{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:30:43Z","timestamp":1785684643677,"version":"3.56.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1016\/j.jaad.2010.07.031","type":"journal-article","created":{"date-parts":[[2011,5,9]],"date-time":"2011-05-09T05:22:28Z","timestamp":1304918548000},"page":"357-363","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":96,"title":["p16 Expression: A\u00a0marker of differentiation between childhood malignant melanomas and Spitz nevi"],"prefix":"10.1016","volume":"65","author":[{"given":"Rola","family":"Al Dhaybi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Agoumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Gagn\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"McCuaig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Kokta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaad.2010.07.031_bib1","first-page":"341","article-title":"Childhood malignant melanoma: incidence and etiology","volume":"7","author":"Bader","year":"1985","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"10.1016\/j.jaad.2010.07.031_bib2","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.jaad.2005.07.013","article-title":"Malignant melanoma in childhood and adolescence: a report of 13 cases","volume":"53","author":"Jafarian","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2010.07.031_bib3","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/j.1600-0560.2008.01153.x","article-title":"Spitzoid melanoma in children: clinicopathological study and application of immunohistochemistry as an adjunct diagnostic tool","volume":"36","author":"Paradela","year":"2009","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.jaad.2010.07.031_bib4","first-page":"171","article-title":"Nevus Spitz\u2013everlasting diagnostic difficulties\u2013the review","volume":"32","author":"Situm","year":"2008","journal-title":"Coll Antropol"},{"key":"10.1016\/j.jaad.2010.07.031_bib5","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.clindermatol.2008.09.013","article-title":"Spitzoid melanoma","volume":"27","author":"Kamino","year":"2009","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.jaad.2010.07.031_bib6","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1067\/mjd.2001.111635","article-title":"MIB-1 monoclonal antibody to determine proliferative activity of Ki-67 antigen as an adjunct to the histopathologic differential diagnosis of Spitz nevi","volume":"44","author":"Bergman","year":"2001","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2010.07.031_bib7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/modpathol.3800281","article-title":"Spitz nevi and atypical Spitz nevi\/tumors: a histologic and immunohistochemical analysis","volume":"18","author":"Kapur","year":"2005","journal-title":"Mod Pathol"},{"key":"10.1016\/j.jaad.2010.07.031_bib8","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/01.MP.0000071128.67149.FD","article-title":"S100A6 protein expression is different in Spitz nevi and melanomas","volume":"16","author":"Ribe","year":"2003","journal-title":"Mod Pathol"},{"key":"10.1016\/j.jaad.2010.07.031_bib9","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/j.1600-0560.2006.00670.x","article-title":"Differentiating Spitzoid melanomas from Spitz nevi through CD9 expression","volume":"34","author":"King","year":"2007","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.jaad.2010.07.031_bib10","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/j.1600-0560.2008.01154.x","article-title":"p16 Expression differentiates between desmoplastic Spitz nevus and desmoplastic melanoma","volume":"36","author":"Hilliard","year":"2009","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.jaad.2010.07.031_bib11","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1309\/AJCP52YVYCTLUOPI","article-title":"Immunohistochemical evaluation of p16 INK4A, E-cadherin, and cyclin D1 expression in melanoma and Spitz tumors","volume":"133","author":"George","year":"2010","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.jaad.2010.07.031_bib12","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00428-007-0459-7","article-title":"Melanocytic nevi simulant of melanoma with medicolegal relevance","volume":"451","author":"Massi","year":"2007","journal-title":"Virchows Arch"},{"key":"10.1016\/j.jaad.2010.07.031_bib13","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/modpathol.2009.163","article-title":"Expression of CD133+ cancer stem cells in childhood malignant melanoma and its correlation with metastasis","volume":"23","author":"Al Dhaybi","year":"2010","journal-title":"Mod Pathol"},{"key":"10.1016\/j.jaad.2010.07.031_bib14","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/S0002-9440(10)63736-4","article-title":"Mechanisms of cell-cycle arrest in Spitz nevi with constitutive activation of the MAP-kinase pathway","volume":"164","author":"Maldonado","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaad.2010.07.031_bib15","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/00000372-199806000-00006","article-title":"p16 and p21WAF1 Protein expression in melanocytic tumors by immunohistochemistry","volume":"20","author":"Sparrow","year":"1998","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.jaad.2010.07.031_bib16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.tripleo.2008.08.027","article-title":"Alterations of p16 and p14ARF genes and their 9p21 locus in oral squamous cell carcinoma","volume":"107","author":"Ohta","year":"2009","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.jaad.2010.07.031_bib17","first-page":"4483","article-title":"Numerical abnormalities of chromosome 9 and p16CDKN2A gene deletion detected by FISH in non-small cell lung cancer","volume":"29","author":"Panani","year":"2009","journal-title":"Anticancer Res"},{"key":"10.1016\/j.jaad.2010.07.031_bib18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000209392","article-title":"p16ink4a Is a surrogate marker for high-risk and malignant cervical lesions in the presence of human papillomavirus","volume":"76","author":"Lakshmi","year":"2009","journal-title":"Pathobiology"},{"key":"10.1016\/j.jaad.2010.07.031_bib19","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s00432-008-0534-8","article-title":"Methylation status of p16 INK4A tumor suppressor gene in Iranian patients with sporadic breast cancer","volume":"135","author":"Vallian","year":"2009","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.jaad.2010.07.031_bib20","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1177\/1066896909336177","article-title":"Reduced p16 and increased cyclin D1 and pRb expression are correlated with progression in cutaneous melanocytic tumors","volume":"17","author":"Karim","year":"2009","journal-title":"Int J Surg Pathol"},{"key":"10.1016\/j.jaad.2010.07.031_bib21","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/(SICI)1097-0215(19971021)74:5<535::AID-IJC10>3.0.CO;2-5","article-title":"Alterations and prognostic significance of p16 and p53 protein expression in subgroups of cutaneous melanoma","volume":"74","author":"Straume","year":"1997","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jaad.2010.07.031_bib22","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1080\/00313020701684409","article-title":"Reduced expression of p16 and p27 is correlated with tumor progression in cutaneous melanoma","volume":"39","author":"Sanki","year":"2007","journal-title":"Pathology"},{"key":"10.1016\/j.jaad.2010.07.031_bib23","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1002\/ijc.21608","article-title":"p16 Expression in primary malignant melanoma is associated with prognosis and lymph node status","volume":"118","author":"Mihic-Probst","year":"2006","journal-title":"Int J\u00a0Cancer"},{"key":"10.1016\/j.jaad.2010.07.031_bib24","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1093\/jnci\/88.10.680","article-title":"Reduced survival in patients with ductal pancreatic adenocarcinoma associated with CDNK2 mutation","volume":"88","author":"Bartsch","year":"1996","journal-title":"J Natl Cancer Inst"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962210008728?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962210008728?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T22:19:35Z","timestamp":1759270775000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962210008728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["S0190962210008728"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2010.07.031","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13340018.14707140","asserted-by":"object"}]},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"p16 Expression: A\u00a0marker of differentiation between childhood malignant melanomas and Spitz nevi","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2010.07.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}