{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:41:22Z","timestamp":1787956882313,"version":"build-2784847793"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100019018","name":"CAMS Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","award":["2021-I2M-1-018"],"award-info":[{"award-number":["2021-I2M-1-018"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130091"],"award-info":[{"award-number":["82130091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jaad.2025.04.082","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T11:02:53Z","timestamp":1747738973000},"page":"980-987","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Safety and efficacy of topical simvastatin plus cholesterol cream versus topical simvastatin cream alone for porokeratosis ptychotropica: A randomized, single-blind, split-body, placebo-controlled, investigator-initiated trial"],"prefix":"10.1016","volume":"93","author":[{"given":"Zhiming","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihe","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyu","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jaad.2025.04.082_bib1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jaad.2008.06.038","article-title":"Porokeratosis ptychotropica: a clinically distinct variant of porokeratosis","volume":"60","author":"McGuigan","year":"2009","journal-title":"J Am Acad Dermatol"},{"issue":"5 Suppl","key":"10.1016\/j.jaad.2025.04.082_bib2","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jaad.2005.12.009","article-title":"A rare variant of porokeratosis: porokeratosis ptychotropica","volume":"55","author":"Lee","year":"2006","journal-title":"J Am Acad Dermatol"},{"issue":"8","key":"10.1016\/j.jaad.2025.04.082_bib3","doi-asserted-by":"crossref","first-page":"e895","DOI":"10.1111\/j.1365-2230.2009.03664.x","article-title":"Porokeratosis ptychotropica: a lesser-known variant","volume":"34","author":"Tallon","year":"2009","journal-title":"Clin Exp Dermatol"},{"issue":"4","key":"10.1016\/j.jaad.2025.04.082_bib4","article-title":"Genomic variations of the mevalonate pathway in porokeratosis","volume":"23","author":"Zhang","year":"2015","journal-title":"Elife"},{"issue":"10","key":"10.1016\/j.jaad.2025.04.082_bib5","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1038\/ng.2409","article-title":"Exome sequencing identifies MVK mutations in disseminated superficial actinic porokeratosis","volume":"44","author":"Zhang","year":"2012","journal-title":"Nat Genet"},{"issue":"5","key":"10.1016\/j.jaad.2025.04.082_bib6","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.ajhg.2024.03.017","article-title":"Gene-specific somatic epigenetic mosaicism of FDFT1 underlies a non-hereditary localized form of porokeratosis","volume":"111","author":"Saito","year":"2024","journal-title":"Am J Hum Genet"},{"issue":"12","key":"10.1016\/j.jaad.2025.04.082_bib7","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1016\/j.jid.2019.05.020","article-title":"Clonal expansion of second-hit cells with somatic recombinations or C>T transitions form porokeratosis in MVD or MVK mutant heterozygotes","volume":"139","author":"Kubo","year":"2019","journal-title":"J Invest Dermatol"},{"issue":"5","key":"10.1016\/j.jaad.2025.04.082_bib8","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/jamadermatol.2019.0016","article-title":"Second-hit, postzygotic PMVK and MVD mutations in linear porokeratosis","volume":"155","author":"Atzmony","year":"2019","journal-title":"JAMA Dermatol"},{"issue":"2","key":"10.1016\/j.jaad.2025.04.082_bib9","doi-asserted-by":"crossref","DOI":"10.2340\/00015555-3753","article-title":"Porokeratosis Plantaris, Palmaris et Disseminata Caused by Con- genital Pathogenic Variants in the MVD Gene and Loss of Hetero-zygosity in Affected Skin","volume":"101","author":"J\u00e4gle","year":"2021","journal-title":"Acta Derm Venereol"},{"issue":"6","key":"10.1016\/j.jaad.2025.04.082_bib10","article-title":"Loss-of-function mutation in PMVK causes autosomal dominant disseminated superficial porokeratosis","volume":"7","author":"Wang","year":"2016","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.jaad.2025.04.082_bib11","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jaad.2019.08.043","article-title":"Topical cholesterol\/lovastatin for the treatment of porokeratosis: a pathogenesis-directed therapy","volume":"82","author":"Atzmony","year":"2020","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"10.1016\/j.jaad.2025.04.082_bib12","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1111\/jdv.16768","article-title":"Lack of effect of topical statins in linear porokeratosis","volume":"35","author":"Saleva-Stateva","year":"2021","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"5","key":"10.1016\/j.jaad.2025.04.082_bib13","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1001\/jamadermatol.2023.0205","article-title":"Safety and efficacy of topical lovastatin plus cholesterol cream vs topical lovastatin cream alone for the treatment of disseminated superficial actinic porokeratosis: a randomized clinical trial","volume":"159","author":"Santa","year":"2023","journal-title":"JAMA Dermatol"},{"issue":"1","key":"10.1016\/j.jaad.2025.04.082_bib14","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/cod.14220","article-title":"Novel topical statin treatments of disseminated actinic porokeratosis risk provoking cutaneous sensitization","volume":"88","author":"Aerts","year":"2023","journal-title":"Contact dermatitis"},{"issue":"5","key":"10.1016\/j.jaad.2025.04.082_bib15","article-title":"Treating linear porokeratosis with topical lovastatin\/cholesterol cream","volume":"28","author":"Buhle","year":"2022","journal-title":"Dermatol Online J"},{"issue":"4","key":"10.1016\/j.jaad.2025.04.082_bib16","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1001\/jamadermatol.2022.6591","article-title":"Treatment of porokeratosis ptychotropica with a topical combination of cholesterol and simvastatin","volume":"159","author":"Albanell-Fern\u00e1ndez","year":"2023","journal-title":"JAMA