{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:17:56Z","timestamp":1789838276645,"version":"4.0.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.jaad.2015.07.017","type":"journal-article","created":{"date-parts":[[2015,9,6]],"date-time":"2015-09-06T15:46:37Z","timestamp":1441554397000},"page":"843-848","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":292,"title":["Acute generalized exanthematous pustulosis (AGEP): A review and update"],"prefix":"10.1016","volume":"73","author":[{"given":"Jesse","family":"Szatkowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaad.2015.07.017_bib1","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/j.1365-2133.1968.tb11947.x","article-title":"Generalized pustular psoriasis. A clinical and epidemiological study of 104 cases","volume":"80","author":"Baker","year":"1968","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2015.07.017_bib2","first-page":"37","article-title":"Pustuloses exanth\u00e9matiques aigu\u00ebs g\u00e9n\u00e9ralis\u00e9es, \u00e0 propos de 4 cas","volume":"107","author":"Beylot","year":"1980","journal-title":"Ann Dermatol Venereol"},{"key":"10.1016\/j.jaad.2015.07.017_bib3","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1586\/eci.11.66","article-title":"The current understanding of Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"7","author":"Mockenhaupt","year":"2011","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.jaad.2015.07.017_bib4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jaad.2013.05.002","article-title":"Toxic epidermal necrolysis: part I. Introduction, history, classification, clinical features, systemic manifestations, etiology, and immunopathogenesis","volume":"69","author":"Schwartz","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2015.07.017_bib5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jaad.2013.05.002","article-title":"Toxic epidermal necrolysis: part II. Prognosis, sequelae, diagnosis, differential diagnosis, prevention, and treatment","volume":"69","author":"Schwartz","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2015.07.017_bib6","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jaad.2013.01.032","article-title":"DRESS syndrome: part I. Clinical perspectives","volume":"68","author":"Husain","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2015.07.017_bib7","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.jaad.2013.01.032","article-title":"DRESS syndrome: part II. Management and therapeutics","volume":"68","author":"Husain","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2015.07.017_bib8","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1111\/j.1365-2133.2007.08156.x","article-title":"Risk factors for acute generalized exanthematous pustulosis (AGEP)-results of a multinational case-control study (EuroSCAR)","volume":"157","author":"Sidoroff","year":"2007","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2015.07.017_bib9","first-page":"267","article-title":"Childhood acute generalized exanthematous pustulosis induced by oral ketoconazole","volume":"18","author":"Miteva","year":"2010","journal-title":"Acta Dermatovenerol Croat"},{"key":"10.1016\/j.jaad.2015.07.017_bib10","first-page":"281","article-title":"Acute generalized exanthematous pustulosis: report of five cases and systematic review of clinical and histopathological findings","volume":"149","author":"Vassallo","year":"2014","journal-title":"G Ital Dermatol Venereol"},{"key":"10.1016\/j.jaad.2015.07.017_bib11","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4103\/0019-5154.152572","article-title":"Fluconazole-induced acute generalized exanthematous pustulosis","volume":"60","author":"Di Lernia","year":"2015","journal-title":"Indian J Dermatol"},{"key":"10.1016\/j.jaad.2015.07.017_bib12","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3109\/15569527.2011.645978","article-title":"Acute generalized exanthematous pustulosis to amoxicillin associated with parvovirus B19 reactivation","volume":"31","author":"Calistru","year":"2012","journal-title":"Cutan Ocul Toxicol"},{"key":"10.1016\/j.jaad.2015.07.017_bib13","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.arcped.2006.06.004","article-title":"Acute generalized exanthematous pustulosis: first case associated with a Chlamydia pneumoniae infection","volume":"13","author":"Manzano","year":"2006","journal-title":"Arch Pediatr"},{"key":"10.1016\/j.jaad.2015.07.017_bib14","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/j.1365-4362.1996.tb00653.x","article-title":"Acute generalized exanthematous pustulosis with cytomegalovirus infection","volume":"35","author":"Haro-Gabald\u00f3n","year":"1996","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.jaad.2015.07.017_bib15","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1600-0536.2007.01306.x","article-title":"Mercury-induced acute generalized exanthematous pustulosis misdiagnosed as a drug-related case","volume":"59","author":"Belhadjali","year":"2008","journal-title":"Contact Dermat"},{"key":"10.1016\/j.jaad.2015.07.017_bib16","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.jaad.2006.05.010","article-title":"Acute