syndrome, and nonspecific mental retardation","volume":"102","author":"Dykens","year":"1997","journal-title":"Am J Ment Retard"},{"key":"10.1016\/j.jaac.2022.06.020_bib28","first-page":"1","article-title":"Psychiatric disorders in adolescents and young adults with Down syndrome and other intellectual disabilities","volume":"7","author":"Dykens","year":"2015","journal-title":"J\u00a0Neurodev Disord"},{"key":"10.1016\/j.jaac.2022.06.020_bib29","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11920-007-0083-x","article-title":"Neuropsychiatric and behavioral aspects of trisomy 21","volume":"9","author":"Visootsak","year":"2007","journal-title":"Curr Psychiatry Rep"},{"key":"10.1016\/j.jaac.2022.06.020_bib30","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1352\/1944-7558-114.4.254-268","article-title":"The Down syndrome advantage: Fact or fiction?","volume":"114","author":"Corrice","year":"2009","journal-title":"Am J Intellect Dev Disabil"},{"key":"10.1016\/j.jaac.2022.06.020_bib31","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/ajmg.c.30097","article-title":"Neurobehavioral disorders in children, adolescents, and young adults with Down syndrome","volume":"142","author":"Capone","year":"2006","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.jaac.2022.06.020_bib32","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3104\/reports.313","article-title":"Mental health, behaviour and intellectual abilities of people with Down syndrome","volume":"11","author":"M\u00e4\u00e4tt\u00e4","year":"2006","journal-title":"Downs Syndr Res Pract"},{"key":"10.1016\/j.jaac.2022.06.020_bib33","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1023\/B:JADD.0000037420.16169.28","article-title":"Self-regulation and affective expression during play in children with autism or Down syndrome: A short-term longitudinal study","volume":"34","author":"Bieberich","year":"2004","journal-title":"J\u00a0Autism Dev Disord"},{"key":"10.1016\/j.jaac.2022.06.020_bib34","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1352\/1944-7558-124.3.220","article-title":"Reliability of informant-report measures of executive functioning in children with down syndrome","volume":"124","author":"Esbensen","year":"2019","journal-title":"Am J Intellect Dev Disabil"},{"key":"10.1016\/j.jaac.2022.06.020_bib35","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1046\/j.1365-2788.1998.00123.x","article-title":"Daytime behaviour problems and maternal stress in children with Down\u2019s syndrome, their siblings, and non-intellectually disabled and other intellectually disabled peers","volume":"42","author":"Stores","year":"1998","journal-title":"J\u00a0Intellect Disabil Res"},{"key":"10.1016\/j.jaac.2022.06.020_bib36","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1352\/0895-8017(2001)106<0039:EOCBAT>2.0.CO;2","article-title":"Emergence of compulsive behavior and tantrums in children with Prader-Willi syndrome","volume":"106","author":"Dimitropoulos","year":"2001","journal-title":"Am J Ment Retard"},{"key":"10.1016\/j.jaac.2022.06.020_bib37","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/ajmg.c.31442","article-title":"The developmental trajectory of disruptive behavior in Down syndrome, fragile X syndrome, Prader-Willi syndrome and Williams syndrome","volume":"169","author":"Rice","year":"2015","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.jaac.2022.06.020_bib38","doi-asserted-by":"crossref","first-page":"e113111","DOI":"10.1371\/journal.pone.0113111","article-title":"Age-related changes of adaptive and neuropsychological features in persons with Down Syndrome","volume":"9","author":"Ghezzo","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jaac.2022.06.020_bib39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3104\/reports.302","article-title":"Temperament and behaviour problems in young children with Down syndrome at 12, 30, and 45 months","volume":"10","author":"Fidler","year":"2006","journal-title":"Downs Syndr Res Pract"},{"key":"10.1016\/j.jaac.2022.06.020_bib40","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/jir.12541","article-title":"Risk factors for challenging behaviour and psychopathology in adults with Down syndrome","volume":"62","author":"Nevill","year":"2018","journal-title":"J\u00a0Intellect Disabil Res"},{"key":"10.1016\/j.jaac.2022.06.020_bib41","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1352\/1944-7558-122.3.235","article-title":"Associations of child and adolescent mastery motivation and self-regulation with adult outcomes: A longitudinal study of individuals with Down syndrome","volume":"122","author":"Gilmore","year":"2017","journal-title":"Am J Intellect Dev Disabil"},{"key":"10.1016\/j.jaac.2022.06.020_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41572-019-0143-7","article-title":"Down syndrome","volume":"6","author":"Antonarakis","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jaac.2022.06.020_bib43","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1080\/15402002.2019.1641501","article-title":"Obstructive sleep apnoea contributes to executive function impairment in young children with Down syndrome","volume":"18","author":"Joyce","year":"2020","journal-title":"Behav Sleep Med"},{"key":"10.1016\/j.jaac.2022.06.020_bib44","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/chd.12322","article-title":"Does congenital heart disease affect neurodevelopmental outcomes in children with Down syndrome?","volume":"11","author":"Alsaied","year":"2016","journal-title":"Congenit Heart Dis"},{"key":"10.1016\/j.jaac.2022.06.020_bib45","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ridd.2016.07.006","article-title":"Cross-syndrome comparison of real-world executive functioning and problem solving using a new problem-solving questionnaire","volume":"59","author":"Camp","year":"2016","journal-title":"Res Dev Disabil"},{"key":"10.1016\/j.jaac.2022.06.020_bib46","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1007\/s10803-017-3140-2","article-title":"Brief report: Contrasting profiles of everyday executive functioning in Smith-Magenis syndrome and Down syndrome","volume":"47","author":"Wilde","year":"2017","journal-title":"J\u00a0Autism Dev Disord"},{"key":"10.1016\/j.jaac.2022.06.020_bib47","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ridd.2011.09.014","article-title":"The effects of diagnostic group and gender on challenging behaviors in infants and toddlers with cerebral palsy, Down syndrome or seizures","volume":"33","author":"Hattier","year":"2012","journal-title":"Res Dev Disabil"},{"key":"10.1016\/j.jaac.2022.06.020_bib48","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1352\/1944-7558-116.4.290","article-title":"Caregiver