{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T10:33:49Z","timestamp":1793270029636,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471546"],"award-info":[{"award-number":["82471546"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82322024"],"award-info":[{"award-number":["82322024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaacap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Child &amp; Adolescent Psychiatry"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jaac.2025.12.011","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T23:33:33Z","timestamp":1767224013000},"page":"1373-1384","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Transcriptional Signatures of Mitochondrial Metabolism Predict Esketamine-Induced rACC Structural Changes in Adolescent Major Depression"],"prefix":"10.1016","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8741-9394","authenticated-orcid":false,"given":"Yanling","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weicheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7042-084X","authenticated-orcid":false,"given":"Xiaofeng","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0516-332X","authenticated-orcid":false,"given":"Chengyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5785-198X","authenticated-orcid":false,"given":"Xiaoyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9168-1511","authenticated-orcid":false,"given":"Zhanjie","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9990-6595","authenticated-orcid":false,"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8891-9588","authenticated-orcid":false,"given":"Guanxi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4945-479X","authenticated-orcid":false,"given":"Zitao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5070-0931","authenticated-orcid":false,"given":"Junhao","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1125-2804","authenticated-orcid":false,"given":"Ziying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5317-7512","authenticated-orcid":false,"given":"Haobing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0088-9417","authenticated-orcid":false,"given":"Xuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6348-435X","authenticated-orcid":false,"given":"Yiyun","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9090-258X","authenticated-orcid":false,"given":"Hanna","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6035-6867","authenticated-orcid":false,"given":"Jichun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0051-1463","authenticated-orcid":false,"given":"Xiangdong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8892-0439","authenticated-orcid":false,"given":"Kenji","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5727-2782","authenticated-orcid":false,"given":"Yuping","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10258","key":"10.1016\/j.jaac.2025.12.011_bib1","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","year":"2020","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.jaac.2025.12.011_bib2","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1001\/jamapediatrics.2021.2482","article-title":"Global prevalence of depressive and anxiety symptoms in children and adolescents during COVID-19: a meta-analysis","volume":"175","author":"Racine","year":"2021","journal-title":"JAMA Pediatr"},{"issue":"1","key":"10.1016\/j.jaac.2025.12.011_bib3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jaac.2018.07.896","article-title":"Systematic review and meta-analysis: adolescent depression and long-term psychosocial outcomes","volume":"58","author":"Clayborne","year":"2019","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"2","key":"10.1016\/j.jaac.2025.12.011_bib4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/bjc.12333","article-title":"Global prevalence of depression and elevated depressive symptoms among adolescents: a systematic review and meta-analysis","volume":"61","author":"Shorey","year":"2022","journal-title":"Br J Clin Psychol"},{"issue":"4","key":"10.1016\/j.jaac.2025.12.011_bib5","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1176\/appi.ajp.2020.20010018","article-title":"Efficacy of intravenous ketamine in adolescent treatment-resistant depression: a randomized midazolam-controlled trial","volume":"178","author":"Dwyer","year":"2021","journal-title":"Am J Psychiatry"},{"issue":"7","key":"10.1016\/j.jaac.2025.12.011_bib6","article-title":"A systematic review on ketamine and esketamine for treatment-resistant depression and suicidality in adolescents: a new hope?","volume":"11","author":"Pardossi","year":"2024","journal-title":"Children (Basel)"},{"issue":"6","key":"10.1016\/j.jaac.2025.12.011_bib7","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.biopsych.2015.10.018","article-title":"Intravenous esketamine in adult treatment-resistant depression: a double-blind, double-randomization, placebo-controlled study","volume":"80","author":"Singh","year":"2016","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jaac.2025.12.011_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2022.860882","article-title":"The