{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:19:25Z","timestamp":1793110765888,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1016\/j.jaad.2008.05.018","type":"journal-article","created":{"date-parts":[[2008,8,10]],"date-time":"2008-08-10T04:13:36Z","timestamp":1218341616000},"page":"524-529","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":157,"title":["Toxic erythema of chemotherapy: A useful clinical term"],"prefix":"10.1016","volume":"59","author":[{"given":"Jean L.","family":"Bolognia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis L.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Earl J.","family":"Glusac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaad.2008.05.018_bib1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1001\/archderm.1985.01660010106031","article-title":"Distinctive acral erythema occurring during therapy for severe myelogenous leukemia","volume":"121","author":"Levine","year":"1985","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/0277-5379(90)90102-Y","article-title":"Erythema and swelling of the ears after treatment with cytarabine for leukemia","volume":"26","author":"Krulder","year":"1990","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jaad.2008.05.018_bib3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1046\/j.1365-2230.1999.00419.x","article-title":"Chemotherapy-induced acral erythema (CIAE) with bullous reaction","volume":"24","author":"Azurdia","year":"1999","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1001\/archderm.1993.01680220055012","article-title":"Bullous variant of chemotherapy-induced acral erythema","volume":"129","author":"Waltzer","year":"1993","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib5","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1046\/j.1365-4362.1997.00040.x","article-title":"Chemotherapy-induced acral erythema in leukemic patients: a report of 15 cases","volume":"36","author":"Demircay","year":"1997","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib6","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/j.1365-4632.2004.02440.x","article-title":"Eccrine squamous syringometaplasia mimicking a herpetic infection","volume":"45","author":"Alonso","year":"2006","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib7","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000251603","article-title":"Erythematous eruption of the palms and soles associated with mitotane therapy","volume":"148","author":"Zuehlke","year":"1974","journal-title":"Dermatologica"},{"key":"10.1016\/j.jaad.2008.05.018_bib8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.7326\/0003-4819-97-1-61","article-title":"Peculiar acral erythema secondary to high-dose chemotherapy for acute myelogenous leukemia","volume":"97","author":"Burgdorf","year":"1982","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jaad.2008.05.018_bib9","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1182\/blood.V62.2.361.361","article-title":"High-dose cytosine arabinoside therapy for refractory leukemia","volume":"622","author":"Herzig","year":"1983","journal-title":"Blood"},{"key":"10.1016\/j.jaad.2008.05.018_bib10","doi-asserted-by":"crossref","first-page":"783","DOI":"10.7326\/0003-4819-97-5-783","article-title":"Cancer chemotherapy and acral erythema","volume":"97","author":"Cordonnier","year":"1982","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jaad.2008.05.018_bib11","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/00000421-198302000-00017","article-title":"Protracted ambulatory venous infusion of 5-fluorouracil","volume":"6","author":"Lokich","year":"1983","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.jaad.2008.05.018_bib12","doi-asserted-by":"crossref","first-page":"675","DOI":"10.7326\/0003-4819-98-5-675_2","article-title":"Acral erythema and hydroxyurea","volume":"98","author":"Silver","year":"1983","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jaad.2008.05.018_bib13","doi-asserted-by":"crossref","first-page":"611","DOI":"10.7326\/0003-4819-98-5-611","article-title":"Erythema and desquamation after high-dose methotrexate","volume":"98","author":"Doyle","year":"1983","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jaad.2008.05.018_bib14","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1001\/archderm.1985.01660100020006","article-title":"Cytarabine-induced palmar-plantar erythema","volume":"121","author":"Walker","year":"1985","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib15","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1001\/jama.1985.03360240091043","article-title":"Fluorouracil-associated dermatitis of the hands and feet","volume":"254","author":"Feldman","year":"1985","journal-title":"JAMA"},{"key":"10.1016\/j.jaad.2008.05.018_bib16","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1001\/archderm.1986.01660210073021","article-title":"Chemotherapy-induced acral erythema in patients receiving bone marrow transplantation","volume":"122","author":"Crider","year":"1986","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib17","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1001\/archderm.1986.01660240077020","article-title":"Toxic erythema of palms and soles associated with high-dose mercaptopurine chemotherapy","volume":"122","author":"Cox","year":"1986","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib18","doi-asserted-by":"crossref","first-page":"798","DOI":"10.7326\/0003-4819-101-6-798","article-title":"Chemotherapy-associated palmar-plantar erythrodysesthesia