{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:28:15Z","timestamp":1792621695980,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.jaad.2023.04.034","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T20:36:03Z","timestamp":1682541363000},"page":"677-684","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"title":["Adalimumab in conjunction with surgery compared with adalimumab monotherapy for hidradenitis suppurativa: A Randomized Controlled Trial in a real-world setting"],"prefix":"10.1016","volume":"89","author":[{"given":"Pim","family":"Aarts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna C.","family":"van Huijstee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hessel H.","family":"van der Zee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn B.A.","family":"van Doorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey R.","family":"van Straalen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Errol P.","family":"Prens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaad.2023.04.034_bib1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41572-020-0149-1","article-title":"Hidradenitis suppurativa","volume":"6","author":"Sabat","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jaad.2023.04.034_bib2","doi-asserted-by":"crossref","first-page":"6709","DOI":"10.3390\/ijerph18136709","article-title":"The burden of hidradenitis suppurativa signs and symptoms in quality of life: systematic review and meta-analysis","volume":"18","author":"Montero-Vilchez","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.jaad.2023.04.034_bib3","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1056\/NEJMoa1504370","article-title":"Two phase 3 trials of adalimumab for hidradenitis suppurativa","volume":"375","author":"Kimball","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaad.2023.04.034_bib4","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1111\/1346-8138.16143","article-title":"Hidradenitis suppurativa successfully treated with two-stage surgery under disease control with adalimumab","volume":"49","author":"Orita","year":"2022","journal-title":"J Dermatol"},{"key":"10.1016\/j.jaad.2023.04.034_bib5","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1111\/1346-8138.16146","article-title":"Possible beneficial impact of surgical deroofing procedure to cover the disadvantage of adalimumab treatment for hidradenitis suppurativa","volume":"49","author":"Saito-Sasaki","year":"2022","journal-title":"J Dermatol"},{"key":"10.1016\/j.jaad.2023.04.034_bib6","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1111\/jdv.17598","article-title":"Real-world effectiveness of adalimumab in patients with moderate-to-severe hidradenitis suppurativa: the 1-year SOLACE study","volume":"35","author":"Gulliver","year":"2021","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaad.2023.04.034_bib7","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1111\/jdv.17551","article-title":"Improvement in Hidradenitis suppurativa and quality of life in patients treated with adalimumab: real-world results from the HARMONY Study","volume":"35","author":"Hafner","year":"2021","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaad.2023.04.034_bib8","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/jdv.12966","article-title":"European S1 guideline for the treatment of hidradenitis suppurativa\/acne inversa","volume":"29","author":"Zouboulis","year":"2015","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaad.2023.04.034_bib9","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1007\/s40265-021-01566-2","article-title":"Clinical implementation of biologics and small molecules in the treatment of hidradenitis suppurativa","volume":"81","author":"Aarts","year":"2021","journal-title":"Drugs"},{"key":"10.1016\/j.jaad.2023.04.034_bib10","doi-asserted-by":"crossref","DOI":"10.1111\/dth.13877","article-title":"Immunomodulatory drugs alone and adjuvant to surgery for hidradenitis suppurativa\/acne inversa-A narrative review","volume":"33","author":"Wollina","year":"2020","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.jaad.2023.04.034_bib11","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1001\/jamasurg.2021.3655","article-title":"Efficacy and safety of adalimumab in conjunction with surgery in moderate to severe hidradenitis suppurativa: the SHARPS Randomized Clinical Trial","volume":"156","author":"Bechara","year":"2021","journal-title":"JAMA Surg"},{"key":"10.1016\/j.jaad.2023.04.034_bib12","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jaad.2009.12.018","article-title":"Deroofing: a tissue-saving surgical technique for the treatment of mild to moderate hidradenitis suppurativa lesions","volume":"63","author":"van der Zee","year":"2010","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2023.04.034_bib13","doi-asserted-by":"crossref","first-page":"E94","DOI":"10.1503\/cjs.003119","article-title":"The surgeon's perspective: a retrospective study of wide local excisions taken to healthy subcutaneous fat in the management of advanced hidradenitis suppurativa","volume":"63","author":"Shavit","year":"2020","journal-title":"Can J Surg"},{"key":"10.1016\/j.jaad.2023.04.034_bib14","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1159\/000431175","article-title":"Hidradenitis suppurativa\/acne inversa: criteria for diagnosis, severity assessment, classification and disease evaluation","volume":"231","author":"Zouboulis","year":"2015","journal-title":"Dermatology"},{"key":"10.1016\/j.jaad.2023.04.034_bib15","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1111\/bjd.15748","article-title":"Development and validation of the International Hidradenitis Suppurativa Severity Score System (IHS4), a novel dynamic scoring system to assess HS severity","volume":"177","author":"Zouboulis","year":"2017","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2023.04.034_bib16","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1111\/jdv.16642","article-title":"Validity of EQ-5D-5L, Skindex-16, DLQI and DLQI-R in patients with hidradenitis suppurativa","volume":"34","author":"Gergely","year":"2020","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaad.2023.04.034_bib17","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1111\/bjd.13270","article-title":"Assessing the validity, responsiveness and meaningfulness of the Hidradenitis Suppurativa Clinical Response (HiSCR) as the clinical endpoint for hidradenitis suppurativa treatment","volume":"171","author":"Kimball","year":"2014","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2023.04.034_bib18","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/jdv.18632","article-title":"Development and validation of IHS4-55, an IHS4 dichotomous outcome to assess treatment effect for hidradenitis suppurativa","volume":"37","author":"Tzellos","year":"2022","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaad.2023.04.034_bib19","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jaad.2018.05.040","article-title":"Long-term adalimumab efficacy in patients with moderate-to-severe hidradenitis suppurativa\/acne inversa: 3-year results of a phase 3 open-label extension study","volume":"80","author":"Zouboulis","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2023.04.034_bib20","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/ijd.13798","article-title":"Longitudinal observational study of hidradenitis suppurativa: impact of surgical intervention with adjunctive biologic therapy","volume":"57","author":"Shanmugam","year":"2018","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.jaad.2023.04.034_bib21","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.jaad.2019.12.044","article-title":"Clinical response rates, placebo response rates, and significantly associated covariates are dependent on choice of outcome measure in hidradenitis suppurativa: a post hoc analysis of PIONEER 1 and 2 individual patient data","volume":"82","author":"Frew","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2023.04.034_bib22","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/ced.14448","article-title":"Dermal tunnels influence time to clinical response and family history influences time to loss of clinical response in patients with hidradenitis suppurativa treated with adalimumab","volume":"46","author":"Frew","year":"2021","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jaad.2023.04.034_bib23","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/j.jaci.2020.12.651","article-title":"Epithelialized tunnels are a source of inflammation in hidradenitis suppurativa","volume":"147","author":"Navrazhina","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaad.2023.04.034_bib24","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/DSS.0000000000002892","article-title":"Current surgical management of hidradenitis suppurativa: a systematic review and meta-analysis","volume":"47","author":"Riddle","year":"2021","journal-title":"Dermatol Surg"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019096222300734X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S019096222300734X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T23:28:44Z","timestamp":1759274924000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S019096222300734X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S019096222300734X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2023.04.034","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adalimumab in conjunction with surgery compared with adalimumab monotherapy for hidradenitis suppurativa: A Randomized Controlled Trial in a real-world setting","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2023.04.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 by the American Academy of Dermatology, Inc. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}