{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T19:07:54Z","timestamp":1775156874348,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2016R1D1A1B01010316"],"award-info":[{"award-number":["2016R1D1A1B01010316"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.jaad.2018.05.016","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T22:11:12Z","timestamp":1526940672000},"page":"843-852","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Dermatofibrosarcoma protuberans: A retrospective study of clinicopathologic features and related Akt\/mTOR, STAT3, ERK, cyclin D1, and PD-L1 expression"],"prefix":"10.1016","volume":"79","author":[{"given":"Sunyoung","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soyun","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minji","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Ung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eui Cheol","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Euno","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Hwan","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheol","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mee Soo","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jaad.2018.05.016_bib1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3892\/mco.2017.1197","article-title":"Programmed death-ligand 1 expression is associated with fibrosarcomatous transformation of dermatofibrosarcoma protuberans","volume":"6","author":"Tsuchihashi","year":"2017","journal-title":"Mol Clin Oncol"},{"issue":"3","key":"10.1016\/j.jaad.2018.05.016_bib2","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jaad.2014.11.020","article-title":"Prognostic impact of fibrosarcomatous transformation in dermatofibrosarcoma protuberans: a cohort study","volume":"72","author":"Hoesly","year":"2015","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"10.1016\/j.jaad.2018.05.016_bib3","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.jaad.2014.03.018","article-title":"A systemic review of outcome data for dermatofibrosarcoma protuberans with and without fibrosarcomatous change","volume":"71","author":"Liang","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2018.05.016_bib4","doi-asserted-by":"crossref","first-page":"642549","DOI":"10.1155\/2015\/642549","article-title":"Wide local excision for dermatofibrosarcoma protuberans: a single-center series of 90 patients","volume":"2015","author":"Kim","year":"2015","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jaad.2018.05.016_bib5","series-title":"Enzinger and Weiss's Soft Tissue Tumors","first-page":"387","article-title":"Fibrohistiocytic tumors of intermediate malignancy","author":"Goldblum","year":"2013"},{"issue":"6","key":"10.1016\/j.jaad.2018.05.016_bib6","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1529-8019.2008.00242.x","article-title":"Dermatofibrosarcoma protuberans","volume":"21","author":"Dimitropoulos","year":"2008","journal-title":"Dermatol Ther"},{"issue":"3","key":"10.1016\/j.jaad.2018.05.016_bib7","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.bjps.2015.10.027","article-title":"Long-term outcomes of surgical treatment for dermatofibrosarcoma protuberans according to width of gross resection margin","volume":"69","author":"Woo","year":"2016","journal-title":"J Plast Resconstr Aesthet Surg"},{"key":"10.1016\/j.jaad.2018.05.016_bib8","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.jaad.2017.11.030","article-title":"Survival in patients with primary dermatofibrosarcoma protuberans: National Cancer Database analysis","volume":"78","author":"Trofymenko","year":"2018","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"10.1016\/j.jaad.2018.05.016_bib9","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3892\/ol.2015.3966","article-title":"Clinicopathological features of dermatofibrosarcoma protuberans","volume":"11","author":"Larbcharoensub","year":"2016","journal-title":"Oncol Lett"},{"key":"10.1016\/j.jaad.2018.05.016_bib10","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.anndiagpath.2016.09.013","article-title":"Dermatofibrosarcoma protuberans: pathology, genetics, and potential therapeutic strategies","volume":"25","author":"Thway","year":"2016","journal-title":"Ann Diagn Pathol"},{"issue":"8","key":"10.1016\/j.jaad.2018.05.016_bib11","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1097\/00000478-200008000-00010","article-title":"Sarcomas arising in dermatofibrosarcoma protuberans: a reappraisal of biologic behavior in eighteen cases treated by wide local excision with extended clinical follow up","volume":"24","author":"Goldblum","year":"2000","journal-title":"Am J Surg Pathol"},{"issue":"1","key":"10.1016\/j.jaad.2018.05.016_bib12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/ng0197-95","article-title":"Deregulation of the platelet-derived growth factor \u03b2-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma","volume":"15","author":"Simon","year":"1997","journal-title":"Nat Genet"},{"issue":"2","key":"10.1016\/j.jaad.2018.05.016_bib13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0165-4608(90)90142-W","article-title":"Cytogenetic analysis of dermatofibrosarcoma protuberans","volume":"49","author":"Bridge","year":"1990","journal-title":"Cancer Genet Cytogenet"},{"issue":"12","key":"10.1016\/j.jaad.2018.05.016_bib14","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1001\/jamadermatol.2015.2389","article-title":"A novel chromosomal translocation associated with COL1A2- PDGFB gene fusion in dermatofibrosarcoma protuberans: PDGF expression as a new diagnostic tool","volume":"151","author":"Nakamura","year":"2015","journal-title":"JAMA Dermatol"},{"issue":"15","key":"10.1016\/j.jaad.2018.05.016_bib15","first-page":"3719","article-title":"The dermatofibrosarcoma protuberans-associated collagen type Ia1\/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB","volume":"59","author":"Shimizu","year":"1999","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.jaad.2018.05.016_bib16","first-page":"F79","article-title":"Signal transduction via platelet-derived growth factor recepotos","volume":"1378","author":"Helden","year":"1998","journal-title":"Biochem Biophys Acta"},{"issue":"10","key":"10.1016\/j.jaad.2018.05.016_bib17","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1101\/gad.1653708","article-title":"Role of platelet-derived growth factors in physiology and medicine","volume":"22","author":"Andrae","year":"2008","journal-title":"Genes Dev"},{"issue":"10","key":"10.1016\/j.jaad.2018.05.016_bib18","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1245\/s10434-007-9480-y","article-title":"Dermatofibrosarcoma protuberans: recent clinical progress","volume":"14","author":"McArthur","year":"2007","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.jaad.2018.05.016_bib19","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.humpath.2017.07.001","article-title":"Alteration of PDGFR\u03b2-Akt-mTOR pathway signaling in fibrosarcomatous transformation of dermatofibrosarcoma protuberans","volume":"67","author":"Hiraki-Hotokebuchi","year":"2017","journal-title":"Hum Pathol"},{"issue":"3","key":"10.1016\/j.jaad.2018.05.016_bib20","first-page":"262","article-title":"Overexpression of phosphorylated-STAT3 and phosphorylated-ERK protein in dermatofibrosarcoma protuberans","volume":"16","author":"Lin","year":"2006","journal-title":"Eur J Dermatol"},{"issue":"9","key":"10.1016\/j.jaad.2018.05.016_bib21","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1245\/s10434-016-5341-x","article-title":"Targeting cyclin-dependent kinases in synovial sarcoma: palbociclib as a potential treatment for synovial sarcoma patients","volume":"23","author":"Vlenterie","year":"2016","journal-title":"Ann Surg Oncol"},{"issue":"3","key":"10.1016\/j.jaad.2018.05.016_bib22","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/annonc\/mdv615","article-title":"Regulation of PD-L1: a novel role of pro-survival signalling in cancer","volume":"27","author":"Chen","year":"2016","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jaad.2018.05.016_bib23","doi-asserted-by":"crossref","first-page":"e29288","DOI":"10.4161\/onci.29288","article-title":"PD-L1 expression and tumor-infiltrating lymphocytes: revisiting the antitumor immune response potential in breast cancer","volume":"3","author":"Schalper","year":"2014","journal-title":"Oncoimmunology"},{"issue":"9","key":"10.1016\/j.jaad.2018.05.016_bib24","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1158\/2326-6066.CIR-15-0296","article-title":"Myeloma drug resistance induced by binding of myeloma B7-H1 (PD-L1) to PD-1","volume":"4","author":"Ishibashi","year":"2016","journal-title":"Cancer Immunol Res"},{"issue":"6","key":"10.1016\/j.jaad.2018.05.016_bib25","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1007\/s10147-017-1161-7","article-title":"PD-L1 induced by IFN-\u03b3 from tumor-associated macrophages via the JAK\/STAT3 and PI3K\/AKT signaling pathways promoted progression of lung cancer","volume":"22","author":"Zhang","year":"2017","journal-title":"Int J Clin Oncol"},{"issue":"8","key":"10.1016\/j.jaad.2018.05.016_bib26","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1080\/01635581.2017.1362446","article-title":"The protective and immunomodulatory effects of fucoidan against 7,12-dimethyl benz[a]anthracene-induced experimental mammary carcinogenesis through the PD1\/PDL1 signaling pathway in rats","volume":"69","author":"Xue","year":"2017","journal-title":"Nutr Cancer"},{"issue":"4","key":"10.1016\/j.jaad.2018.05.016_bib27","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00403-014-1452-z","article-title":"miR-205 down-regulation promotes proliferation of dermatofibrosarcoma protuberans tumor cells by regulating LRP-1 and ERK phosphorylation","volume":"306","author":"Kajihara","year":"2014","journal-title":"Arch