{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T12:41:54Z","timestamp":1785156114142,"version":"3.55.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jaad.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.jaad.2017.05.050","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T17:46:48Z","timestamp":1502732808000},"page":"893-901","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Cancer risks and survival in patients with multiple primary melanomas: Association with family history of melanoma and germline CDKN2A mutation status"],"prefix":"10.1016","volume":"77","author":[{"given":"Hildur","family":"Helgadottir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Tuominen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan","family":"Olsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"H\u00f6iom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaad.2017.05.050_bib1","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1016\/j.jid.2016.03.014","article-title":"Ten-year survival after multiple invasive melanomas is worse than after a single melanoma: a population-based study","volume":"136","author":"Youlden","year":"2016","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2017.05.050_bib2","first-page":"3145986","article-title":"Eleven primary melanomas, colon cancer, and atypical nevi in the same patient: a case report and literature review","volume":"2016","author":"Juul Nielsen","year":"2016","journal-title":"Case Rep Dermatol Med"},{"key":"10.1016\/j.jaad.2017.05.050_bib3","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1001\/jamadermatol.2014.4777","article-title":"Risk of next melanoma in patients with familial and sporadic melanoma by number of previous melanomas","volume":"151","author":"Chen","year":"2015","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jaad.2017.05.050_bib4","first-page":"6864","article-title":"CDKN2A germ-line mutations in individuals with multiple cutaneous melanomas","volume":"60","author":"Hashemi","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.jaad.2017.05.050_bib5","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1056\/NEJM199803263381305","article-title":"CDKN2A mutations in multiple primary melanomas","volume":"338","author":"Monzon","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaad.2017.05.050_bib6","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1158\/1055-9965.EPI-06-0270","article-title":"The prevalence of CDKN2A germ-line mutations and relative risk for cutaneous malignant melanoma: an international population-based study","volume":"15","author":"Berwick","year":"2006","journal-title":"Canc Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.jaad.2017.05.050_bib7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1136\/jmg.2006.043802","article-title":"Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma-prone families from three continents","volume":"44","author":"Goldstein","year":"2007","journal-title":"J Med Genet"},{"key":"10.1016\/j.jaad.2017.05.050_bib8","doi-asserted-by":"crossref","first-page":"677.e1","DOI":"10.1016\/j.jaad.2009.03.016","article-title":"Selection criteria for genetic assessment of patients with familial melanoma","volume":"61","author":"Leachman","year":"2009","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2017.05.050_bib9","doi-asserted-by":"crossref","first-page":"dju408","DOI":"10.1093\/jnci\/dju408","article-title":"Nonsense\u00a0mutations in the shelterin complex genes ACD and TERF2IP in familial melanoma","volume":"107","author":"Aoude","year":"2015","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jaad.2017.05.050_bib10","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1230062","article-title":"TERT promoter mutations\u00a0in familial and sporadic melanoma","volume":"339","author":"Horn","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jaad.2017.05.050_bib11","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/ng.2947","article-title":"POT1 loss-of-function variants predispose to familial melanoma","volume":"46","author":"Robles-Espinoza","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaad.2017.05.050_bib12","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/ng.2941","article-title":"Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma","volume":"46","author":"Shi","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaad.2017.05.050_bib13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/ng0196-97","article-title":"Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma","volume":"12","author":"Zuo","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaad.2017.05.050_bib14","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1200\/JCO.2007.11.4108","article-title":"Monitoring of kindreds with hereditary predisposition for cutaneous melanoma and dysplastic nevus syndrome: results of a\u00a0Swedish preventive program","volume":"25","author":"Hansson","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jaad.2017.05.050_bib15","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1136\/jmedgenet-2014-102320","article-title":"High risk of tobacco-related cancers in CDKN2A mutation-positive melanoma families","volume":"51","author":"Helgadottir","year":"2014","journal-title":"J Med Genet"},{"key":"10.1016\/j.jaad.2017.05.050_bib16","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1002\/ijc.29595","article-title":"CDKN2a mutation-negative melanoma families have increased risk exclusively for skin cancers but not for other malignancies","volume":"137","author":"Helgadottir","year":"2015","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jaad.2017.05.050_bib17","series-title":"Multi-generation register 2011. A description of contents and quality","author":"Department of Population and Welfare Statistics","year":"2012"},{"key":"10.1016\/j.jaad.2017.05.050_bib18","series-title":"The Swedish Cancer Registry","year":"2015"},{"key":"10.1016\/j.jaad.2017.05.050_bib19","doi-asserted-by":"crossref","first-page":"6199","DOI":"10.1200\/JCO.2009.23.4799","article-title":"Final version of 2009 AJCC melanoma staging and classification","volume":"27","author":"Balch","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jaad.2017.05.050_bib20","series-title":"D\u00f6dsorsaksregistret (Swedish Cause of Death Registry)","author":"Socialstyrelsen (The National Board of Health and Welfare)","year":"2015"},{"key":"10.1016\/j.jaad.2017.05.050_bib21","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1093\/jnci\/92.15.1260","article-title":"High frequency of multiple melanomas and breast and pancreas carcinomas in CDKN2A mutation-positive melanoma families","volume":"92","author":"Borg","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jaad.2017.05.050_bib22","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1093\/jnci\/89.10.697","article-title":"Screening of germline mutations in the CDKN2A and CDKN2B genes in Swedish families with hereditary cutaneous melanoma","volume":"89","author":"Platz","year":"1997","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jaad.2017.05.050_bib23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0304-3835(02)00027-7","article-title":"A melanoma-predisposing germline CDKN2A mutation with functional significance for both p16 and p14ARF","volume":"180","author":"Hashemi","year":"2002","journal-title":"Cancer Lett"},{"key":"10.1016\/j.jaad.2017.05.050_bib24","doi-asserted-by":"crossref","first-page":"djw135","DOI":"10.1093\/jnci\/djw135","article-title":"Germline CDKN2A mutation status and survival in familial melanoma cases","volume":"108","author":"Helgadottir","year":"2016","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jaad.2017.05.050_bib25","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1755-148X.2008.00526.x","article-title":"MC1R variation and melanoma risk in the Swedish population in relation to clinical and pathological parameters","volume":"22","author":"Hoiom","year":"2009","journal-title":"Pigment Cell Melanoma Res"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962217318066?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962217318066?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T10:55:10Z","timestamp":1535453710000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962217318066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S0190962217318066"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2017.05.050","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cancer risks and survival in patients with multiple primary melanomas: Association with family history of melanoma and germline CDKN2A mutation status","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2017.05.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by the American Academy of Dermatology, Inc.","name":"copyright","label":"Copyright"}]}}