{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:28:07Z","timestamp":1788251287188,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.jaad.2006.12.026","type":"journal-article","created":{"date-parts":[[2007,2,8]],"date-time":"2007-02-08T07:07:17Z","timestamp":1170918437000},"page":"588-597","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["New prognostic relevant factors in primary cutaneous diffuse large B-cell lymphomas"],"prefix":"10.1016","volume":"56","author":[{"given":"Christian","family":"Hallermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Niermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf-Josef","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Joachim","family":"Schulze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaad.2006.12.026_bib1","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1182\/blood-2004-09-3502","article-title":"WHO-EORTC classification for cutaneous lymphomas","volume":"105","author":"Willemze","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jaad.2006.12.026_bib2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.0303-6987.2005.00495.x","article-title":"WHO\/EORTC classification of cutaneous lymphomas 2005: histological and molecular aspects","volume":"32","author":"Burg","year":"2005","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.jaad.2006.12.026_bib3","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1001\/archderm.1996.03890350042008","article-title":"Primary cutaneous large B-cell lymphomas of the legs: a distinct type of cutaneous B-cell lymphoma with an intermediate prognosis; Dutch cutaneous lymphoma working group","volume":"132","author":"Vermeer","year":"1996","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2006.12.026_bib4","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1200\/JCO.1998.16.6.2080","article-title":"Bcl-2 protein expression in primary cutaneous large B-cell lymphoma is site-related","volume":"16","author":"Geelen","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jaad.2006.12.026_bib5","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/gcc.10104","article-title":"Comparative genomic hybridization analysis of primary cutaneous B-cell lymphomas: identification of common genomic alterations in disease pathogenesis","volume":"35","author":"Mao","year":"2002","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.jaad.2006.12.026_bib6","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1111\/j.0022-202X.2003.12635.x","article-title":"Chromosomal aberration patterns differ in subtypes of primary cutaneous B cell lymphomas","volume":"122","author":"Hallermann","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2006.12.026_bib7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.0022-202X.2004.22720.x","article-title":"Molecular cytogenetic analysis of chromosomal breakpoints in the IGH, MYC, BCL6, and MALT1 gene loci in primary cutaneous B-cell lymphomas","volume":"123","author":"Hallermann","year":"2004","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jaad.2006.12.026_bib8","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1182\/blood-2004-04-1594","article-title":"Distinct types of primary cutaneous large B-cell lymphoma identified by gene expression profiling","volume":"105","author":"Hoefnagel","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jaad.2006.12.026_bib9","first-page":"354","article-title":"EORTC classification for primary cutaneous lymphomas: a proposal from the cutaneous lymphoma study group of the European Organization for Research and Treatment of Cancer","volume":"90","author":"Willemze","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.jaad.2006.12.026_bib10","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/35000501","article-title":"Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling","volume":"403","author":"Alizadeh","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jaad.2006.12.026_bib11","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s002920050384","article-title":"Large B-cell lymphomas: variants and entities","volume":"21","author":"Anagnostopoulos","year":"2000","journal-title":"Pathologe"},{"key":"10.1016\/j.jaad.2006.12.026_bib12","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1182\/blood-2003-08-2726","article-title":"Bcl-2 protein expression is the strongest independent prognostic factor of survival in primary cutaneous large B-cell lymphomas","volume":"103","author":"Grange","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jaad.2006.12.026_bib13","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1001\/archderm.142.6.737","article-title":"Errors in the Archives of Dermatology and the Journal of the American Academy of Dermatology from January through December 2003","volume":"142","author":"Neville","year":"2006","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2006.12.026_bib14","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1200\/JCO.2001.19.16.3602","article-title":"Prognostic factors in primary cutaneous large B-cell lymphomas: a European multicenter study","volume":"19","author":"Grange","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jaad.2006.12.026_bib15","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1200\/JCO.2005.08.137","article-title":"The cutaneous B-cell lymphoma prognostic index: a novel prognostic index derived from a population-based registry","volume":"23","author":"Smith","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jaad.2006.12.026_bib16","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1200\/JCO.2005.03.6285","article-title":"Prognostic factors in primary cutaneous B-cell lymphoma: the Italian study group for cutaneous