{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:49:05Z","timestamp":1789926545717,"version":"4.0.1"},"reference-count":101,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.jaad.2012.03.013","type":"journal-article","created":{"date-parts":[[2012,6,13]],"date-time":"2012-06-13T10:10:26Z","timestamp":1339582226000},"page":"19.e1-19.e12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":71,"title":["The dysplastic nevus: From historical perspective to management in the modern era"],"prefix":"10.1016","volume":"67","author":[{"given":"Keith","family":"Duffy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Grossman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaad.2012.03.013_bib1","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1001\/archderm.1978.01640170032006","article-title":"Origin of familial malignant melanomas from heritable melanocytic lesions. \u2018The B-K mole syndrome\u2019","volume":"114","author":"Clark","year":"1978","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0190-9622(90)70037-I","article-title":"Histologic atypia in clinically benign nevi. A prospective study","volume":"22","author":"Klein","year":"1990","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1067\/mjd.2001.114580","article-title":"Correlation between clinical atypia and histologic dysplasia in acquired melanocytic nevi","volume":"45","author":"Annessi","year":"2001","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib4","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1001\/jama.1997.03540420035026","article-title":"Clinically recognized dysplastic nevi. A central risk factor for cutaneous melanoma","volume":"277","author":"Tucker","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.jaad.2012.03.013_bib5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.5694\/j.1326-5377.1997.tb138843.x","article-title":"A high incidence of melanoma found in patients with multiple dysplastic naevi by photographic surveillance","volume":"167","author":"Kelly","year":"1997","journal-title":"Med J Aust"},{"key":"10.1016\/j.jaad.2012.03.013_bib6","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1001\/jama.1992.03490100112037","article-title":"Diagnosis and treatment of early melanoma","volume":"268","year":"1992","journal-title":"JAMA"},{"key":"10.1016\/j.jaad.2012.03.013_bib7","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/00000372-199302000-00007","article-title":"What is early melanoma?","volume":"15","author":"Kopf","year":"1993","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.jaad.2012.03.013_bib8","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/00000372-199302000-00010","article-title":"A critique of an N.I.H. Consensus Development Conference about \u201cearly\u201d melanoma","volume":"15","author":"Ackerman","year":"1993","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.jaad.2012.03.013_bib9","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.0303-6987.2004.00217.x","article-title":"What to call the LEJC-BFV nevus?","volume":"31","author":"Glusac","year":"2004","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.jaad.2012.03.013_bib10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.0303-6987.2005.0315a.x","article-title":"War and peace in the realm of dysplastic nevi","volume":"32","author":"Cramer","year":"2005","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.jaad.2012.03.013_bib11","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.0303-6987.2005.00354.x","article-title":"The melanocytic nevus described by Clark et\u00a0al. What is its nature? What should it be named? An answer from history and from logic","volume":"32","author":"Hurt","year":"2005","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.jaad.2012.03.013_bib12","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1067\/mjd.2002.121029","article-title":"Management of dysplastic nevi: a survey of fellows of the American Academy of Dermatology","volume":"46","author":"Tripp","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib13","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.amjsurg.2010.09.011","article-title":"Predictors of positive sentinel lymph node in thin melanoma","volume":"201","author":"Yonick","year":"2011","journal-title":"Am J Surg"},{"key":"10.1016\/j.jaad.2012.03.013_bib14","first-page":"1177","article-title":"Differentiation between Spitz nevi and malignant melanomas by interphase fluorescence in situ hybridization","volume":"14","author":"Wettengel","year":"1999","journal-title":"Int J Oncol"},{"key":"10.1016\/j.jaad.2012.03.013_bib15","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S0002-9440(10)64609-3","article-title":"Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features","volume":"157","author":"Bastian","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaad.2012.03.013_bib16","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1097\/PAS.0b013e3181ba6db6","article-title":"Fluorescence in situ hybridization for distinguishing nevoid melanomas from mitotically active