{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T20:04:19Z","timestamp":1770840259835,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.jaad.2008.11.015","type":"journal-article","created":{"date-parts":[[2009,6,19]],"date-time":"2009-06-19T04:33:35Z","timestamp":1245386015000},"page":"80-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Carney complex: A clinicopathologic and molecular biological study of a sporadic case, including extracutaneous and cutaneous lesions and a novel mutation of the PRKAR1A gene"],"prefix":"10.1016","volume":"61","author":[{"given":"Denisa","family":"Kacerovska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radek","family":"Sima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Michal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ondrej","family":"Hes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrik","family":"Roucka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Zarybnicka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Hora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zdenek","family":"Chudacek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry V.","family":"Kazakov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaad.2008.11.015_bib1","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1136\/hrt.35.8.874","article-title":"Lentiginosis and left atrial myxoma","volume":"35","author":"Rees","year":"1973","journal-title":"Br Heart J"},{"key":"10.1016\/j.jaad.2008.11.015_bib2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/00005792-198507000-00007","article-title":"The complex of myxomas, spotty pigmentation, and endocrine overactivity","volume":"64","author":"Carney","year":"1985","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jaad.2008.11.015_bib3","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.4049\/jimmunol.134.3.1804","article-title":"Elimination of terminal complement intermediates from the plasma membrane of nucleated cells: the rate of disappearance differs for cells carrying C5b-7 or C5b-8 or a mixture of C5b-8 with a limited number of C5b-9","volume":"134","author":"Carney","year":"1985","journal-title":"J Immunol"},{"key":"10.1016\/j.jaad.2008.11.015_bib4","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S0022-5347(05)65285-8","article-title":"Testicular tumors in Carney's complex","volume":"167","author":"Washecka","year":"2002","journal-title":"J Urol"},{"key":"10.1016\/j.jaad.2008.11.015_bib5","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/00000478-199003000-00002","article-title":"Psammomatous melanotic schwannoma. A distinctive, heritable tumor with special associations, including cardiac myxoma and the Cushing syndrome","volume":"14","author":"Carney","year":"1990","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jaad.2008.11.015_bib6","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1093\/ajcp\/95.4.484","article-title":"Psammomatous melanotic schwannoma: an additional component of Carney's complex. Report of a case","volume":"95","author":"Martin-Reay","year":"1991","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.jaad.2008.11.015_bib7","first-page":"216","article-title":"Epithelioid blue nevus and psammomatous melanotic schwannoma: the unusual pigmented skin tumors of the Carney complex","volume":"15","author":"Carney","year":"1998","journal-title":"Semin Diagn Pathol"},{"key":"10.1016\/j.jaad.2008.11.015_bib8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/00000478-199603000-00001","article-title":"The epithelioid blue nevus. A multicentric familial tumor with important associations, including cardiac myxoma and psammomatous melanotic schwannoma","volume":"20","author":"Carney","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jaad.2008.11.015_bib9","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/00000478-200102000-00004","article-title":"Osteochondromyxoma of bone: a congenital tumor associated with lentigines and other unusual disorders","volume":"25","author":"Carney","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jaad.2008.11.015_bib10","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1210\/jcem.82.7.4079","article-title":"Thyroid gland abnormalities in patients with the syndrome of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas (Carney complex)","volume":"82","author":"Stratakis","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jaad.2008.11.015_bib11","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0190-9622(00)90027-6","article-title":"Pigmented lesions of the conjunctiva in Carney's complex","volume":"42","author":"Cohen","year":"2000","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2008.11.015_bib12","first-page":"337","article-title":"Ovarian tumors associated with multiple endocrine neoplasias and related syndromes (Carney complex, Peutz-Jeghers syndrome, von Hippel-Lindau disease, Cowden's disease)","volume":"12","author":"Papageorgiou","year":"2002","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.jaad.2008.11.015_bib13","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1055\/s-2007-1013711","article-title":"Surgical treatment of left-atrial myxoma in Carney's complex","volume":"45","author":"Akbas","year":"1997","journal-title":"Thorac