{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:38:45Z","timestamp":1791272325311,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.jaad.2009.09.042","type":"journal-article","created":{"date-parts":[[2010,6,4]],"date-time":"2010-06-04T04:32:38Z","timestamp":1275625958000},"page":"440-447","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Phenotypic variability among caf\u00e9-au-lait macules in neurofibromatosis type 1"],"prefix":"10.1016","volume":"63","author":[{"given":"Kevin P.","family":"Boyd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Beasley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwine","family":"Messiaen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce R.","family":"Korf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Theos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaad.2009.09.042_bib1","first-page":"575","article-title":"Neurofibromatosis. Conference statement. National Institutes of Health Consensus Development Conference","volume":"45","year":"1988","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jaad.2009.09.042_bib2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1001\/jama.1997.03550010065042","article-title":"The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2","volume":"278","author":"Gutmann","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.jaad.2009.09.042_bib3","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1542\/peds.105.3.608","article-title":"Use of the National Institutes of Health criteria for diagnosis of neurofibromatosis 1 in children","volume":"105","author":"DeBella","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaad.2009.09.042_bib4","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1177\/088307380201700806","article-title":"Clinical features and pathobiology of neurofibromatosis 1","volume":"17","author":"Korf","year":"2002","journal-title":"J Child Neurol"},{"key":"10.1016\/j.jaad.2009.09.042_bib5","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S0190-9622(99)70075-7","article-title":"The diagnostic value of caf\u00e9-au-lait macules","volume":"40","author":"Landau","year":"1999","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2009.09.042_bib6","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1177\/088307380201700802","article-title":"Neurofibromatosis 1: clinical manifestations and diagnostic criteria","volume":"17","author":"Friedman","year":"2002","journal-title":"J Child Neurol"},{"key":"10.1016\/j.jaad.2009.09.042_bib7","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0092-8674(01)00245-8","article-title":"NF1 tumor suppressor gene function: narrowing the GAP","volume":"104","author":"Cichowski","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.jaad.2009.09.042_bib8","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1242\/jcs.013912","article-title":"Neurofibromin as a regulator of melanocyte development and differentiation","volume":"121","author":"Diwakar","year":"2008","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jaad.2009.09.042_bib9","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1002\/humu.20389","article-title":"Comprehensive NF1 screening on cultured Schwann cells from neurofibromas","volume":"27","author":"Maertens","year":"2006","journal-title":"Hum Mutat"},{"key":"10.1016\/j.jaad.2009.09.042_bib10","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1093\/hmg\/9.7.1059","article-title":"Genetic and cellular defects contributing to benign tumor formation in neurofibromatosis type 1","volume":"9","author":"Rutkowski","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jaad.2009.09.042_bib11","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/sj.jid.5701095","article-title":"Somatic mutation analysis in NF1 caf\u00e9-au-lait spots reveals two NF1 hits in the melanocytes","volume":"128","author":"De Schepper","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2009.09.042_bib12","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1086\/519562","article-title":"Molecular dissection of isolated features in mosaic neurofibromatosis type 1","volume":"81","author":"Maertens","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jaad.2009.09.042_bib13","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/1098-1004(200006)15:6<541::AID-HUMU6>3.0.CO;2-N","article-title":"Exhaustive mutation analysis of the NF1 gene allows identification of 95% of mutations and reveals a high frequency of unusual splicing defects","volume":"15","author":"Messiaen","year":"2000","journal-title":"Hum Mutat"},{"issue":"Suppl","key":"10.1016\/j.jaad.2009.09.042_bib14","doi-asserted-by":"crossref","first-page":"S282","DOI":"10.1016\/j.jaad.2005.12.041","article-title":"Noninvasive techniques for the evaluation of skin color","volume":"54","author":"Taylor","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2009.09.042_bib15","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/j.1600-0749.2004.00204.x","article-title":"Non-invasive measurements of skin pigmentation in situ","volume":"17","author":"Stamatas","year":"2004","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jaad.2009.09.042_bib16","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1034\/j.1600-0846.2000.006004230.x","article-title":"Skin color measurements; comparison between three instruments: the Chromameter, the DermaSpectrometer, and the Mexameter","volume":"6","author":"Clarys","year":"2000","journal-title":"Skin Res Technol"},{"key":"10.1016\/j.jaad.2009.09.042_bib17","series-title":"Generalized linear models","author":"McCullagh","year":"1989"},{"key":"10.1016\/j.jaad.2009.09.042_bib18","series-title":"Linear mixed models for longitudinal data","author":"Verbeke","year":"2000"},{"key":"10.1016\/j.jaad.2009.09.042_bib19","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1620\/tjem.118.255","article-title":"Studies on caf\u00e9 au lait spots in neurofibromatosis and pigmented macules of nevus spilus","volume":"118","author":"Takahasi","year":"1976","journal-title":"Tohoku J Exp Med"},{"key":"10.1016\/j.jaad.2009.09.042_bib20","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1001\/archderm.1970.04000100090019","article-title":"Caf\u00e9 au lait spot in neurofibromatosis and in normal individuals","volume":"102","author":"Johnson","year":"1970","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2009.09.042_bib21","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1001\/jama.1968.03140350028006","article-title":"Melanotic macules in Albright's syndrome and in neurofibromatosis","volume":"205","author":"Benedict","year":"1968","journal-title":"JAMA"},{"key":"10.1016\/j.jaad.2009.09.042_bib22","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/1523-1747.ep12261648","article-title":"Neurofibromatosis of von Recklinghausen: a quantitative study of the epidermal keratinocyte and melanocyte populations","volume":"83","author":"Frenk","year":"1984","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2009.09.042_bib23","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00403-006-0644-6","article-title":"Caf\u00e9-au-lait spots in neurofibromatosis type 1 and in healthy control individuals: hyperpigmentation of a different kind?","volume":"297","author":"De Schepper","year":"2006","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jaad.2009.09.042_bib24","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/ajmg.a.20354","article-title":"Analysis of neurofibromatosis 1 (NF1) lesions by body segment","volume":"125A","author":"Palmer","year":"2004","journal-title":"Am J\u00a0Med Genet A"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962209012511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962209012511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T22:17:59Z","timestamp":1759270679000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962209012511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0190962209012511"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2009.09.042","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phenotypic variability among caf\u00e9-au-lait macules in neurofibromatosis type 1","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2009.09.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}