mechanisms behind rapid antidepressant effects of ketamine: a systematic review with a focus on molecular neuroplasticity","volume":"13","author":"Kang","year":"2022","journal-title":"Front Psychiatry"},{"issue":"1","key":"10.1016\/j.jaac.2025.12.011_bib9","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.biopsych.2017.05.016","article-title":"Mechanistic target of rapamycin-independent antidepressant effects of (r)-ketamine in a social defeat stress model","volume":"83","author":"Yang","year":"2018","journal-title":"Biol Psychiatry"},{"issue":"2","key":"10.1016\/j.jaac.2025.12.011_bib10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00406-020-01095-1","article-title":"Brain-derived neurotrophic factor-TrkB signaling and the mechanism of antidepressant activity by ketamine in mood disorders","volume":"270","author":"Hashimoto","year":"2020","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"issue":"12","key":"10.1016\/j.jaac.2025.12.011_bib11","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1176\/appi.ajp.2018.18020138","article-title":"Attenuation of antidepressant effects of ketamine by opioid receptor antagonism","volume":"175","author":"Williams","year":"2018","journal-title":"Am J Psychiatry"},{"issue":"12","key":"10.1016\/j.jaac.2025.12.011_bib12","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1038\/s41380-019-0503-4","article-title":"Attenuation of antidepressant and antisuicidal effects of ketamine by opioid receptor antagonism","volume":"24","author":"Williams","year":"2019","journal-title":"Mol Psychiatry"},{"issue":"6747","key":"10.1016\/j.jaac.2025.12.011_bib13","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1126\/science.adx4559","article-title":"Extending ketamine's antidepressant effects","volume":"388","author":"Hashimoto","year":"2025","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jaac.2025.12.011_bib14","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neuron.2019.03.013","article-title":"Altered connectivity in depression: gaba and glutamate neurotransmitter deficits and reversal by novel treatments","volume":"102","author":"Duman","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.jaac.2025.12.011_bib15","article-title":"The correlation of esketamine with specific adverse events: a deep dive into the FAERS database","author":"Jiang","year":"2023","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"issue":"5","key":"10.1016\/j.jaac.2025.12.011_bib16","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jaac.2023.05.031","article-title":"Effect of repeated intravenous esketamine on adolescents with major depressive disorder and suicidal ideation: a randomized active-placebo-controlled trial","volume":"63","author":"Zhou","year":"2024","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"1","key":"10.1016\/j.jaac.2025.12.011_bib17","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jaac.2025.02.015","article-title":"Effect of esketamine on depressive symptoms in adolescents with major depressive disorder at imminent suicide risk: a randomized psychoactive-controlled study","volume":"65","author":"Kosik-Gonzalez","year":"2026","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.jaac.2025.12.011_bib18","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jad.2025.01.035","article-title":"Effects of bright light therapy on cingulate cortex dynamic functional connectivity and neurotransmitter activity in young adults with subthreshold depression","volume":"374","author":"Tang","year":"2025","journal-title":"J Affect Disord"},{"issue":"6","key":"10.1016\/j.jaac.2025.12.011_bib19","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/s41386-019-0591-5","article-title":"Ketamine normalizes subgenual cingulate cortex hyper-activity in depression","volume":"45","author":"Morris","year":"2020","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.jaac.2025.12.011_bib20","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.biopsych.2007.07.018","article-title":"Rostral anterior cingulate cortex volume correlates with depressed mood in normal healthy children","volume":"63","author":"Boes","year":"2008","journal-title":"Biol Psychiatry"},{"issue":"1","key":"10.1016\/j.jaac.2025.12.011_bib21","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41398-023-02674-1","article-title":"Preliminary evidence that ketamine alters anterior cingulate resting-state functional connectivity in depressed individuals","volume":"13","author":"Alexander","year":"2023","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.jaac.2025.12.011_bib22","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1017\/S0033291724003283","article-title":"Structural brain changes in the anterior cingulate cortex of major depressive disorder individuals with suicidal ideation: evidence from the REST-meta-MDD project","volume":"55","author":"Yi","year":"2025","journal-title":"Psychol Med"},{"key":"10.1016\/j.jaac.2025.12.011_bib23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.euroneuro.2020.11.017","article-title":"Gray