{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:08:53Z","timestamp":1788174533880,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.jaad.2020.06.1024","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T22:05:35Z","timestamp":1594850735000},"page":"1581-1589","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Delineation of clinical and biological factors associated with cutaneous squamous cell carcinoma among patients with chronic lymphocytic leukemia"],"prefix":"10.1016","volume":"83","author":[{"given":"Geffen","family":"Kleinstern","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Rishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara J.","family":"Achenbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari G.","family":"Rabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil E.","family":"Kay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tait D.","family":"Shanafelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe F.","family":"Leis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron D.","family":"Norman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy G.","family":"Call","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Cerhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer A.","family":"Parikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian L.","family":"Baum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Slager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jaad.2020.06.1024_bib1","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1182\/blood-2007-06-093906","article-title":"Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines","volume":"111","author":"Hallek","year":"2008","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.jaad.2020.06.1024_bib2","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1056\/NEJMra041720","article-title":"Chronic lymphocytic leukemia","volume":"352","author":"Chiorazzi","year":"2005","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.jaad.2020.06.1024_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5826\/dpc.0702a01","article-title":"Epidemiological trends in skin cancer","volume":"7","author":"Apalla","year":"2017","journal-title":"Dermatol Pract Concept"},{"key":"10.1016\/j.jaad.2020.06.1024_bib4","first-page":"120","article-title":"Epidemiology of skin cancer","volume":"810","author":"Leiter","year":"2014","journal-title":"Adv Exp Med Biol"},{"issue":"6","key":"10.1016\/j.jaad.2020.06.1024_bib5","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1111\/j.1365-2133.2003.05554.x","article-title":"Epidemiology of cutaneous melanoma and non-melanoma skin cancer in Schleswig-Holstein, Germany: incidence, clinical subtypes, tumour stages and localization (epidemiology of skin cancer)","volume":"149","author":"Katalinic","year":"2003","journal-title":"Br J Dermatol"},{"issue":"12","key":"10.1016\/j.jaad.2020.06.1024_bib6","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1001\/archdermatol.2009.276","article-title":"Incidence of and risk factors for skin cancer after heart transplant","volume":"145","author":"Brewer","year":"2009","journal-title":"Arch Dermatol"},{"issue":"4","key":"10.1016\/j.jaad.2020.06.1024_bib7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/00062752-200007000-00005","article-title":"Chronic lymphocytic leukemia","volume":"7","author":"Kipps","year":"2000","journal-title":"Curr Opin Hematol"},{"issue":"7","key":"10.1016\/j.jaad.2020.06.1024_bib8","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1002\/ijc.24931","article-title":"Skin cancers associated with HIV infection and solid-organ transplantation among elderly adults","volume":"126","author":"Lanoy","year":"2010","journal-title":"Int J Cancer"},{"issue":"10","key":"10.1016\/j.jaad.2020.06.1024_bib9","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1002\/ijc.31801","article-title":"Second primary cancers in non-Hodgkin lymphoma: bidirectional analyses suggesting role for immune dysfunction","volume":"143","author":"Chattopadhyay","year":"2018","journal-title":"Int J Cancer"},{"issue":"2","key":"10.1016\/j.jaad.2020.06.1024_bib10","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jaad.2014.10.028","article-title":"Increased incidence and recurrence rates of nonmelanoma skin cancer in patients with non-Hodgkin lymphoma: a Rochester Epidemiology Project population-based study in Minnesota","volume":"72","author":"Brewer","year":"2015","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"10.1016\/j.jaad.2020.06.1024_bib11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1001\/jama.1975.03250030023012","article-title":"Subsequent neoplasia in chronic lymphocytic leukemia","volume":"232","author":"Manusow","year":"1975","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.jaad.2020.06.1024_bib12","first-page":"16","article-title":"Merkel cell tumor and chronic lymphocytic leukemia\u2014coincidence or a possible association?","volume":"11","author":"Ben-David","year":"2005","journal-title":"Dermatol Online J"},{"issue":"11","key":"10.1016\/j.jaad.2020.06.1024_bib13","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1038\/bjc.1996.642","article-title":"Non-Hodgkin's lymphomas, chronic lymphocytic leukaemias and skin cancers","volume":"74","author":"Levi","year":"1996","journal-title":"Br J Cancer"},{"issue":"2","key":"10.1016\/j.jaad.2020.06.1024_bib14","first-page":"337","article-title":"Subsequent cancer in patients with chronic lymphocytic leukemia\u2014a possible immunologic mechanism","volume":"61","author":"Greene","year":"1978","journal-title":"J Natl Cancer Inst"},{"issue":"6","key":"10.1016\/j.jaad.2020.06.1024_bib15","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1093\/annonc\/mdw072","article-title":"Incidence