{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T14:33:53Z","timestamp":1769265233183,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaacap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Child & Adolescent Psychiatry"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.jaac.2023.06.009","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T15:27:14Z","timestamp":1687620434000},"page":"1340-1350","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Association Between Prenatal Infection and Adolescent Behavior: Investigating Multiple Prenatal, Perinatal, and Childhood Second Hits"],"prefix":"10.1016","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4860-7277","authenticated-orcid":false,"given":"Anna","family":"Suleri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0271-1896","authenticated-orcid":false,"given":"Tonya","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7943-3903","authenticated-orcid":false,"given":"Elisabet","family":"Blok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2389-5922","authenticated-orcid":false,"given":"Charlotte A.M.","family":"Cecil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9474-6895","authenticated-orcid":false,"given":"Irwin","family":"Reiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2939-0041","authenticated-orcid":false,"given":"Vincent W.V.","family":"Jaddoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5476-8814","authenticated-orcid":false,"given":"F.A.J.","family":"Gigase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4877-282X","authenticated-orcid":false,"given":"Manon H.J.","family":"Hillegers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7235-9958","authenticated-orcid":false,"given":"Lot","family":"de Witte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0936-6968","authenticated-orcid":false,"given":"Veerle","family":"Bergink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4121-8631","authenticated-orcid":false,"given":"Anna-Sophie","family":"Rommel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jaac.2023.06.009_bib1","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1001\/jamapsychiatry.2019.0029","article-title":"Long-term risk of neuropsychiatric disease after exposure to infection in utero","volume":"76","author":"Al-Haddad","year":"2019","journal-title":"JAMA Psychiatry"},{"issue":"9","key":"10.1016\/j.jaac.2023.06.009_bib2","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41582-021-00530-8","article-title":"Maternal immune activation and neuroinflammation in human neurodevelopmental disorders","volume":"17","author":"Han","year":"2021","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.jaac.2023.06.009_bib3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.reprotox.2022.09.002","article-title":"Neuropsychiatric outcomes in offspring after fetal exposure to maternal influenza infection during pregnancy: a systematic review","volume":"113","author":"Fung","year":"2022","journal-title":"Reprod Toxicol"},{"issue":"1","key":"10.1016\/j.jaac.2023.06.009_bib4","first-page":"125","article-title":"Associations between maternal infection during pregnancy, childhood infections and the risk of subsequent psychotic disorder\u2014a Swedish cohort study of nearly 2 million individuals","volume":"42","author":"Blomstr\u00f6m","year":"2016","journal-title":"Schizophr Bull"},{"issue":"1","key":"10.1016\/j.jaac.2023.06.009_bib5","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13229-021-00464-4","article-title":"Fever during pregnancy as a risk factor for neurodevelopmental disorders: results from a systematic review and meta-analysis","volume":"12","author":"Antoun","year":"2021","journal-title":"Mol Autism"},{"key":"10.1016\/j.jaac.2023.06.009_bib6","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.3389\/fmicb.2019.01924","article-title":"The impact of infection in pregnancy on placental vascular development and adverse birth outcomes","volume":"10","author":"Weckman","year":"2019","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jaac.2023.06.009_bib7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.placenta.2017.07.006","article-title":"The association between placental histopathology and autism spectrum disorder","volume":"57","author":"Straughen","year":"2017","journal-title":"Placenta"},{"issue":"5","key":"10.1016\/j.jaac.2023.06.009_bib8","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1017\/S0033291714001998","article-title":"Late preterm birth, post-term birth, and abnormal fetal growth as risk factors for severe mental disorders from early to late adulthood","volume":"45","author":"Lahti","year":"2015","journal-title":"Psychol Med"},{"key":"10.1016\/j.jaac.2023.06.009_bib9","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jri.2018.01.004","article-title":"Microglia, the missing link in maternal immune activation and fetal neurodevelopment; and a possible link in preeclampsia and disturbed neurodevelopment?","volume":"126","author":"Prins","year":"2018","journal-title":"J\u00a0Reprod Immunol"},{"issue":"9","key":"10.1016\/j.jaac.2023.06.009_bib10","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1038\/mp.2017.191","article-title":"Gestational diabetes exacerbates maternal