report of executive functioning in a population-based sample of young children with Down syndrome","volume":"116","author":"Lee","year":"2011","journal-title":"Am J Intellect Dev Disabil"},{"key":"10.1016\/j.jaac.2022.06.020_bib49","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/jir.12396","article-title":"A\u00a0cross-sectional analysis of executive function in Down syndrome from 2 to 35 years","volume":"61","author":"Loveall","year":"2017","journal-title":"J\u00a0Intellect Disabil Res"},{"key":"10.1016\/j.jaac.2022.06.020_bib50","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1352\/1944-7558-119.4.303","article-title":"Profiles of everyday executive functioning in young children with Down syndrome","volume":"119","author":"Daunhauer","year":"2014","journal-title":"Am J Intellect Dev Disabil"},{"key":"10.1016\/j.jaac.2022.06.020_bib51","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/jir.12575","article-title":"Parenting behaviour and executive function in children with Down syndrome","volume":"63","author":"Schworer","year":"2019","journal-title":"J\u00a0Intellect Disabil Res"},{"key":"10.1016\/j.jaac.2022.06.020_bib52","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/jir.12098","article-title":"Executive function in children with intellectual disability\u2014the effects of sex, level and aetiology of intellectual disability","volume":"58","author":"Memisevic","year":"2014","journal-title":"J\u00a0Intellect Disabil Res"},{"key":"10.1016\/j.jaac.2022.06.020_bib53","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1352\/1944-7558-122.3.215","article-title":"The Arizona Cognitive Test Battery for Down Syndrome: Test-retest reliability and practice effects","volume":"122","author":"Edgin","year":"2017","journal-title":"Am J Intellect Dev Disabil"},{"key":"10.1016\/j.jaac.2022.06.020_bib54","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/87565641.2017.1360303","article-title":"Performance and ratings based measures of executive function in school-aged children with Down syndrome","volume":"42","author":"Daunhauer","year":"2017","journal-title":"Dev Neuropsychol"},{"key":"10.1016\/j.jaac.2022.06.020_bib55","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/ajmg.a.20007","article-title":"Behavioral assessment of children with Down syndrome using the Reiss psychopathology scale","volume":"118","author":"Clark","year":"2003","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jaac.2022.06.020_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0236087","article-title":"Assessment of emotional intelligence in adults with down syndrome: Psychometric properties of the Emotional Quotient Inventory","volume":"15","author":"S\u00e1nchez-Teruel","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jaac.2022.06.020_bib57","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0154596","article-title":"Developing an informant questionnaire for cognitive abilities in Down syndrome: The Cognitive Scale for Down Syndrome (CS-DS)","volume":"11","author":"Startin","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jaac.2022.06.020_bib58","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1352\/0895-8017(2008)113[32:ECICWD]2.0.CO;2","article-title":"Emotional competence in children with Down syndrome: Negativity and regulation","volume":"113","author":"Jahromi","year":"2008","journal-title":"Am J Ment Retard"},{"key":"10.1016\/j.jaac.2022.06.020_bib59","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1177\/0883073816634854","article-title":"Guanfacine use in children with Down syndrome and comorbid attention-deficit hyperactivity disorder (ADHD) with disruptive behaviors","volume":"31","author":"Capone","year":"2016","journal-title":"J\u00a0Child Neurol"},{"key":"10.1016\/j.jaac.2022.06.020_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13052-017-0355-y","article-title":"Fragile X syndrome: A review of clinical and molecular diagnoses","volume":"43","author":"Ciaccio","year":"2017","journal-title":"Ital J Pediatr"},{"key":"10.1016\/j.jaac.2022.06.020_bib61","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11689-010-9067-y","article-title":"Clinical assessment of DSM-IV anxiety disorders in fragile X syndrome: Prevalence and characterization","volume":"3","author":"Cordeiro","year":"2011","journal-title":"J\u00a0Neurodev Disord"},{"key":"10.1016\/j.jaac.2022.06.020_bib62","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fnint.2019.00060","article-title":"Auditory EEG biomarkers in fragile X syndrome: Clinical relevance","volume":"13","author":"Ethridge","year":"2019","journal-title":"Front Integr Neurosci"},{"key":"10.1016\/j.jaac.2022.06.020_bib63","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1176\/appi.ajp.2014.13111464","article-title":"Aberrant face and gaze habituation in fragile X syndrome","volume":"171","author":"Bruno","year":"2014","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.jaac.2022.06.020_bib64","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s11689-020-09310-9","article-title":"Developmental studies in fragile X syndrome","volume":"12","author":"Razak","year":"2020","journal-title":"J\u00a0Neurodev Disord"},{"key":"10.1016\/j.jaac.2022.06.020_bib65","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/1096-8628(20001113)95:2<150::AID-AJMG11>3.0.CO;2-1","article-title":"Cognitive and behavioral profile of fragile X boys: Correlations to molecular data","volume":"95","author":"Backes","year":"2000","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jaac.2022.06.020_bib66","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/00004583-198905000-00021","article-title":"Adaptive and maladaptive functioning of institutionalized and noninstitutionalized fragile X males","volume":"28","author":"Dykens","year":"1989","journal-title":"J\u00a0Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.jaac.2022.06.020_bib67","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/ajmg.1320510417","article-title":"Behavioural and emotional disturbance in fragile X syndrome","volume":"51","author":"Einfeld","year":"1994","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jaac.2022.06.020_bib68","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1542\/peds.91.2.321","article-title":"Psychiatric disorders associated with Fragile X in the young female","volume":"91","author":"Freund","year":"1993","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaac.2022.06.020_bib69","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1007\/s10803-011-1370-2","article-title":"Psychometric study of the aberrant behavior checklist