{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T20:31:08Z","timestamp":1787085068452,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaacap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Child &amp; Adolescent Psychiatry"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jaac.2026.06.006","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:21:20Z","timestamp":1781659280000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Discontinuation, Medication Switching, and Augmentation After SSRI in Pediatric Depression"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8111-4664","authenticated-orcid":false,"given":"Haeyoung","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1336-8106","authenticated-orcid":false,"given":"Wendy","family":"Camelo Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danya M.","family":"Qato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5309-4547","authenticated-orcid":false,"given":"Roderick","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8070-673X","authenticated-orcid":false,"given":"Gloria","family":"Reeves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2210-6650","authenticated-orcid":false,"given":"Susan","family":"dosReis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaac.2026.06.006_bib1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.jad.2024.03.074","article-title":"Global burden of depression or depressive symptoms in children and adolescents: a systematic review and meta-analysis","volume":"354","author":"Lu","year":"2024","journal-title":"J Affect Disord"},{"issue":"3","key":"10.1016\/j.jaac.2026.06.006_bib2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S1056-4993(02)00011-1","article-title":"Course and outcome of child and adolescent major depressive disorder","volume":"11","author":"Birmaher","year":"2002","journal-title":"Child Adolesc Psychiatr Clin N Am"},{"key":"10.1016\/j.jaac.2026.06.006_bib3","series-title":"APA Clinical Practice guideline for the treatment of depression across three age cohorts: (505892019-001)","year":"2019"},{"issue":"3","key":"10.1016\/j.jaac.2026.06.006_bib4","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2017-4082","article-title":"Guidelines for Adolescent Depression in Primary Care (GLAD-PC): part II. Treatment and ongoing management","volume":"141","author":"Cheung","year":"2018","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.jaac.2026.06.006_bib5","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jaac.2022.10.001","article-title":"Clinical practice guideline for the assessment and treatment of children and adolescents with major and persistent depressive disorders","volume":"62","author":"Walter","year":"2023","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"10","key":"10.1016\/j.jaac.2026.06.006_bib6","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1097\/00004583-200210000-00010","article-title":"Fluoxetine for acute treatment of depression in children and adolescents: a placebo-controlled, randomized clinical trial","volume":"41","author":"Emslie","year":"2002","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"7","key":"10.1016\/j.jaac.2026.06.006_bib7","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/CHI.0b013e3181a2b304","article-title":"Escitalopram in the treatment of adolescent depression: a randomized placebo-controlled multisite trial","volume":"48","author":"Emslie","year":"2009","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"2","key":"10.1016\/j.jaac.2026.06.006_bib8","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/pds.4138","article-title":"Outpatient antidepressant drug use in children and adolescents in Germany between 2004 and 2011","volume":"26","author":"Schr\u00f6der","year":"2017","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"3","key":"10.1016\/j.jaac.2026.06.006_bib9","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/jcpp.13202","article-title":"Annual research review: defining and treating pediatric treatment-resistant depression","volume":"61","author":"Dwyer","year":"2020","journal-title":"J Child Psychol Psychiatry"},{"issue":"11","key":"10.1016\/j.jaac.2026.06.006_bib10","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/da.20884","article-title":"Treatment-resistant depression in adolescents: review and updates on clinical management","volume":"28","author":"Maalouf","year":"2011","journal-title":"Depress Anxiety"},{"issue":"5","key":"10.1016\/j.jaac.2026.06.006_bib11","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s40272-014-0088-y","article-title":"Management of treatment-resistant depression in children and adolescents","volume":"16","author":"DeFilippis","year":"2014","journal-title":"Paediatr Drugs"},{"issue":"8","key":"10.1016\/j.jaac.2026.06.006_bib12","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1001\/jama.299.8.901","article-title":"Switching