{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:25:43Z","timestamp":1786991143241,"version":"build-2736575974"},"reference-count":54,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.jaad.2021.06.902","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T11:02:58Z","timestamp":1651316578000},"page":"197-208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Part I: Cutaneous manifestations of cardiovascular disease"],"prefix":"10.1016","volume":"89","author":[{"given":"Jamie","family":"Karch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aishwarya","family":"Raja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henriette","family":"De La Garza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"De Jesus Diaz Zepeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra B.C.","family":"Maymone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania J.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Secemsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelam","family":"Vashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaad.2021.06.902_bib1","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1177\/1925362118821493","article-title":"Accidental finding of atherosclerosis with 90% stenosis of the coronary artery in a 17-year-old white male","volume":"8","author":"Bao","year":"2018","journal-title":"Acad Forensic Pathol"},{"key":"10.1016\/j.jaad.2021.06.902_bib2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0140-6736(98)10279-9","article-title":"Lifetime risk of developing coronary heart disease","volume":"353","author":"Lloyd-Jones","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jaad.2021.06.902_bib3","first-page":"102","article-title":"Edema: diagnosis and management","volume":"88","author":"Trayes","year":"2013","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.jaad.2021.06.902_bib4","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.amjmed.2012.11.004","article-title":"Cyanosis","volume":"126","author":"McMullen","year":"2013","journal-title":"Am J Med"},{"key":"10.1016\/j.jaad.2021.06.902_bib5","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.amjmed.2007.06.029","article-title":"Clubbing of the digits","volume":"120","author":"Marrie","year":"2007","journal-title":"Am J Med"},{"key":"10.1016\/j.jaad.2021.06.902_bib6","doi-asserted-by":"crossref","first-page":"1324.e1","DOI":"10.1016\/j.amjmed.2017.03.059","article-title":"Diagonal earlobe crease (Frank's sign): a predictor of cerebral vascular events","volume":"130","author":"Nazzal","year":"2017","journal-title":"Am J Med"},{"key":"10.1016\/j.jaad.2021.06.902_bib7","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.4317\/medoral.17390","article-title":"Diagonal ear lobe crease and atherosclerosis: a review of the medical literature and dental implications","volume":"17","author":"Friedlander","year":"2012","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"10.1016\/j.jaad.2021.06.902_bib8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.17161\/kjm.v12i2.11709","article-title":"Quincke's pulse","volume":"12","author":"Vindhyal","year":"2019","journal-title":"Kans J Med"},{"key":"10.1016\/j.jaad.2021.06.902_bib9","series-title":"Inflammatory Skin Disorders","first-page":"164","article-title":"Cutaneous Deposition and Metabolic Disorders","author":"Plaza","year":"2009"},{"key":"10.1016\/j.jaad.2021.06.902_bib10","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.4103\/0975-7406.155765","article-title":"Significance of corneal arcus","volume":"7","author":"Raj","year":"2015","journal-title":"J Pharm Bioallied Sci"},{"key":"10.1016\/j.jaad.2021.06.902_bib11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.clindermatol.2007.10.014","article-title":"Cutaneous manifestations of cardiovascular diseases","volume":"26","author":"Uliasz","year":"2008","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.jaad.2021.06.902_bib12","series-title":"Fitzpatrick\u2019s Dermatology","article-title":"The skin in infective endocarditis, sepsis, septic shock, and disseminated intravascular coagulation","author":"English","year":"2019"},{"key":"10.1016\/j.jaad.2021.06.902_bib13","series-title":"Fitzpatrick\u2019s Dermatology","article-title":"Rheumatoid arthritis, juvenile idiopathic arthritis, adult-onset Still disease, and rheumatic fever","author":"Piette","year":"2019"},{"key":"10.1016\/j.jaad.2021.06.902_bib14","series-title":"Critical Care of Children with Heart Disease","first-page":"265","article-title":"Mitral valve anomalies and related disorders","author":"Tissot","year":"2020"},{"key":"10.1016\/j.jaad.2021.06.902_bib15","series-title":"Fitzpatrick\u2019s Dermatology","article-title":"Kawasaki disease","author":"Rowley","year":"2019"},{"key":"10.1016\/j.jaad.2021.06.902_bib16","doi-asserted-by":"crossref","first-page":"e927","DOI":"10.1161\/CIR.0000000000000484","article-title":"Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association","volume":"135","author":"McCrindle","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.jaad.2021.06.902_bib17","series-title":"The Requisites in Dermatology, Pediatric Dermatology","first-page":"185","article-title":"The skin in systemic