syndrome","volume":"101","author":"Lokich","year":"1984","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jaad.2008.05.018_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000372-199002000-00001","article-title":"Syringosquamous metaplasia. A distinctive eruption in patients receiving chemotherapy","volume":"12","author":"Bhawan","year":"1990","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.jaad.2008.05.018_bib20","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1046\/j.1365-2133.2001.04383.x","article-title":"Flexural erythematous eruption following autologous peripheral blood stem cell transplantation; a study of four cases","volume":"145","author":"Brazzelli","year":"2001","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib21","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1111\/j.1468-3083.2006.01616.x","article-title":"Severe palmoplantar erythrodysesthesia and intertrigolike eruption induced by polyethylene glycol-coated liposomal doxorubicin","volume":"20","author":"Campanelli","year":"2006","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaad.2008.05.018_bib22","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1001\/archderm.1990.01670250079013","article-title":"Eccrine squamous syringometaplasia. A cutaneous sweat gland reaction in the histologic spectrum of \u2018chemotherapy-associated eccrine hidradenitis\u2019 and \u2018neutrophilic eccrine hidradenitis.\u2019","volume":"126","author":"Hurt","year":"1990","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib23","first-page":"901","article-title":"An intertrigo-like eruption from pegylated liposomal doxorubicin","volume":"5","author":"Korver","year":"2006","journal-title":"J Drugs Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib24","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1001\/archderm.136.12.1475","article-title":"Skin toxic effects of polyethylene glycol-coated liposomal doxorubicin","volume":"136","author":"Lotem","year":"2000","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib25","first-page":"72A","article-title":"Epidermal dystrophy: clinicopathologic study of chemotherapeutic agent toxicity in ten patients","volume":"46","author":"Santa Cruz","year":"1982","journal-title":"Lab Invest"},{"key":"10.1016\/j.jaad.2008.05.018_bib26","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1001\/archderm.1997.03890430089012","article-title":"Chemotherapy-induced eccrine squamous syringometaplasia: a distinctive eruption in patients receiving hematopoietic progenitor cells","volume":"133","author":"Valks","year":"1997","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib27","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1001\/archderm.143.1.67","article-title":"Intertriginous eruption associated with chemotherapy in pediatric patients","volume":"143","author":"Webber","year":"2007","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/00043426-198921000-00011","article-title":"Chemotherapy-induced painful acral erythema in childhood: Burgdorf's reaction","volume":"11","author":"Burke","year":"1989","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"10.1016\/j.jaad.2008.05.018_bib29","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1034\/j.1600-0560.2003.00113.x","article-title":"Intertriginous epidermal dysmaturation from pegylated liposomal doxorubicin","volume":"30","author":"English","year":"2003","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.jaad.2008.05.018_bib30","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1067\/mjd.2000.101589","article-title":"A case of cutaneous reaction to chemotherapeutic agents showing epidermal dysmaturation","volume":"43","author":"Chun","year":"2000","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib31","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1600-0560.1991.tb01384.x","article-title":"Necrotizing eccrine squamous syringometaplasia presenting as acral erythema","volume":"18","author":"Rongioletti","year":"1991","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.jaad.2008.05.018_bib32","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1111\/j.1468-3083.2006.02123.x","article-title":"Eccrine squamous syringometaplasia associated with sunitinib therapy","volume":"21","author":"Sheen","year":"2007","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaad.2008.05.018_bib33","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/j.1346-8138.2005.tb00873.x","article-title":"A case of bleomycin-induced acral erythema (AE) with eccrine squamous syringometaplasia (ESS) and summary of reports of AE with ESS in the literature","volume":"32","author":"Tsuboi","year":"2005","journal-title":"J Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib34","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0190-9622(84)70210-6","article-title":"Neutrophilic eccrine hidradenitis: a distinctive rash associated with cytarabine therapy and acute leukemia","volume":"11","author":"Flynn","year":"1984","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib35","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.1016\/j.jaad.2004.11.065","article-title":"Methotrexate-induced bullous acral erythema in a child","volume":"52","author":"Werchniak","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib36","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1346-8138.2004.tb00692.x","article-title":"A case of docetaxel-induced erythrodysesthesia","volume":"31","author":"Katoh","year":"2004","journal-title":"J Dermatol"},{"issue":"suppl 1","key":"10.1016\/j.jaad.2008.05.018_bib37","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1016\/j.jaad.2006.04.076","article-title":"Chemotherapy-induced toxic erythema under