{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:07:09Z","timestamp":1776298029967,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1016\/j.jaad.2004.04.032","type":"journal-article","created":{"date-parts":[[2004,11,8]],"date-time":"2004-11-08T13:47:18Z","timestamp":1099921638000},"page":"709-717","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Effect of a single course of isotretinoin therapy on bone mineral density in adolescent patients with severe, recalcitrant, nodular acne"],"prefix":"10.1016","volume":"51","author":[{"given":"John J.","family":"DiGiovanna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig B.","family":"Langman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo H.","family":"Tschen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Menter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas J.","family":"Lowe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Eichenfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelaide A.","family":"Hebert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Pariser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald P.","family":"Savin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacy R.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Jarratt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan K.","family":"Chalker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Kempers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elyse S.","family":"Rafal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabra","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sewon","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leena P.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Newhouse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Pak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas R.","family":"Eberhardt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme F.","family":"Bryce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"McLane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Ondovik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Chin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ko-Chin","family":"Khoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phoebe","family":"Rich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaad.2004.04.032_BIB1","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/S0190-9622(80)80074-0","article-title":"The treatment of severe cystic acne with 13-cis-retinoic acid: evaluation of sebum production and the clinical response in a multiple-dose trial","volume":"3","author":"Farrell","year":"1980","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2004.04.032_BIB2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJM197902153000701","article-title":"Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid","volume":"300","author":"Peck","year":"1979","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaad.2004.04.032_BIB3","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S0140-6736(80)92273-4","article-title":"13-cis-retinoic acid and acne","volume":"2","author":"Jones","year":"1980","journal-title":"Lancet"},{"key":"10.1016\/j.jaad.2004.04.032_BIB4","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/S0190-9622(87)70133-9","article-title":"Hypervitaminosis A syndrome: a paradigm of retinoid side effects","volume":"16","author":"Silverman","year":"1987","journal-title":"J Am Acad Dermatol"},{"issue":"Suppl","key":"10.1016\/j.jaad.2004.04.032_BIB5","doi-asserted-by":"crossref","first-page":"S176","DOI":"10.1067\/mjd.2001.113721","article-title":"Isotretinoin effects on bone","volume":"45","author":"DiGiovanna","year":"2001","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2004.04.032_BIB6","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1056\/NEJM198304283081707","article-title":"Skeletal toxicity associated with long-term administration of 13-cis-retinoic acid for refractory ichthyosis","volume":"308","author":"Pittsley","year":"1983","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaad.2004.04.032_BIB7","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/S0190-9622(84)80329-1","article-title":"Isotretinoin therapy is associated with early skeletal radiographic changes","volume":"10","author":"Ellis","year":"1984","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2004.04.032_BIB8","first-page":"979","article-title":"Early skeletal hyperostoses secondary to 13-cis-retinoic acid","volume":"142","author":"Pennes","year":"1984","journal-title":"Am J Radiol"},{"key":"10.1016\/j.jaad.2004.04.032_BIB9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00004424-198601000-00007","article-title":"Minimal spinal hyperostosis with low-dose isotretinoin therapy","volume":"21","author":"Kilcoyne","year":"1986","journal-title":"Invest Radiol"},{"key":"10.1016\/j.jaad.2004.04.032_BIB10","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1365-4362.1995.tb04666.x","article-title":"13-cis-Retinoic acid and bone density","volume":"34","author":"Kocijancic","year":"1995","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.jaad.2004.04.032_BIB11","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1001\/archderm.1996.03890310053007","article-title":"Effects of isotretinoin on bone mineralization during routine therapy with isotretinoin for acne vulgaris","volume":"132","author":"Margolis","year":"1996","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2004.04.032_BIB12","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1001\/archderm.135.8.961","article-title":"Bone densities in patients receiving isotretinoin for cystic acne","volume":"135","author":"Leachman","year":"1999","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2004.04.032_BIB13","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1001\/archderm.1995.01690230041007","article-title":"Osteoporosis is a toxic effect of long-tern etretinate therapy","volume":"131","author":"DiGiovanna","year":"1995","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2004.04.032_BIB14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1001\/archderm.1982.01650130027012","article-title":"Various parameters for grading acne