{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T15:09:06Z","timestamp":1781449746879,"version":"3.54.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100001582","name":"Dermatology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001582","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","jaad.org","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.jaad.2017.07.031","type":"journal-article","created":{"date-parts":[[2017,9,13]],"date-time":"2017-09-13T23:45:28Z","timestamp":1505346328000},"page":"141-147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["A new evidence-based risk stratification system for cutaneous squamous cell carcinoma into low, intermediate, and high risk groups with implications for management"],"prefix":"10.1016","volume":"78","author":[{"given":"Christian L.","family":"Baum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam C.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Carlos","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Arpey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry D.","family":"Brewer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall K.","family":"Roenigk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clark C.","family":"Otley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jaad.2017.07.031_bib1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1001\/archdermatol.2010.19","article-title":"Incidence estimate of nonmelanoma skin cancer in the United States, 2006","volume":"146","author":"Rogers","year":"2010","journal-title":"Arch Dermatol"},{"issue":"6","key":"10.1016\/j.jaad.2017.07.031_bib2","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.mayocp.2017.02.015","article-title":"Incidence and trends of basal cell carcinoma and cutaneous squamous cell carcinoma: a population-based study in Olmsted County, Minnesota, 2000 to 2010","volume":"92","author":"Muzic","year":"2017","journal-title":"Mayo Clin Proc"},{"issue":"6","key":"10.1016\/j.jaad.2017.07.031_bib3","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.jaad.2012.11.037","article-title":"Cutaneous squamous cell carcinoma: estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012","volume":"68","author":"Karia","year":"2013","journal-title":"J Am Acad Dermatol"},{"issue":"8","key":"10.1016\/j.jaad.2017.07.031_bib4","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S1470-2045(08)70178-5","article-title":"Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study","volume":"9","author":"Brantsch","year":"2008","journal-title":"Lancet Oncol"},{"issue":"9","key":"10.1016\/j.jaad.2017.07.031_bib5","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1097\/01.mlg.0000173202.56739.9f","article-title":"Lymph node metastases from cutaneous squamous cell carcinoma of the head and neck","volume":"115","author":"Moore","year":"2005","journal-title":"Laryngoscope"},{"issue":"7","key":"10.1016\/j.jaad.2017.07.031_bib6","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/jso.23155","article-title":"The incidence of metastasis from cutaneous squamous cell carcinoma and the impact of its risk factors","volume":"106","author":"Brougham","year":"2012","journal-title":"J Surg Oncol"},{"issue":"2","key":"10.1016\/j.jaad.2017.07.031_bib7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.amepre.2014.08.036","article-title":"Prevalence and costs of skin cancer treatment in the U.S., 2002-2006 and 2007-2011","volume":"48","author":"Guy","year":"2015","journal-title":"Am J Prev Med"},{"issue":"4","key":"10.1016\/j.jaad.2017.07.031_bib8","first-page":"410","article-title":"High-risk cutaneous squamous cell carcinoma without palpable lymphadenopathy: is there a therapeutic role for elective neck dissection?","volume":"33","author":"Martinez","year":"2007","journal-title":"Dermatol Surg"},{"issue":"5","key":"10.1016\/j.jaad.2017.07.031_bib9","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1245\/s10434-015-5070-6","article-title":"Prognostic significance of lymph node ratio in metastatic cutaneous squamous cell carcinoma of the head and neck","volume":"23","author":"Tseros","year":"2016","journal-title":"Ann Surg Oncol"},{"issue":"11","key":"10.1016\/j.jaad.2017.07.031_bib10","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1002\/cncr.30601","article-title":"A multi-institutional comparison of outcomes of immunosuppressed and immunocompetent patients treated with surgery and radiation therapy for cutaneous squamous cell carcinoma of the head and neck","volume":"123","author":"Manyam","year":"2017","journal-title":"Cancer"},{"issue":"10","key":"10.1016\/j.jaad.2017.07.031_bib11","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1111\/j.1524-4725.2010.01576.x","article-title":"Mohs surgery is effective for high-risk cutaneous