Dermatol Res"},{"issue":"4","key":"10.1016\/j.jaad.2018.05.016_bib28","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1046\/j.1523-1747.2002.00383.x","article-title":"Mitogenic activity of dermatofibrosarcoma protuberans is mediated via an extracellular signal related kinase dependent pathway","volume":"119","author":"Ihn","year":"2002","journal-title":"J Invest Dermatol"},{"issue":"3","key":"10.1016\/j.jaad.2018.05.016_bib29","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.cll.2017.05.007","article-title":"Fibrohistiocytic tumors","volume":"37","author":"Romano","year":"2017","journal-title":"Clin Lab Med"},{"issue":"7","key":"10.1016\/j.jaad.2018.05.016_bib30","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1136\/jcp.2004.019349","article-title":"Transformed dermatofibrosarcoma protuberans: a clinicopathological study of eight cases","volume":"58","author":"Szollosi","year":"2005","journal-title":"J Clin Pathol"},{"issue":"8","key":"10.1016\/j.jaad.2018.05.016_bib31","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1111\/j.1468-3083.2011.04190.x","article-title":"A study on the prognostic value of clinical and surgical features of dermatofibrosarcoma protuberans in Korean patients","volume":"26","author":"Kim","year":"2012","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"3","key":"10.1016\/j.jaad.2018.05.016_bib32","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s10195-016-0415-x","article-title":"Risk factors for distant metastasis of dermatofibrosarcoma protuberans","volume":"17","author":"Hayakawa","year":"2016","journal-title":"J Orthop Traumatol"},{"issue":"10","key":"10.1016\/j.jaad.2018.05.016_bib33","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1097\/00000478-199210000-00001","article-title":"Dermatofibrosarcoma protuberans. A clinicopathologic review with emphasis on fibrosarcomatous areas","volume":"16","author":"Connelly","year":"1992","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"10.1016\/j.jaad.2018.05.016_bib34","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1097\/00000478-199805000-00009","article-title":"Fibrosarcomatous (\u201chigh-grade\u201d) dermatofibrosarcoma protuberans: clinicopathologic and immunohistochemical study of a series of 41 cases with emphasis on prognostic significance","volume":"22","author":"Mentzel","year":"1998","journal-title":"Am J Surg Pathol"},{"issue":"12","key":"10.1016\/j.jaad.2018.05.016_bib35","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1002\/1097-0142(20000615)88:12<2711::AID-CNCR9>3.0.CO;2-M","article-title":"Dermatofibrosarcoma protuberans: a clinicopathologic analysis of patients treated and followed at a single institution","volume":"88","author":"Bowne","year":"2000","journal-title":"Cancer"},{"issue":"4","key":"10.1016\/j.jaad.2018.05.016_bib36","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/00000478-200604000-00002","article-title":"The prognostic significance of fibrosarcomatous transformation in dermatofibrosarcoma protuberans","volume":"30","author":"Abbott","year":"2006","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"10.1016\/j.jaad.2018.05.016_bib37","doi-asserted-by":"crossref","first-page":"e0185826","DOI":"10.1371\/journal.pone.0185826","article-title":"Unforeseen clonal evolution of tumor cell population in recurrent and metastatic dermatofibrosarcoma protuberans","volume":"12","author":"Oh","year":"2017","journal-title":"PLoS One"},{"issue":"4260","key":"10.1016\/j.jaad.2018.05.016_bib38","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1126\/science.959840","article-title":"The clonal evolution of tumor cell populations","volume":"194","author":"Nowell","year":"1976","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.jaad.2018.05.016_bib39","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1002\/ijc.25826","article-title":"Dermatofibrosarcoma protuberans-derived fibrosarcoma: clinical history, biological profile and sensitivity to imatinib","volume":"129","author":"Stacchiotti","year":"2011","journal-title":"Int J Cancer"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962218308107?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962218308107?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T22:47:15Z","timestamp":1759272435000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962218308107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S0190962218308107"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2018.05.016","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dermatofibrosarcoma protuberans: A retrospective study of clinicopathologic features and related Akt\/mTOR, STAT3, ERK, cyclin D1, and PD-L1 expression","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2018.05.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 by the American Academy of Dermatology, Inc.","name":"copyright","label":"Copyright"}]}}