{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:51:59Z","timestamp":1791881519297,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur Le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"INCa","doi-asserted-by":"publisher","award":["PLBIO23-005"],"award-info":[{"award-number":["PLBIO23-005"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jaad.2025.08.054","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T15:12:50Z","timestamp":1755961970000},"page":"1529-1535","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Genomic and clinical characterization of anogenital basal cell carcinoma: A retrospective and prospective cohort study"],"prefix":"10.1016","volume":"93","author":[{"given":"Lea","family":"Dousset","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey A.","family":"Yurchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Chanal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Beylot-Barry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahtab","family":"Samimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dounia","family":"Chabane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selim","family":"Aractingi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dany","family":"Nassar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansour","family":"Alkobtawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaelle","family":"Quereux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Berard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance","family":"Geffrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francoise","family":"Plantier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Ly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Herms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Laure","family":"Jullie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Jouary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Lamant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Battistella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey I.","family":"Nikolaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Basset-Seguin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jaad.2025.08.054_bib1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1067\/mjd.2001.114588","article-title":"Perianal and genital basal cell carcinoma: a clinicopathologic review of 51 cases","volume":"45","author":"Gibson","year":"2001","journal-title":"J Am Acad Dermatol"},{"issue":"6","key":"10.1016\/j.jaad.2025.08.054_bib2","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/bjd\/ljad033","article-title":"'Get Data Out' skin: national cancer registry incidence and survival rates for all registered skin tumour groups for 2013-2019 in England","volume":"188","author":"van Bodegraven","year":"2023","journal-title":"Br J Dermatol"},{"issue":"6255","key":"10.1016\/j.jaad.2025.08.054_bib3","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1126\/science.aab4082","article-title":"Somatic mutation in cancer and normal cells","volume":"349","author":"Martincorena","year":"2015","journal-title":"Science"},{"issue":"7463","key":"10.1016\/j.jaad.2025.08.054_bib4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature12477","article-title":"Signatures of mutational processes in human cancer","volume":"500","author":"Alexandrov","year":"2013","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.jaad.2025.08.054_bib5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00403-024-03068-z","article-title":"Clinic and dermoscopy of genital basal cell carcinomas (gBCCs): a retrospective analysis among 169 patients referred with genital skin neoplasms","volume":"316","author":"Scotti","year":"2024","journal-title":"Arch Dermatol Res"},{"issue":"4","key":"10.1016\/j.jaad.2025.08.054_bib6","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.jaad.2020.11.060","article-title":"Mohs micrographic surgery for male genital tumors: local recurrence rates and patient-reported outcomes","volume":"84","author":"Lukowiak","year":"2021","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"10.1016\/j.jaad.2025.08.054_bib7","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jaad.2019.03.087","article-title":"Defining skin cancer local recurrence","volume":"81","author":"Wysong","year":"2019","journal-title":"J Am Acad Dermatol"},{"issue":"11","key":"10.1016\/j.jaad.2025.08.054_bib8","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1101\/gr.239244.118","article-title":"Maftools: efficient and comprehensive analysis of somatic variants in cancer","volume":"28","author":"Mayakonda","year":"2018","journal-title":"Genome Res"},{"issue":"4","key":"10.1016\/j.jaad.2025.08.054_bib9","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/ng.3525","article-title":"Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma","volume":"48","author":"Bonilla","year":"2016","journal-title":"Nat Genet"},{"issue":"11","key":"10.1016\/j.jaad.2025.08.054_bib10","article-title":"Interventions for basal cell carcinoma of the skin","volume":"11","author":"Thomson","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"10.1016\/j.jaad.2025.08.054_bib11","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1111\/jdv.19743","article-title":"Efficacy of micrographic surgery versus conventional excision in reducing recurrence for basal cell carcinoma and squamous cell carcinoma: a systematic review and meta-analysis","volume":"38","author":"Lacerda","year":"2024","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"5 Pt 2","key":"10.1016\/j.jaad.2025.08.054_bib12","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/0190-9622(93)70112-7","article-title":"Bilateral vulvar basal cell carcinomata","volume":"28","author":"Stiller","year":"1993","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"10.1016\/j.jaad.2025.08.054_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaad.2021.05.069","article-title":"Reply to: \"Mohs micrographic surgery for male genital tumors: local recurrence rates and patient-reported outcomes\"","volume":"85","author":"Dika","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2025.08.054_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejca.2023.113254","article-title":"European consensus-based interdisciplinary guideline for diagnosis and treatment of basal cell carcinoma-update 2023","volume":"192","author":"Peris","year":"2023","journal-title":"Eur J