matter volume of rostral anterior cingulate cortex predicts rapid antidepressant response to ketamine","volume":"43","author":"Herrera-Melendez","year":"2021","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.jaac.2025.12.011_bib24","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3389\/fnins.2018.00386","article-title":"Mitochondria and mood: mitochondrial dysfunction as a key player in the manifestation of depression","volume":"12","author":"Allen","year":"2018","journal-title":"Front Neurosci"},{"key":"10.1016\/j.jaac.2025.12.011_bib25","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2972968","article-title":"Targeting inflammatory-mitochondrial response in major depression: current evidence and further challenges","volume":"2020","author":"Visentin","year":"2020","journal-title":"Oxid Med Cell Longev"},{"issue":"4","key":"10.1016\/j.jaac.2025.12.011_bib26","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/ajmg.b.31062","article-title":"Analysis of whole genome biomarker expression in blood and brain","volume":"153B","author":"Rollins","year":"2010","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"issue":"1-3","key":"10.1016\/j.jaac.2025.12.011_bib27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0165-0327(02)00067-8","article-title":"Alterations of mitochondrial function and correlations with personality traits in selected major depressive disorder patients","volume":"76","author":"Gardner","year":"2003","journal-title":"J Affect Disord"},{"key":"10.1016\/j.jaac.2025.12.011_bib28","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neuroimage.2019.01.011","article-title":"A practical guide to linking brain-wide gene expression and neuroimaging data","volume":"189","author":"Arnatkeviciute","year":"2019","journal-title":"Neuroimage"},{"issue":"6","key":"10.1016\/j.jaac.2025.12.011_bib30","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/mp.2016.60","article-title":"Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group","volume":"22","author":"Schmaal","year":"2017","journal-title":"Mol Psychiatry"},{"issue":"1","key":"10.1016\/j.jaac.2025.12.011_bib31","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/npp.2010.166","article-title":"Frontocingulate dysfunction in depression: toward biomarkers of treatment response","volume":"36","author":"Pizzagalli","year":"2011","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.jaac.2025.12.011_bib32","first-page":"255","article-title":"Rostral anterior cingulate cortex morphology predicts treatment response to Internet-based cognitive behavioral therapy for depression","volume":"3","author":"Webb","year":"2018","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"key":"10.1016\/j.jaac.2025.12.011_bib33","article-title":"Ketamine normalizes the structural alterations of inferior frontal gyrus in depression","volume":"4","author":"Dai","year":"2020","journal-title":"Chronic Stress (Thousand Oaks)"},{"issue":"1","key":"10.1016\/j.jaac.2025.12.011_bib34","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41398-023-02451-0","article-title":"Rapid neuroplasticity changes and response to intravenous ketamine: a randomized controlled trial in treatment-resistant depression","volume":"13","author":"Kopelman","year":"2023","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.jaac.2025.12.011_bib36","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.pharmthera.2018.05.010","article-title":"The neurobiology of depression, ketamine and rapid-acting antidepressants: is it glutamate inhibition or activation?","volume":"190","author":"Abdallah","year":"2018","journal-title":"Pharmacol Ther"},{"issue":"4","key":"10.1016\/j.jaac.2025.12.011_bib37","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nn.3045","article-title":"Plasticity in gray and white: neuroimaging changes in brain structure during learning","volume":"15","author":"Zatorre","year":"2012","journal-title":"Nat Neurosci"},{"issue":"6436","key":"10.1016\/j.jaac.2025.12.011_bib38","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat8078","article-title":"Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation","volume":"364","author":"Moda-Sava","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.jaac.2025.12.011_bib39","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jad.2021.04.073","article-title":"Prevalence, risk factors and clinical correlates of suicidal ideation in adolescent patients with depression in a large sample of Chinese","volume":"290","author":"Kang","year":"2021","journal-title":"J Affect Disord"},{"issue":"1","key":"10.1016\/j.jaac.2025.12.011_bib40","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.mcna.2022.04.005","article-title":"Depression and suicidal behavior in adolescents","volume":"107","author":"Grossberg","year":"2023","journal-title":"Med Clin North Am"},{"issue":"12","key":"10.1016\/j.jaac.2025.12.011_bib41","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/nrd3295","article-title":"Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders","volume":"9","author":"Rupprecht","year":"2010","journal-title":"Nat