generalized exanthematous pustulosis following a spider bite: report of 3 cases","volume":"55","author":"Davidovici","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2015.07.017_bib17","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/01.dad.0000160982.75176.6c","article-title":"Cross-comparison of patch test and lymphocyte proliferation responses in patients with a history of acute generalized exanthematous pustulosis","volume":"27","author":"Girardi","year":"2005","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.jaad.2015.07.017_bib18","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1172\/JCI12118","article-title":"T-cell involvement in drug-induced acute generalized exanthematous pustulosis","volume":"107","author":"Britschgi","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaad.2015.07.017_bib19","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1016\/S0002-9440(10)64486-0","article-title":"Acute generalized exanthematous pustulosis: role of cytotoxic T cells in pustule formation","volume":"161","author":"Schmid","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaad.2015.07.017_bib20","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.4049\/jimmunol.173.3.2151","article-title":"Characterization of human T cells that regulate neutrophilic skin inflammation","volume":"173","author":"Schaerli","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.jaad.2015.07.017_bib21","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1046\/j.1365-2230.2000.00729.x","article-title":"Acute generalized exanthematous pustulosis associated with polysensitivity to paracetamol and bromhexine: the diagnostic role of in\u00a0vitro interferon-gamma release test","volume":"25","author":"Halevy","year":"2000","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jaad.2015.07.017_bib22","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1468-3083.1998.tb00925.x","article-title":"Generalized pustular drug eruptions: confirmation by in\u00a0vitro tests","volume":"10","author":"Lazarov","year":"1998","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaad.2015.07.017_bib23","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1038\/jid.2008.111","article-title":"Possible pathogenic role of Th17 cells for atopic dermatitis","volume":"128","author":"Koga","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2015.07.017_bib24","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s00403-014-1488-0","article-title":"Innate immune cells express IL-17A\/F in acute generalized exanthematous pustulosis and generalized pustular psoriasis","volume":"306","author":"Kakeda","year":"2014","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jaad.2015.07.017_bib25","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1468-3083.2010.03771.x","article-title":"Increased circulating Th17 frequencies and serum IL-22 levels in patients with acute generalized exanthematous pustulosis","volume":"25","author":"Kabashima","year":"2011","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaad.2015.07.017_bib26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2332\/allergolint.13-LE-0582","article-title":"Hapten-specific TH17 cells in the peripheral blood of \u03b2-lactam-induced AGEP","volume":"63","author":"Fil\u00ec","year":"2014","journal-title":"Allergology International"},{"key":"10.1016\/j.jaad.2015.07.017_bib27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jdermsci.2014.02.006","article-title":"The genetic background of generalized pustular psoriasis: IL36RN mutations and CARD14 gain-of-function variants","volume":"74","author":"Sugiura","year":"2014","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jaad.2015.07.017_bib28","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1038\/jid.2013.361","article-title":"IL36RN mutations in generalized pustular psoriasis: just the tip of the iceberg?","volume":"133","author":"Capon","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2015.07.017_bib29","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1001\/jamadermatol.2014.3848","article-title":"Homozygous missense mutation in il36rn in generalized pustular dermatosis with intraoral involvement compatible with both AGEP and generalized pustular psoriasis","volume":"151","author":"Navarini","year":"2015","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jaad.2015.07.017_bib30","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/bjd.12502","article-title":"Systemic involvement of acute generalized exanthematous pustulosis: a retrospective study on 58 patients","volume":"169","author":"Hotz","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2015.07.017_bib31","doi-asserted-by":"crossref","first-page":"314","DOI":"10.2340\/00015555-0616","article-title":"Prolonged course of acute generalized exanthematous pustulosis with liver involvement due to sensitization to amoxicillin and paracetamol","volume":"89","author":"Treudler","year":"2009","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jaad.2015.07.017_bib32","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4037\/ajcc2013987","article-title":"Acute