{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:08:39Z","timestamp":1777518519057,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.jaad.2014.10.033","type":"journal-article","created":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T19:48:18Z","timestamp":1417722498000},"page":"333-339","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Generalized lymphedema associated with neurologic signs (GLANS) syndrome: A new entity?"],"prefix":"10.1016","volume":"72","author":[{"given":"Marine","family":"Berton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9rard","family":"Lorette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Baulieu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Lagrue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Blesson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Cambazard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lo\u00efc","family":"Vaillant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annabel","family":"Maruani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaad.2014.10.033_bib1","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.annder.2012.06.043","article-title":"Lymphoed\u00e8me primaire de l'enfant","volume":"139","author":"Blein","year":"2012","journal-title":"Ann Dermatol Venereol"},{"key":"10.1016\/j.jaad.2014.10.033_bib2","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.lpm.2010.09.009","article-title":"Le syst\u00e8me lymphatique: anatomie, histologie et physiologie","volume":"39","author":"Qu\u00e9r\u00e9","year":"2010","journal-title":"Presse Med"},{"key":"10.1016\/j.jaad.2014.10.033_bib3","first-page":"58","article-title":"Lymphoscintigraphy of primary lymphedema in children","volume":"6","author":"Baulieu","year":"1997","journal-title":"Eur J Lymphology"},{"key":"10.1016\/j.jaad.2014.10.033_bib4","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.lpm.2009.11.023","article-title":"Exploration lymphoscintigraphique dans la maladie lymphatique des membres","volume":"39","author":"Baulieu","year":"2010","journal-title":"Presse Med"},{"key":"10.1016\/j.jaad.2014.10.033_bib5","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1086\/303019","article-title":"Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase","volume":"67","author":"Irrthum","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jaad.2014.10.033_bib6","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/75997","article-title":"Missense\u00a0mutations interfere with VEGFR-3 signaling in primary lymphedema","volume":"25","author":"Karkkainen","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaad.2014.10.033_bib7","doi-asserted-by":"crossref","first-page":"E1002","DOI":"10.1002\/humu.21127","article-title":"Novel missense mutations in the FOXC2 gene alter transcriptional activity","volume":"30","author":"Van Steensel","year":"2009","journal-title":"Hum Mutat"},{"key":"10.1016\/j.jaad.2014.10.033_bib8","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1083\/jcb.201012094","article-title":"Lymphatic vascular morphogenesis in development, physiology, and disease","volume":"193","author":"Schulte-Merker","year":"2011","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jaad.2014.10.033_bib9","first-page":"10","article-title":"The brain and the lymphatic system (II)","volume":"29","author":"F\u00f6ldi","year":"1996","journal-title":"Lymphology"},{"key":"10.1016\/j.jaad.2014.10.033_bib10","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/cge.12173","article-title":"The classification and diagnostic algorithm for primary lymphatic dysplasia: an update from 2010 to include molecular findings","volume":"84","author":"Connell","year":"2013","journal-title":"Clin Genet"},{"key":"10.1016\/j.jaad.2014.10.033_bib11","doi-asserted-by":"crossref","first-page":"794","DOI":"10.4103\/2230-8210.117197","article-title":"The other side of Turner's: Noonan's syndrome","volume":"17","author":"Agarwal","year":"2013","journal-title":"Indian J Endocrinol Metab"},{"issue":"S1","key":"10.1016\/j.jaad.2014.10.033_bib12","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1365-4632.2008.03959.x","article-title":"Lymphedema in Prader-Willi syndrome","volume":"47","author":"Heitink","year":"2008","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.jaad.2014.10.033_bib13","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1002\/ajmg.a.33200","article-title":"Agenesis of the corpus callosum and congenital lymphedema: a novel recognizable syndrome?","volume":"152A","author":"O'Driscoll","year":"2010","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jaad.2014.10.033_bib14","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1399-0004.1991.tb03027.x","article-title":"Progressive\u00a0encephalopathy with edema, hypsarrhythmia, and optic atrophy (PEHO syndrome)","volume":"39","author":"Salonen","year":"1991","journal-title":"Clin