{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:48:57Z","timestamp":1791384537765,"version":"4.3.3"},"reference-count":41,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.jaad.2016.02.1161","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T10:01:23Z","timestamp":1476439283000},"page":"1007-1014","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"title":["Hair follicle\u2013containing punch grafts accelerate chronic ulcer healing: A randomized controlled trial"],"prefix":"10.1016","volume":"75","author":[{"given":"Mar\u00eda-Luisa","family":"Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Escario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Poblet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando-Francisco","family":"Buch\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ander","family":"Izeta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaad.2016.02.1161_bib1","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/nm1328","article-title":"Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis","volume":"11","author":"Ito","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.jaad.2016.02.1161_bib2","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1096\/fj.06-6926com","article-title":"Epidermal stem cells arise from the hair follicle after wounding","volume":"21","author":"Levy","year":"2007","journal-title":"FASEB J"},{"key":"10.1016\/j.jaad.2016.02.1161_bib3","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1038\/sj.jid.5701178","article-title":"An extended epidermal response heals cutaneous wounds in the absence of a hair follicle\u00a0stem cell contribution","volume":"128","author":"Langton","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2016.02.1161_bib4","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/jid.2008.86","article-title":"Is the hair follicle necessary for normal wound healing?","volume":"128","author":"Ito","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2016.02.1161_bib5","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/j.1600-0625.2009.00942.x","article-title":"Exploring the role of stem cells in cutaneous wound healing","volume":"18","author":"Lau","year":"2009","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jaad.2016.02.1161_bib6","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/jid.2010.291","article-title":"Exploring the \u2018hair growth-wound healing connection\u2019: anagen phase promotes wound re-epithelialization","volume":"131","author":"Ansell","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2016.02.1161_bib7","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/jid.2010.334","article-title":"Hair cycling and wound healing: to pluck or not to pluck?","volume":"131","author":"Stojadinovic","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2016.02.1161_bib8","doi-asserted-by":"crossref","first-page":"a023267","DOI":"10.1101\/cshperspect.a023267","article-title":"Wound healing and skin regeneration","volume":"5","author":"Takeo","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.jaad.2016.02.1161_bib9","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.5966\/sctm.2013-0217","article-title":"Dermal papilla cells improve the wound healing process and generate hair bud-like structures in grafted skin substitutes using hair follicle stem cells","volume":"3","author":"Leir\u00f3s","year":"2014","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.jaad.2016.02.1161_bib10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/exd.12607","article-title":"Hair follicles and their potential in wound healing","volume":"24","author":"Baquerizo-Nole","year":"2015","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jaad.2016.02.1161_bib11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/exd.12488","article-title":"Epigenetic control of skin and hair regeneration after wounding","volume":"24","author":"Plikus","year":"2015","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jaad.2016.02.1161_bib12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/aja.1000760202","article-title":"Regeneration after experimental removal of skin in man","volume":"76","author":"Bishop","year":"1945","journal-title":"Am J Anat"},{"key":"10.1016\/j.jaad.2016.02.1161_bib13","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/1523-1747.ep12298415","article-title":"Successful treatments of chronic leg ulcers with epidermal equivalents generated from cultured autologous outer root sheath cells","volume":"107","author":"Limat","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2016.02.1161_bib14","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1097\/01.PRS.0000105632.86651.EF","article-title":"Reepithelialization of a full-thickness burn from stem cells of hair follicles micrografted into a tissue-engineered dermal template (Integra)","volume":"113","author":"Navsaria","year":"2004","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.jaad.2016.02.1161_bib15","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1742-481X.2009.00609.x","article-title":"Transplantation of chronic wounds with epidermal sheets derived from autologous hair follicles- the Leipzig experience","volume":"67","author":"Renner","year":"2009","journal-title":"Int Wound J"},{"key":"10.1016\/j.jaad.2016.02.1161_bib16","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1111\/j.1524-4725.2011.02025.x","article-title":"Hair transplantation for reconstruction of scalp defects using artificial dermis","volume":"37","author":"Narushima","year":"2011","journal-title":"Dermatologic Surg"},{"key":"10.1016\/j.jaad.2016.02.1161_bib17","doi-asserted-by":"crossref","first-page":"42e","DOI":"10.1097\/PRS.0b013e318254fa21","article-title":"Reepithelialization from stem cells of hair follicles of dermal graft of the scalp in acute treatment of third-degree burns: first clinical and histologic study","volume":"130","author":"Zakine","year":"2012","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.jaad.2016.02.1161_bib18","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/j.1524-475X.2012.00846.x","article-title":"A pilot clinical study of hair grafting in chronic leg ulcers","volume":"20","author":"Jim\u00e9nez","year":"2012","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.jaad.2016.02.1161_bib19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/exd.12521","article-title":"Reflections on how wound healing-promoting effects of the hair follicle can be translated into clinical practice","volume":"24","author":"Jim\u00e9nez","year":"2014","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jaad.2016.02.1161_bib20","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1097\/DSS.0000000000000446","article-title":"Healing of recalcitrant chronic venous leg ulcers by punch grafts harvested from the scalp","volume":"41","author":"Martinez-Martinez","year":"2015","journal-title":"Dermatol Surg"},{"key":"10.1016\/j.jaad.2016.02.1161_bib21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3892\/etm.2015.2465","article-title":"Hair