{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:48:02Z","timestamp":1793918882860,"version":"4.8.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.jaad.2022.06.1169","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T20:52:34Z","timestamp":1656103954000},"page":"109-117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Clinical outcomes of high-risk cutaneous squamous cell carcinomas treated with Mohs surgery alone: An analysis of local recurrence, regional nodal metastases, progression-free survival, and disease-specific death"],"prefix":"10.1016","volume":"88","author":[{"given":"Teo","family":"Soleymani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Brodland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Arzeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny J.","family":"Sharon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Zitelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jaad.2022.06.1169_bib1","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.jaad.2012.11.037","article-title":"Cutaneous squamous cell carcinoma: estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012","volume":"68","author":"Karia","year":"2013","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"10.1016\/j.jaad.2022.06.1169_bib2","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1001\/jamadermatol.2013.2139","article-title":"Factors predictive of recurrence and death from cutaneous squamous cell carcinoma: a 10-year, single-institution cohort study","volume":"149","author":"Schmults","year":"2013","journal-title":"JAMA Dermatol"},{"issue":"2","key":"10.1016\/j.jaad.2022.06.1169_bib3","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jaad.2017.08.059","article-title":"Cutaneous squamous cell carcinoma: incidence, risk factors, diagnosis, and staging","volume":"78","author":"Que","year":"2018","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"10.1016\/j.jaad.2022.06.1169_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.hoc.2018.08.001","article-title":"Cutaneous squamous cell carcinoma","volume":"33","author":"Waldman","year":"2019","journal-title":"Hematol Oncol Clin North Am"},{"issue":"2","key":"10.1016\/j.jaad.2022.06.1169_bib5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.semradonc.2018.11.012","article-title":"Integrating the management of nodal metastasis into the treatment of nonmelanoma skin cancer","volume":"29","author":"Yom","year":"2019","journal-title":"Semin Radiat Oncol"},{"issue":"4","key":"10.1016\/j.jaad.2022.06.1169_bib6","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1056\/NEJMoa1805131","article-title":"PD-1 blockade with cemiplimab in advanced cutaneous squamous-cell carcinoma","volume":"379","author":"Migden","year":"2018","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.jaad.2022.06.1169_bib7","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1001\/jamaoto.2018.4515","article-title":"Outcomes of cutaneous squamous cell carcinoma in the head and neck region with regional lymph node metastasis: a systematic review and meta-analysis","volume":"145","author":"Sahovaler","year":"2019","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"4","key":"10.1016\/j.jaad.2022.06.1169_bib8","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s11864-019-0629-2","article-title":"Systemic immunotherapy for advanced cutaneous squamous cell carcinoma","volume":"20","author":"Ogata","year":"2019","journal-title":"Curr Treat Options Oncol"},{"issue":"6","key":"10.1016\/j.jaad.2022.06.1169_bib9","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1097\/DSS.0000000000001828","article-title":"A retrospective cohort study of cutaneous squamous cell carcinoma with lymph node metastasis: risk factors and clinical course","volume":"45","author":"Feinstein","year":"2019","journal-title":"Dermatol Surg"},{"issue":"2","key":"10.1016\/j.jaad.2022.06.1169_bib10","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jaad.2020.04.088","article-title":"Validation of a 40-gene expression profile test to predict metastatic risk in localized high-risk cutaneous squamous cell carcinoma","volume":"84","author":"Wysong","year":"2021","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"10.1016\/j.jaad.2022.06.1169_bib11","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1001\/jamadermatol.2013.2456","article-title":"Evaluation of AJCC Tumor Staging for cutaneous squamous cell carcinoma and a proposed alternative tumor staging system","volume":"149","author":"Jambusaria-Pahlajani","year":"2013","journal-title":"JAMA