in fragile X syndrome and implications for targeted treatment","volume":"42","author":"Sansone","year":"2012","journal-title":"J\u00a0Autism Dev Disord"},{"issue":"Pt. 6","key":"10.1016\/j.jaac.2022.06.020_bib70","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1365-2788.2006.00896.x","article-title":"Correlates of maternal behaviours in mothers of children with fragile X syndrome","volume":"51","author":"Wheeler","year":"2007","journal-title":"J\u00a0Intellect Disabil Res"},{"key":"10.1016\/j.jaac.2022.06.020_bib71","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1017\/S002196309800256X","article-title":"Family contexts, parental behaviour, and personality profiles of children and adolescents with Prader-Willi, fragile-X, or Williams syndrome","volume":"39","author":"van Lieshout","year":"1998","journal-title":"J\u00a0Child Psychol Psychiatry"},{"key":"10.1016\/j.jaac.2022.06.020_bib72","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/1469-7610.00098","article-title":"Psychopathology and familial stress\u2014comparison of boys with fragile X syndrome and spinal muscular atrophy","volume":"43","author":"Von Gontard","year":"2002","journal-title":"J\u00a0Child Psychol Psychiatry"},{"key":"10.1016\/j.jaac.2022.06.020_bib73","doi-asserted-by":"crossref","first-page":"4595","DOI":"10.1007\/s10803-019-04173-z","article-title":"Pharmacologic interventions for irritability, aggression, agitation and self-injurious behavior in fragile X syndrome: An initial cross-sectional analysis","volume":"49","author":"Eckert","year":"2019","journal-title":"J\u00a0Autism Dev Disord"},{"key":"10.1016\/j.jaac.2022.06.020_bib74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1352\/1944-7558-117.1.1","article-title":"Behavioral phenotype of fragile X syndrome in adolescence and adulthood","volume":"117","author":"Smith","year":"2012","journal-title":"Am J Intellect Dev Disabil"},{"key":"10.1016\/j.jaac.2022.06.020_bib75","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.ridd.2014.01.032","article-title":"Psychiatric symptoms in boys with fragile X syndrome: A comparison with nonsyndromic autism spectrum disorder","volume":"35","author":"Thurman","year":"2014","journal-title":"Res Dev Disabil"},{"key":"10.1016\/j.jaac.2022.06.020_bib76","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/j.1365-2788.2008.01074.x","article-title":"Early temperament and negative reactivity in boys with fragile X syndrome","volume":"52","author":"Shanahan","year":"2008","journal-title":"J\u00a0Intellect Disabil Res"},{"key":"10.1016\/j.jaac.2022.06.020_bib77","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.ridd.2014.04.009","article-title":"A\u00a0comparison of family financial and employment impacts of fragile X syndrome, autism spectrum disorders, and intellectual disability","volume":"35","author":"Ouyang","year":"2014","journal-title":"Res Dev Disabil"},{"key":"10.1016\/j.jaac.2022.06.020_bib78","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/ajmg.a.32240","article-title":"Child and genetic variables associated with maternal adaptation to fragile X syndrome: A multidimensional analysis","volume":"146","author":"Bailey","year":"2008","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jaac.2022.06.020_bib79","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1542\/peds.83.4.547","article-title":"Fragile X syndrome: Recognition in young children","volume":"83","author":"Simko","year":"1989","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaac.2022.06.020_bib80","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/00004703-200010000-00001","article-title":"Family experiences and factors associated with the diagnosis of fragile X syndrome","volume":"21","author":"Bailey","year":"2000","journal-title":"J\u00a0Dev Behav Pediatr"},{"key":"10.1016\/j.jaac.2022.06.020_bib81","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3109\/13668250.2018.1496379","article-title":"Mothers\u2019 perspectives on challenging behaviours in their children with fragile X syndrome","volume":"44","author":"Muller","year":"2019","journal-title":"J\u00a0Intellect Dev Disabil"},{"key":"10.1016\/j.jaac.2022.06.020_bib82","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/jir.12238","article-title":"Aggression in fragile X syndrome","volume":"60","author":"Wheeler","year":"2016","journal-title":"J\u00a0Intellect Disabil Res"},{"key":"10.1016\/j.jaac.2022.06.020_bib83","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1365-2788.2006.00899.x","article-title":"Behavioural equivalents of anxiety in children with fragile X syndrome: Parent and teacher report","volume":"51","author":"Sullivan","year":"2007","journal-title":"J\u00a0Intellect Disabil Res"},{"key":"10.1016\/j.jaac.2022.06.020_bib84","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/ajmg.10216","article-title":"Problem behavior in boys with fragile X syndrome","volume":"108","author":"Hatton","year":"2002","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jaac.2022.06.020_bib85","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/(SICI)1096-8628(19991222)87:5<436::AID-AJMG13>3.0.CO;2-M","article-title":"Longitudinal course of behavioral and emotional problems in fragile X syndrome","volume":"87","author":"Einfeld","year":"1999","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jaac.2022.06.020_bib86","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/jir.12165","article-title":"Developmental changes in cognitive and behavioural functioning of adolescents with fragile-X syndrome","volume":"59","author":"Frolli","year":"2015","journal-title":"J\u00a0Intellect Disabil Res"},{"key":"10.1016\/j.jaac.2022.06.020_bib87","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1016\/j.ridd.2014.07.003","article-title":"Longitudinal trajectories of aberrant behavior in fragile X syndrome","volume":"35","author":"Hustyi","year":"2014","journal-title":"Res Dev Disabil"},{"key":"10.1016\/j.jaac.2022.06.020_bib88","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1007\/s10803-016-2714-8","article-title":"Change in the behavioral phenotype of adolescents and adults with FXS: Role of the family environment","volume":"46","author":"Smith","year":"2016","journal-title":"J\u00a0Autism Dev Disord"},{"key":"10.1016\/j.jaac.2022.06.020_bib89","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/ajmg.a.36232","article-title":"Anxiety, attention problems, hyperactivity, and the Aberrant Behavior Checklist in fragile X syndrome","volume":"164A","author":"Wheeler","year":"2014","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jaac.2022.06.020_bib90","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1002\/ajmg.a.32439","article-title":"Co-occurring