Cancer"},{"issue":"2","key":"10.1016\/j.jaad.2025.08.054_bib15","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jaad.2023.02.050","article-title":"A retrospective case series of Mohs micrographic surgery and interdisciplinary management of female genital skin cancers: local recurrence rates and patient-reported outcomes","volume":"89","author":"Nugent","year":"2023","journal-title":"J Am Acad Dermatol"},{"issue":"6","key":"10.1016\/j.jaad.2025.08.054_bib16","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1097\/PAT.0b013e328357a001","article-title":"Basal cell carcinoma of the vulva: a case series","volume":"44","author":"Mulvany","year":"2012","journal-title":"Pathology"},{"issue":"1","key":"10.1016\/j.jaad.2025.08.054_bib17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jdcr.2018.07.012","article-title":"Vulvar basal cell carcinoma in a patient with long-standing Lichen sclerosus","volume":"5","author":"Comstock","year":"2019","journal-title":"JAAD Case Rep"},{"issue":"1","key":"10.1016\/j.jaad.2025.08.054_bib18","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/his.12034","article-title":"Pathways of vulvar intraepithelial neoplasia and squamous cell carcinoma","volume":"62","author":"Del Pino","year":"2013","journal-title":"Histopathology"},{"issue":"17","key":"10.1016\/j.jaad.2025.08.054_bib19","doi-asserted-by":"crossref","DOI":"10.2340\/00015555-3664","article-title":"Incidence of Lichen Planus and subsequent mortality in Finnish women","volume":"100","author":"Halonen","year":"2020","journal-title":"Acta Derm Venereol"},{"issue":"4","key":"10.1016\/j.jaad.2025.08.054_bib20","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1468-3083.2006.01456.x","article-title":"Basal cell carcinoma of the vulva","volume":"20","author":"Pisani","year":"2006","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"3","key":"10.1016\/j.jaad.2025.08.054_bib21","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/(SICI)1096-9098(199903)70:3<172::AID-JSO5>3.0.CO;2-I","article-title":"Basal cell carcinoma of the vulva","volume":"70","author":"Piura","year":"1999","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.jaad.2025.08.054_bib22","article-title":"Basal cell carcinoma of the external genitalia: a population-based analysis","volume":"10","author":"Chen","year":"2020","journal-title":"Front Oncol"},{"issue":"2","key":"10.1016\/j.jaad.2025.08.054_bib23","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41379-020-00672-y","article-title":"CYLD mutation characterizes a subset of HPV-positive head and neck squamous cell carcinomas with distinctive genomics and frequent cylindroma-like histologic features","volume":"34","author":"Williams","year":"2021","journal-title":"Mod Pathol"},{"issue":"12","key":"10.1016\/j.jaad.2025.08.054_bib24","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1038\/s41379-020-0584-2","article-title":"CYLD-mutant cylindroma-like basaloid carcinoma of the anus: a genetically and morphologically distinct class of HPV-related anal carcinoma","volume":"33","author":"Williams","year":"2020","journal-title":"Mod Pathol"},{"issue":"5 Pt 1","key":"10.1016\/j.jaad.2025.08.054_bib25","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/0190-9622(90)70299-W","article-title":"Occurrence of human papillomavirus type 16 DNA in cutaneous squamous and basal cell neoplasms","volume":"23","author":"Eliezri","year":"1990","journal-title":"J Am Acad Dermatol"},{"issue":"9","key":"10.1016\/j.jaad.2025.08.054_bib26","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1111\/cup.13304","article-title":"Genital basal cell carcinoma, a different pathogenesis from sun-exposed basal cell carcinoma? A case-control study of 30 cases","volume":"45","author":"Wang","year":"2018","journal-title":"J Cutan Pathol"},{"issue":"4","key":"10.1016\/j.jaad.2025.08.054_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061916","article-title":"The tyrosine phosphatase PTPN14 is a negative regulator of YAP activity","volume":"8","author":"Michaloglou","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.jaad.2025.08.054_bib28","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1158\/0008-5472.CAN-20-3065","article-title":"Loss-of-Function variants in the tumor-suppressor gene PTPN14 confer increased cancer risk","volume":"81","author":"Olafsdottir","year":"2021","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.jaad.2025.08.054_bib29","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13073-017-0424-2","article-title":"Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden","volume":"9","author":"Chalmers","year":"2017","journal-title":"Genome Med"},{"issue":"11","key":"10.1016\/j.jaad.2025.08.054_bib30","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1158\/0008-5472.CAN-21-2542","article-title":"Immune determinants of the association between tumor mutational burden and immunotherapy response across cancer types","volume":"82","author":"Sinha","year":"2022","journal-title":"Cancer Res"},{"issue":"7","key":"10.1016\/j.jaad.2025.08.054_bib31","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1158\/1078-0432.CCR-21-3764","article-title":"Frequency and genomic aspects of intrinsic resistance to vismodegib in locally advanced basal cell carcinoma","volume":"28","author":"Yurchenko","year":"2022","journal-title":"Clin Cancer Res"},{"issue":"4","key":"10.1016\/j.jaad.2025.08.054_bib32","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/PAS.0000000000002366","article-title":"Clinicopathologic and molecular characterization of basal cell carcinoma arising at sun-protected sites","volume":"49","author":"Draper","year":"2025","journal-title":"Am J Surg Pathol"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962225026805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962225026805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:26:41Z","timestamp":1791880001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962225026805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0190962225026805"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2025.08.054","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genomic and clinical characterization of anogenital basal cell carcinoma: A retrospective and prospective cohort study","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2025.08.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 by the American Academy of Dermatology, Inc.","name":"copyright","label":"Copyright"}]}}