Cardiovasc Surg"},{"key":"10.1016\/j.jaad.2008.11.015_bib14","first-page":"305","article-title":"Association of Fallot tetralogy with Carney's complex","volume":"94","author":"Yarman","year":"2001","journal-title":"Ir Med J"},{"key":"10.1016\/j.jaad.2008.11.015_bib15","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1172\/JCI118467","article-title":"Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2","volume":"97","author":"Stratakis","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaad.2008.11.015_bib16","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1161\/01.CIR.98.23.2560","article-title":"Identification of a novel genetic locus for familial cardiac myxomas and Carney complex","volume":"98","author":"Casey","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jaad.2008.11.015_bib17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1357-2725(97)00093-9","article-title":"Coupling gene expression to cAMP signalling: role of CREB and CREM","volume":"30","author":"Sassone-Corsi","year":"1998","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jaad.2008.11.015_bib18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/79238","article-title":"Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex","volume":"26","author":"Kirschner","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaad.2008.11.015_bib19","series-title":"Pathology & Genetics Skin Tumours. World Health Organization Classification of Tumours","author":"LeBoit","year":"2006"},{"key":"10.1016\/j.jaad.2008.11.015_bib20","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1136\/jmg.40.4.268","article-title":"Chromosome 2 (2p16) abnormalities in Carney complex tumours","volume":"40","author":"Matyakhina","year":"2003","journal-title":"J Med Genet"},{"key":"10.1016\/j.jaad.2008.11.015_bib21","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1210\/jcem.86.9.7903","article-title":"Clinical and molecular features of the Carney complex: diagnostic criteria and recommendations for patient evaluation","volume":"86","author":"Stratakis","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jaad.2008.11.015_bib22","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0002-9394(14)74112-1","article-title":"Ocular pigmented spots and eyelid myxomas","volume":"104","author":"Kennedy","year":"1987","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jaad.2008.11.015_bib23","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1136\/bjo.75.4.251","article-title":"Bilateral eyelid myxomas in Carney's complex","volume":"75","author":"Grossniklaus","year":"1991","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jaad.2008.11.015_bib24","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1017\/S0022215100116019","article-title":"Myxoma of the external auditory meatus","volume":"105","author":"Palva","year":"1991","journal-title":"J Laryngol Otol"},{"key":"10.1016\/j.jaad.2008.11.015_bib25","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/00000478-199403000-00007","article-title":"Myxomas of the external ear and their significance","volume":"18","author":"Ferreiro","year":"1994","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jaad.2008.11.015_bib26","first-page":"207","article-title":"Lesions of testes observed in certain patients with widespread choriocarcinoma and related tumors. The significance and genesis of hematoxylin-staining bodies in the human testis","volume":"38","author":"Azzopardi","year":"1961","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaad.2008.11.015_bib27","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/S0022-5347(01)62364-4","article-title":"Testicular calcifications: incidence, histology and proposed pathological criteria for testicular microlithiasis","volume":"160","author":"Renshaw","year":"1998","journal-title":"J Urol"},{"key":"10.1016\/j.jaad.2008.11.015_bib28","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1001\/archderm.1986.01660190068018","article-title":"Cutaneous myxomas. A major component of the complex of myxomas, spotty pigmentation, and endocrine overactivity","volume":"122","author":"Carney","year":"1986","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2008.11.015_bib29","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1001\/archderm.141.7.916","article-title":"The Carney complex: unusual skin findings and recurrent cardiac myxoma","volume":"141","author":"Bennett","year":"2005","journal-title":"Arch Dermatol"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962208014461?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962208014461?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T22:14:19Z","timestamp":1759270459000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962208014461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0190962208014461"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2008.11.015","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Carney complex: A clinicopathologic and molecular biological study of a sporadic case, including extracutaneous and cutaneous lesions and a novel mutation of the PRKAR1A gene","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2008.11.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}