lymphomas","volume":"24","author":"Zinzani","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jaad.2006.12.026_bib17","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1038\/sj.leu.2401487","article-title":"Molecular and immunological dissection of diffuse large B cell lymphoma: CD5+, and CD5\u2212 with CD10+ groups may constitute clinically relevant subtypes","volume":"13","author":"Harada","year":"1999","journal-title":"Leukemia"},{"key":"10.1016\/j.jaad.2006.12.026_bib18","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1182\/blood.V99.3.815","article-title":"De novo CD5+ diffuse large B-cell lymphoma: a clinicopathologic study of 109 patients","volume":"99","author":"Yamaguchi","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.jaad.2006.12.026_bib19","doi-asserted-by":"crossref","first-page":"5948","DOI":"10.1158\/0008-5472.CAN-03-4056","article-title":"Genome-wide array-based comparative genomic hybridization of diffuse large B-cell lymphoma: comparison between CD5-positive and CD5-negative cases","volume":"64","author":"Tagawa","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.jaad.2006.12.026_bib20","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1046\/j.0022-202x.2001.01543.x","article-title":"Primary cutaneous follicle center cell lymphomas and large B cell lymphomas of the leg descend from germinal center cells: a single cell polymerase chain reaction analysis","volume":"117","author":"Gellrich","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2006.12.026_bib21","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1046\/j.1365-2141.1999.01211.x","article-title":"Syndecan-1 (CD138) expression in human non-Hodgkin lymphomas","volume":"104","author":"Sebestyen","year":"1999","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jaad.2006.12.026_bib22","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1111\/j.1365-2133.2005.06905.x","article-title":"The new World Health Organization-European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas: a practical marriage of two giants","volume":"153","author":"Slater","year":"2005","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2006.12.026_bib23","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1182\/blood-2005-03-1175","article-title":"Primary cutaneous large B-cell lymphomas: clinicopathologic features, classification, and prognostic factors in a large series of patients","volume":"106","author":"Kodama","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jaad.2006.12.026_bib24","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1053\/hupa.2002.126881","article-title":"Primary cutaneous large B-cell lymphoma of the leg: histogenetic analysis of a controversial clinicopathologic entity","volume":"33","author":"Paulli","year":"2002","journal-title":"Hum Pathol"},{"key":"10.1016\/j.jaad.2006.12.026_bib25","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1182\/blood.V95.6.2084","article-title":"A monoclonal antibody (MUM1p) detects expression of the MUM1\/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells","volume":"95","author":"Falini","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.jaad.2006.12.026_bib26","doi-asserted-by":"crossref","first-page":"9991","DOI":"10.1073\/pnas.1732008100","article-title":"A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma","volume":"100","author":"Wright","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaad.2006.12.026_bib27","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.0303-6987.2005.00298.x","article-title":"Expression of the bcl-6 and MUM1\/IRF4 proteins correlate with overall and disease-specific survival in patients with primary cutaneous large B-cell lymphoma: a tissue microarray study","volume":"32","author":"Sundram","year":"2005","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.jaad.2006.12.026_bib28","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/j.1365-2133.2003.05649.x","article-title":"Bcl-2, Bcl-6 and CD10 expression in cutaneous B-cell lymphoma: further support for a follicle center cell origin and differential diagnostic significance","volume":"149","author":"Hoefnagel","year":"2003","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2006.12.026_bib29","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/modpathol.3800650","article-title":"Expression of B-cell transcription factors in primary cutaneous B-cell lymphoma","volume":"19","author":"Hoefnagel","year":"2006","journal-title":"Mod Pathol"},{"key":"10.1016\/j.jaad.2006.12.026_bib30","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1182\/blood.V98.4.945","article-title":"Expression of a single gene, BCL-6, strongly predicts survival in patients with diffuse large B-cell lymphoma","volume":"98","author":"Lossos","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.jaad.2006.12.026_bib31","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa012914","article-title":"Lymphoma\/leukemia molecular profiling project: the use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma","volume":"346","author":"Rosenwald","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaad.2006.12.026_bib32","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/modpathol.3800396","article-title":"Evaluation of immunophenotype in diffuse large B-cell lymphoma and its impact on prognosis","volume":"18","author":"Berglund","year":"2005","journal-title":"Mod Pathol"},{"key":"10.1016\/j.jaad.2006.12.026_bib33","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1182\/blood-2003-05-1545","article-title":"Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray","volume":"103","author":"Hans","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jaad.2006.12.026_bib34","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1056\/NEJMoa032520","article-title":"Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes","volume":"350","author":"Lossos","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaad.2006.12.026_bib35","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1126\/science.3399892","article-title":"Cloning