treatment with pegylated liposomal doxorubicin: no restriction to palms and soles","volume":"58","author":"Ziemer","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib38","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1002\/1097-0142(197810)42:4<1747::AID-CNCR2820420413>3.0.CO;2-T","article-title":"Cytosine arabinoside induced gastrointestinal toxic alterations in sequential chemotherapeutic protocols","volume":"42","author":"Slavin","year":"1978","journal-title":"Cancer"},{"key":"10.1016\/j.jaad.2008.05.018_bib39","first-page":"89","article-title":"Pericarditis associated with acral erythema of chemotherapy: a syndrome of cutaneous and serosal toxicities","volume":"52","author":"Vukelja","year":"1993","journal-title":"Cutis"},{"key":"10.1016\/j.jaad.2008.05.018_bib40","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1093\/annonc\/mdh097","article-title":"Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX\/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer","volume":"15","author":"O'Brien","year":"2004","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jaad.2008.05.018_bib41","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1001\/archderm.1997.03890430123017","article-title":"Antineoplastic chemotherapy, sweat, and the skin","volume":"133","author":"Horn","year":"1997","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib42","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1093\/annonc\/mdi204","article-title":"Release of doxorubicin in sweat: first step to induce the palmar-plantar erythrodysesthesia syndrome?","volume":"16","author":"Jacobi","year":"2005","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jaad.2008.05.018_bib43","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1001\/archderm.1989.01670160072011","article-title":"Observations and proposed mechanism of N,N\u2032,N\u2033-triethylenethiophosphoramide (thiotepa)-induced hyperpigmentation","volume":"125","author":"Horn","year":"1989","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib44","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1600-0560.1989.tb00032.x","article-title":"Histologic changes induced in skin by extravasation of doxorubicin (adriamycin)","volume":"16","author":"Bhawan","year":"1989","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.jaad.2008.05.018_bib45","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1600-0560.1993.tb01251.x","article-title":"Eccrine squamous syringometaplasia. A prospective clinicopathologic study","volume":"20","author":"Serrano","year":"1993","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.jaad.2008.05.018_bib46","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0190-9622(08)80126-0","article-title":"Treatment of cytarabine acral erythema with corticosteroids","volume":"24","author":"Brown","year":"1991","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib47","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4103\/0022-3859.32222","article-title":"Successful treatment of palmar-plantar erythrodysesthesia possibly due to temozolomide with dexamethasone","volume":"53","author":"Kanat","year":"2007","journal-title":"J Postgrad Med"},{"key":"10.1016\/j.jaad.2008.05.018_bib48","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s002800050981","article-title":"Topical DMSO treatment for pegylated liposomal doxorubicin-induced palmar-plantar erythrodysesthesia","volume":"44","author":"Lopez","year":"1999","journal-title":"Cancer Chemother Pharmacol"},{"issue":"suppl","key":"10.1016\/j.jaad.2008.05.018_bib49","first-page":"31","article-title":"Effect of celecoxib on capecitabine-induced hand-foot syndrome and antitumor activity","volume":"16","author":"Lin","year":"2002","journal-title":"Oncology"},{"key":"10.1016\/j.jaad.2008.05.018_bib50","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF00216925","article-title":"Pyridoxine therapy for palmar-plantar erythrodysesthesia associated with continuous 5-fluorouracil infusion","volume":"8","author":"Fabian","year":"1990","journal-title":"Invest New Drugs"},{"key":"10.1016\/j.jaad.2008.05.018_bib51","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.breast.2005.07.007","article-title":"Palmar-plantar erythrodysesthesia due to docetaxel-capecitabine therapy is treated with vitamin E without dose reduction","volume":"15","author":"Kara","year":"2006","journal-title":"Breast"},{"key":"10.1016\/j.jaad.2008.05.018_bib52","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0190-9622(91)70073-B","article-title":"Chemotherapy-induced acral erythema","volume":"24","author":"Baack","year":"1991","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2008.05.018_bib53","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/mpo.2950160513","article-title":"Chemotherapy-associated eccrine hidradenitis: neutrophilic eccrine hidradenitis reevaluated: the role of neutrophilic infiltration","volume":"16","author":"Greenbaum","year":"1988","journal-title":"Med Pediatr Oncol"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962208006014?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962208006014?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T22:10:35Z","timestamp":1759270235000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962208006014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S0190962208006014"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2008.05.018","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toxic erythema of chemotherapy: A useful clinical term","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2008.05.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}