Dermatol"},{"issue":"1","key":"10.1016\/j.jaad.2025.04.082_bib17","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/pde.14447","article-title":"Linear porokeratosis with bone abnormalities treated with compounded topical 2% cholesterol\/2% lovastatin ointment","volume":"38","author":"Blue","year":"2021","journal-title":"Pediatr Dermatol"},{"issue":"3","key":"10.1016\/j.jaad.2025.04.082_bib18","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/ajd.13601","article-title":"Topical simvastatin-cholesterol for disseminated superficial actinic porokeratosis: an open-label, split-body clinical trial","volume":"62","author":"Byth","year":"2021","journal-title":"Australas J Dermatol"},{"issue":"2","key":"10.1016\/j.jaad.2025.04.082_bib19","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/pde.15427","article-title":"Pathogenesis-directed treatment of linear porokeratosis with topical cholesterol-lovastatin","volume":"41","author":"Maredia","year":"2024","journal-title":"Pediatr Dermatol"},{"issue":"1","key":"10.1016\/j.jaad.2025.04.082_bib20","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1111\/jdv.17619","article-title":"Successful treatment of disseminated superficial actinic porokeratosis with topical 2% cholesterol\/2% lovastatin cream: a case series with 7 patients","volume":"36","author":"Tomsitz","year":"2022","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"1","key":"10.1016\/j.jaad.2025.04.082_bib21","doi-asserted-by":"crossref","DOI":"10.1111\/dth.14583","article-title":"Refractory disseminated superficial actinic porokeratosis effectively treated with cholesterol\/lovastatin cream: a case report","volume":"34","author":"Maronese","year":"2021","journal-title":"Dermatol Ther"},{"issue":"1","key":"10.1016\/j.jaad.2025.04.082_bib22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/ajd.13473","article-title":"Effective treatment of disseminated superficial actinic porokeratosis using a novel topical cholesterol\/simvastatin combination cream","volume":"62","author":"Jerjen","year":"2021","journal-title":"Australas J Dermatol"},{"issue":"5","key":"10.1016\/j.jaad.2025.04.082_bib23","article-title":"Combining isotretinoin and topical cholesterol\/atorvastatin in the treatment of linear porokeratosis: a case report","volume":"15","author":"Alakeel","year":"2023","journal-title":"Cureus"},{"issue":"10","key":"10.1016\/j.jaad.2025.04.082_bib24","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.jdcr.2020.08.017","article-title":"Two percent lovastatin ointment as a pathogenesis-directed monotherapy for porokeratosis","volume":"6","author":"Ugwu","year":"2020","journal-title":"JAAD Case Rep"},{"issue":"10","key":"10.1016\/j.jaad.2025.04.082_bib25","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1093\/ced\/llae156","article-title":"Effective treatment of solar facial porokeratosis in one patient with topical atorvastatin\/cholesterol cream","volume":"49","author":"Peng","year":"2024","journal-title":"Clin Exp Dermatol"},{"issue":"1","key":"10.1016\/j.jaad.2025.04.082_bib26","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1111\/jdv.15838","article-title":"An excellent response to topical therapy of four congenital hemidysplasia with ichthyosiform erythroderma and limb defects syndrome patients with an increased concentration of simvastatin ointment","volume":"34","author":"Yu","year":"2020","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"9","key":"10.1016\/j.jaad.2025.04.082_bib27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1750-1172-9-33","article-title":"Targeting epidermal lipids for treatment of Mendelian disorders of cornification","volume":"7","author":"Kiritsi","year":"2014","journal-title":"Orphanet J Rare Dis"},{"issue":"11","key":"10.1016\/j.jaad.2025.04.082_bib28","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1038\/jid.2011.189","article-title":"Pathogenesis-based therapy reverses cutaneous abnormalities in an inherited disorder of distal cholesterol metabolism","volume":"131","author":"Paller","year":"2011","journal-title":"J Invest Dermatol"},{"issue":"1","key":"10.1016\/j.jaad.2025.04.082_bib29","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1529-8019.2012.01528.x","article-title":"Pathogenesis-based therapies in ichthyoses","volume":"26","author":"Lai-Cheong","year":"2013","journal-title":"Dermatol Ther"},{"issue":"4","key":"10.1016\/j.jaad.2025.04.082_bib30","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1194\/jlr.R800002-JLR200","article-title":"Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism","volume":"49","author":"Elias","year":"2008","journal-title":"J lipid Res"},{"issue":"2","key":"10.1016\/j.jaad.2025.04.082_bib31","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/1523-1747.ep12461153","article-title":"The lovastatin-treated rodent: a new model of barrier disruption and epidermal hyperplasia","volume":"96","author":"Feingold","year":"1991","journal-title":"J Invest Dermatol"},{"issue":"1","key":"10.1016\/j.jaad.2025.04.082_bib32","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4082\/kjfm.2018.39.1.51","article-title":"A possible case of statin-induced ichthyosis in an elderly woman","volume":"39","author":"Ko","year":"2018","journal-title":"Korean J Fam Med"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962225021802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962225021802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T12:13:45Z","timestamp":1758197625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962225021802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0190962225021802"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2025.04.082","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and efficacy of topical simvastatin plus cholesterol cream versus topical simvastatin cream alone for porokeratosis ptychotropica: A randomized, single-blind, split-body, placebo-controlled, investigator-initiated trial","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2025.04.082","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 by the American Academy of Dermatology, Inc.","name":"copyright","label":"Copyright"}]}}