conditions associated with FMR1 gene variations: Findings from a national parent survey","volume":"146A","author":"Bailey","year":"2008","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jaac.2022.06.020_bib91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-68465-6","article-title":"FMR1 mRNA from full mutation alleles is associated with ABC-C FX scores in males with fragile X syndrome","volume":"10","author":"Baker","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaac.2022.06.020_bib92","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1542\/peds.95.5.744","article-title":"Specification of the neurobehavioral phenotype in males with fragile X syndrome","volume":"95","author":"Baumgardner","year":"1995","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaac.2022.06.020_bib93","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1352\/1944-7558-123.2.89","article-title":"The emergence of effortful control in young boys with fragile X syndrome","volume":"123","author":"Robinson","year":"2018","journal-title":"Am J Intellect Dev Disabil"},{"key":"10.1016\/j.jaac.2022.06.020_bib94","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1097\/DBP.0b013e318272dcbc","article-title":"Health and economic consequences of fragile X syndrome for caregivers","volume":"33","author":"Bailey","year":"2012","journal-title":"J\u00a0Dev Behav Pediatr"},{"key":"10.1016\/j.jaac.2022.06.020_bib95","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/j.1469-7610.2005.01556.x","article-title":"Social behavior and cortisol reactivity in children with fragile X syndrome","volume":"47","author":"Hessl","year":"2006","journal-title":"J\u00a0Child Psychol Psychiatry"},{"key":"10.1016\/j.jaac.2022.06.020_bib96","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/jpepsy\/jss114","article-title":"Cardiovascular and behavioral response to auditory stimuli in boys with fragile X syndrome","volume":"38","author":"Roberts","year":"2013","journal-title":"J\u00a0Pediatr Psychol"},{"key":"10.1016\/j.jaac.2022.06.020_bib97","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/ajmg.b.30786","article-title":"Mood and anxiety disorders in females with the FMR1 premutation","volume":"150B","author":"Roberts","year":"2009","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.jaac.2022.06.020_bib98","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.ridd.2005.10.002","article-title":"Predictors of stress in mothers and fathers of children with fragile X syndrome","volume":"27","author":"McCarthy","year":"2006","journal-title":"Res Dev Disabil"},{"key":"10.1016\/j.jaac.2022.06.020_bib99","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1016\/j.ridd.2014.06.012","article-title":"Maternal well-being and child behavior in families with fragile X syndrome","volume":"35","author":"Hauser","year":"2014","journal-title":"Res Dev Disabil"},{"key":"10.1016\/j.jaac.2022.06.020_bib100","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.nurt.2010.04.001","article-title":"Aripiprazole in autism spectrum disorders and fragile X syndrome","volume":"7","author":"Erickson","year":"2010","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.jaac.2022.06.020_bib101","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00213-011-2194-7","article-title":"A\u00a0prospective open-label study of aripiprazole in fragile X syndrome","volume":"216","author":"Erickson","year":"2011","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.jaac.2022.06.020_bib102","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1089\/cap.2017.0057","article-title":"Risperidone treatment for irritability in fragile X syndrome","volume":"28","author":"Dominick","year":"2018","journal-title":"J\u00a0Child Adolesc Psychopharmacol"},{"key":"10.1016\/j.jaac.2022.06.020_bib103","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s11689-017-9186-9","article-title":"Fragile X targeted pharmacotherapy: Lessons learned and future directions","volume":"9","author":"Erickson","year":"2017","journal-title":"J\u00a0Neurodev Disord"},{"key":"10.1016\/j.jaac.2022.06.020_bib104","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1007\/s10803-009-0807-3","article-title":"Open-label memantine in fragile X syndrome","volume":"39","author":"Erickson","year":"2009","journal-title":"J\u00a0Autism Dev Disord"},{"key":"10.1016\/j.jaac.2022.06.020_bib105","doi-asserted-by":"crossref","first-page":"321ra5","DOI":"10.1126\/scitranslmed.aab4109","article-title":"Mavoglurant in fragile X syndrome: Results of two randomized, double-blind, placebo-controlled trials","volume":"8","author":"Berry-Kravis","year":"2016","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jaac.2022.06.020_bib106","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s11689-017-9207-8","article-title":"A\u00a0randomized double-blind, placebo-controlled trial of ganaxolone in children and adolescents with fragile X syndrome","volume":"9","author":"Ligsay","year":"2017","journal-title":"J\u00a0Neurodev Disord"},{"key":"10.1016\/j.jaac.2022.06.020_bib107","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s11689-019-9277-x","article-title":"A\u00a0phase 1\/2, open-label assessment of the safety, tolerability, and efficacy of transdermal cannabidiol (ZYN002) for the treatment of pediatric fragile X syndrome","volume":"11","author":"Heussler","year":"2019","journal-title":"J\u00a0Neurodev Disord"},{"key":"10.1016\/j.jaac.2022.06.020_bib108","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/DBP.0b013e318287cd17","article-title":"A\u00a0randomized double-blind, placebo-controlled trial of minocycline in children and adolescents with fragile X syndrome","volume":"34","author":"Leigh","year":"2013","journal-title":"J\u00a0Dev Behav Pediatr"},{"key":"10.1016\/j.jaac.2022.06.020_bib109","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-2377-10-91","article-title":"Open-label add-on treatment trial of minocycline in fragile X syndrome","volume":"10","author":"Paribello","year":"2010","journal-title":"BMC Neurol"},{"key":"10.1016\/j.jaac.2022.06.020_bib110","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S1474-4422(15)00069-1","article-title":"Neurological and neuropsychiatric aspects of tuberous sclerosis complex","volume":"14","author":"Curatolo","year":"2015","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jaac.2022.06.020_bib111","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/S0140-6736(05)78872-3","article-title":"Prevalence of tuberous sclerosis estimated by capture-recapture