to another SSRI or to venlafaxine with or without cognitive behavioral therapy for adolescents with SSRI- resistant depression: the TORDIA randomized controlled trial","volume":"299","author":"Brent","year":"2008","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.jaac.2026.06.006_bib13","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1176\/appi.ajp.2010.09040552","article-title":"Treatment of Resistant Depression in Adolescents (TORDIA): week 24 outcomes","volume":"167","author":"Emslie","year":"2010","journal-title":"Am J Psychiatry"},{"issue":"12","key":"10.1016\/j.jaac.2026.06.006_bib14","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1016\/j.clinthera.2010.11.011","article-title":"Antidepressant monotherapy: a claims database analysis of treatment changes and treatment duration","volume":"32","author":"Milea","year":"2010","journal-title":"Clin Ther"},{"issue":"7-8","key":"10.1016\/j.jaac.2026.06.006_bib15","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1345\/aph.1Q020","article-title":"Factors associated with antidepressant adherence for Medicaid-enrolled children and adolescents","volume":"45","author":"Fontanella","year":"2011","journal-title":"Ann Pharmacother"},{"issue":"Suppl 11-a","key":"10.1016\/j.jaac.2026.06.006_bib16","first-page":"S2","article-title":"Economic burden and antidepressant treatment patterns among patients with major depressive disorder in the United States","volume":"28","author":"Zhu","year":"2022","journal-title":"J Manag Care Spec Pharm"},{"issue":"1","key":"10.1016\/j.jaac.2026.06.006_bib17","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s12888-017-1385-0","article-title":"Treatment patterns, healthcare resource utilization, and costs following first-line antidepressant treatment in major depressive disorder: a retrospective US claims database analysis","volume":"17","author":"Gauthier","year":"2017","journal-title":"BMC Psychiatry"},{"issue":"6","key":"10.1016\/j.jaac.2026.06.006_bib18","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/YIC.0000000000000574","article-title":"Resistance to antidepressant treatment among patients with major depressive disorder: a nationwide study","volume":"40","author":"Chen","year":"2025","journal-title":"Int Clin Psychopharmacol"},{"issue":"12","key":"10.1016\/j.jaac.2026.06.006_bib19","first-page":"1455","article-title":"Antidepressant therapeutic strategies and health care utilization in patients with depression","volume":"30","author":"Tran","year":"2024","journal-title":"J Manag Care Spec Pharm"},{"issue":"16","key":"10.1016\/j.jaac.2026.06.006_bib20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s12888-016-0963-x","article-title":"Can mental health diagnoses in administrative data be used for research? A systematic review of the accuracy of routinely collected diagnoses","volume":"26","author":"Davis","year":"2016","journal-title":"BMC Psychiatry"},{"issue":"3","key":"10.1016\/j.jaac.2026.06.006_bib21","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1176\/appi.ps.201500088","article-title":"Dosing of selective serotonin reuptake inhibitors among children and adults before and after the FDA black-box warning","volume":"67","author":"Bushnell","year":"2016","journal-title":"Psychiatr Serv"},{"issue":"7","key":"10.1016\/j.jaac.2026.06.006_bib22","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/phar.2767","article-title":"Adverse effects of antidepressant medications and their management in children and adolescents","volume":"43","author":"Strawn","year":"2023","journal-title":"Pharmacotherapy"},{"issue":"10","key":"10.1016\/j.jaac.2026.06.006_bib23","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1001\/archpsyc.64.10.1132","article-title":"The Treatment for Adolescents With Depression Study (TADS): long-term effectiveness and safety outcomes","volume":"64","author":"March","year":"2007","journal-title":"Arch Gen Psychiatry"},{"issue":"7","key":"10.1016\/j.jaac.2026.06.006_bib24","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1001\/jama.292.7.807","article-title":"Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents with Depression Study (TADS) randomized controlled trial","volume":"292","author":"March","year":"2004","journal-title":"JAMA"},{"issue":"10","key":"10.1016\/j.jaac.2026.06.006_bib25","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1002\/pds.5490","article-title":"Core concepts in pharmacoepidemiology: measures of drug utilization based on individual-level drug dispensing data","volume":"31","author":"Rasmussen","year":"2022","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"1","key":"10.1016\/j.jaac.2026.06.006_bib26","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3949\/ccjm.89a.21020","article-title":"Discontinuing