follicle units promote re-epithelialization in chronic cutaneous wounds: a clinical case series study","volume":"10","author":"Liu","year":"2015","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jaad.2016.02.1161_bib22","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1365-2133.1996.tb01164.x","article-title":"Skin grafts as pharmacological agents: pre-wounding of the donor site","volume":"135","author":"Kirsner","year":"1996","journal-title":"Br J Dermatol"},{"issue":"1","key":"10.1016\/j.jaad.2016.02.1161_bib23","first-page":"CD001737","article-title":"Skin grafting for venous leg ulcers","author":"Jones","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jaad.2016.02.1161_bib24","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/dth.12051","article-title":"Evidence-based management of common chronic lower extremity ulcers","volume":"26","author":"Richmond","year":"2013","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.jaad.2016.02.1161_bib25","doi-asserted-by":"crossref","first-page":"532","DOI":"10.7326\/0003-4819-159-8-201310150-00006","article-title":"Advanced wound care therapies for nonhealing diabetic, venous, and arterial ulcers","volume":"159","author":"Greer","year":"2013","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jaad.2016.02.1161_bib26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0190-9622(91)70015-T","article-title":"Grafting of venous leg ulcers. An intraindividual comparison between cultured skin equivalents and full-thickness skin punch grafts","volume":"24","author":"Mol","year":"1991","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2016.02.1161_bib27","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2340\/00015555-0443","article-title":"Punch-grafting to enhance healing and to reduce pain in complicated leg and foot ulcers","volume":"88","author":"Nordstr\u00f6m","year":"2008","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.jaad.2016.02.1161_bib28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0190-9622(03)02735-X","article-title":"Surgical pearl: full-thickness punch grafting in chronic nonhealing ulcers","volume":"50","author":"Thami","year":"2004","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2016.02.1161_bib29","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.jvs.2010.06.161","article-title":"Revision of the venous clinical severity score: venous outcomes consensus statement: special communication of the American Venous Forum Ad Hoc Outcomes Working Group","volume":"52","author":"Vasquez","year":"2010","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.jaad.2016.02.1161_bib30","first-page":"36","article-title":"Image processing with ImageJ","volume":"11","author":"Abr\u00e0moff","year":"2004","journal-title":"Biophotonics"},{"key":"10.1016\/j.jaad.2016.02.1161_bib31","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1755-148X.2011.00855.x","article-title":"Melanocyte stem cells: a melanocyte reservoir in hair follicles for hair and skin pigmentation","volume":"24","author":"Nishimura","year":"2011","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jaad.2016.02.1161_bib32","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/bies.201300166","article-title":"Human epithelial hair follicle stem cells and their progeny: current state of knowledge, the widening gap in translational research and future challenges","volume":"36","author":"Purba","year":"2014","journal-title":"Bioessays"},{"key":"10.1016\/j.jaad.2016.02.1161_bib33","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/S0140-6736(01)06532-1","article-title":"Hair follicle dermal sheath cells: unsung participants in wound healing","volume":"358","author":"Jahoda","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.jaad.2016.02.1161_bib34","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1034\/j.1600-0625.2003.00106.x","article-title":"Plasticity of hair follicle dermal cells in wound healing and induction","volume":"12","author":"Gharzi","year":"2003","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jaad.2016.02.1161_bib35","first-page":"515","article-title":"Immunophenotypical analyses of myofibroblasts in rat excisional wound healing: Possible transdifferentiation of blood vessel pericytes and perifollicular dermal sheath cells into myofibroblasts","volume":"27","author":"Juniantito","year":"2012","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.jaad.2016.02.1161_bib36","first-page":"831","article-title":"CD34+ stromal cells\/fibroblasts\/fibrocytes\/telocytes as a tissue reserve and a principal source of mesenchymal cells. Location, morphology, function and role in pathology","volume":"29","author":"D\u00edaz-Flores","year":"2014","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.jaad.2016.02.1161_bib37","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/jid.1957.87","article-title":"The growing hair roots of the human scalp and morphologic changes therein following amethopterin therapy","volume":"29","author":"Van Scott","year":"1957","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2016.02.1161_bib38","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1111\/j.1524-4725.2009.01308.x","article-title":"Split-skin grafting from the scalp: the hidden advantage","volume":"35","author":"Weyandt","year":"2009","journal-title":"Dermatol Surg"},{"key":"10.1016\/j.jaad.2016.02.1161_bib39","first-page":"135","article-title":"Clinical and experimental studies of transplantation of living hairs","volume":"46","author":"Okuda","year":"1939","journal-title":"Jpn J Dermatol Urol"},{"key":"10.1016\/j.jaad.2016.02.1161_bib40","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1177\/1090820X12468314","article-title":"Hair restoration surgery: the state of the art","volume":"33","author":"Vogel","year":"2013","journal-title":"Aesthet Surg J"},{"key":"10.1016\/j.jaad.2016.02.1161_bib41","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1111\/j.1524-4725.2009.01175.x","article-title":"Recipient-site influence in hair transplantation: a confirmative study","volume":"35","author":"Hwang","year":"2009","journal-title":"Dermatologic Surg"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962216013979?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962216013979?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T22:41:00Z","timestamp":1759272060000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962216013979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S0190962216013979"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2016.02.1161","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hair follicle\u2013containing punch grafts accelerate chronic ulcer healing: A randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2016.02.1161","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 by the American Academy of Dermatology, Inc.","name":"copyright","label":"Copyright"}]}}