analysis","volume":"351","author":"O\u2019Callaghan","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.jaac.2022.06.020_bib112","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/ejhg.2011.241","article-title":"Genotype and cognitive phenotype of patients with tuberous sclerosis complex","volume":"20","author":"van Eeghen","year":"2012","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.jaac.2022.06.020_bib113","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.pediatrneurol.2013.08.001","article-title":"Tuberous sclerosis complex diagnostic criteria update: recommendations of the 2012 Iinternational Tuberous Sclerosis Complex Consensus Conference","volume":"49","author":"Northrup","year":"2013","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.jaac.2022.06.020_bib114","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1440-1789.2008.00920.x","article-title":"Clinicopathological and immunohistochemical findings in an autopsy case of tuberous sclerosis complex","volume":"28","author":"Boer","year":"2008","journal-title":"Neuropathology"},{"key":"10.1016\/j.jaac.2022.06.020_bib115","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1002\/aur.2193","article-title":"Early patterns of functional brain development associated with autism spectrum disorder in tuberous sclerosis complex","volume":"12","author":"Dickinson","year":"2019","journal-title":"Autism Res"},{"key":"10.1016\/j.jaac.2022.06.020_bib116","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1111\/j.1528-1167.2009.02474.x","article-title":"The natural history of epilepsy in tuberous sclerosis complex","volume":"51","author":"Chu-Shore","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.jaac.2022.06.020_bib117","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1186\/s13023-020-01488-4","article-title":"The TAND checklist: A useful screening tool in children with tuberous sclerosis and neurofibromatosis type 1","volume":"15","author":"Cervi","year":"2020","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.jaac.2022.06.020_bib118","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1212\/01.wnl.0000280579.04974.c0","article-title":"Cognitive impairment in tuberous sclerosis complex is a multifactorial condition","volume":"70","author":"Jansen","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.jaac.2022.06.020_bib119","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1136\/jmg.31.10.761","article-title":"Phenotypic variation of tuberous sclerosis in a single extended kindred","volume":"31","author":"Smalley","year":"1994","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.jaac.2022.06.020_bib120","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00787-006-0570-3","article-title":"The psychopathologies of children and adolescents with tuberous sclerosis complex (TSC): A postal survey of UK families","volume":"16","author":"de Vries","year":"2007","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"10.1016\/j.jaac.2022.06.020_bib121","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1866-1955-6-10","article-title":"Self-injury and aggression in tuberous sclerosis complex: Cross syndrome comparison and associated risk markers","volume":"6","author":"Eden","year":"2014","journal-title":"J\u00a0Neurodev Disord"},{"key":"10.1016\/j.jaac.2022.06.020_bib122","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.yebeh.2008.05.010","article-title":"Behavior problems in children with tuberous sclerosis complex and parental stress","volume":"13","author":"Kopp","year":"2008","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.jaac.2022.06.020_bib123","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.pediatrneurol.2014.10.004","article-title":"Tuberous sclerosis associated neuropsychiatric disorders (TAND) and the TAND Checklist","volume":"52","author":"de Vries","year":"2015","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.jaac.2022.06.020_bib124","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.pediatrneurol.2014.10.006","article-title":"Pilot validation of the tuberous sclerosis-associated neuropsychiatric disorders (TAND) checklist","volume":"52","author":"Leclezio","year":"2015","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.jaac.2022.06.020_bib125","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.pediatrneurol.2017.12.006","article-title":"Is it feasible to identify natural clusters of TSC-associated neuropsychiatric disorders (TAND)?","volume":"81","author":"Leclezio","year":"2018","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.jaac.2022.06.020_bib126","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.ejmg.2018.02.005","article-title":"Deep phenotyping of patients with tuberous sclerosis complex and no mutation identified in TSC1 and TSC2","volume":"61","author":"Peron","year":"2018","journal-title":"Eur J Med Genet"},{"key":"10.1016\/j.jaac.2022.06.020_bib127","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/acn3.494","article-title":"Everolimus for treatment of tuberous sclerosis complex-associated neuropsychiatric disorders","volume":"4","author":"Krueger","year":"2017","journal-title":"Ann Clin Transl Neurol"},{"key":"10.1016\/j.jaac.2022.06.020_bib128","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13229-020-00335-4","article-title":"Effects of bumetanide on neurodevelopmental impairments in patients with tuberous sclerosis complex: An open-label pilot study","volume":"11","author":"van Andel","year":"2020","journal-title":"Mol Autism"},{"key":"10.1016\/j.jaac.2022.06.020_bib129","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mcp.2017.12.005","article-title":"The contribution of GTF2I haploinsufficiency to Williams syndrome","volume":"40","author":"Chailangkarn","year":"2018","journal-title":"Mol Cell Probes"},{"key":"10.1016\/j.jaac.2022.06.020_bib130","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1080\/13803395.2011.645019","article-title":"Physiological reactivity to faces via live and video-mediated communication in typical and atypical development","volume":"34","author":"Riby","year":"2012","journal-title":"J\u00a0Clin Exp Neuropsychol"},{"key":"10.1016\/j.jaac.2022.06.020_bib131","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1007\/s10803-015-2429-2","article-title":"Patterns of sensitivity to emotion in children with Williams syndrome and autism: Relations between autonomic nervous system reactivity and social functioning","volume":"45","author":"J\u00e4rvinen","year":"2015","journal-title":"J\u00a0Autism and Dev Disord"},{"key":"10.1016\/j.jaac.2022.06.020_bib132","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neuropsychologia.2015.04.035","article-title":"Relations between social-perceptual ability in multi- and