{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T06:03:11Z","timestamp":1783749791743,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.jaad.2005.12.003","type":"journal-article","created":{"date-parts":[[2006,2,20]],"date-time":"2006-02-20T10:57:23Z","timestamp":1140433043000},"page":"513-516","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["A novel explanation for acantholysis in pemphigus vulgaris: The basal cell shrinkage hypothesis"],"prefix":"10.1016","volume":"54","author":[{"given":"Jean-Claude","family":"Bystryn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei A.","family":"Grando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaad.2005.12.003_bib1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1365-2133.1993.tb00192.x","article-title":"An immunohistological study of desmosomal components in pemphigus","volume":"128","author":"Burge","year":"1993","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/1523-1747.ep12613668","article-title":"Adhesion molecules, I: keratinocyte-keratinocyte interactions; cadherins and pemphigus","volume":"104","author":"Amagai","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib3","first-page":"107","article-title":"Defective cell-cell adhesion in the epidermis","volume":"189","author":"Stanley","year":"1995","journal-title":"Ciba Found Symp"},{"key":"10.1016\/j.jaad.2005.12.003_bib4","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1172\/JCI5252","article-title":"Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris","volume":"103","author":"Mahoney","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaad.2005.12.003_bib5","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1001\/jama.282.6.572","article-title":"Pemphigus\u2013diseases of antidesmosomal autoimmunity","volume":"282","author":"Udey","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.jaad.2005.12.003_bib6","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/jid.1967.86","article-title":"An electron microscopic study on pemphigus vulgaris of the mouth and the skin with special reference to the intercellular cement","volume":"48","author":"Hashimoto","year":"1967","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000254157","article-title":"The intercellular cement in pemphigus vulgaris, an electron microscopic study","volume":"135","author":"Hashimoto","year":"1967","journal-title":"Dermatologica"},{"key":"10.1016\/j.jaad.2005.12.003_bib8","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/jid.1961.58","article-title":"An electron microscopic study of acantholysis in pemphigus vulgaris","volume":"36","author":"Wilgram","year":"1961","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib9","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0190-9622(82)70036-2","article-title":"Mechanism of lesion production in pemphigus and pemphigoid","volume":"6","author":"Sams","year":"1982","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib10","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1046\/j.1523-1747.1998.00085.x","article-title":"Lack of mucosal involvement in pemphigus foliaceus may be due to low expression of desmoglein 1","volume":"110","author":"Shirakata","year":"1998","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib11","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/1523-1747.ep12337524","article-title":"Mucosal and mucocutaneous (generalized) pemphigus vulgaris show distinct autoantibody profiles","volume":"109","author":"Ding","year":"1997","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib12","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1001\/archderm.138.9.1252","article-title":"Limitations in enzyme-linked immunosorbent assays for antibodies against desmogleins 1 and 3 in patients with pemphigus","volume":"138","author":"Bystryn","year":"2002","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib13","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0190-9622(99)70183-0","article-title":"The clinical phenotype of pemphigus is defined by the anti-desmoglein autoantibody profile","volume":"40","author":"Amagai","year":"1999","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib14","first-page":"377","article-title":"Influence of intravenous immunoglobulin therapy on autoantibody titers to desmoglein 3 and desmoglein 1 in pemphigus vulgaris","volume":"13","author":"Sami","year":"2003","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib15","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1067\/mjd.2003.438","article-title":"Antibodies to desmoglein 1 and 3, and the clinical phenotype of pemphigus vulgaris","volume":"48","author":"Jamora","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib16","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1046\/j.1523-1747.1999.00585.x","article-title":"The anti-desmoglein 1 autoantibodies in pemphigus vulgaris sera are pathogenic","volume":"112","author":"Ding","year":"1999","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib17","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1365-2133.1986.tb02795.x","article-title":"Effects of pemphigus antibody on the organization of microtubules and keratin-intermediate filaments in cultured human keratinocytes","volume":"114","author":"Kitajima","year":"1986","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib18","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/0923-1811(92)90003-T","article-title":"Different effects of pemphigus antibody and plasmin on the distribution of keratin intermediate filaments and desmoplakins between cultured oral and epidermal keratinocytes","volume":"3","author":"Jinbu","year":"1992","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jaad.2005.12.003_bib19","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/j.1365-2133.2004.05919.x","article-title":"Pemphigus serum and captopril induce heat shock protein 70 and inducible nitric oxide synthase overexpression, triggering apoptosis in human keratinocytes","volume":"150","author":"Baroni","year":"2004","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib20","doi-asserted-by":"crossref","unstructured":"Lever WF. Pemphigus. Medicine (Baltimore) 1953;32:2-123.","DOI":"10.1097\/00005792-195302000-00001"},{"key":"10.1016\/j.jaad.2005.12.003_bib21","first-page":"345","article-title":"Epidermal acantholysis induced in vitro by pemphigus autoantibody: an ultrastructural study","volume":"90","author":"Hu","year":"1978","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaad.2005.12.003_bib22","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1600-0714.1991.tb00427.x","article-title":"Ultrastructural alterations associated with in vivo and in vitro bound pemphigus antibodies in cultured oral epithelial cells","volume":"20","author":"Barlow","year":"1991","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.jaad.2005.12.003_bib23","series-title":"Pemphigus and pemphigoid","author":"Lever","year":"1965"},{"issue":"Suppl","key":"10.1016\/j.jaad.2005.12.003_bib24","article-title":"Calcium-regulated differentiation of normal human epidermal keratinocytes in chemically defined clonal culture and serum-free serial