{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:07:11Z","timestamp":1759334831811,"version":"build-2065373602"},"reference-count":7,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.jaad.2009.06.077","type":"journal-article","created":{"date-parts":[[2009,11,18]],"date-time":"2009-11-18T09:08:56Z","timestamp":1258535336000},"page":"1082-1083","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Reporting clinical trials: Why one plus one does not equal two"],"prefix":"10.1016","volume":"61","author":[{"given":"Kenneth A.","family":"Katz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara Y.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hywel C.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaad.2009.06.077_bib1","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.jaad.2008.06.040","article-title":"An aqueous gel fixed combination of clindamycin phosphate 1.2% and benzoyl peroxide 2.5% for the once-daily treatment of moderate to severe acne vulgaris: assessment of efficacy and safety in 2813 patients","volume":"59","author":"Thiboutot","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2009.06.077_bib2","unstructured":"US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Biologics Evaluation and Research (CBER). Guidance for industry: Providing clinical evidence of effectiveness for human drug and biological products, May 1998. Available at: http:\/\/www.fda.gov\/cder\/guidance\/1397fnl.pdf. Accessed August 6, 2009."},{"key":"10.1016\/j.jaad.2009.06.077_bib3","unstructured":"US National Library of Medicine Web site. Daily Med current medication information. Bethesda, MD: US National Library of Medicine. Available at: http:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?id = 8909. Accessed August 6, 2009."},{"key":"10.1016\/j.jaad.2009.06.077_bib4","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1136\/bmj.315.7121.1533","article-title":"Meta-analysis: principles and procedures","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.jaad.2009.06.077_bib5","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1001\/archderm.138.12.1602","article-title":"Another vehicle-controlled study of 1% pimecrolimus in atopic dermatitis: how does it help clinicians and patients, and is it ethically sound?","volume":"138","author":"Williams","year":"2002","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2009.06.077_bib6","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1001\/archderm.139.10.1369","article-title":"1% pimecrolimus cream for atopic dermatitis","volume":"139","author":"Eichenfield","year":"2003","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2009.06.077_bib7","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1001\/archderm.136.3.381","article-title":"How well are randomized controlled trials reported in the dermatology literature?","volume":"136","author":"Adetugbo","year":"2000","journal-title":"Arch Dermatol"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962209008408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962209008408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T22:14:13Z","timestamp":1759270453000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962209008408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0190962209008408"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2009.06.077","relation":{},"ISSN":["0190-9622"],"issn-type":[{"type":"print","value":"0190-9622"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reporting clinical trials: Why one plus one does not equal two","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2009.06.077","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2008.06.040","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}