unisensory contexts, autonomic reactivity, and social functioning in individuals with Williams syndrome","volume":"73","author":"J\u00e4rvinen","year":"2015","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.jaac.2022.06.020_bib133","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1111\/jir.12327","article-title":"Predictors of specific phobia in children with Williams syndrome","volume":"60","author":"Pitts","year":"2016","journal-title":"J\u00a0Intellect Disabil Res"},{"key":"10.1016\/j.jaac.2022.06.020_bib134","doi-asserted-by":"crossref","DOI":"10.1590\/2317-1782\/20182017188","article-title":"Cognitive and behavioral profile of Williams syndrome toddlers","volume":"30","author":"Braga","year":"2018","journal-title":"Codas"},{"key":"10.1016\/j.jaac.2022.06.020_bib135","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/ajmg.c.30259","article-title":"Longitudinal course of anxiety in children and adolescents with Williams syndrome","volume":"154C","author":"Woodruff-Borden","year":"2010","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.jaac.2022.06.020_bib136","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/jir.12367","article-title":"Problem behaviour and psychosocial functioning in young children with Williams syndrome: parent and teacher perspectives","volume":"61","author":"Klein-Tasman","year":"2017","journal-title":"J\u00a0Intellect Disabil Res"},{"key":"10.1016\/j.jaac.2022.06.020_bib137","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/(SICI)1096-8628(19970919)74:5<521::AID-AJMG13>3.0.CO;2-E","article-title":"Cognitive, adaptive, and behavioral characteristics of Williams syndrome","volume":"74","author":"Greer","year":"1997","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jaac.2022.06.020_bib138","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1007\/s10803-017-3357-0","article-title":"Anxiety in Williams syndrome: The role of social behaviour, executive functions and change over time","volume":"48","author":"Ng-Cordell","year":"2018","journal-title":"J\u00a0Autism Dev Disord"},{"key":"10.1016\/j.jaac.2022.06.020_bib139","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/ajmg.c.30260","article-title":"Sensory modulation impairments in children with Williams syndrome","volume":"154C","author":"John","year":"2010","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.jaac.2022.06.020_bib140","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1007\/s10803-012-1482-3","article-title":"Factor structure of the Children\u2019s Behavior Questionnaire in children with Williams syndrome","volume":"42","author":"Leyfer","year":"2012","journal-title":"J\u00a0Autism Dev Disord"},{"key":"10.1016\/j.jaac.2022.06.020_bib141","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.ridd.2013.02.015","article-title":"Caregiver survey of pharmacotherapy to treat attention deficit\/hyperactivity disorder in individuals with Williams syndrome","volume":"34","author":"Martens","year":"2013","journal-title":"Res Dev Disabil"},{"key":"10.1016\/j.jaac.2022.06.020_bib142","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/ng0997-75","article-title":"Imprinted expression of the murine Angelman syndrome gene, Ube3a, in hippocampal and Purkinje neurons","volume":"17","author":"Albrecht","year":"1997","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaac.2022.06.020_bib143","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ajmg.a.33775","article-title":"Angelman syndrome: Mutations influence features in early childhood","volume":"155A","author":"Tan","year":"2011","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jaac.2022.06.020_bib144","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/ajmg.1320590331","article-title":"On the prevalence of Angelman syndrome","volume":"59","author":"Kyllerman","year":"1995","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jaac.2022.06.020_bib145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162817","article-title":"From cortical and subcortical grey matter abnormalities to neurobehavioral phenotype of Angelman syndrome: A voxel-based morphometry study","volume":"11","author":"Aghakhanyan","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jaac.2022.06.020_bib146","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1352\/0895-8017(2000)105<0025:PBAWQA>2.0.CO;2","article-title":"Problem behaviors associated with 15q- Angelman syndrome","volume":"105","author":"Clarke","year":"2000","journal-title":"Am J Ment Retard"},{"key":"10.1016\/j.jaac.2022.06.020_bib147","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1365-2788.2010.01337.x","article-title":"The prevalence and phenomenology of self-injurious and aggressive behaviour in genetic syndromes","volume":"55","author":"Arron","year":"2011","journal-title":"J\u00a0Intellect Disabil Res"},{"issue":"Pt 2","key":"10.1016\/j.jaac.2022.06.020_bib148","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1365-2788.1995.tb00477.x","article-title":"Behaviour problems in Angelman syndrome","volume":"39","author":"Summers","year":"1995","journal-title":"J\u00a0Intellect Disabil Res"},{"key":"10.1016\/j.jaac.2022.06.020_bib149","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1007\/s10803-006-0233-8","article-title":"Parent report of stereotyped behaviors, social interaction, and developmental disturbances in individuals with Angelman syndrome","volume":"37","author":"Walz","year":"2007","journal-title":"J\u00a0Autism Dev Disord"},{"key":"10.1016\/j.jaac.2022.06.020_bib150","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s10803-018-3853-x","article-title":"Brief report: Challenging behaviors in toddlers and preschoolers with Angelman, Prader-Willi, and Williams syndromes","volume":"49","author":"Neo","year":"2019","journal-title":"J\u00a0Autism Dev Disord"},{"key":"10.1016\/j.jaac.2022.06.020_bib151","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1023\/A:1020326701399","article-title":"Behavioral phenotypes in children with Down syndrome, Prader-Willi syndrome, or Angelman syndrome","volume":"14","author":"Walz","year":"2002","journal-title":"J\u00a0Dev Phys Disabil"},{"issue":"Pt 6","key":"10.1016\/j.jaac.2022.06.020_bib152","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1365-2788.2008.01055.x","article-title":"Behavioural flexibility in individuals with Angelman syndrome, Down syndrome, non-specific intellectual disability and autism spectrum disorder","volume":"52","author":"Didden","year":"2008","journal-title":"J\u00a0Intellect Disabil Res"},{"key":"10.1016\/j.jaac.2022.06.020_bib153","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1352\/0895-8017(1999)104<0376:DPOBFI>2.0.CO;2","article-title":"Distinctive