nevi","volume":"33","author":"Gerami","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jaad.2012.03.013_bib17","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/00008390-199812000-00004","article-title":"Human acquired naevi are clonal","volume":"8","author":"Robinson","year":"1998","journal-title":"Melanoma Res"},{"key":"10.1016\/j.jaad.2012.03.013_bib18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1001\/archderm.139.3.289","article-title":"Analysis of heterogeneity of atypia within melanocytic nevi","volume":"139","author":"Barr","year":"2003","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib19","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1002\/ijc.24899","article-title":"Altered molecular pathways in melanocytic lesions","volume":"126","author":"Scatolini","year":"2010","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jaad.2012.03.013_bib20","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/nature00766","article-title":"Mutations of the BRAF gene in human cancer","volume":"417","author":"Davies","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jaad.2012.03.013_bib21","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1056\/NEJMoa1002011","article-title":"Inhibition of mutated, activated BRAF in metastatic melanoma","volume":"363","author":"Flaherty","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaad.2012.03.013_bib22","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ng1054","article-title":"High frequency of BRAF mutations in nevi","volume":"33","author":"Pollock","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaad.2012.03.013_bib23","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/DAD.0b013e3181584950","article-title":"Distribution of BRAF T1799A(V600E) mutations across various types of benign nevi: implications for melanocytic tumorigenesis","volume":"29","author":"Wu","year":"2007","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.jaad.2012.03.013_bib24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/sj.jid.5700011","article-title":"Lack of association between BRAF mutation and MAPK ERK activation in melanocytic nevi","volume":"126","author":"Uribe","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib25","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/sj.jid.5700490","article-title":"Congenital melanocytic nevi frequently harbor NRAS mutations but no BRAF mutations","volume":"127","author":"Bauer","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib26","doi-asserted-by":"crossref","first-page":"E14","DOI":"10.1136\/jmg.40.2.e14","article-title":"Mutational analysis of N-ras, p53, CDKN2A (p16(INK4a)), p14(ARF), CDK4, and MC1R genes in human dysplastic melanocytic naevi","volume":"40","author":"Papp","year":"2003","journal-title":"J Med Genet"},{"key":"10.1016\/j.jaad.2012.03.013_bib27","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/00008390-200510000-00008","article-title":"Mutational analysis of the BRAF gene in human congenital and dysplastic melanocytic naevi","volume":"15","author":"Papp","year":"2005","journal-title":"Melanoma Res"},{"key":"10.1016\/j.jaad.2012.03.013_bib28","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1126\/science.274.5293.1672","article-title":"Cancer cell cycles","volume":"274","author":"Sherr","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.jaad.2012.03.013_bib29","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/sj.bjc.6603283","article-title":"Cellular senescence in naevi and immortalisation in melanoma: a role for p16?","volume":"95","author":"Gray-Schopfer","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jaad.2012.03.013_bib30","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1002\/cncr.10605","article-title":"A natural history of melanomas and dysplastic nevi: an atlas of lesions in melanoma-prone families","volume":"94","author":"Tucker","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.jaad.2012.03.013_bib31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1001\/archderm.141.2.177","article-title":"A search for CDKN2A\/p16INK4a mutations in melanocytic nevi from patients with melanoma and spouse controls by use of laser-captured microdissection","volume":"141","author":"Wang","year":"2005","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib32","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1006\/bbrc.1997.7212","article-title":"Genetic alterations of p16INK4a and p53 genes in sporadic dysplastic nevus","volume":"237","author":"Lee","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jaad.2012.03.013_bib33","doi-asserted-by":"crossref","first-page":"10124","DOI":"10.1073\/pnas.88.22.10124","article-title":"A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma","volume":"88","author":"Brash","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaad.2012.03.013_bib34","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/978-0-387-77574-6_21","article-title":"P53 protein and pathogenesis of melanoma and nonmelanoma skin cancer","volume":"624","author":"Benjamin","year":"2008","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jaad.2012.03.013_bib35","first-page":"4278","article-title":"Valadares