culture","volume":"81","author":"Boyce","year":"1983","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib25","series-title":"Physiology, biochemistry, and molecular biology of the skin","first-page":"113","article-title":"Molecular and cellular biology of keratins","author":"Steiner","year":"1991"},{"key":"10.1016\/j.jaad.2005.12.003_bib26","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1046\/j.1523-1747.1998.00299.x","article-title":"Identification and mapping of keratinocyte muscarinic acetylcholine receptor subtypes in human epidermis","volume":"111","author":"Ndoye","year":"1998","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib27","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1002\/(SICI)1521-4141(199907)29:07<2233::AID-IMMU2233>3.0.CO;2-4","article-title":"A pathogenic autoantibody, pemphigus vulgaris-IgG, induces phosphorylation of desmoglein 3, and its dissociation from plakoglobin in cultured keratinocytes","volume":"29","author":"Aoyama","year":"1999","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaad.2005.12.003_bib28","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1074\/jbc.M309000200","article-title":"Pemphigus vulgaris IgG and methylprednisolone exhibit reciprocal effects on keratinocytes","volume":"279","author":"Nguyen","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaad.2005.12.003_bib29","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1001\/archderm.140.3.327","article-title":"Pemphigus vulgaris acantholysis ameliorated by cholinergic agonists","volume":"140","author":"Nguyen","year":"2004","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib30","doi-asserted-by":"crossref","first-page":"23778","DOI":"10.1074\/jbc.M501365200","article-title":"Desmosome signaling: inhibition of p38MAPK prevents pemphigus vulgaris IgG induced cytoskeleton reorganization","volume":"280","author":"Berkowitz","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaad.2005.12.003_bib31","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/1523-1747.ep12319948","article-title":"Pharmacologic evidence for involvement of phospholipase C in pemphigus IgG-induced inositol 1,4,5-trisphosphate generation, intracellular calcium increase, and plasminogen activator secretion in DJM-1 cells, a squamous cell carcinoma line","volume":"105","author":"Esaki","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/1523-1747.ep12613469","article-title":"Pemphigus IgG, but not bullous pemphigoid IgG, causes a transient increase in intracellular calcium and inositol 1,4,5-triphosphate in DJM-1 cells, a squamous cell carcinoma line","volume":"104","author":"Seishima","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib33","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1007\/s004030050462","article-title":"Phosphatidylcholine-specific phospholipase C, but not phospholipase D, is involved in pemphigus IgG-induced signal transduction","volume":"291","author":"Seishima","year":"1999","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jaad.2005.12.003_bib34","series-title":"Pemphigus antibody-induced intercellular separation of cultivated murine epidermocytes is accompanied by change in ratio of intraepidermocytic cAMP\/cGMP","author":"Grando","year":"1988"},{"key":"10.1016\/j.jaad.2005.12.003_bib35","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/1523-1747.ep12337662","article-title":"Pemphigus IgG induces expression of urokinase plasminogen activator receptor on the cell surface of cultured keratinocytes","volume":"109","author":"Seishima","year":"1997","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib36","series-title":"The decade of autoimmunity","first-page":"606","article-title":"Pemphigus an autoimmune disease of the skin: cell-cell separation versus membrane signaling and apoptosis in acantholysis","author":"Milner","year":"1999"},{"key":"10.1016\/j.jaad.2005.12.003_bib37","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1046\/j.1523-1747.2003.12014.x","article-title":"Fas ligand in pemphigus sera induces keratinocyte apoptosis through the activation of caspase-8","volume":"120","author":"Puviani","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib38","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.febslet.2004.03.107","article-title":"Pemphigus vulgaris autoantibodies induce apoptosis in HaCaT keratinocytes","volume":"566","author":"Pelacho","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jaad.2005.12.003_bib39","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/S0002-9440(10)61239-4","article-title":"Novel mechanisms of target cell death and survival and of therapeutic action of IVIg in pemphigus","volume":"167","author":"Arredondo","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaad.2005.12.003_bib40","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0167-5699(00)01593-0","article-title":"Bioenergetics of immune functions: fundamental and therapeutic aspects","volume":"21","author":"Buttgereit","year":"2000","journal-title":"Immunol Today"},{"key":"10.1016\/j.jaad.2005.12.003_bib41","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1034\/j.1600-0714.2002.00085.x","article-title":"High-dose intravenous \u2018pulse\u2019 methylprednisone in the treatment of severe oropharyngeal pemphigus: a pilot study","volume":"31","author":"Mignogna","year":"2002","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.jaad.2005.12.003_bib42","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1001\/archderm.1996.03890360021005","article-title":"Treatment of pemphigus vulgaris with brief, high-dose intravenous glucocorticoids","volume":"132","author":"Werth","year":"1996","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib43","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/S0190-9622(98)70476-1","article-title":"Use of topical cyclosporin in oral pemphigus","volume":"38","author":"Gooptu","year":"1998","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2005.12.003_bib44","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1902\/jop.1983.54.11.685","article-title":"Chronic pemphigus vulgaris of the gingiva: a case report with a 6-year follow-up","volume":"54","author":"Orlowski","year":"1983","journal-title":"J Periodontol"},{"key":"10.1016\/j.jaad.2005.12.003_bib45","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1046\/j.1365-2133.1999.02895.x","article-title":"The treatment of mild pemphigus vulgaris and pemphigus foliaceus with a topical corticosteroid","volume":"140","author":"Dumas","year":"1999","journal-title":"Br J Dermatol"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962205046943?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962205046943?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T22:02:34Z","timestamp":1759269754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962205046943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0190962205046943"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2005.12.003","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel explanation for acantholysis in pemphigus vulgaris: The basal cell shrinkage hypothesis","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2005.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}