{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:29:12Z","timestamp":1773887352846,"version":"3.50.1"},"reference-count":14,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.jaad.2021.03.075","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T12:10:04Z","timestamp":1616847004000},"page":"901-909","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Clinical, biochemical, and serologic predictors of drug reaction with eosinophilia and systemic symptoms syndrome: A prospective case\u2013control study"],"prefix":"10.1016","volume":"85","author":[{"given":"Rajat","family":"Choudhary","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keshavamurthy","family":"Vinay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niharika","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuradha","family":"Bishnoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divya","family":"Kamat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davinder","family":"Parsad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alka","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muthu Sendhil","family":"Kumaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jaad.2021.03.075_bib1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/ACI.0000000000000546","article-title":"Making a diagnosis in severe cutaneous drug hypersensitivity reactions","volume":"19","author":"Ardern-Jones","year":"2019","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.jaad.2021.03.075_bib2","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1365-2133.2006.07704.x","article-title":"Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist?","volume":"156","author":"Kardaun","year":"2007","journal-title":"Br J Dermatol"},{"issue":"1","key":"10.1016\/j.jaad.2021.03.075_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2332\/allergolint.55.1","article-title":"Drug-induced hypersensitivity syndrome (DIHS): a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug immune responses","volume":"55","author":"Shiohara","year":"2006","journal-title":"Allergol Int"},{"issue":"2","key":"10.1016\/j.jaad.2021.03.075_bib4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jdermsci.2016.05.001","article-title":"Preferential expression of CD134, an HHV-6 cellular receptor, on CD4T cells in drug-induced hypersensitivity syndrome (DIHS)\/drug reaction with eosinophilia and systemic symptoms (DRESS)","volume":"83","author":"Miyagawa","year":"2016","journal-title":"J Dermatol Sci"},{"issue":"5","key":"10.1016\/j.jaad.2021.03.075_bib5","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/all.12138","article-title":"Skin recruitment of monomyeloid precursors involves human herpesvirus-6 reactivation in drug allergy","volume":"68","author":"Hashizume","year":"2013","journal-title":"Allergy"},{"issue":"1","key":"10.1016\/j.jaad.2021.03.075_bib6","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1684\/ejd.2010.0821","article-title":"Amoxicillin-induced flare in patients with DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms): report of seven cases and demonstration of a direct effect of amoxicillin on human herpesvirus 6 replication in\u00a0vitro","volume":"20","author":"Mardivirin","year":"2010","journal-title":"Eur J Dermatol"},{"issue":"1","key":"10.1016\/j.jaad.2021.03.075_bib7","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/clpt.2009.252","article-title":"ALDEN, an algorithm for assessment of drug causality in Stevens-Johnson syndrome and toxic epidermal necrolysis: comparison with case-control analysis","volume":"88","author":"Sassolas","year":"2010","journal-title":"Clin Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.jaad.2021.03.075_bib8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.clindermatol.2018.12.004","article-title":"The rash with maculopapules and fever in adults","volume":"37","author":"Muzumdar","year":"2019","journal-title":"Clin Dermatol"},{"issue":"3","key":"10.1016\/j.jaad.2021.03.075_bib9","doi-asserted-by":"crossref","first-page":"266","DOI":"10.4103\/ijdvl.IJDVL_482_17","article-title":"Predictors of disease severity in drug reaction with eosinophilia and systemic symptoms","volume":"85","author":"Sasidharanpillai","year":"2019","journal-title":"Indian J Dermatol Venereol Leprol"},{"issue":"7","key":"10.1016\/j.jaad.2021.03.075_bib10","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.amjmed.2011.01.017","article-title":"The DRESS syndrome: a literature review","volume":"124","author":"Cacoub","year":"2011","journal-title":"Am J Med"},{"issue":"23","key":"10.1016\/j.jaad.2021.03.075_bib11","doi-asserted-by":"crossref","first-page":"15036","DOI":"10.1074\/jbc.272.23.15036","article-title":"The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4","volume":"272","author":"Imai","year":"1997","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.jaad.2021.03.075_bib12","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/bjd.12948","article-title":"Elevated serum thymus and activation-regulated chemokine (TARC\/CCL17) relates to reactivation of human herpesvirus 6 in drug reaction with eosinophilia and systemic symptoms (DRESS)\/drug-induced hypersensitivity syndrome (DIHS)","volume":"171","author":"Ogawa","year":"2014","journal-title":"Br J Dermatol"},{"issue":"1","key":"10.1016\/j.jaad.2021.03.075_bib13","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.alit.2017.06.001","article-title":"The thymus and activation-regulated chemokine (TARC) level in serum at an early stage of a drug eruption is a prognostic biomarker of severity of systemic inflammation","volume":"67","author":"Komatsu-Fujii","year":"2018","journal-title":"Allergol Int"},{"issue":"1","key":"10.1016\/j.jaad.2021.03.075_bib14","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jdermsci.2012.10.002","volume":"69","author":"Ogawa","year":"2013","journal-title":"J Dermatol Sci"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962221006344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962221006344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T22:59:09Z","timestamp":1759273149000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962221006344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S0190962221006344"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2021.03.075","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical, biochemical, and serologic predictors of drug reaction with eosinophilia and systemic symptoms syndrome: A prospective case\u2013control study","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2021.03.075","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the American Academy of Dermatology, Inc.","name":"copyright","label":"Copyright"}]}}