{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T14:25:27Z","timestamp":1770042327412,"version":"3.49.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.jaad.2005.11.1062","type":"journal-article","created":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T09:34:59Z","timestamp":1152696899000},"page":"S11-S15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"S","title":["Early congenital syphilis and erythema multiforme\u2013like bullous targetoid lesions in a 1-day-old newborn: Detection of Treponema pallidum genomic DNA from the targetoid plaque using nested polymerase chain reaction"],"prefix":"10.1016","volume":"55","author":[{"given":"Chao-Chang","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Neu","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Rou","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Shang","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Hui","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaad.2005.11.1062_bib1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/00006454-199801000-00015","article-title":"Laboratory tests for congenital syphilis","volume":"17","author":"Sanchez","year":"1998","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jaad.2005.11.1062_bib2","first-page":"52","article-title":"Dealing with maternal and congenital syphilis","volume":"6","author":"Reyes","year":"1995","journal-title":"Contemp OB\/GYN"},{"key":"10.1016\/j.jaad.2005.11.1062_bib3","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1365-2230.1992.tb02533.x","article-title":"Bullous secondary syphilis","volume":"17","author":"Lawrence","year":"1992","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jaad.2005.11.1062_bib4","first-page":"40","article-title":"1993 sexually transmitted diseases treatment guidelines","volume":"42","author":"Centers for Disease Control and Prevention","year":"1993","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.jaad.2005.11.1062_bib5","first-page":"2163","article-title":"Syphilis","volume":"Vol 2","author":"Sanchez","year":"2002"},{"key":"10.1016\/j.jaad.2005.11.1062_bib6","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0738-081X(00)00152-8","article-title":"Treponemal infections in the pediatric population","volume":"18","author":"Parish","year":"2000","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.jaad.2005.11.1062_bib7","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0190-9622(91)70057-9","article-title":"Recent advances in pediatric infectious diseases and their impact on dermatology","volume":"24","author":"Grossman","year":"1991","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2005.11.1062_bib8","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0190-9622(83)80003-6","article-title":"Erythema multiforme: a critical review of characteristics, diagnostic criteria, and causes","volume":"8","author":"Huff","year":"1983","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2005.11.1062_bib9","first-page":"543","article-title":"Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis","volume":"Vol 1","author":"Fritsch","year":"2002"},{"key":"10.1016\/j.jaad.2005.11.1062_bib10","series-title":"Lever's Histopathology of the Skin","first-page":"243","article-title":"Noninfectious vesiculobullous and vesiculopustular diseases","author":"Wu","year":"2004"},{"key":"10.1016\/j.jaad.2005.11.1062_bib11","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1128\/JCM.39.5.1941-1946.2001","article-title":"New tests for syphilis: rational design of a PCR method for detection of Treponema pallidum in clinical specimens using unique regions of the DNA polymerase I gene","volume":"39","author":"Liu","year":"2001","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jaad.2005.11.1062_bib12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/00129039-200209000-00015","article-title":"Extraction and amplification of DNA from formalin-fixed, paraffin-embedded tissues","volume":"10","author":"Wu","year":"2002","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1016\/j.jaad.2005.11.1062_bib13","first-page":"256","article-title":"Sexually transmitted diseases in neonates and infants","volume":"13","author":"Treadwell","year":"1994","journal-title":"Semin Dermatol"},{"key":"10.1016\/j.jaad.2005.11.1062_bib14","first-page":"327","article-title":"Congenital syphilis presenting as desquamative dermatitis","volume":"35","author":"Wood","year":"1992","journal-title":"J Fam Pract"},{"key":"10.1016\/j.jaad.2005.11.1062_bib15","first-page":"1237","article-title":"The Treponematoses","volume":"Vol 2","author":"Morton","year":"1999"},{"key":"10.1016\/j.jaad.2005.11.1062_bib16","first-page":"195","article-title":"Annular lesions in congenital syphilis","volume":"68","author":"Agarwal","year":"1992","journal-title":"Genitourin Med"},{"key":"10.1016\/j.jaad.2005.11.1062_bib17","series-title":"Lever's Histopathology of the Skin","first-page":"591","article-title":"Treponemal Diseases","author":"Crowson","year":"2004"},{"key":"10.1016\/j.jaad.2005.11.1062_bib18","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1046\/j.1365-2133.2003.05512.x","article-title":"Erythema multiforme-like lesions in syphilis","volume":"149","author":"Lee","year":"2003","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2005.11.1062_bib19","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0022-3476(51)80050-7","article-title":"Erythema multiforme as a manifestation of neonatal