de Amorim G, Webber J, Kenny P, Kusser W. Detection of p53 mutations in benign and dysplastic nevi","volume":"55","author":"Levin","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/j.jaad.2012.03.013_bib36","first-page":"2235","article-title":"Overexpression of p53 is a late event in the development of malignant melanoma","volume":"53","author":"Lassam","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/j.jaad.2012.03.013_bib37","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1177\/120347549900300603","article-title":"Malignant melanoma arising from nevi, p53, p16, and Bcl-2: expression in benign versus malignant components","volume":"3","author":"Radhi","year":"1999","journal-title":"J Cutan Med Surg"},{"key":"10.1016\/j.jaad.2012.03.013_bib38","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1365-2133.1993.tb00253.x","article-title":"p53 immunoreactivity in human malignant melanoma and dysplastic naevi","volume":"128","author":"McGregor","year":"1993","journal-title":"Br J Dermatol"},{"issue":"suppl 1","key":"10.1016\/j.jaad.2012.03.013_bib39","first-page":"17","article-title":"Expression of cell cycle and apoptosis regulatory proteins and telomerase in melanocitic lesions","volume":"31","author":"Batinac","year":"2007","journal-title":"Coll Antropol"},{"key":"10.1016\/j.jaad.2012.03.013_bib40","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.1038\/onc.2008.248","article-title":"The role of PTEN signaling perturbations in cancer and in targeted therapy","volume":"27","author":"Keniry","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.jaad.2012.03.013_bib41","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0190-9622(03)02473-3","article-title":"PTEN expression in normal skin, acquired melanocytic nevi, and cutaneous melanoma","volume":"49","author":"Tsao","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib42","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1600-0560.2006.00592.x","article-title":"Phosphoinositide 3-kinase is not overexpressed in melanocytic lesions","volume":"34","author":"Singh","year":"2007","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.jaad.2012.03.013_bib43","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1034\/j.1600-0560.2001.280702.x","article-title":"Comprehensive analysis of 112 melanocytic skin lesions demonstrates microsatellite instability in melanomas and dysplastic nevi, but not in benign nevi","volume":"28","author":"Hussein","year":"2001","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.jaad.2012.03.013_bib44","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1001\/archderm.134.7.882","article-title":"Loss of heterozygosity detected on 1p and 9q in microdissected atypical nevi","volume":"134","author":"Boni","year":"1998","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib45","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1056\/NEJM198905253202102","article-title":"Mapping the gene for hereditary cutaneous malignant melanoma-dysplastic nevus to chromosome 1p","volume":"320","author":"Bale","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaad.2012.03.013_bib46","first-page":"537","article-title":"Further evidence for a locus for cutaneous malignant melanoma-dysplastic nevus (CMM\/DN) on chromosome 1p, and evidence for genetic heterogeneity","volume":"52","author":"Goldstein","year":"1993","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jaad.2012.03.013_bib47","first-page":"1050","article-title":"Two-locus linkage analysis of cutaneous malignant melanoma\/dysplastic nevi","volume":"58","author":"Goldstein","year":"1996","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jaad.2012.03.013_bib48","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/ng.410","article-title":"Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi","volume":"41","author":"Falchi","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaad.2012.03.013_bib49","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/(SICI)1097-0215(20000415)86:2<255::AID-IJC16>3.0.CO;2-L","article-title":"Detection of microsatellite alterations in the spectrum of melanocytic nevi in patients with or without individual or family history of melanoma","volume":"86","author":"Birindelli","year":"2000","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jaad.2012.03.013_bib50","first-page":"675","article-title":"Alteration of chromosome 9p21 and\/or p16 in benign and dysplastic nevi suggests a role in early melanoma progression","volume":"13","author":"Tran","year":"2002","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.jaad.2012.03.013_bib51","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0046-8177(98)90221-0","article-title":"Allelic deletion at chromosome 9p21(p16) and 17p13(p53) in microdissected sporadic dysplastic nevus","volume":"29","author":"Park","year":"1998","journal-title":"Hum Pathol"},{"key":"10.1016\/j.jaad.2012.03.013_bib52","first-page":"243","article-title":"Molecular alterations at chromosome 9p21 