Dermatol"},{"issue":"4","key":"10.1016\/j.jaad.2022.06.1169_bib12","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1200\/JCO.2012.48.5326","article-title":"Evaluation of American Joint Committee on Cancer, International Union Against Cancer, and Brigham and Women\u2019s Hospital tumor staging for cutaneous squamous cell carcinoma","volume":"32","author":"Karia","year":"2014","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.jaad.2022.06.1169_bib13","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.jaad.2018.09.015","article-title":"Clinical outcomes in high-risk squamous cell carcinoma patients treated with Mohs micrographic surgery alone","volume":"80","author":"Marrazzo","year":"2019","journal-title":"J Am Acad Dermatol"},{"issue":"12","key":"10.1016\/j.jaad.2022.06.1169_bib14","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1097\/DSS.0000000000000526","article-title":"Clinical and pathologic factors predictive of positive radiologic findings in high-risk cutaneous squamous cell carcinoma","volume":"41","author":"Marrazzo","year":"2015","journal-title":"Dermatol Surg"},{"issue":"1","key":"10.1016\/j.jaad.2022.06.1169_bib15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jaad.2019.06.1303","article-title":"Long-term clinical outcomes of patients with invasive cutaneous squamous cell carcinoma treated with Mohs micrographic surgery: a 5-year, multicenter, prospective cohort study","volume":"82","author":"Tschetter","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2022.06.1169_bib16","article-title":"Part II head and neck","year":"2017"},{"issue":"12","key":"10.1016\/j.jaad.2022.06.1169_bib17","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.6004\/jnccn.2021.0059","article-title":"NCCN guidelines insights: squamous cell skin cancer","volume":"19","author":"Schmults","year":"2021","journal-title":"J Natl Compr Canc Netw"},{"issue":"13","key":"10.1016\/j.jaad.2022.06.1169_bib18","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1200\/JCO.2017.77.0941","article-title":"Postoperative concurrent chemoradiotherapy versus postoperative radiotherapy in high-risk cutaneous squamous cell carcinoma of the head and neck: the randomized Phase III TROG 05.01 trial","volume":"36","author":"Porceddu","year":"2018","journal-title":"J Clin Oncol"},{"issue":"5","key":"10.1016\/j.jaad.2022.06.1169_bib19","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/jdv.15396","article-title":"Metastasis of cutaneous squamous cell carcinoma in organ transplant recipients and the immunocompetent population: is there a difference? A systematic review and meta-analysis","volume":"33","author":"Genders","year":"2019","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"3","key":"10.1016\/j.jaad.2022.06.1169_bib20","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.amjoto.2017.01.035","article-title":"Rate of regional nodal metastases of cutaneous squamous cell carcinoma in the immunosuppressed patient","volume":"38","author":"McLaughlin","year":"2017","journal-title":"Am J Otolaryngol"},{"issue":"3","key":"10.1016\/j.jaad.2022.06.1169_bib21","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/jso.24675","article-title":"SLNB in cutaneous SCC: a review of the current state of literature and the direction for the future","volume":"116","author":"Ahadiat","year":"2017","journal-title":"J Surg Oncol"},{"issue":"2","key":"10.1016\/j.jaad.2022.06.1169_bib22","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1001\/jamaoto.2019.3751","article-title":"Association of immunosuppression with outcomes of patients with cutaneous squamous cell carcinoma of the head and neck","volume":"146","author":"Tam","year":"2020","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"11","key":"10.1016\/j.jaad.2022.06.1169_bib23","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1002\/cncr.30601","article-title":"A multi-institutional comparison of outcomes of immunosuppressed and immunocompetent patients treated with surgery and radiation therapy for cutaneous squamous cell carcinoma of the head and neck","volume":"123","author":"Manyam","year":"2017","journal-title":"Cancer"},{"issue":"2","key":"10.1016\/j.jaad.2022.06.1169_bib24","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jaad.2015.04.037","article-title":"Inferior outcomes in immunosuppressed patients with high-risk cutaneous squamous cell carcinoma of the head and neck treated with surgery and radiation therapy","volume":"73","author":"Manyam","year":"2015","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"10.1016\/j.jaad.2022.06.1169_bib25","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.jaad.2019.08.027","article-title":"Prognostic