{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:19:31Z","timestamp":1792667971826,"version":"4.5.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1016\/j.jaad.2010.02.049","type":"journal-article","created":{"date-parts":[[2011,2,12]],"date-time":"2011-02-12T05:48:50Z","timestamp":1297489730000},"page":"879-887","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["Markedly elevated serum levels of calcium-binding S100A8\/A9 proteins in psoriatic arthritis are due to activated monocytes\/macrophages"],"prefix":"10.1016","volume":"64","author":[{"given":"Seiko","family":"Aochi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakiyo","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namho","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Tsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyofumi","family":"Yamanishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Komine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Iwatsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaad.2010.02.049_bib1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0140-6736(07)61128-3","article-title":"Pathogenesis and clinical features of psoriasis","volume":"370","author":"Griffiths","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.jaad.2010.02.049_bib2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nm1162","article-title":"Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model","volume":"11","author":"Sano","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.jaad.2010.02.049_bib3","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s11926-007-0075-1","article-title":"Pathophysiology of psoriasis: recent advances on IL-23 and Th17 cytokines","volume":"9","author":"Fitch","year":"2007","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.jaad.2010.02.049_bib4","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev.immunol.22.012703.104758","article-title":"Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of\u00a0inflammation","volume":"25","author":"Kastelein","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaad.2010.02.049_bib5","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/nature03963","article-title":"Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins","volume":"437","author":"Zenz","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jaad.2010.02.049_bib6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1471-4906(03)00062-0","article-title":"Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules","volume":"24","author":"Roth","year":"2003","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jaad.2010.02.049_bib7","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.4049\/jimmunol.170.6.3233","article-title":"Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8\/A9 induce neutrophil chemotaxis and adhesion","volume":"170","author":"Ryckman","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jaad.2010.02.049_bib8","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cccn.2004.02.023","article-title":"Phagocyte-specific calcium-binding S100 proteins as clinical laboratory markers of inflammation","volume":"344","author":"Foell","year":"2004","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jaad.2010.02.049_bib9","doi-asserted-by":"crossref","first-page":"13462","DOI":"10.1016\/S0021-9258(18)98862-9","article-title":"Calcium-dependent complex assembly of the myeloic differentiation proteins MRP-8 and MRP-14","volume":"266","author":"Teigelkamp","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaad.2010.02.049_bib10","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/jcb.21639","article-title":"S100A8\/A9, a key mediator for positive feedback growth stimulation of normal human keratinocytes","volume":"104","author":"Nukui","year":"2008","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jaad.2010.02.049_bib11","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-2133.2008.08904.x","article-title":"Detection of psoriasin\/S100A7 in the sera of patients with psoriasis","volume":"160","author":"Anderson","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2010.02.049_bib12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1365-2133.2006.07198.x","article-title":"Elevated serum levels of calcium-binding S100 proteins A8 and A9 reflect disease activity and abnormal differentiation of keratinocytes in psoriasis","volume":"155","author":"Benoit","year":"2006","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2010.02.049_bib13","doi-asserted-by":"crossref","first-page":"3792","DOI":"10.1002\/art.20720","article-title":"Use of mass spectrometry to identify protein biomarkers of disease severity in the synovial fluid and serum of patients with rheumatoid arthritis","volume":"50","author":"Liao","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaad.2010.02.049_bib14","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1002\/art.10988","article-title":"Increased perivascular synovial membrane expression of myeloid-related proteins in psoriatic arthritis","volume":"48","author":"Kane","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaad.2010.02.049_bib15","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0304-3940(98)00263-8","article-title":"Serum levels of macrophage-derived protein MRP-8\/14 are elevated in active multiple sclerosis","volume":"247","author":"Bogumil","year":"1998","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jaad.2010.02.049_bib16","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1159\/000201267","article-title":"Immunohistochemical distribution and serum levels of the Ca(2+)-binding proteins MRP8, MRP14 and their heterodimeric form MRP8\/14 in Crohn's disease","volume":"56","author":"Lugering","year":"1995","journal-title":"Digestion"},{"key":"10.1016\/j.jaad.2010.02.049_bib17","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/oxfordjournals.jbchem.a123257","article-title":"Myeloid calcium binding proteins: expression in the differentiated HL-60 cells and detection in sera of patients with connective tissue diseases","volume":"108","author":"Kuruto","year":"1990","journal-title":"J Biochem (Tokyo)"},{"key":"10.1016\/j.jaad.2010.02.049_bib18","doi-asserted-by":"crossref","first-page":"35818","DOI":"10.1074\/jbc.M104871200","article-title":"The Ca2+-binding proteins S100A8 and S100A9 are encoded by novel injury-regulated genes","volume":"276","author":"Thorey","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaad.2010.02.049_bib19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.bbrc.2006.12.203","article-title":"S100A9 mediates neutrophil adhesion to fibronectin through activation of beta2 integrins","volume":"354","author":"Anceriz","year":"2007","journal-title":"Biochem Biophy Res Commun"},{"key":"10.1016\/j.jaad.2010.02.049_bib20","doi-asserted-by":"crossref","first-page":"9496","DOI":"10.1074\/jbc.272.14.9496","article-title":"Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway","volume":"272","author":"Rammes","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaad.2010.02.049_bib21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0923-1811(99)00031-6","article-title":"Overexpression of monocyte-derived cytokines in active psoriasis: a relation to coexistent arthropathy","volume":"21","author":"Nishibu","year":"1999","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jaad.2010.02.049_bib22","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1139\/Y09-054","article-title":"S100A8\/A9: a mediator of severe asthma pathogenesis and morbidity?","volume":"87","author":"Halayko","year":"2009","journal-title":"Can J Physiol Pharmacol"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962210003221?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962210003221?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T22:19:32Z","timestamp":1759270772000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962210003221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S0190962210003221"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2010.02.049","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Markedly elevated serum levels of calcium-binding S100A8\/A9 proteins in psoriatic arthritis are due to activated monocytes\/macrophages","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2010.02.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}