pattern of behavioral functioning in Angelman syndrome","volume":"104","author":"Summers","year":"1999","journal-title":"Am J Ment Retard"},{"key":"10.1016\/j.jaac.2022.06.020_bib154","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1097\/DBP.0b013e3181ee408e","article-title":"A\u00a0neurodevelopmental survey of Angelman syndrome with genotype-phenotype correlations","volume":"31","author":"Gentile","year":"2010","journal-title":"J\u00a0Dev Behav Pediatr"},{"key":"10.1016\/j.jaac.2022.06.020_bib155","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/ajmg.a.61140","article-title":"Maladaptive behaviors in individuals with Angelman syndrome","volume":"179","author":"Sadhwani","year":"2019","journal-title":"Am J Med Genet A"},{"issue":"Pt 2","key":"10.1016\/j.jaac.2022.06.020_bib156","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1365-2788.2004.00556.x","article-title":"Cognitive abilities and genotype in a population-based sample of people with Prader-Willi syndrome","volume":"48","author":"Whittington","year":"2004","journal-title":"J\u00a0Intellect Disabil Res"},{"issue":"Pt 3","key":"10.1016\/j.jaac.2022.06.020_bib157","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1365-2788.1995.tb00506.x","article-title":"Personality profiles of youngsters with Prader-Willi syndrome and youngsters attending regular schools","volume":"39","author":"Curfs","year":"1995","journal-title":"J\u00a0Intellect Disabil Res"},{"key":"10.1016\/j.jaac.2022.06.020_bib158","first-page":"248","article-title":"Prevalence of, and risk factors for, physical ill-health in people with Prader-Willi syndrome: A population-based study","volume":"44","author":"Butler","year":"2002","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.jaac.2022.06.020_bib159","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1007\/s40618-015-0312-9","article-title":"Prader-Willi syndrome: A review of clinical, genetic, and endocrine findings","volume":"38","author":"Angulo","year":"2015","journal-title":"J\u00a0Endocrinol Invest"},{"key":"10.1016\/j.jaac.2022.06.020_bib160","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1002\/ajmg.b.32472","article-title":"Reduced gamma-aminobutyric acid is associated with emotional and behavioral problems in Prader-Willi syndrome","volume":"171","author":"Rice","year":"2016","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.jaac.2022.06.020_bib161","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.jaac.2020.01.006","article-title":"Systematic review and meta-analysis: Mental health in children with neurogenetic disorders associated with intellectual disability","volume":"59","author":"Glasson","year":"2020","journal-title":"J\u00a0Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.jaac.2022.06.020_bib162","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1002\/ajmg.a.40480","article-title":"The characteristics of temper outbursts in Prader-Willi syndrome","volume":"176","author":"Rice","year":"2018","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jaac.2022.06.020_bib163","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1111\/j.1469-7610.2008.01913.x","article-title":"Behavior in Prader-Willi syndrome: Relationship to genetic subtypes and age","volume":"49","author":"Dykens","year":"2008","journal-title":"J\u00a0Child Psychology Psychiatry"},{"issue":"Pt 8","key":"10.1016\/j.jaac.2022.06.020_bib164","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1365-2788.2005.00717.x","article-title":"An investigation of executive function abilities in adults with Prader-Willi syndrome","volume":"49","author":"Walley","year":"2005","journal-title":"J\u00a0Intellect Disabil Res"},{"key":"10.1016\/j.jaac.2022.06.020_bib165","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s10803-014-2308-2","article-title":"Increased exposure to rigid routines can lead to increased challenging behavior following changes to those routines","volume":"45","author":"Bull","year":"2015","journal-title":"J\u00a0Autism Dev Disord"},{"key":"10.1016\/j.jaac.2022.06.020_bib166","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.1469-7610.2011.02365.x","article-title":"TPH2 G\/T polymorphism is associated with hyperphagia, IQ, and internalizing problems in Prader-Willi syndrome","volume":"52","author":"Dykens","year":"2011","journal-title":"J\u00a0Child Psychology Psychiatry"},{"key":"10.1016\/j.jaac.2022.06.020_bib167","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/jir.12010","article-title":"Temper outbursts in Prader-Willi syndrome: Causes, behavioural and emotional sequence and responses by carers","volume":"58","author":"Tunnicliffe","year":"2014","journal-title":"J\u00a0Intellect Disabil Res"},{"key":"10.1016\/j.jaac.2022.06.020_bib168","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2788.2008.01122.x","article-title":"Associations between repetitive questioning, resistance to change, temper outbursts and anxiety in Prader-Willi and fragile-X syndromes","volume":"53","author":"Woodcock","year":"2009","journal-title":"J\u00a0Intellect Disabil Res"},{"key":"10.1016\/j.jaac.2022.06.020_bib169","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1111\/cen.13169","article-title":"Promising effects of oxytocin on social and food-related behaviour in young children with Prader-Willi syndrome: A randomized, double-blind, controlled crossover trial","volume":"85","author":"Kuppens","year":"2016","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.jaac.2022.06.020_bib170","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1017\/S0033291702006736","article-title":"Behavioural phenotypes associated with specific genetic disorders: Evidence from a population-based study of people with Prader-Willi syndrome","volume":"33","author":"Holland","year":"2003","journal-title":"Psychol Med"},{"key":"10.1016\/j.jaac.2022.06.020_bib171","first-page":"265","article-title":"Personality profiles of youngsters with velo-cardio-facial syndrome","volume":"13","author":"Prinzie","year":"2002","journal-title":"Genet Couns"},{"key":"10.1016\/j.jaac.2022.06.020_bib172","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.braindev.2007.01.005","article-title":"Behavioral and psychiatric disorders in Prader-Willi syndrome: A population study in Japan","volume":"29","author":"Hiraiwa","year":"2007","journal-title":"Brain Dev"},{"key":"10.1016\/j.jaac.2022.06.020_bib173","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1097\/00004583-199211000-00023","article-title":"Adaptive and maladaptive behavior in Prader-Willi