vulgaris","volume":"118","author":"Allen","year":"1982","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2004.04.032_BIB15","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s001980070020","article-title":"Peak bone mass","volume":"11","author":"Heaney","year":"2000","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jaad.2004.04.032_BIB16","first-page":"4702","article-title":"Bone mineral acquisition in healthy Asian, Hispanic, black, and Caucasian youth: a longitudinal study","volume":"84","author":"Bachrach","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl","key":"10.1016\/j.jaad.2004.04.032_BIB17","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1385\/JCD:5:3S:S01","article-title":"Executive summary, International Society for Clinical Densitometry position development conference, Denver, Colorado, July 20-22, 2001","volume":"5","author":"Lenchik","year":"2002","journal-title":"J Clin Densitom"},{"issue":"Suppl","key":"10.1016\/j.jaad.2004.04.032_BIB18","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1385\/JCD:5:3S:S11","article-title":"Which central dual x-ray absorptiometry skeletal sites and regions of interest should be used to determine the diagnosis of osteoporosis?","volume":"5","author":"Hamdy","year":"2002","journal-title":"J Clin Densitom"},{"issue":"Suppl","key":"10.1016\/j.jaad.2004.04.032_BIB19","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1385\/JCD:5:3S:S29","article-title":"What is the role of serial bone mineral density measurements in patient management?","volume":"5","author":"Lenchik","year":"2002","journal-title":"J Clin Densitom"},{"key":"10.1016\/j.jaad.2004.04.032_BIB20","first-page":"967","article-title":"Evolution of skeletal hyperostoses caused by 13-cis-retinoic acid therapy","volume":"151","author":"Pennes","year":"1988","journal-title":"Am J Radiol"},{"key":"10.1016\/j.jaad.2004.04.032_BIB21","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1365-2133.1988.tb03471.x","article-title":"Skeletal toxicity with isotretinoin therapy: a clinico-radiological evaluation","volume":"119","author":"Carey","year":"1988","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2004.04.032_BIB22","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1365-2133.1988.tb01763.x","article-title":"Bone x-ray examinations in patients treated with isotretinoin: a prospective study","volume":"118","author":"T\u00f6r\u00f6k","year":"1988","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2004.04.032_BIB23","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1001\/archderm.138.11.1516-a","article-title":"Is retinoid induced osteopenia reversible?","volume":"138","author":"Milstone","year":"2002","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2004.04.032_BIB24","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1359\/jbmr.1997.12.5.832","article-title":"A new trabecular region of interest for femoral dual x-ray absorptiometry: short-term precision, age-related bone loss, and fracture discrimination compared with current femoral regions of interest","volume":"12","author":"Takada","year":"1997","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jaad.2004.04.032_BIB25","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/BF02652557","article-title":"Asynchrony between the rates of standing height gain and bone mass accumulation during puberty","volume":"7","author":"Fournier","year":"1997","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jaad.2004.04.032_BIB26","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1210\/jcem-73-6-1332","article-title":"Clinical and anthropometric correlates of bone mineral acquisition in healthy adolescent girls","volume":"73","author":"Katzman","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jaad.2004.04.032_BIB27","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S1043-2760(00)00336-2","article-title":"Acquisition of optimal bone mass in childhood and adolescence","volume":"12","author":"Bachrach","year":"2001","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jaad.2004.04.032_BIB28","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1172\/JCI117034","article-title":"Timing of peak bone mass in Caucasian females and its implication for the prevention of osteoporosis","volume":"93","author":"Matkovic","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaad.2004.04.032_BIB29","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1067\/mjd.2001.115965","article-title":"A randomized trial of the efficacy of a new micronized formulation versus a standard formulation of isotretinoin in patients with severe recalcitrant nodular acne","volume":"45","author":"Strauss","year":"2001","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2004.04.032_BIB30","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1067\/mjd.2001.115966","article-title":"Safety of a new micronized formulation of isotretinoin in patients with severe recalcitrant nodular acne: a randomized trial comparing micronized isotretinoin with standard isotretinoin","volume":"45","author":"Strauss","year":"2001","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2004.04.032_BIB31","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/S0190-9622(84)80100-0","article-title":"Isotretinoin therapy for acne: results of a multicenter dose-response study","volume":"10","author":"Strauss","year":"1984","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2004.04.032_BIB32","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1056\/NEJMoa021171","article-title":"Serum retinol levels and the risk of fracture","volume":"348","author":"Micha\u00eblsson","year":"2003","journal-title":"N Engl J Med"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962204012976?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962204012976?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T21:34:47Z","timestamp":1759268087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962204012976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S0190962204012976"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2004.04.032","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of a single course of isotretinoin therapy on bone mineral density in adolescent patients with severe, recalcitrant, nodular acne","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2004.04.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}