squamous cell carcinoma","volume":"36","author":"Pugliano-Mauro","year":"2010","journal-title":"Dermatol Surg"},{"issue":"4","key":"10.1016\/j.jaad.2017.07.031_bib12","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jaad.2013.05.011","article-title":"An evolving paradigm for the workup and management of high-risk cutaneous squamous cell carcinoma","volume":"69","author":"O'Bryan","year":"2013","journal-title":"J Am Acad Dermatol"},{"issue":"11","key":"10.1016\/j.jaad.2017.07.031_bib13","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1111\/cup.12766","article-title":"Prognostic variables in high-risk cutaneous squamous cell carcinoma: a review","volume":"43","author":"Cheng","year":"2016","journal-title":"J Cutan Pathol"},{"issue":"suppl 1","key":"10.1016\/j.jaad.2017.07.031_bib14","first-page":"E884","article-title":"Prospective study of sentinel node biopsy for high-risk cutaneous squamous cell carcinoma of the head and neck","volume":"38","author":"Gore","year":"2016","journal-title":"Head Neck"},{"issue":"12","key":"10.1016\/j.jaad.2017.07.031_bib15","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1001\/jamaoto.2016.1927","article-title":"Sentinel lymph node biopsy for cutaneous squamous cell carcinoma on the head and neck","volume":"142","author":"Durham","year":"2016","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"4","key":"10.1016\/j.jaad.2017.07.031_bib16","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1200\/JCO.2012.48.5326","article-title":"Evaluation of American Joint Committee on Cancer, International Union Against Cancer, and Brigham and Women's Hospital tumor staging for cutaneous squamous cell carcinoma","volume":"32","author":"Karia","year":"2014","journal-title":"J Clin Oncol"},{"issue":"7","key":"10.1016\/j.jaad.2017.07.031_bib17","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1056\/NEJMoa1310460","article-title":"Final trial report of sentinel-node biopsy versus nodal observation in melanoma","volume":"370","author":"Morton","year":"2014","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.jaad.2017.07.031_bib18","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1001\/jamadermatol.2015.4994","article-title":"Risk factors for cutaneous squamous cell carcinoma recurrence, metastasis, and disease-specific death: a systematic review and meta-analysis","volume":"152","author":"Thompson","year":"2016","journal-title":"JAMA Dermatol"},{"issue":"11","key":"10.1016\/j.jaad.2017.07.031_bib19","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"key":"10.1016\/j.jaad.2017.07.031_bib20","series-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011)","author":"Higgins","year":"2011"},{"key":"10.1016\/j.jaad.2017.07.031_bib21","series-title":"AJCC Cancer Staging Manual","year":"2010"},{"key":"10.1016\/j.jaad.2017.07.031_bib22","series-title":"TNM Classification of Malignant Tumours","year":"2017"},{"issue":"2","key":"10.1016\/j.jaad.2017.07.031_bib23","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jaad.2014.10.028","article-title":"Increased incidence and recurrence rates of nonmelanoma skin cancer in patients with non-Hodgkin lymphoma: a Rochester Epidemiology Project population-based study in Minnesota","volume":"72","author":"Brewer","year":"2015","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"10.1016\/j.jaad.2017.07.031_bib24","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1182\/blood.V46.2.219.219","article-title":"Clinical staging of chronic lymphocytic leukemia","volume":"46","author":"Rai","year":"1975","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.jaad.2017.07.031_bib25","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1001\/jamadermatol.2013.6249","article-title":"Association of advanced leukemic stage and skin cancer tumor stage with poor skin cancer outcomes in patients with chronic lymphocytic leukemia","volume":"150","author":"Velez","year":"2014","journal-title":"JAMA Dermatol"},{"issue":"1","key":"10.1016\/j.jaad.2017.07.031_bib26","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1001\/jamadermatol.2013.6675","article-title":"Staging for cutaneous squamous cell carcinoma as a predictor of sentinel lymph node biopsy results: meta-analysis of American Joint Committee on Cancer criteria and a proposed alternative system","volume":"150","author":"Schmitt","year":"2014","journal-title":"JAMA Dermatol"},{"issue":"3","key":"10.1016\/j.jaad.2017.07.031_bib27","doi-asserted-by":"crossref","first-page":"e90360","DOI":"10.1371\/journal.pone.0090360","article-title":"Staging of cervical lymph nodes in oral squamous cell carcinoma: adding ultrasound in clinically lymph node negative patients may improve diagnostic