septicemia","volume":"38","author":"Starr","year":"1951","journal-title":"J Pediatr"},{"key":"10.1016\/j.jaad.2005.11.1062_bib20","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/S0022-3476(55)80104-7","article-title":"Septicemia and meningitis in a newborn infant","volume":"47","author":"Smith","year":"1955","journal-title":"J Pediatr"},{"key":"10.1016\/j.jaad.2005.11.1062_bib21","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1542\/peds.39.1.120","article-title":"Erythema multiforme in a premature infant associated with sepsis due to Pseudomonas","volume":"39","author":"Washington","year":"1967","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaad.2005.11.1062_bib22","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1136\/pgmj.40.468.590","article-title":"The investigation of an outbreak of Pseudomonas pyocyanea infection in a pediatric unit","volume":"40","author":"Jacobs","year":"1964","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.jaad.2005.11.1062_bib23","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1439-0507.1991.tb00805.x","article-title":"Erythema multiforme and dermatitis seborroides infantum as concomitant id-reactions to widespread candidosis in a suckling","volume":"34","author":"Korting","year":"1991","journal-title":"Mycoses"},{"key":"10.1016\/j.jaad.2005.11.1062_bib24","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/j.1651-2227.1992.tb12349.x","article-title":"Erythema multiforme as a single manifestation of cow's milk intolerance","volume":"81","author":"Ashkenazi","year":"1992","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jaad.2005.11.1062_bib25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1525-1470.1986.tb00504.x","article-title":"Erythema multiforme in childhood and early infancy","volume":"3","author":"Dikland","year":"1986","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.jaad.2005.11.1062_bib26","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1067\/mjd.2003.152","article-title":"Erythema multiforme in a neonate","volume":"48","author":"Torrelo","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2005.11.1062_bib27","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1128\/jcm.29.9.1976-1984.1991","article-title":"Detection by polymerase chain reaction of Treponema pallidum DNA in cerebrospinal fluid from neurosyphilis patients before and after antibiotic treatment","volume":"29","author":"Noordhoek","year":"1991","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jaad.2005.11.1062_bib28","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1056\/NEJM199412013312204","article-title":"Brief report: cerebral syphilitic gumma confirmed by the polymerase chain reaction in a man with human immunodeficiency virus infection","volume":"331","author":"Horowitz","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaad.2005.11.1062_bib29","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1128\/jcm.30.2.497-500.1992","article-title":"Detection of Treponema pallidum in early syphilis by DNA amplification","volume":"30","author":"Wicher","year":"1992","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jaad.2005.11.1062_bib30","first-page":"428","article-title":"Detection of treponemal DNA in the CSF of patients with syphilis and HIV infection using polymerase chain reaction","volume":"66","author":"Hay","year":"1990","journal-title":"Genitourin Med"},{"key":"10.1016\/j.jaad.2005.11.1062_bib31","doi-asserted-by":"crossref","first-page":"11611","DOI":"10.1073\/pnas.91.24.11611","article-title":"The 47-kDa major lipoprotein immunogen of Treponema pallidum is a penicillin-binding protein with carboxypeptidase activity","volume":"91","author":"Weigel","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaad.2005.11.1062_bib32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1128\/jcm.34.1.49-54.1996","article-title":"Simultaneous PCR detection of Haemophilus ducreyi, Treponema pallidum, and herpes simplex virus types 1 and 2 from genital ulcers","volume":"34","author":"Orle","year":"1996","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jaad.2005.11.1062_bib33","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1542\/peds.89.1.32","article-title":"Herpes simplex virus in childhood erythema multiforme","volume":"89","author":"Weston","year":"1992","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaad.2005.11.1062_bib34","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1001\/archpedi.1997.02170470048009","article-title":"Herpes simplex virus-associated erythema multiforme in prepubertal children","volume":"151","author":"Weston","year":"1997","journal-title":"Arch Pediatr Adolesc Med"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962205046062?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962205046062?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T22:02:44Z","timestamp":1759269764000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962205046062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S0190962205046062"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2005.11.1062","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early congenital syphilis and erythema multiforme\u2013like bullous targetoid lesions in a 1-day-old newborn: Detection of Treponema pallidum genomic DNA from the targetoid plaque using nested polymerase chain reaction","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2005.11.1062","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}