syndrome","volume":"31","author":"Dykens","year":"1992","journal-title":"J\u00a0Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.jaac.2022.06.020_bib174","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3109\/17518423.2016.1141436","article-title":"A\u00a0mindfulness-based intervention for self-management of verbal and physical aggression by adolescents with Prader-Willi syndrome","volume":"20","author":"Singh","year":"2017","journal-title":"Dev Neurorehabil"},{"key":"10.1016\/j.jaac.2022.06.020_bib175","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/jcpp.12601","article-title":"Cognitive and adaptive advantages of growth hormone treatment in children with Prader-Willi syndrome","volume":"58","author":"Dykens","year":"2017","journal-title":"J\u00a0Child Psychol Psychiatry"},{"key":"10.1016\/j.jaac.2022.06.020_bib176","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1352\/1944-7558-120.4.315","article-title":"Beneficial effects of long-term growth hormone treatment on adaptive functioning in infants with Prader-Willi syndrome","volume":"120","author":"Lo","year":"2015","journal-title":"Am J Intellect Dev Disabil"},{"key":"10.1016\/j.jaac.2022.06.020_bib177","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s00787-014-0662-4","article-title":"Behavior in children with Prader-Willi syndrome before and during growth hormone treatment: A randomized controlled trial and 8-year longitudinal study","volume":"24","author":"Lo","year":"2015","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"10.1016\/j.jaac.2022.06.020_bib178","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41398-019-0597-0","article-title":"Effect of topiramate on eating behaviours in Prader-Willi syndrome: TOPRADER double-blind randomised placebo-controlled study","volume":"9","author":"Consoli","year":"2019","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.jaac.2022.06.020_bib179","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1750-1172-6-47","article-title":"Oxytocin may be useful to increase trust in others and decrease disruptive behaviours in patients with Prader-Willi syndrome: A randomised placebo-controlled trial in 24 patients","volume":"6","author":"Tauber","year":"2011","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.jaac.2022.06.020_bib180","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1002\/ajmg.a.36653","article-title":"A\u00a0double-blind randomized controlled trial of oxytocin nasal spray in Prader Willi syndrome","volume":"164A","author":"Einfeld","year":"2014","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jaac.2022.06.020_bib181","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1002\/ajmg.a.38160","article-title":"Oxytocin treatment in children with Prader-Willi syndrome: A double-blind, placebo-controlled, crossover study","volume":"173","author":"Miller","year":"2017","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jaac.2022.06.020_bib182","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/ajmg.a.20218","article-title":"Social behavior profile in young males with fragile X syndrome: Characteristics and specificity","volume":"126A","author":"Kau","year":"2004","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jaac.2022.06.020_bib183","doi-asserted-by":"crossref","first-page":"3736","DOI":"10.1007\/s10803-016-2907-1","article-title":"Development of the Emotion Dysregulation Inventory: A PROMIS\u00aeing method for creating sensitive and unbiased questionnaires for autism spectrum disorder","volume":"48","author":"Mazefsky","year":"2018","journal-title":"J\u00a0Autism Dev Disord"},{"key":"10.1016\/j.jaac.2022.06.020_bib184","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.chc.2020.02.003","article-title":"Assessment and treatment of emotion regulation impairment in autism spectrum disorder across the life span: Current state of the science and future directions","volume":"29","author":"Beck","year":"2020","journal-title":"Child Adolesc Psychiatr Clin N Am"},{"key":"10.1016\/j.jaac.2022.06.020_bib185","first-page":"38","article-title":"Emotion regulation and intellectual disability","volume":"15","author":"Mcclure","year":"2009","journal-title":"J\u00a0Dev Disabil"},{"key":"10.1016\/j.jaac.2022.06.020_bib186","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.jaac.2022.06.020_bib187","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/DBP.0b013e31817dc447","article-title":"Open-label treatment trial of lithium to target the underlying defect in fragile X syndrome","volume":"29","author":"Berry-Kravis","year":"2008","journal-title":"J\u00a0Dev Behav Pediatr"},{"key":"10.1016\/j.jaac.2022.06.020_bib188","doi-asserted-by":"crossref","first-page":"152ra127","DOI":"10.1126\/scitranslmed.3004214","article-title":"Effects of STX209 (arbaclofen) on neurobehavioral function in children and adults with fragile X syndrome: A randomized, controlled, phase 2 trial","volume":"4","author":"Berry-Kravis","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jaac.2022.06.020_bib189","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s10803-007-0365-5","article-title":"Brief report: Aggression and stereotypic behavior in males with fragile X syndrome\u2014moderating secondary genes in a \u201csingle gene\u201d disorder","volume":"38","author":"Hessl","year":"2008","journal-title":"J\u00a0Autism Dev Disord"},{"key":"10.1016\/j.jaac.2022.06.020_bib190","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/ajmg.a.30229","article-title":"Autism spectrum disorder in fragile X syndrome: Communication, social interaction, and specific behaviors","volume":"129A","author":"Kaufmann","year":"2004","journal-title":"Am J Med Genet A"}],"container-title":["Journal of the American Academy of Child &amp; Adolescent Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890856722012485?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890856722012485?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:34:55Z","timestamp":1760193295000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890856722012485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":190,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S0890856722012485"],"URL":"https:\/\/doi.org\/10.1016\/j.jaac.2022.06.020","relation":{},"ISSN":["0890-8567"],"issn-type":[{"value":"0890-8567","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systematic Review: Emotion Dysregulation in Syndromic Causes of Intellectual and Developmental Disabilities","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Child & Adolescent Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaac.2022.06.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92022 American Academy of Child and Adolescent Psychiatry","name":"copyright","label":"Copyright"}]}}