{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T16:53:20Z","timestamp":1790268800889,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009857","name":"Regeneron Pharmaceuticals Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi US","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.jaad.2021.10.038","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T19:53:32Z","timestamp":1635450812000},"page":"758-765","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Prevalence of type 2 inflammatory diseases in pediatric patients with atopic dermatitis: Real-world evidence"],"prefix":"10.1016","volume":"86","author":[{"given":"Amy S.","family":"Paller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Mina-Osorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Vekeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Boklage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha G.","family":"Mallya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohini","family":"Ganguli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandeep","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-No\u00eblle","family":"Robitaille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine C.","family":"Siegfried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jaad.2021.10.038_bib1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nrd4624","article-title":"Targeting key proximal drivers of type 2 inflammation in disease","volume":"15","author":"Gandhi","year":"2016","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"10.1016\/j.jaad.2021.10.038_bib2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/all.12268","article-title":"Atopic dermatitis and the atopic march revisited","volume":"69","author":"Dharmage","year":"2014","journal-title":"Allergy"},{"issue":"1","key":"10.1016\/j.jaad.2021.10.038_bib3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jid.2016.07.012","article-title":"The burden of atopic dermatitis: summary of a report for the National Eczema Association","volume":"137","author":"Drucker","year":"2017","journal-title":"J Invest Dermatol"},{"issue":"1","key":"10.1016\/j.jaad.2021.10.038_bib4","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000012309","article-title":"Infants with atopic dermatitis: maternal hopelessness, child-rearing attitudes and perceived infant temperament","volume":"68","author":"Pauli-Pott","year":"1999","journal-title":"Psychother Psychosom"},{"issue":"1","key":"10.1016\/j.jaad.2021.10.038_bib5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2340\/00015555-2457","article-title":"Atopic eczema and stress among single parents and families: an empirical study of 96 mothers","volume":"97","author":"Gieler","year":"2017","journal-title":"Acta Derm Venereol"},{"issue":"1","key":"10.1016\/j.jaad.2021.10.038_bib6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/jid.2010.251","article-title":"Eczema prevalence in the United States: data from the 2003 National Survey of Children's Health","volume":"131","author":"Shaw","year":"2011","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2021.10.038_bib7","unstructured":"National Eczema Association. Eczema Facts."},{"issue":"3","key":"10.1016\/j.jaad.2021.10.038_bib8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/DER.0000000000000034","article-title":"Associations of childhood eczema severity: a US population-based study","volume":"25","author":"Silverberg","year":"2014","journal-title":"Dermatitis"},{"issue":"1","key":"10.1016\/j.jaad.2021.10.038_bib9","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jaci.2018.11.006","article-title":"The atopic march and atopic multimorbidity: many trajectories, many pathways","volume":"143","author":"Paller","year":"2019","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.jaad.2021.10.038_bib10","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/pde.12867","article-title":"Study of the atopic march: development of atopic comorbidities","volume":"33","author":"Schneider","year":"2016","journal-title":"Pediatr Dermatol"},{"issue":"1","key":"10.1016\/j.jaad.2021.10.038_bib11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s13671-011-0003-5","article-title":"Comorbidity in atopic dermatitis","volume":"1","author":"Simpson","year":"2012","journal-title":"Curr Dermatol Rep"},{"issue":"1","key":"10.1016\/j.jaad.2021.10.038_bib12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jid.2016.08.022","article-title":"Increasing comorbidities suggest that atopic dermatitis is a systemic disorder","volume":"137","author":"Brunner","year":"2017","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2021.10.038_bib13","first-page":"4","article-title":"The Emerging Role of the Type 2 Inflammatory Cascade in Atopic Diseases","volume":"2","year":"2019","journal-title":"Perspect Type Inflamm"},{"issue":"9","key":"10.1016\/j.jaad.2021.10.038_bib14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/2040622318773686","article-title":"Dupilumab in atopic dermatitis: rationale, latest evidence and place in therapy","volume":"9","author":"Ari\u00ebns","year":"2018","journal-title":"Ther Adv Chronic Dis"},{"issue":"2","key":"10.1016\/j.jaad.2021.10.038_bib15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4168\/aair.2011.3.2.67","article-title":"The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma","volume":"3","author":"Zheng","year":"2011","journal-title":"Allergy Asthma Immunol Res"},{"issue":"Suppl 2","key":"10.1016\/j.jaad.2021.10.038_bib16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13223-018-0281-6","article-title":"Atopic dermatitis","volume":"14","author":"Kapur","year":"2018","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"5","key":"10.1016\/j.jaad.2021.10.038_bib17","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/bjd.17766","article-title":"Disease