work-up","volume":"9","author":"Norling","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jaad.2017.07.031_bib28","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1148\/radiology.180.2.2068312","article-title":"Occult metastatic neck disease: detection with US and US-guided fine-needle aspiration cytology","volume":"180","author":"van den Brekel","year":"1991","journal-title":"Radiology"},{"issue":"5-6","key":"10.1016\/j.jaad.2017.07.031_bib29","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1159\/000323494","article-title":"Contrast-enhanced ultrasound: a filter role in AJCC stage I\/II melanoma patients","volume":"79","author":"De Giorgi","year":"2010","journal-title":"Oncology"},{"issue":"1","key":"10.1016\/j.jaad.2017.07.031_bib30","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1067\/j.cpradiol.2009.04.001","article-title":"Cutaneous melanoma: role of ultrasound in the assessment of locoregional spread","volume":"39","author":"Catalano","year":"2010","journal-title":"Curr Probl Diagn Radiol"},{"issue":"2","key":"10.1016\/j.jaad.2017.07.031_bib31","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jaad.2016.08.051","article-title":"The positive impact of radiologic imaging on high-stage cutaneous squamous cell carcinoma management","volume":"76","author":"Ruiz","year":"2017","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"10.1016\/j.jaad.2017.07.031_bib32","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.amjoto.2013.08.014","article-title":"Utility of positron emission tomography\/computed tomography for nodal staging of cutaneous squamous cell carcinoma in patients with chronic lymphocytic leukemia","volume":"35","author":"Tomaszewski","year":"2014","journal-title":"Am J Otolaryngol"},{"issue":"11","key":"10.1016\/j.jaad.2017.07.031_bib33","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1002\/hed.21965","article-title":"Predictors of outcome in patients with metastatic cutaneous head and neck squamous cell carcinoma involving cervical lymph nodes: improved survival with the addition of adjuvant radiotherapy","volume":"34","author":"Wang","year":"2012","journal-title":"Head Neck"},{"issue":"10","key":"10.1016\/j.jaad.2017.07.031_bib34","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1002\/lary.20608","article-title":"Radiotherapy for cutaneous squamous and basal cell carcinomas of the head and neck","volume":"119","author":"Mendenhall","year":"2009","journal-title":"Laryngoscope"},{"issue":"6","key":"10.1016\/j.jaad.2017.07.031_bib35","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/cncr.22509","article-title":"What is the role of adjuvant radiotherapy in the treatment of cutaneous squamous cell carcinoma with perineural invasion?","volume":"109","author":"Han","year":"2007","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.jaad.2017.07.031_bib36","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.amjoto.2012.12.017","article-title":"Mohs resection and postoperative radiotherapy for head and neck cancers with incidental perineural invasion","volume":"34","author":"Kropp","year":"2013","journal-title":"Am J Otolaryngol"},{"issue":"1","key":"10.1016\/j.jaad.2017.07.031_bib37","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.radonc.2016.06.011","article-title":"Skin cancer of the head and neck with gross or microscopic perineural involvement: patterns of failure","volume":"120","author":"Sapir","year":"2016","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.jaad.2017.07.031_bib38","unstructured":"Chang T, Schwartz DJ, Hochwalt PC, et\u00a0al. Outcomes of adjuvant radiotherapy following negative surgical margins for cutaneous squamous cell carcinoma. Paper presented at: 48th Meeting of the American College of Mohs Surgery. April 28-May 1, 2016; Orlando, Florida."}],"updated-by":[{"DOI":"10.1016\/j.jaad.2018.04.001","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000}}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962217321606?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962217321606?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T19:57:16Z","timestamp":1723665436000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962217321606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0190962217321606"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2017.07.031","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.jaad.2018.04.001","asserted-by":"object"}]},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A new evidence-based risk stratification system for cutaneous squamous cell carcinoma into low, intermediate, and high risk groups with implications for management","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2017.07.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 by the American Academy of Dermatology, Inc.","name":"copyright","label":"Copyright"}]}}