of a lymphoid-specific cDNA encoding a protein binding the regulatory octamer DNA motif","volume":"241","author":"Staudt","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.jaad.2006.12.026_bib36","first-page":"3149","article-title":"Induction of the POU domain transcription factor Oct-2 during T-cell activation by cognate antigen","volume":"12","author":"Kang","year":"1992","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jaad.2006.12.026_bib37","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1182\/blood.V88.10.4072a.bloodjournal88104072a","article-title":"Transcription factor Oct-2 is expressed in primary murine macrophages","volume":"88","author":"Dunn","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.jaad.2006.12.026_bib38","doi-asserted-by":"crossref","first-page":"6961","DOI":"10.1073\/pnas.88.16.6961","article-title":"BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death","volume":"88","author":"Hockenbery","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Suppl","key":"10.1016\/j.jaad.2006.12.026_bib39","first-page":"S38","article-title":"Primary cutaneous marginal zone B-cell lymphoma","volume":"125","author":"Cho-Vega","year":"2006","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.jaad.2006.12.026_bib40","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1200\/JCO.2005.03.4264","article-title":"BCL2 expression is a prognostic marker for the activated B-cell-like type of diffuse large B-cell lymphoma","volume":"24","author":"Iqbal","year":"2006","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.jaad.2006.12.026_bib41","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/path.1924","article-title":"Immunohistochemical profiling based on Bcl-2, CD10 and MUM1 expression improves risk stratification in patients with primary nodal diffuse large B cell lymphoma","volume":"208","author":"Muris","year":"2006","journal-title":"J Pathol"},{"key":"10.1016\/j.jaad.2006.12.026_bib42","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1182\/blood.V96.3.808","article-title":"The role of immunoglobulin translocations in the pathogenesis of B-cell malignancies","volume":"96","author":"Willis","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.jaad.2006.12.026_bib43","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1046\/j.1365-2133.2001.04128.x","article-title":"Absence of the t(14;18) chromosomal translocation in primary cutaneous B-cell lymphoma","volume":"144","author":"Child","year":"2001","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2006.12.026_bib44","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1200\/JCO.2005.02.0842","article-title":"Array-based comparative genomic hybridization analysis reveals recurrent chromosomal alterations and prognostic parameters in primary cutaneous large B-cell lymphoma","volume":"24","author":"Dijkman","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jaad.2006.12.026_bib45","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/sj.onc.1209127","article-title":"Oct transcription factors mediate t(14;18) lymphoma cell survival by directly regulating bcl-2 expression","volume":"25","author":"Heckman","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.jaad.2006.12.026_bib46","first-page":"8820","article-title":"The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p","volume":"61","author":"Banham","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.jaad.2006.12.026_bib47","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/nri953","article-title":"Lymphoid malignancies: the dark side of B-cell differentiation","volume":"2","author":"Shaffer","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaad.2006.12.026_bib48","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1158\/1078-0432.1065.11.3","article-title":"Expression of the FOXP1 transcription factor is strongly associated with inferior survival in patients with diffuse large B-cell lymphoma","volume":"11","author":"Banham","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.jaad.2006.12.026_bib49","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1200\/JCO.2000.18.3.510","article-title":"Molecular and clinical features of non-Burkitt's, diffuse large-cell lymphoma of B-cell type associated with the c-MYC\/immunoglobulin heavy-chain fusion gene","volume":"18","author":"Akasaka","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jaad.2006.12.026_bib50","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.3109\/10428190109097730","article-title":"Rearrangements of bcl-1, bcl-2, bcl-6, and c-myc in diffuse large B-cell lymphomas","volume":"42","author":"Kawasaki","year":"2001","journal-title":"Leuk Lymphoma"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962207000187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962207000187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T22:06:11Z","timestamp":1759269971000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962207000187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0190962207000187"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2006.12.026","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1078774.531696","asserted-by":"object"}]},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New prognostic relevant factors in primary cutaneous diffuse large B-cell lymphomas","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2006.12.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}