Genet"},{"key":"10.1016\/j.jaad.2014.10.033_bib15","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/ca.22009","article-title":"Cutaneous lymphatics and chronic lymphedema of the head and neck","volume":"25","author":"Feely","year":"2012","journal-title":"Clin Anat"},{"key":"10.1016\/j.jaad.2014.10.033_bib16","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jpainsymman.2011.03.019","article-title":"Prevalence of secondary lymphedema in patients with head and neck cancer","volume":"43","author":"Deng","year":"2012","journal-title":"J Pain Symptom Manage"},{"key":"10.1016\/j.jaad.2014.10.033_bib17","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/BF02146675","article-title":"Lymphatic drainage of the brain","volume":"24","author":"F\u00f6ldi","year":"1968","journal-title":"Experientia"},{"key":"10.1016\/j.jaad.2014.10.033_bib18","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.pathophys.2009.10.007","article-title":"Pathophysiology of the lymphatic drainage of the central nervous system: implications for pathogenesis and therapy of multiple sclerosis","volume":"17","author":"Weller","year":"2010","journal-title":"Pathophysiology"},{"key":"10.1016\/j.jaad.2014.10.033_bib19","first-page":"44","article-title":"La lymphe c\u00e9r\u00e9brale et m\u00e9dullaire","volume":"49","author":"Picard","year":"1997","journal-title":"Angeiologie"},{"key":"10.1016\/j.jaad.2014.10.033_bib20","first-page":"5","article-title":"In search of the lymphatic system of the central nervous system [in French]","volume":"15","author":"Picard","year":"1990","journal-title":"J Mal Vasc"},{"key":"10.1016\/j.jaad.2014.10.033_bib21","first-page":"F835","article-title":"Drainage of interstitial fluid from different regions of rat brain","volume":"246","author":"Szentistvanyi","year":"1984","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jaad.2014.10.033_bib22","first-page":"111","article-title":"Interrelationships of the pia mater and the perivascular (Virchow-Robin) spaces in the human cerebrum","volume":"170","author":"Zhang","year":"1990","journal-title":"J Anat"},{"key":"10.1016\/j.jaad.2014.10.033_bib23","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.anorl.2011.03.002","article-title":"Anatomy and physiology of cerebrospinal fluid","volume":"128","author":"Sakka","year":"2011","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"key":"10.1016\/j.jaad.2014.10.033_bib24","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1743-8454-1-2","article-title":"Evidence of connections between cerebrospinal fluid and nasal lymphatic vessels in humans, non human primates and other mammalian species","volume":"1","author":"Johnston","year":"2004","journal-title":"Cerebrospinal Fluid Res"},{"key":"10.1016\/j.jaad.2014.10.033_bib25","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1365-2990.1993.tb00476.x","article-title":"CSF drains directly from the subarachnoid space into nasal lymphatics in the rat: anatomy, histology and immunological significance","volume":"19","author":"Kida","year":"1993","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1016\/j.jaad.2014.10.033_bib26","doi-asserted-by":"crossref","first-page":"926","DOI":"10.3171\/jns.1989.70.6.0926","article-title":"Ultrastructure of the orbital pathway for cerebrospinal fluid drainage in rabbits","volume":"70","author":"Erlich","year":"1989","journal-title":"J Neurosurg"},{"key":"10.1016\/j.jaad.2014.10.033_bib27","first-page":"39","article-title":"Increase of slow wave sleep after cervical lymphatic blockage","volume":"50","author":"Obal","year":"1997","journal-title":"Acta Med Acad Sci Hung"},{"key":"10.1016\/j.jaad.2014.10.033_bib28","first-page":"55","article-title":"Cerebral edema as a consequence of experimental cervical lymphatic blockage","volume":"5","author":"Csanda","year":"1968","journal-title":"Angiologica"},{"key":"10.1016\/j.jaad.2014.10.033_bib29","first-page":"50","article-title":"Electron microscopic alterations in the central nervous system in experimental lymphogenic encephalopathy","volume":"4","author":"F\u00f6ldi","year":"1967","journal-title":"Angiologica"},{"key":"10.1016\/j.jaad.2014.10.033_bib30","first-page":"317","article-title":"Effect of tonsillectomy on the EEG","volume":"26","author":"Obal","year":"1969","journal-title":"Acta Med Acad Sci Hung"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962214021100?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962214021100?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T22:32:35Z","timestamp":1759271555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962214021100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0190962214021100"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2014.10.033","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generalized lymphedema associated with neurologic signs (GLANS) syndrome: A new entity?","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2014.10.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}