in melanocytic naevi and melanoma","volume":"158","author":"Sini","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib53","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1046\/j.1523-1747.1998.00211.x","article-title":"Expression of the tumor suppressor gene product p16INK4 in benign and malignant melanocytic lesions","volume":"110","author":"Keller-Melchior","year":"1998","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib54","first-page":"142","article-title":"Dermoscopy of melanocytic neoplasms: subpatterns of dysplastic\/atypical nevi","volume":"140","author":"Grichnik","year":"2004","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib55","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/01.pai.0000209868.58699.64","article-title":"The significance of Ki-67 proliferative index and cyclin D1 expression of dysplastic nevi in the biologic spectrum of melanocytic lesions","volume":"15","author":"Lebe","year":"2007","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1016\/j.jaad.2012.03.013_bib56","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00403-010-1054-3","article-title":"Cyclin D1 and D3 expression in melanocytic skin lesions","volume":"302","author":"Alekseenko","year":"2010","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jaad.2012.03.013_bib57","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/DAD.0b013e3181624054","article-title":"Comparison of pHH3, Ki-67, and survivin immunoreactivity in benign and malignant melanocytic lesions","volume":"30","author":"Nasr","year":"2008","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.jaad.2012.03.013_bib58","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1046\/j.1523-1747.1999.00636.x","article-title":"FGF expression allows nevus cells to survive in three-dimensional collagen gel under conditions that induce apoptosis in normal human melanocytes","volume":"113","author":"Alanko","year":"1999","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib59","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1001\/archderm.1995.01690200051010","article-title":"bcl-2 expression in melanocytic nevi. Insights into the biology of dermal maturation","volume":"131","author":"Morales-Ducret","year":"1995","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib60","first-page":"643","article-title":"Immunohistochemical analysis of Bcl-2 protein regulation in cutaneous melanoma","volume":"146","author":"Tron","year":"1995","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaad.2012.03.013_bib61","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1046\/j.1523-1747.1999.00776.x","article-title":"Expression and targeting of the apoptosis inhibitor, survivin, in human melanoma","volume":"113","author":"Grossman","year":"1999","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib62","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.0303-6987.2005.00242.x","article-title":"Proliferation, apoptosis, and survivin expression in a spectrum of melanocytic nevi","volume":"32","author":"Florell","year":"2005","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.jaad.2012.03.013_bib63","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.humpath.2006.04.026","article-title":"Progression in melanoma is associated with decreased expression of death receptors for tumor necrosis factor-related apoptosis-inducing ligand","volume":"37","author":"Zhuang","year":"2006","journal-title":"Hum Pathol"},{"key":"10.1016\/j.jaad.2012.03.013_bib64","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1002\/cncr.25838","article-title":"Prognostic significance of RUNX3 expression in human melanoma","volume":"117","author":"Zhang","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.jaad.2012.03.013_bib65","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.ejca.2003.11.035","article-title":"Disturbed melanin synthesis and chronic oxidative stress in dysplastic naevi","volume":"40","author":"Pavel","year":"2004","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.jaad.2012.03.013_bib66","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.1751-1097.2007.00242.x","article-title":"Increased melanogenesis is a risk factor for oxidative DNA damage\u2014study on cultured melanocytes and atypical nevus cells","volume":"84","author":"Smit","year":"2008","journal-title":"Photochem Photobiol"},{"key":"10.1016\/j.jaad.2012.03.013_bib67","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1056\/NEJMra062285","article-title":"Oncogene-induced cell senescence\u2014halting on the road to cancer","volume":"355","author":"Mooi","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaad.2012.03.013_bib68","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1038\/sj.onc.1203438","article-title":"p16 INK4a can initiate an autonomous senescence program","volume":"19","author":"Dai","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.jaad.2012.03.013_bib69","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nature03890","article-title":"BRAFE600-associated senescence-like cell cycle arrest of human