generalized exanthematous pustulosis with multiple organ dysfunction syndrome","volume":"22","author":"Mohyuddin","year":"2013","journal-title":"Am J Crit Care"},{"key":"10.1016\/j.jaad.2015.07.017_bib33","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1503\/cmaj.090137","article-title":"Acute generalized exanthematous pustulosis with severe organ dysfunction","volume":"181","author":"Leclair","year":"2009","journal-title":"CMAJ"},{"key":"10.1016\/j.jaad.2015.07.017_bib34","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1093\/ndt\/17.10.1857","article-title":"Acute reversible renal failure in acute generalized exanthematous pustulosis","volume":"17","author":"Brandenburg","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.jaad.2015.07.017_bib35","first-page":"612","article-title":"Centres R\u00e9gionaux de Pharmacovigilance. [Drugs associated with acute generalized exanthematic pustulosis]","volume":"130","author":"Saissi","year":"2003","journal-title":"Ann Dermatol Venereol"},{"key":"10.1016\/j.jaad.2015.07.017_bib36","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.tox.2004.12.022","article-title":"Clinical heterogeneity of drug hypersensitivity","volume":"209","author":"Roujeau","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.jaad.2015.07.017_bib37","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1016\/j.jaad.2014.03.007","article-title":"A rapidly progressive and fatal case of atypical acute generalized exanthematous pustulosis","volume":"71","author":"Krishna","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2015.07.017_bib38","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1111\/j.1365-2133.2010.09967.x","article-title":"The spectrum of histopathological features in acute generalized exanthematous pustulosis: a study of 102 cases","volume":"163","author":"Halevy","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2015.07.017_bib39","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1111\/j.1600-0560.2010.01612.x","article-title":"The histopathological spectrum of acute generalized exanthematous pustulosis (AGEP) and its differentiation from generalized pustular psoriasis","volume":"37","author":"Kardaun","year":"2010","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.jaad.2015.07.017_bib40","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1034\/j.1600-0560.2001.028003113.x","article-title":"Acute generalized exanthematous pustulosis (AGEP)\u2013a clinical reaction pattern","volume":"28","author":"Sidoroff","year":"2001","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.jaad.2015.07.017_bib41","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/s11882-014-0442-8","article-title":"Skin testing and patch testing in non-IgE-mediated drug allergy","volume":"14","author":"Barbaud","year":"2014","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaad.2015.07.017_bib42","first-page":"603","article-title":"Sweet's syndrome: an update and review","volume":"144","author":"Yi","year":"2009","journal-title":"G Ital Dermatol Venereol"},{"key":"10.1016\/j.jaad.2015.07.017_bib43","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1111\/bjd.13540","article-title":"Acute generalized exanthematous pustulosis: a retrospective audit of practice between 1994 and 2011 in a single center","volume":"172","author":"Ingen-Housz-Oro","year":"2015","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2015.07.017_bib44","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1365-4632.2010.04313.x","article-title":"Acute generalized exanthematous pustulosis: analysis of cases managed in a tertiary hospital in Singapore","volume":"49","author":"Lee","year":"2010","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.jaad.2015.07.017_bib45","doi-asserted-by":"crossref","first-page":"163","DOI":"10.5021\/ad.2010.22.2.163","article-title":"Clinicopathologic manifestations of 36 Korean patients with acute generalized exanthematous pustulosis: a case series and review of the literature","volume":"22","author":"Choi","year":"2010","journal-title":"Ann Dermatol"},{"key":"10.1016\/j.jaad.2015.07.017_bib46","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2340\/00015555-0438","article-title":"Clinical manifestations and characteristics of patients with acute generalized exanthematous pustulosis in Asia","volume":"88","author":"Chang","year":"2008","journal-title":"Acta Derm Venereol"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962215019313?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962215019313?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T22:36:55Z","timestamp":1759271815000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962215019313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["S0190962215019313"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2015.07.017","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute generalized exanthematous pustulosis (AGEP): A review and update","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2015.07.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}