and prognostic impact of other cancers in a population of long-term survivors of chronic lymphocytic leukemia","volume":"27","author":"Falchi","year":"2016","journal-title":"Ann Oncol"},{"issue":"7","key":"10.1016\/j.jaad.2020.06.1024_bib16","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1080\/10428190500096989","article-title":"Accelerated growth of skin carcinoma following fludarabine therapy for chronic lymphocytic leukemia","volume":"46","author":"Rashid","year":"2005","journal-title":"Leuk Lymphoma"},{"issue":"11","key":"10.1016\/j.jaad.2020.06.1024_bib17","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/ng.234","article-title":"Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits","volume":"40","author":"Stacey","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaad.2020.06.1024_bib18","doi-asserted-by":"crossref","first-page":"12510","DOI":"10.1038\/ncomms12510","article-title":"Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma","volume":"7","author":"Chahal","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaad.2020.06.1024_bib19","doi-asserted-by":"crossref","first-page":"12048","DOI":"10.1038\/ncomms12048","article-title":"Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma","volume":"7","author":"Chahal","year":"2016","journal-title":"Nat Commun"},{"issue":"Suppl 1","key":"10.1016\/j.jaad.2020.06.1024_bib20","article-title":"Common genetic polymorphisms contribute to the association between non-melanoma skin cancer and chronic lymphocytic leukemia","volume":"130","author":"Besson","year":"2017","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.jaad.2020.06.1024_bib21","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S1470-2045(08)70178-5","article-title":"Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study","volume":"9","author":"Brantsch","year":"2008","journal-title":"Lancet Oncol"},{"issue":"9","key":"10.1016\/j.jaad.2020.06.1024_bib22","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1097\/01.mlg.0000173202.56739.9f","article-title":"Lymph node metastases from cutaneous squamous cell carcinoma of the head and neck","volume":"115","author":"Moore","year":"2005","journal-title":"Laryngoscope"},{"issue":"7","key":"10.1016\/j.jaad.2020.06.1024_bib23","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/jso.23155","article-title":"The incidence of metastasis from cutaneous squamous cell carcinoma and the impact of its risk factors","volume":"106","author":"Brougham","year":"2012","journal-title":"J Surg Oncol"},{"issue":"6","key":"10.1016\/j.jaad.2020.06.1024_bib24","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.jaad.2012.11.037","article-title":"Cutaneous squamous cell carcinoma: estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012","volume":"68","author":"Karia","year":"2013","journal-title":"J Am Acad Dermatol"},{"issue":"9","key":"10.1016\/j.jaad.2020.06.1024_bib25","first-page":"571","article-title":"Skin cancer in patients with chronic lymphocytic leukemia and non-Hodgkin lymphoma","volume":"10","author":"Onajin","year":"2012","journal-title":"Clin Adv Hematol Oncol"},{"issue":"8","key":"10.1016\/j.jaad.2020.06.1024_bib26","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1200\/JCO.2011.34.9605","article-title":"Chronic lymphocytic leukemia is associated with decreased survival of patients with malignant melanoma and Merkel cell carcinoma in a SEER population-based study","volume":"30","author":"Brewer","year":"2012","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1016\/j.jaad.2020.06.1024_bib27","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/bjh.15777","article-title":"Second primary cancers in patients with acute lymphoblastic, chronic lymphocytic and hairy cell leukaemia","volume":"185","author":"Zheng","year":"2019","journal-title":"Br J Haematol"},{"issue":"6","key":"10.1016\/j.jaad.2020.06.1024_bib28","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S1470-2045(16)30029-8","article-title":"An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI): a meta-analysis of individual patient data","volume":"17","year":"2016","journal-title":"Lancet Oncol"},{"issue":"23","key":"10.1016\/j.jaad.2020.06.1024_bib29","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1182\/blood-2017-11-814608","article-title":"Association of polygenic risk score with the risk of chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis","volume":"131","author":"Kleinstern","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.jaad.2020.06.1024_bib30","doi-asserted-by":"crossref","first-page":"14175","DOI":"10.1038\/ncomms14175","article-title":"Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia","volume":"8","author":"Law","year":"2017","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jaad.2020.06.1024_bib31","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/EDE.0b013e3181c30fb2","article-title":"Assessing the performance of prediction models: a framework for traditional and novel measures","volume":"21","author":"Steyerberg","year":"2010","journal-title":"Epidemiology"},{"issue":"1","key":"10.1016\/j.jaad.2020.06.1024_bib32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1148\/radiology.143.1.7063747","article-title":"The meaning and use of the area under a receiver operating characteristic (ROC) curve","volume":"143","author":"Hanley","year":"1982","journal-title":"Radiology"},{"key":"10.1016\/j.jaad.2020.06.1024_bib33","series-title":"Applied Logistic Regression","author":"Hosmer","year":"2000"},{"issue":"12","key":"10.1016\/j.jaad.2020.06.1024_bib34","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1001\/archderm.136.12.1524","article-title":"Risk of developing a subsequent nonmelanoma skin cancer in patients with a