naevi","volume":"436","author":"Michaloglou","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jaad.2012.03.013_bib70","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1038\/sj.jid.5700903","article-title":"Absence of senescence-associated beta-galactosidase activity in human melanocytic nevi in\u00a0vivo","volume":"127","author":"Cotter","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib71","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1038\/sj.jid.5701220","article-title":"Comment on \u201cAbsence of senescence-associated beta-galactosidase activity in human melanocytic nevi in\u00a0vivo\u201d","volume":"128","author":"Gray-Schopfer","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib72","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1038\/sj.jid.5701221","article-title":"Comment on \u201cAbsence of senescence-associated beta-galactosidase activity in human melanocytic nevi in\u00a0vivo\u201d","volume":"128","author":"Michaloglou","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib73","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/sj.jid.5701222","article-title":"Reply to responses to \u201cAbsence of senescence-associated \u03b2-galactosidase activity in human melanocytic nevi in\u00a0vivo\u201d","volume":"128","author":"Cotter","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib74","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1038\/sj.onc.1206446","article-title":"Human melanocyte senescence and melanoma susceptibility genes","volume":"22","author":"Bennett","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.jaad.2012.03.013_bib75","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cell.2007.12.032","article-title":"Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7","volume":"132","author":"Wajapeyee","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.jaad.2012.03.013_bib76","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.cell.2010.05.014","article-title":"Role for IGFBP7 in senescence induction by BRAF","volume":"141","author":"Wajapeyee","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jaad.2012.03.013_bib77","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.humpath.2009.12.002","article-title":"Oncogenic BRAF-positive dysplastic nevi and the tumor suppressor IGFBP7\u2014challenging the concept of dysplastic nevi as precursor lesions?","volume":"41","author":"Decarlo","year":"2010","journal-title":"Hum Pathol"},{"key":"10.1016\/j.jaad.2012.03.013_bib78","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1365-2133.2009.09558.x","article-title":"BRAF V600E mutation and the tumour suppressor IGFBP7 in atypical genital naevi","volume":"162","author":"Nguyen","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib79","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00000372-199302000-00006","article-title":"National Institutes of Health Consensus Development Conference Statement on Diagnosis and Treatment of Early Melanoma, January 27-29, 1992","volume":"15","year":"1993","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.jaad.2012.03.013_bib80","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jaad.2008.10.065","article-title":"Strategies for early melanoma detection: approaches to the patient with nevi","volume":"60","author":"Goodson","year":"2009","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib81","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/0190-9622(90)70304-Z","article-title":"Ocular melanoma in families with dysplastic nevus syndrome","volume":"23","author":"Vink","year":"1990","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib82","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/gcc.20202","article-title":"A large Norwegian family with inherited malignant melanoma, multiple atypical nevi, and CDK4 mutation","volume":"44","author":"Molven","year":"2005","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.jaad.2012.03.013_bib83","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/0002-9394(84)90135-1","article-title":"Lack of association between intraocular melanoma and cutaneous dysplastic nevi","volume":"98","author":"Taylor","year":"1984","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jaad.2012.03.013_bib84","first-page":"56","article-title":"Treatment of dysplastic nevi with 5% imiquimod cream, a pilot study","volume":"5","author":"Dusza","year":"2006","journal-title":"J Drugs Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib85","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1001\/archderm.143.3.379","article-title":"Treatment of atypical nevi with imiquimod 5% cream","volume":"143","author":"Somani","year":"2007","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib86","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1001\/archderm.1981.01650020031020","article-title":"Guerry D 4th, Greene MH. Topical chemotherapy of dysplastic melanocytic nevi with 5% fluorouracil","volume":"117","author":"Bondi","year":"1981","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib87","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/00008390-199812000-00009","article-title":"Effect