disease","author":"Pride","year":"2008"},{"key":"10.1016\/j.jaad.2021.06.902_bib53","doi-asserted-by":"crossref","first-page":"70","DOI":"10.5021\/ad.2019.31.1.70","article-title":"Two cases of infective endocarditis in patients with atopic dermatitis","volume":"31","author":"Park","year":"2019","journal-title":"Ann Dermatol"},{"key":"10.1016\/j.jaad.2021.06.902_bib18","series-title":"Fitzpatrick\u2019s Dermatology","article-title":"Cutaneous changes in arterial, venous, and lymphatic dysfunction","author":"Newman","year":"2019"},{"key":"10.1016\/j.jaad.2021.06.902_bib19","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2147\/VHRM.S175150","article-title":"Cholesterol-embolization syndrome: current perspectives","volume":"15","author":"Ozkok","year":"2019","journal-title":"Vasc Health Risk Manag"},{"key":"10.1016\/j.jaad.2021.06.902_bib20","series-title":"Cholesterol emboli (atheroembolism, blue or purple toe syndrome)","author":"Shah","year":"2020"},{"key":"10.1016\/j.jaad.2021.06.902_bib21","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0735-1097(03)00579-5","article-title":"Cholesterol Embolism Study(CHEST) Investigators. The incidence and risk factors of cholesterol embolization syndrome, a complication of cardiac catheterization: a prospective study","volume":"42","author":"Fukumoto","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jaad.2021.06.902_bib22","first-page":"376","article-title":"Treatment of cholesterol embolization syndrome in the setting of an acute indication for anticoagulation therapy","volume":"5","author":"Kim","year":"2014","journal-title":"J Med Cases"},{"key":"10.1016\/j.jaad.2021.06.902_bib23","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1161\/CIRCULATIONAHA.106.174516","article-title":"AHA\/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update: endorsed by the National Heart, Lung, and Blood Institute","volume":"113","author":"Smith","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jaad.2021.06.902_bib24","series-title":"Fitzpatrick\u2019s Dermatology","article-title":"Xanthomas and lipoprotein disorders","author":"Sathiyakumar","year":"2019"},{"key":"10.1016\/j.jaad.2021.06.902_bib25","unstructured":"Herink M, Ito MK. Medication Induced Changes in Lipid and Lipoproteins. Endotext. MDText.com, Inc; 2018. Accessed April, 2021. https:\/\/europepmc.org\/article\/NBK\/nbk326739"},{"key":"10.1016\/j.jaad.2021.06.902_bib26","doi-asserted-by":"crossref","first-page":"181","DOI":"10.5507\/bp.2014.016","article-title":"Xanthomas: clinical and pathophysiological relations","volume":"158","author":"Zak","year":"2014","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"10.1016\/j.jaad.2021.06.902_bib27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jacl.2012.05.002","article-title":"Prevalence of lipid abnormalities in the United States: the National Health and Nutrition Examination survey 2003\u20132006","volume":"6","author":"T\u00f3th","year":"2012","journal-title":"J Clin Lipidol"},{"key":"10.1016\/j.jaad.2021.06.902_bib28","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1001\/jamapediatrics.2014.3216","article-title":"Prevalence of and trends in dyslipidemia and blood pressure among US children and adolescents, 1999-2012","volume":"169","author":"Kit","year":"2015","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.jaad.2021.06.902_bib29","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/hc0902.104353","article-title":"Inflammation and atherosclerosis","volume":"105","author":"Libby","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jaad.2021.06.902_bib30","unstructured":"Cutaneous xanthomas. Uptodate. Accessed April 4, 2020. https:\/\/www.uptodate.com\/contents\/cutaneous-xanthomas?search=cutaneous%20xanthomas&source=search_result&selectedTitle=1\u223c150&usage_type=default&display_rank=1"},{"key":"10.1016\/j.jaad.2021.06.902_bib31","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1093\/eurheartj\/eht273","article-title":"Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society","volume":"34","author":"Nordestgaard","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jaad.2021.06.902_bib32","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s11552-009-9206-7","article-title":"Palmar xanthoma\u2014an indicator of a more sinister problem","volume":"5","author":"Sharma","year":"2010","journal-title":"Hand (N Y)"},{"key":"10.1016\/j.jaad.2021.06.902_bib33","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/ijd.14277","article-title":"Palmar crease xanthomas in familial hypercholesterolemia","volume":"58","author":"Daroach","year":"2019","journal-title":"Int J Dermatol"},{"issue":"25","key":"10.1016\/j.jaad.2021.06.902_bib34","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1161\/circ.106.25.3143","volume":"106","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jaad.2021.06.902_bib35","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.3892\/ol.2016.5282","article-title":"Multiple large xanthomas: a case report","volume":"12","author":"Zhao","year":"2016","journal-title":"Oncol Lett"},{"key":"10.1016\/j.jaad.2021.06.902_bib36","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.amjmed.2011.04.013","article-title":"Cardiac amyloidosis: a practical approach to diagnosis and management","volume":"124","author":"Kapoor","year":"2011","journal-title":"Am J