history of nonmelanoma skin cancer","volume":"136","author":"Marcil","year":"2000","journal-title":"Arch Dermatol"},{"issue":"13","key":"10.1016\/j.jaad.2020.06.1024_bib35","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1080\/10428194.2019.1620941","article-title":"Risk factors for skin cancer and solid tumors in newly diagnosed patients with chronic lymphocytic leukemia and the impact of skin surveillance on survival","volume":"60","author":"Ishdorj","year":"2019","journal-title":"Leuk Lymphoma"},{"issue":"1","key":"10.1016\/j.jaad.2020.06.1024_bib36","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13073-020-00742-5","article-title":"Polygenic risk scores: from research tools to clinical instruments","volume":"12","author":"Lewis","year":"2020","journal-title":"Genome Med"},{"issue":"1","key":"10.1016\/j.jaad.2020.06.1024_bib37","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1038\/s41467-019-11112-0","article-title":"Analysis of polygenic risk score usage and performance in diverse human populations","volume":"10","author":"Duncan","year":"2019","journal-title":"Nat Commun"},{"issue":"7","key":"10.1016\/j.jaad.2020.06.1024_bib38","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.jid.2018.01.031","article-title":"Quantifying the polygenic contribution to cutaneous squamous cell carcinoma risk","volume":"138","author":"Sordillo","year":"2018","journal-title":"J Investig Dermatol"},{"issue":"3","key":"10.1016\/j.jaad.2020.06.1024_bib39","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/ajt.15057","article-title":"Polygenic risk score as a determinant of risk of non-melanoma skin cancer in a European-descent renal transplant cohort","volume":"19","author":"Stapleton","year":"2019","journal-title":"Am J Transplant"},{"issue":"3","key":"10.1016\/j.jaad.2020.06.1024_bib40","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/ijd.12208","article-title":"Lymphoma-associated skin cancer: incidence, natural history, and clinical management","volume":"53","author":"Brewer","year":"2014","journal-title":"Int J Dermatol"},{"issue":"6","key":"10.1016\/j.jaad.2020.06.1024_bib41","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1200\/JCO.2008.17.5398","article-title":"Other malignancies in chronic lymphocytic leukemia\/small lymphocytic lymphoma","volume":"27","author":"Tsimberidou","year":"2009","journal-title":"J Clin Oncol"},{"issue":"18","key":"10.1016\/j.jaad.2020.06.1024_bib42","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1093\/jnci\/84.18.1422","article-title":"Second cancers in patients with chronic lymphocytic leukemia","volume":"84","author":"Travis","year":"1992","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"10.1016\/j.jaad.2020.06.1024_bib43","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/10428190400007524","article-title":"Second neoplasms in chronic lymphocytic leukemia: incidence and pathogenesis with emphasis on the role of different therapies","volume":"46","author":"Molica","year":"2005","journal-title":"Leuk Lymphoma"},{"issue":"33","key":"10.1016\/j.jaad.2020.06.1024_bib44","doi-asserted-by":"crossref","first-page":"4935","DOI":"10.1200\/JCO.2010.29.1112","article-title":"Second malignancy risks after non-Hodgkin's lymphoma and chronic lymphocytic leukemia: differences by lymphoma subtype","volume":"28","author":"Morton","year":"2010","journal-title":"J Clin Oncol"},{"issue":"11","key":"10.1016\/j.jaad.2020.06.1024_bib45","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.3109\/10428194.2012.698276","article-title":"Chronic lymphocytic leukemia in African Americans","volume":"53","author":"Coombs","year":"2012","journal-title":"Leuk Lymphoma"},{"issue":"6","key":"10.1016\/j.jaad.2020.06.1024_bib46","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.clml.2011.07.002","article-title":"Racial differences in the presentation and outcomes of chronic lymphocytic leukemia and variants in the United States","volume":"11","author":"Shenoy","year":"2011","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"17","key":"10.1016\/j.jaad.2020.06.1024_bib47","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1002\/cncr.28030","article-title":"Clinical characteristics, response to therapy, and survival of African American patients diagnosed with chronic lymphocytic leukemia: joint experience of the MD Anderson Cancer Center and Duke University Medical Center","volume":"119","author":"Falchi","year":"2013","journal-title":"Cancer"},{"issue":"6","key":"10.1016\/j.jaad.2020.06.1024_bib48","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.jaad.2005.08.055","article-title":"Increased metastasis and mortality from cutaneous squamous cell carcinoma in patients with chronic lymphocytic leukemia","volume":"53","author":"Mehrany","year":"2005","journal-title":"J Am Acad Dermatol"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962220321964?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962220321964?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T22:54:49Z","timestamp":1759272889000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962220321964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S0190962220321964"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2020.06.1024","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.738351436.793583782","asserted-by":"object"}]},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Delineation of clinical and biological factors associated with cutaneous squamous cell carcinoma among patients with chronic lymphocytic leukemia","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2020.06.1024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 by the American Academy of Dermatology, Inc.","name":"copyright","label":"Copyright"}]}}