trajectories in childhood atopic dermatitis: an update and practitioner's guide","volume":"181","author":"Irvine","year":"2019","journal-title":"Br J Dermatol"},{"issue":"3","key":"10.1016\/j.jaad.2021.10.038_bib18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.12788\/j.sder.2017.028","article-title":"Diagnosis, comorbidity, and psychosocial impact of atopic dermatitis","volume":"36","author":"Davis","year":"2017","journal-title":"Semin Cutan Med\u00a0Surg"},{"issue":"3","key":"10.1016\/j.jaad.2021.10.038_bib19","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/all.13320","article-title":"The prevalence of atopic dermatitis beyond childhood: a systematic review and meta-analysis of longitudinal studies","volume":"73","author":"Abuabara","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaad.2021.10.038_bib20","unstructured":"World Health Organization. Classification of Topical Corticosteroids. WHO Model Prescribing Information: Drugs Used in Skin Diseases. Accessed October 3, 2021. https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/41975\/9241401060.pdf?sequence=1&isAllowed=y"},{"issue":"9","key":"10.1016\/j.jaad.2021.10.038_bib22","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.annepidem.2005.12.003","article-title":"ICD-9-CM coding of emergency department visits for food and insect sting allergy","volume":"16","author":"Clark","year":"2006","journal-title":"Ann Epidemiol"},{"issue":"2","key":"10.1016\/j.jaad.2021.10.038_bib23","doi-asserted-by":"crossref","first-page":"e20170194","DOI":"10.1542\/peds.2017-0194","article-title":"Critical issues in food allergy: a national academies consensus report","volume":"140","author":"Sicherer","year":"2017","journal-title":"Pediatrics"},{"issue":"9","key":"10.1016\/j.jaad.2021.10.038_bib24","first-page":"778","article-title":"Economic burden of atopic manifestations in patients with atopic dermatitis\u2013analysis of administrative claims","volume":"13","author":"Suh","year":"2007","journal-title":"J Manag Care Pharm"},{"issue":"3","key":"10.1016\/j.jaad.2021.10.038_bib25","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jaci.2007.05.042","article-title":"Risk of developing asthma in young children with atopic eczema: a systematic review","volume":"120","author":"van der Hulst","year":"2007","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"10.1016\/j.jaad.2021.10.038_bib26","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jaad.2017.03.003","article-title":"Incidence, prevalence, and risk of selected ocular disease in adults with atopic dermatitis","volume":"77","author":"Thyssen","year":"2017","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"10.1016\/j.jaad.2021.10.038_bib27","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jped.2013.01.001","article-title":"Epidemiology of ocular allergy and co-morbidities in adolescents","volume":"89","author":"Geraldini","year":"2013","journal-title":"J Pediatr (Rio J)"},{"issue":"3","key":"10.1016\/j.jaad.2021.10.038_bib28","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1034\/j.1398-9995.2000.00391.x","article-title":"Development of allergies and asthma in infants and young children with atopic dermatitis\u2014A prospective follow-up to 7 years age","volume":"55","author":"Gustafsson","year":"2000","journal-title":"Allergy"},{"issue":"F1000 Faculty Rev","key":"10.1016\/j.jaad.2021.10.038_bib29","doi-asserted-by":"crossref","first-page":"303","DOI":"10.12688\/f1000research.12975.1","article-title":"Associations between atopic dermatitis and other disorders [version 1; peer review: 3 approved","volume":"7","author":"Silverberg","year":"2018","journal-title":"F1000Research"},{"issue":"3","key":"10.1016\/j.jaad.2021.10.038_bib30","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.clindermatol.2013.11.007","article-title":"Atopic dermatitis as a systemic disease","volume":"32","author":"Darlenski","year":"2014","journal-title":"Clin Dermatol"},{"issue":"8","key":"10.1016\/j.jaad.2021.10.038_bib31","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1007\/s12325-017-0582-z","article-title":"Burden of atopic dermatitis in the United States: analysis of healthcare claims data in the Commercial, Medicare, and Medi-Cal databases","volume":"34","author":"Shrestha","year":"2017","journal-title":"Adv Ther"},{"issue":"3","key":"10.1016\/j.jaad.2021.10.038_bib32","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.jaad.2019.07.105","article-title":"Treatment patterns of pediatric patients with atopic dermatitis: a claims data analysis","volume":"82","author":"Paller","year":"2020","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"10.1016\/j.jaad.2021.10.038_bib33","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1111\/1475-6773.12008","article-title":"Medical care price indexes for patients with employer-provided insurance: nationally representative estimates from MarketScan data","volume":"48","author":"Dunn","year":"2013","journal-title":"Health Serv Res"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962221027201?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962221027201?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T23:02:48Z","timestamp":1759273368000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962221027201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S0190962221027201"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2021.10.038","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevalence of type 2 inflammatory diseases in pediatric patients with atopic dermatitis: Real-world evidence","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2021.10.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 by the American Academy of Dermatology, Inc. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}