antidepressants: pearls and pitfalls","volume":"89","author":"Zwiebel","year":"2022","journal-title":"Cleve Clin J Med"},{"issue":"3","key":"10.1016\/j.jaac.2026.06.006_bib27","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1177\/02698811221104058","article-title":"Systematic review and meta-analysis of augmentation and combination treatments for early-stage treatment-resistant depression","volume":"37","author":"Scott","year":"2023","journal-title":"J Psychopharmacol"},{"issue":"25","key":"10.1016\/j.jaac.2026.06.006_bib28","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1002\/sim.3697","article-title":"Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples","volume":"28","author":"Austin","year":"2009","journal-title":"Stat Med"},{"issue":"9","key":"10.1016\/j.jaac.2026.06.006_bib29","first-page":"26","article-title":"Antidepressants for pediatric patients","volume":"18","author":"Dwyer","year":"2019","journal-title":"Curr Psychiatr"},{"issue":"4","key":"10.1016\/j.jaac.2026.06.006_bib30","doi-asserted-by":"crossref","first-page":"e996","DOI":"10.1542\/peds.2013-0600","article-title":"Evidence for the management of adolescent depression","volume":"132","author":"Lewandowski","year":"2013","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.jaac.2026.06.006_bib31","first-page":"31","article-title":"Antidepressant treatment duration in pediatric depressive and anxiety disorders: how long is long enough?","volume":"48","author":"Hathaway","year":"2018","journal-title":"Curr Probl Pediatr Adolesc Health Care"},{"issue":"5","key":"10.1016\/j.jaac.2026.06.006_bib32","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s10560-011-0237-x","article-title":"Examining outpatient treatment dropout in adolescents: a literature review","volume":"28","author":"Block","year":"2011","journal-title":"Child Adolesc Soc Work J"},{"issue":"9","key":"10.1016\/j.jaac.2026.06.006_bib33","doi-asserted-by":"crossref","first-page":"826","DOI":"10.4088\/JCP.v63n0913","article-title":"Partial response and nonresponse to antidepressant therapy: current approaches and treatment options","volume":"63","author":"Hirschfeld","year":"2002","journal-title":"J Clin Psychiatry"},{"issue":"5","key":"10.1016\/j.jaac.2026.06.006_bib34","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1592\/phco.25.5.660.63590","article-title":"Persistence, switching, and discontinuation rates among patients receiving sertraline, paroxetine, and citalopram","volume":"25","author":"Mullins","year":"2005","journal-title":"Pharmacotherapy"},{"issue":"5","key":"10.1016\/j.jaac.2026.06.006_bib35","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1159\/000447034","article-title":"The safety, tolerability and risks associated with the use of newer generation antidepressant drugs: a critical review of the literature","volume":"85","author":"Carvalho","year":"2016","journal-title":"Psychother Psychosom"},{"issue":"1","key":"10.1016\/j.jaac.2026.06.006_bib36","doi-asserted-by":"crossref","first-page":"10","DOI":"10.9740\/mhc.2024.02.010","article-title":"Antipsychotics in child and adolescent patients with major depressive disorder: a retrospective analysis of prescribing patterns","volume":"14","author":"Dauchot","year":"2024","journal-title":"Ment Health Clin"},{"issue":"9","key":"10.1016\/j.jaac.2026.06.006_bib37","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1176\/appi.ajp.2009.09030312","article-title":"Atypical antipsychotic augmentation in major depressive disorder: a meta-analysis of placebo-controlled randomized trials","volume":"166","author":"Nelson","year":"2009","journal-title":"Am J Psychiatry"}],"updated-by":[{"DOI":"10.1016\/j.jaac.2026.07.1246","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000}}],"container-title":["Journal of the American Academy of Child &amp; Adolescent Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089085672600273X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089085672600273X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T20:06:54Z","timestamp":1787083614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089085672600273X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":37,"alternative-id":["S089085672600273X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaac.2026.06.006","relation":{},"ISSN":["0890-8567"],"issn-type":[{"value":"0890-8567","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discontinuation, Medication Switching, and Augmentation After SSRI in Pediatric Depression","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Child & Adolescent Psychiatry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaac.2026.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a92026 American Academy of Child and Adolescent Psychiatry","name":"copyright","label":"Copyright"}]}}