Rev Drug Discov"},{"issue":"2","key":"10.1016\/j.jaac.2025.12.011_bib42","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.biopsych.2021.05.008","article-title":"Brain-derived neurotrophic factor signaling in depression and antidepressant action","volume":"90","author":"Castren","year":"2021","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.jaac.2025.12.011_bib43","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.neuropharm.2016.09.011","article-title":"Fast-acting antidepressants rapidly stimulate ERK signaling and BDNF release in primary neuronal cultures","volume":"111","author":"Lepack","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jaac.2025.12.011_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102240","article-title":"A multimodal meta-analytical evidence of functional and structural brain abnormalities across Alzheimer's disease spectrum","volume":"95","author":"Tang","year":"2024","journal-title":"Ageing Res Rev"},{"issue":"11","key":"10.1016\/j.jaac.2025.12.011_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003676","article-title":"Neuroanatomical pattern of mitochondrial complex i pathology varies between schizophrenia, bipolar disorder and major depression","volume":"3","author":"Ben-Shachar","year":"2008","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jaac.2025.12.011_bib46","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.cell.2013.12.042","article-title":"Activity-driven local ATP synthesis is required for synaptic function","volume":"156","author":"Rangaraju","year":"2014","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jaac.2025.12.011_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-16183-x","article-title":"Ketamine's antidepressant effect is mediated by energy metabolism and antioxidant defense system","volume":"7","author":"Weckmann","year":"2017","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.jaac.2025.12.011_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.82","article-title":"NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors","volume":"4","author":"Zhou","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jaac.2025.12.011_bib49","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1038\/ncomms3034","article-title":"Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals","volume":"4","author":"Qiu","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaac.2025.12.011_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpsychires.2025.05.029","article-title":"Drug-related suicidal ideation in the K-12 population: a real-world pharmacovigilance study of the FDA Adverse Event Reporting System (FAERS) database","volume":"188","author":"Ju","year":"2025","journal-title":"J Psychiatr Res"},{"issue":"3","key":"10.1016\/j.jaac.2025.12.011_bib51","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jatmed.2024.07.001","article-title":"Ketamine and its two enantiomers in anesthesiology and psychiatry: a historical review and future directions","volume":"3","author":"Hashimoto","year":"2024","journal-title":"J Anesth Transl Med"},{"issue":"1","key":"10.1016\/j.jaac.2025.12.011_bib52","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/s41380-021-01121-1","article-title":"Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor","volume":"27","author":"Wei","year":"2022","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.jaac.2025.12.011_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109219","article-title":"Arketamine, a new rapid-acting antidepressant: a historical review and future directions","volume":"218","author":"Zhang","year":"2022","journal-title":"Neuropharmacology"},{"issue":"5","key":"10.1016\/j.jaac.2025.12.011_bib54","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1007\/s00406-024-01945-2","article-title":"Arketamine: a scoping review of its use in humans","volume":"275","author":"Leal","year":"2025","journal-title":"Eur Arch Psychiatry Clin Neurosci"}],"container-title":["Journal of the American Academy of Child &amp; Adolescent Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890856725022415?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0890856725022415?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T09:50:49Z","timestamp":1793267449000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0890856725022415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":52,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0890856725022415"],"URL":"https:\/\/doi.org\/10.1016\/j.jaac.2025.12.011","relation":{},"ISSN":["0890-8567"],"issn-type":[{"value":"0890-8567","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptional Signatures of Mitochondrial Metabolism Predict Esketamine-Induced rACC Structural Changes in Adolescent Major Depression","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Child & Adolescent Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaac.2025.12.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92025 American Academy of Child and Adolescent Psychiatry","name":"copyright","label":"Copyright"}]}}