value of inositol polyphosphate-5-phosphatase expression in recurrent and metastatic cutaneous squamous cell carcinoma","volume":"82","author":"Maly","year":"2020","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"10.1016\/j.jaad.2022.06.1169_bib26","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1001\/archotol.124.5.582","article-title":"Regional lymph node metastasis from cutaneous squamous cell carcinoma","volume":"124","author":"Kraus","year":"1998","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"9","key":"10.1016\/j.jaad.2022.06.1169_bib27","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1097\/01.mlg.0000173202.56739.9f","article-title":"Lymph node metastases from cutaneous squamous cell carcinoma of the head and neck","volume":"115","author":"Moore","year":"2005","journal-title":"Laryngoscope"},{"issue":"7","key":"10.1016\/j.jaad.2022.06.1169_bib28","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1001\/jamadermatol.2019.0032","article-title":"Performance of the American Joint Committee on Cancer staging manual, 8th edition vs the Brigham and Women\u2019s Hospital tumor classification system for cutaneous squamous cell carcinoma","volume":"155","author":"Ruiz","year":"2019","journal-title":"JAMA Dermatol"},{"issue":"2","key":"10.1016\/j.jaad.2022.06.1169_bib29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1001\/jamadermatol.2017.3960","article-title":"Comparison of tumor classifications for cutaneous squamous cell carcinoma of the head and neck in the 7th vs 8th edition of the AJCC cancer staging manual","volume":"154","author":"Karia","year":"2018","journal-title":"JAMA Dermatol"},{"issue":"2","key":"10.1016\/j.jaad.2022.06.1169_bib30","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jaad.2019.07.048","article-title":"Evaluation of the utility of localized adjuvant radiation for node-negative primary cutaneous squamous cell carcinoma with clear histologic margins","volume":"82","author":"Ruiz","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2022.06.1169_bib31","series-title":"Oncology: An Evidence-Based Approach","author":"Chang","year":"2006"},{"issue":"7","key":"10.1016\/j.jaad.2022.06.1169_bib32","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/(SICI)1097-0347(199710)19:7<559::AID-HED1>3.0.CO;2-6","article-title":"Management of the neck in a randomized trial comparing concurrent chemotherapy and radiotherapy with radiotherapy alone in resectable stage III and IV squamous cell head and neck cancer","volume":"19","author":"Lavertu","year":"1997","journal-title":"Head Neck"},{"issue":"24","key":"10.1016\/j.jaad.2022.06.1169_bib33","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJM199106133242402","article-title":"Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer","volume":"324","author":"Wolf","year":"1991","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.jaad.2022.06.1169_bib34","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1056\/NEJM199301213280306","article-title":"Head and neck cancer","volume":"328","author":"Vokes","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaad.2022.06.1169_bib35","series-title":"Cancer Medicine","first-page":"1645","article-title":"Head and neck cancer","author":"Clayman","year":"1996"},{"issue":"6","key":"10.1016\/j.jaad.2022.06.1169_bib36","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/(SICI)1097-0347(199611\/12)18:6<552::AID-HED10>3.0.CO;2-A","article-title":"Neck surgery in patients with primary oropharyngeal cancer treated by radiotherapy","volume":"18","author":"Peters","year":"1996","journal-title":"Head Neck"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962222022174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962222022174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T23:06:51Z","timestamp":1759273611000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962222022174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S0190962222022174"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2022.06.1169","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical outcomes of high-risk cutaneous squamous cell carcinomas treated with Mohs surgery alone: An analysis of local recurrence, regional nodal metastases, progression-free survival, and disease-specific death","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2022.06.1169","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the American Academy of Dermatology, Inc. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}