immune activation effects in the developing brain","volume":"23","author":"Money","year":"2018","journal-title":"Mol Psychiatry"},{"issue":"12","key":"10.1016\/j.jaac.2023.06.009_bib11","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1007\/s10654-016-0224-9","article-title":"The Generation R Study: design and cohort update 2017","volume":"31","author":"Kooijman","year":"2016","journal-title":"Eur J Epidemiol"},{"issue":"7","key":"10.1016\/j.jaac.2023.06.009_bib12","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/S0953-6205(02)00132-2","article-title":"C-reactive protein: history and revival","volume":"13","author":"Ablij","year":"2002","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.jaac.2023.06.009_bib13","series-title":"ASEBA School-Age Forms & Profiles","author":"Achenbach","year":"2001"},{"key":"10.1016\/j.jaac.2023.06.009_bib14","series-title":"Social Responsiveness Scale (SRS), Manual","author":"Constantino","year":"2002"},{"key":"10.1016\/j.jaac.2023.06.009_bib15","series-title":"Brief Symptom Inventory","author":"de Beurs","year":"2004"},{"issue":"8","key":"10.1016\/j.jaac.2023.06.009_bib16","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/sj.ejcn.1600611","article-title":"Dietary assessment in the elderly: validation of a semiquantitative food frequency questionnaire","volume":"52","author":"Klipstein-Grobusch","year":"1998","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.jaac.2023.06.009_bib17","doi-asserted-by":"crossref","unstructured":"Schuurmans IK, Luik AI, de Maat DA, Hillegers MHJ, Ikram MA, Cecil CAM. The association of early life stress with IQ-achievement discrepancy in children: a population-based study. Child Dev. Published online July 13, 2022. https:\/\/doi.org\/10.1111\/cdev.13825","DOI":"10.1111\/cdev.13825"},{"key":"10.1016\/j.jaac.2023.06.009_bib18","series-title":"Advanced Progressive Matrices: Sets I and II","author":"Raven","year":"1962"},{"key":"10.1016\/j.jaac.2023.06.009_bib19","first-page":"1","article-title":"Cognitive performance in children and adolescents with psychopathology traits: a cross-sectional multicohort study in the general population","author":"Blok","year":"2022","journal-title":"Dev Psychopathol"},{"issue":"6","key":"10.1016\/j.jaac.2023.06.009_bib20","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1007\/s13524-018-0730-3","article-title":"Maternal age and child development","volume":"55","author":"Duncan","year":"2018","journal-title":"Demography"},{"key":"10.1016\/j.jaac.2023.06.009_bib21","doi-asserted-by":"crossref","first-page":"e155","DOI":"10.1017\/S2045796020000700","article-title":"Children\u2019s behavioural problems and its associations with socioeconomic position and early parenting environment: findings from the UK Millennium Cohort Study","volume":"29","author":"Tamura","year":"2020","journal-title":"Epidemiol Psychiatr Sci"},{"issue":"9","key":"10.1016\/j.jaac.2023.06.009_bib22","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/jcpp.13197","article-title":"Mechanisms linking parental educational attainment with child ADHD, depression, and academic problems: a study of extended families in the Norwegian Mother, Father and Child Cohort Study","volume":"61","author":"Torvik","year":"2020","journal-title":"J\u00a0Child Psychol Psychiatry"},{"issue":"2","key":"10.1016\/j.jaac.2023.06.009_bib23","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/MOP.0000000000000876","article-title":"Review on the role of socioeconomic status in child health and development","volume":"32","author":"Poulain","year":"2020","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.jaac.2023.06.009_bib24","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1186\/1471-2458-12-1092","article-title":"Differences in problem behaviour among ethnic minority and majority preschoolers in the Netherlands and the role of family functioning and parenting factors as mediators: the Generation R Study","volume":"12","author":"Flink","year":"2012","journal-title":"BMC Public Health"},{"issue":"10","key":"10.1016\/j.jaac.2023.06.009_bib25","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1001\/archgenpsychiatry.2011.111","article-title":"Association of maternal and paternal IQ with offspring conduct, emotional, and attention problem scores. Transgenerational evidence from the 1958 British Birth Cohort Study","volume":"68","author":"Whitley","year":"2011","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"10.1016\/j.jaac.2023.06.009_bib26","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1001\/jamapsychiatry.2019.3523","article-title":"Incidence rates and cumulative incidences of the full spectrum of diagnosed mental disorders in childhood and adolescence","volume":"77","author":"Dalsgaard","year":"2020","journal-title":"JAMA Psychiatry"},{"issue":"3","key":"10.1016\/j.jaac.2023.06.009_bib27","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1203\/01.pdr.0000199910.16681.f0","article-title":"Maternal IQ, child IQ, behavior, and achievement in urban 5-7 year olds","volume":"59","author":"Chen","year":"2006","journal-title":"Pediatr