of topical tretinoin under occlusion on atypical naevi","volume":"8","author":"Stam-Posthuma","year":"1998","journal-title":"Melanoma Res"},{"key":"10.1016\/j.jaad.2012.03.013_bib88","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0190-9622(89)70031-1","article-title":"Effect of oral isotretinoin on dysplastic nevi","volume":"20","author":"Edwards","year":"1989","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib89","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1001\/archderm.135.3.290","article-title":"Treatment of benign and atypical nevi with the normal-mode ruby laser and the Q-switched ruby laser: clinical improvement but failure to completely eliminate nevomelanocytes","volume":"135","author":"Duke","year":"1999","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib90","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1001\/archderm.136.7.915","article-title":"Laser treatment of pigmented lesions\u20142000: how far have we gone?","volume":"136","author":"Stratigos","year":"2000","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib91","first-page":"773","article-title":"Dysplastic nevus syndrome with development of multiple melanomas. A surgical concept for prophylaxis","volume":"7","author":"Brod","year":"2009","journal-title":"J Dtsch Dermatol Ges"},{"key":"10.1016\/j.jaad.2012.03.013_bib92","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1001\/archdermatol.2011.2045","article-title":"Clinical decision making based on histopathological grading and margin status of dysplastic nevi","volume":"148","author":"Duffy","year":"2012","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib93","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0190-9622(08)81499-5","article-title":"A multiobserver, population-based analysis of histologic dysplasia in melanocytic nevi","volume":"30","author":"Piepkorn","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib94","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/path.1061","article-title":"Inter-observer variation in the histopathological diagnosis of clinically suspicious pigmented skin lesions","volume":"196","author":"Brochez","year":"2002","journal-title":"J Pathol"},{"key":"10.1016\/j.jaad.2012.03.013_bib95","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.0303-6987.2004.00216.x","article-title":"Variability in nomenclature used for nevi with architectural disorder and cytologic atypia (microscopically dysplastic nevi) by dermatologists and dermatopathologists","volume":"31","author":"Shapiro","year":"2004","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.jaad.2012.03.013_bib96","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1001\/archderm.1975.01630240044008","article-title":"Pseudomelanoma: recurrent melanocytic nevus following partial surgical removal","volume":"111","author":"Kornberg","year":"1975","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/S0300-7073(06)74029-4","article-title":"With dysplastic nevi, pause before you biopsy","author":"Bates","year":"2006","journal-title":"Family Practice News"},{"key":"10.1016\/j.jaad.2012.03.013_bib98","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/modpathol.2009.22","article-title":"Recurrent nevus phenomenon: a clinicopathologic study of 357 cases and histologic comparison with melanoma with regression","volume":"22","author":"King","year":"2009","journal-title":"Mod Pathol"},{"key":"10.1016\/j.jaad.2012.03.013_bib99","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jaad.2009.06.080","article-title":"Low rates of clinical recurrence after biopsy of benign to moderately dysplastic melanocytic nevi","volume":"62","author":"Goodson","year":"2010","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2012.03.013_bib100","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.mehy.2007.03.004","article-title":"A new concept of melanocytic neoplasia pathogenesis based on the phenotype of common acquired nevi","volume":"69","author":"Batistatou","year":"2007","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.jaad.2012.03.013_bib101","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/ng.910","article-title":"Germline mutations in BAP1 predispose to melanocytic tumors","volume":"43","author":"Wiesner","year":"2011","journal-title":"Nat Genet"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962212003556?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962212003556?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T22:22:29Z","timestamp":1759270949000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962212003556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":101,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0190962212003556"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2012.03.013","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The dysplastic nevus: From historical perspective to management in the modern era","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2012.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}