{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:58:18Z","timestamp":1783339098482,"version":"3.54.6"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.jaad.2009.08.013","type":"journal-article","created":{"date-parts":[[2010,7,14]],"date-time":"2010-07-14T04:56:10Z","timestamp":1279083370000},"page":"284-291","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Combined Erdheim-Chester disease and Langerhans cell histiocytosis of skin are both monoclonal: A rare case with human androgen-receptor gene analysis"],"prefix":"10.1016","volume":"63","author":[{"given":"Jen-Wei","family":"Tsai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen-Hui","family":"Tsou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Yi","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Bo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kung-Chao","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaad.2009.08.013_bib1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/BF01942684","article-title":"\u00dcber Lipoidgranulomatose","volume":"279","author":"Chester","year":"1930","journal-title":"Virchows Arch Pathol Anat"},{"key":"10.1016\/j.jaad.2009.08.013_bib2","series-title":"Metabolic, degenerative and inflammatory disease of bone and joints","first-page":"535","article-title":"Gaucher's disease and certain other inborn metabolic disorders: lipid (cholesterol) granulomatosis","year":"1972"},{"key":"10.1016\/j.jaad.2009.08.013_bib3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00005792-199605000-00005","article-title":"Erdheim-Chester disease: clinical and radiologic characteristics of 59 cases","volume":"75","author":"Veyssier-Belot","year":"1996","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jaad.2009.08.013_bib4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00000478-199901000-00002","article-title":"Erdheim-Chester disease: clinical, radiologic, and histopathologic findings in five patients with interstitial lung disease","volume":"23","author":"Egan","year":"1999","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jaad.2009.08.013_bib5","series-title":"World Health Organization classification of tumors. Pathology and genetics of skin tumors","first-page":"217","article-title":"Langerhans cell histiocytosis","author":"Zelger","year":"2006"},{"key":"10.1016\/j.jaad.2009.08.013_bib6","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1600-0609.2006.00648.x","article-title":"Adult Langerhans cell histiocytosis","volume":"76","author":"Stockschlaeder","year":"2006","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.jaad.2009.08.013_bib7","series-title":"World Health Organization classification of tumors. Pathology and genetics of tumors of soft tissue and bone","first-page":"345","article-title":"Langerhans cell histiocytosis","author":"De Young","year":"2002"},{"key":"10.1016\/j.jaad.2009.08.013_bib8","series-title":"World Health Organization classification of tumors of hematopoietic and lymphoid tissues","year":"2008"},{"key":"10.1016\/j.jaad.2009.08.013_bib9","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1056\/NEJM199407213310303","article-title":"Langerhans'-cell histiocytosis (histiocytosis X)\u2013a clonal proliferative disease","volume":"331","author":"Willman","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaad.2009.08.013_bib10","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0140-6736(94)91842-2","article-title":"Clonal proliferation of Langerhans cells in Langerhans cell histiocytosis","volume":"343","author":"Yu","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.jaad.2009.08.013_bib11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.humpath.2005.08.024","article-title":"Lesions resembling Langerhans cell histiocytosis in association with other lymphoproliferative disorders: a reactive or neoplastic phenomenon?","volume":"37","author":"Christie","year":"2006","journal-title":"Hum Pathol"},{"key":"10.1016\/j.jaad.2009.08.013_bib12","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/modpathol.3880583","article-title":"Erdheim-Chester disease: case report, PCR-based analysis of clonality, and review of literature","volume":"15","author":"Al-Quran","year":"2002","journal-title":"Mod Pathol"},{"key":"10.1016\/j.jaad.2009.08.013_bib13","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S0046-8177(99)90228-9","article-title":"Chester-Erdheim disease: a neoplastic disorder","volume":"30","author":"Chetritt","year":"1999","journal-title":"Hum Pathol"},{"key":"10.1016\/j.jaad.2009.08.013_bib14","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00428-007-0538-9","article-title":"Systemic Erdheim-Chester disease","volume":"452","author":"Dickson","year":"2008","journal-title":"Virchows Arch"},{"key":"10.1016\/j.jaad.2009.08.013_bib15","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/sj.leu.2401631","article-title":"Clonality analysis by methylation-specific PCR for the human androgen-receptor gene (HUMARA-MSP)","volume":"14","author":"Uchida","year":"2000","journal-title":"Leukemia"},{"key":"10.1016\/j.jaad.2009.08.013_bib16","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0190-9622(96)80088-0","article-title":"Eruptive xanthoma-like cutaneous Langerhans cell histiocytosis in an adult","volume":"34","author":"Chi","year":"1996","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2009.08.013_bib17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0190-9622(90)70218-7","article-title":"Xanthoma disseminatum with progressive involvement of the central nervous and hepatobiliary systems","volume":"23","author":"Knobler","year":"1990","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2009.08.013_bib18","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1056\/NEJMcpc0804623","article-title":"Case records of the Massachusetts General Hospital, case 25-2008: a 43-year-old man with fatigue and lesions in the pituitary and cerebellum","volume":"359","author":"Mills","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaad.2009.08.013_bib19","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/ajcp\/75.2.131","article-title":"The osseous manifestations of sinus histiocytosis with massive lymphadenopathy","volume":"75","author":"Walker","year":"1981","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.jaad.2009.08.013_bib20","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/00005792-199211000-00002","article-title":"Gaucher disease: clinical, laboratory, radiologic, and genetic features of 53 patients","volume":"71","author":"Zimran","year":"1992","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jaad.2009.08.013_bib21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0022-3476(75)80575-0","article-title":"Histiocytosis X\u2013comparison of three treatment regimens","volume":"87","author":"Lahey","year":"1975","journal-title":"J Pediatr"},{"key":"10.1016\/j.jaad.2009.08.013_bib22","first-page":"289","article-title":"Histiocytosis X","volume":"121","author":"Lucaya","year":"1971","journal-title":"Am J Dis Child"},{"key":"10.1016\/j.jaad.2009.08.013_bib23","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1093\/eurheartj\/ehn082","article-title":"A rare cause of cardiac tumor: an Erdheim-Chester disease with cardiac involvement co-existing with an intracerebral Langerhans cell histiocytosis","volume":"29","author":"Granier","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jaad.2009.08.013_bib24","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1056\/NEJM200003233421208","article-title":"Case records of the Massachusetts General Hospital, weekly clinicopathological exercises, case 9-2000: a 41-year-old man with multiple bony lesions and adjacent soft-tissue masses","volume":"342","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaad.2009.08.013_bib25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1148\/radiology.151.1.6608118","article-title":"Erdheim-Chester disease: a distinct lipoidosis or part of the spectrum of histiocytosis?","volume":"151","author":"Brower","year":"1984","journal-title":"Radiology"},{"key":"10.1016\/j.jaad.2009.08.013_bib26","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1046\/j.1365-2559.1997.d01-614.x","article-title":"Erdheim-Chester disease with prominent pulmonary involvement associated with eosinophilic granuloma of mandibular bone","volume":"30","author":"Kambouchner","year":"1997","journal-title":"Histopathology"},{"key":"10.1016\/j.jaad.2009.08.013_bib27","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/00125480-200305000-00004","article-title":"Erdheim-Chester disease: clinical and pathologic spectrum of four cases from the\u00a0Arkadi M. Rywlin slide seminars","volume":"10","author":"Bisceglia","year":"2003","journal-title":"Adv Anat Pathol"},{"key":"10.1016\/j.jaad.2009.08.013_bib28","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00428-004-1007-3","article-title":"Erdheim-Chester disease of the breast associated with Langerhans-cell histiocytosis of the hard palate","volume":"445","author":"Andrade","year":"2004","journal-title":"Virchows Arch"},{"key":"10.1016\/j.jaad.2009.08.013_bib29","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00256-007-0302-x","article-title":"An unusual case of Erdheim-Chester disease with features of Langerhans cell histiocytosis","volume":"36","author":"Furmanczyk","year":"2007","journal-title":"Skeletal Radiol"},{"key":"10.1016\/j.jaad.2009.08.013_bib30","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1468-3083.2008.02810.x","article-title":"Parallel occurrence of Erdheim-Chester disease and eosinophilic granuloma in the same patient","volume":"23","author":"Kerzl","year":"2009","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaad.2009.08.013_bib31","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1097\/00005072-199711000-00005","article-title":"Pathology of the central nervous system in Chester-Erdheim disease: report of three cases","volume":"56","author":"Adle-Biassette","year":"1997","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.jaad.2009.08.013_bib32","first-page":"71","article-title":"Brain stem infiltration by mixed Langerhans cell histiocytosis and Chester-Erdheim disease: more than just an isolated case?","volume":"47","author":"Vital","year":"1999","journal-title":"Clin Exp Pathol"},{"key":"10.1016\/j.jaad.2009.08.013_bib33","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1084\/jem.20030137","article-title":"Aberrant chemokine receptor expression and chemokine production by Langerhans cells underlies the pathogenesis of Langerhans cell histiocytosis","volume":"197","author":"Annels","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaad.2009.08.013_bib34","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1002\/art.22280","article-title":"Immunohistochemical evidence of a cytokine and chemokine network in three patients with Erdheim-Chester disease: implications for pathogenesis","volume":"54","author":"Stoppacciaro","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaad.2009.08.013_bib35","first-page":"232","article-title":"Biochemical markers of bone turnover, serum levels of interleukin-6\/interleukin-6 soluble receptor and bisphosphonate treatment in Erdheim-Chester disease","volume":"21","author":"Mossetti","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jaad.2009.08.013_bib36","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.4049\/jimmunol.149.8.2681","article-title":"Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow","volume":"149","author":"Reid","year":"1992","journal-title":"J Immunol"},{"key":"10.1016\/j.jaad.2009.08.013_bib37","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/01.pas.0000213366.33627.a0","article-title":"Clonal cytogenetic abnormalities in Erdheim-Chester disease","volume":"31","author":"Vencio","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jaad.2009.08.013_bib38","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1182\/blood-2005-06-2238","article-title":"Successful treatment of Erdheim-Chester disease, a non-Langerhans-cell histiocytosis, with interferon-alpha","volume":"106","author":"Braiteh","year":"2005","journal-title":"Blood"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962209009967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962209009967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T22:16:01Z","timestamp":1759270561000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962209009967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0190962209009967"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2009.08.013","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined Erdheim-Chester disease and Langerhans cell histiocytosis of skin are both monoclonal: A rare case with human androgen-receptor gene analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2009.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}