Res"},{"issue":"1","key":"10.1016\/j.jaac.2023.06.009_bib28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41380-021-01161-7","article-title":"Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies","volume":"27","author":"Solmi","year":"2022","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jaac.2023.06.009_bib29","first-page":"1","article-title":"Maternal immune-related conditions during pregnancy may be a risk factor for neuropsychiatric problems in offspring throughout childhood and adolescence","volume":"1","author":"Patel","year":"2020","journal-title":"Psychol Med. Published online June"},{"issue":"2","key":"10.1016\/j.jaac.2023.06.009_bib30","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.biopsych.2017.05.027","article-title":"Maternal systemic interleukin-6 during pregnancy is associated with newborn amygdala phenotypes and subsequent behavior at 2 years of age","volume":"83","author":"Graham","year":"2018","journal-title":"Biol Psychiatry"},{"issue":"5","key":"10.1016\/j.jaac.2023.06.009_bib31","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.biopsych.2015.11.024","article-title":"Attention-deficit\/hyperactivity disorder in offspring of mothers with inflammatory and immune system diseases","volume":"81","author":"Instanes","year":"2017","journal-title":"Biol Psychiatry"},{"issue":"2","key":"10.1016\/j.jaac.2023.06.009_bib32","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/jcpp.12959","article-title":"Maternal infection requiring hospitalization during pregnancy and attention-deficit hyperactivity disorder in offspring: a quasi-experimental family-based study","volume":"60","author":"Ginsberg","year":"2019","journal-title":"J\u00a0Child Psychol Psychiatry"},{"key":"10.1016\/j.jaac.2023.06.009_bib33","article-title":"Maternal infection during pregnancy and the risk of attention-deficit\/hyperactivity disorder in the offspring: a systematic review and meta-analysis","volume":"68","author":"Zhu","year":"2021","journal-title":"Asian J Psychiatry"},{"issue":"8","key":"10.1016\/j.jaac.2023.06.009_bib34","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1001\/archgenpsychiatry.2010.86","article-title":"Full spectrum of psychiatric outcomes among offspring with parental history of mental disorder","volume":"67","author":"Dean","year":"2010","journal-title":"Arch Gen Psychiatry"},{"issue":"10","key":"10.1016\/j.jaac.2023.06.009_bib35","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s00787-014-0566-3","article-title":"Mechanisms underlying the effects of prenatal psychosocial stress on child outcomes: beyond the HPA axis","volume":"23","author":"Beijers","year":"2014","journal-title":"Eur Child Adolesc Psychiatry"},{"issue":"4","key":"10.1016\/j.jaac.2023.06.009_bib36","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s10519-015-9712-z","article-title":"Childhood ODD and ADHD behavior: the effect of classroom sharing, gender, teacher gender and their interactions","volume":"45","author":"de Zeeuw","year":"2015","journal-title":"Behav Genet"},{"issue":"6","key":"10.1016\/j.jaac.2023.06.009_bib37","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.6587","article-title":"Genetic and environmental risk factors associated with trajectories of depression symptoms from adolescence to young adulthood","volume":"2","author":"Kwong","year":"2019","journal-title":"JAMA Netw Open"},{"issue":"6","key":"10.1016\/j.jaac.2023.06.009_bib38","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1002\/aur.2499","article-title":"Prenatal maternal infection and risk for autism in offspring: a meta-analysis","volume":"14","author":"Tioleco","year":"2021","journal-title":"Autism Res"},{"issue":"18","key":"10.1016\/j.jaac.2023.06.009_bib39","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000006696","article-title":"Prenatal, perinatal, and postnatal factors associated with autism: a meta-analysis","volume":"96","author":"Wang","year":"2017","journal-title":"Medicine (Baltimore)"},{"issue":"10","key":"10.1016\/j.jaac.2023.06.009_bib40","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S2215-0366(22)00264-4","article-title":"Maternal infection during pregnancy and likelihood of autism and intellectual disability in children in Sweden: a negative control and sibling comparison cohort study","volume":"9","author":"Brynge","year":"2022","journal-title":"Lancet Psychiatry"}],"container-title":["Journal of the American Academy of Child & Adolescent Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890856723003258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890856723003258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:35:28Z","timestamp":1760193328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890856723003258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S0890856723003258"],"URL":"https:\/\/doi.org\/10.1016\/j.jaac.2023.06.009","relation":{},"ISSN":["0890-8567"],"issn-type":[{"value":"0890-8567","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Association Between Prenatal Infection and Adolescent Behavior: Investigating Multiple Prenatal, Perinatal, and Childhood Second Hits","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Child & Adolescent Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaac.2023.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92023 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}