Med"},{"key":"10.1016\/j.jaad.2021.06.902_bib37","first-page":"178","article-title":"Amyloid heart disease. New frontiers and insights in pathophysiology, diagnosis, and management","volume":"32","author":"Hassan","year":"2005","journal-title":"Tex Heart Inst J"},{"key":"10.1016\/j.jaad.2021.06.902_bib38","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1016\/j.crvasa.2012.11.018","article-title":"Cardiac amyloidosis: a comprehensive review","volume":"55","author":"Fikrle","year":"2013","journal-title":"Cor Vasa"},{"key":"10.1016\/j.jaad.2021.06.902_bib39","first-page":"981346","article-title":"AL amyloidosis complicated by persistent oral bleeding","volume":"2015","author":"Marconcini","year":"2015","journal-title":"Case Rep Hematol"},{"issue":"suppl 2","key":"10.1016\/j.jaad.2021.06.902_bib40","doi-asserted-by":"crossref","first-page":"s30","DOI":"10.7861\/clinmedicine.18-2-s30","article-title":"Cardiac amyloidosis","volume":"18","author":"Martinez-Naharro","year":"2018","journal-title":"Clin Med (Lond)"},{"key":"10.1016\/j.jaad.2021.06.902_bib41","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1056\/NEJMoa1805689","article-title":"Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy","volume":"379","author":"Maurer","year":"2018","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.jaad.2021.06.902_bib42","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1016\/j.amjmed.2015.04.008","article-title":"Pinch purpura: a cutaneous manifestation of systemic amyloidosis","volume":"128","author":"Agarwal","year":"2015","journal-title":"Am J Med"},{"key":"10.1016\/j.jaad.2021.06.902_bib43","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.3892\/ol.2016.4432","article-title":"Multiple myeloma-associated skin light chain amyloidosis: a case of misdiagnosis","volume":"11","author":"Xiao","year":"2016","journal-title":"Oncol Lett"},{"issue":"1","key":"10.1016\/j.jaad.2021.06.902_bib44","doi-asserted-by":"crossref","DOI":"10.4084\/mjhid.2013.005","article-title":"Skin involvement in primary systemic amyloidosis","volume":"5","author":"Kumar","year":"2013","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"10.1016\/j.jaad.2021.06.902_bib45","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jaad.2012.06.016","article-title":"Cardiac manifestations of cutaneous disorders","volume":"68","author":"O'Neill","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2021.06.902_bib46","article-title":"Utility of abdominal skin plus subcutaneous fat and rectal mucosal biopsy in the diagnosis of AL amyloidosis with renal involvement","volume":"12","author":"Li","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jaad.2021.06.902_bib47","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1001\/archderm.134.5.643","article-title":"Skin biopsy gives the potential\u00a0benefit in the diagnosis of systemic amyloidosis associated with cardiac involvement","volume":"134","author":"Huang","year":"1998","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaad.2021.06.902_bib48","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13019-016-0420-4","article-title":"Risk prediction for emboli and recurrence of primary cardiac myxomas after resection","volume":"11","author":"Wang","year":"2016","journal-title":"J Cardiothorac Surg"},{"key":"10.1016\/j.jaad.2021.06.902_bib49","series-title":"Hurst\u2019s The Heart","article-title":"The diagnosis and management\u00a0of cardiovascular disease in patients with cancer","author":"Sahni","year":"2017"},{"key":"10.1016\/j.jaad.2021.06.902_bib50","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jcmg.2016.06.018","article-title":"Cardiac myxoma: the great mimicker","volume":"10","author":"El Sabbagh","year":"2017","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.jaad.2021.06.902_bib51","series-title":"Fitzpatrick\u2019s Dermatology","article-title":"Melanocytic nevi","author":"Cuda","year":"2019"},{"key":"10.1016\/j.jaad.2021.06.902_bib52","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1177\/0267659117722596","article-title":"Cardiac myxoma: clinical characteristics, surgical intervention, intra-operative challenges and outcome","volume":"32","author":"Abu Abeeleh","year":"2017","journal-title":"Perfusion"},{"key":"10.1016\/j.jaad.2021.06.902_bib54","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1136\/bmj.2.5371.1496","article-title":"Clinical significance of splinter haemorrhages","volume":"2","author":"Gross","year":"1963","journal-title":"Br Med J"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962222007101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962222007101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T23:23:53Z","timestamp":1759274633000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962222007101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S0190962222007101"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2021.06.902","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Part I: Cutaneous manifestations of cardiovascular disease","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2021.06.902","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2021.05.077","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the American Academy of Dermatology, Inc.","name":"copyright","label":"Copyright"}]}}