{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T06:28:04Z","timestamp":1793600884144,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jaad.2026.03.088","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T15:24:36Z","timestamp":1774970676000},"page":"112-120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Topical combined 5-fluorouracil and calcipotriene for actinic keratosis and superficial keratinocyte carcinoma: Modified Delphi expert panel recommendations from ITSCC"],"prefix":"10.1016","volume":"95","author":[{"given":"Nicole","family":"Loranger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Trepanowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payal","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leora","family":"Aizman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"DeSimone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie Jackson","family":"Cullison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Jafarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly M.","family":"Ken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Lohman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Ranario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"R\u00f3zsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa B.","family":"Voss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina L.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha","family":"Loss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie A.","family":"O'Connell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joi B.","family":"Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.jaad.2026.03.088_bib1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s40257-022-00674-3","article-title":"A review of existing therapies for actinic keratosis: current status and future directions","volume":"23","author":"Del Regno","year":"2022","journal-title":"Am J Clin Dermatol"},{"issue":"9","key":"10.1016\/j.jaad.2026.03.088_bib2","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1001\/jamadermatol.2015.0502","article-title":"Long-term efficacy of topical fluorouracil cream, 5%, for treating actinic keratosis: a randomized clinical trial","volume":"151","author":"Pomerantz","year":"2015","journal-title":"JAMA Dermatol"},{"issue":"10","key":"10.1016\/j.jaad.2026.03.088_bib3","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1056\/NEJMoa1811850","article-title":"Randomized trial of four treatment approaches for actinic keratosis","volume":"380","author":"Jansen","year":"2019","journal-title":"N Engl J Med"},{"issue":"15","key":"10.1016\/j.jaad.2026.03.088_bib4","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.3390\/cancers15153927","article-title":"Topical treatments for basal cell carcinoma and actinic keratosis in the United States","volume":"15","author":"Tan","year":"2023","journal-title":"Cancers"},{"issue":"2","key":"10.1016\/j.jaad.2026.03.088_bib5","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jaad.2017.08.059","article-title":"Cutaneous squamous cell carcinoma","volume":"78","author":"Que","year":"2018","journal-title":"J Am Acad Dermatol"},{"issue":"12","key":"10.1016\/j.jaad.2026.03.088_bib6","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1001\/archdermatol.2009.291","article-title":"Topical imiquimod or fluorouracil therapy for basal and squamous cell carcinoma: a systematic review","volume":"145","author":"Love","year":"2009","journal-title":"Arch Dermatol"},{"issue":"7","key":"10.1016\/j.jaad.2026.03.088_bib7","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S1470-2045(13)70143-8","article-title":"Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial","volume":"14","author":"Arits","year":"2013","journal-title":"Lancet Oncol"},{"issue":"12","key":"10.1016\/j.jaad.2026.03.088_bib8","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1097\/DSS.0000000000001225","article-title":"Treatment patterns, outcomes, and patient satisfaction of primary epidermally limited nonmelanoma skin cancer","volume":"43","author":"Drew","year":"2017","journal-title":"Dermatol Surg"},{"issue":"3","key":"10.1016\/j.jaad.2026.03.088_bib9","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jaad.2020.03.127","article-title":"Field cancerization: treatment","volume":"83","author":"Cornejo","year":"2020","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"10.1016\/j.jaad.2026.03.088_bib10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1001\/jamadermatol.2017.3631","article-title":"Chemoprevention of basal and squamous cell carcinoma with a single course of fluorouracil, 5%, cream: a randomized clinical trial","volume":"154","author":"Weinstock","year":"2018","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jaad.2026.03.088_bib11","first-page":"35","article-title":"Non-adherence to topical treatments for actinic keratosis","volume":"8","author":"Shergill","year":"2013","journal-title":"Patient Prefer Adherence"},{"issue":"1","key":"10.1016\/j.jaad.2026.03.088_bib12","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1172\/JCI89820","article-title":"Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy","volume":"127","author":"Cunningham","year":"2017","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.jaad.2026.03.088_bib13","doi-asserted-by":"crossref","DOI":"10.1172\/JCI183274","article-title":"T helper 2 cell-directed immunotherapy eliminates precancerous skin lesions","volume":"135","author":"Oka","year":"2025","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.jaad.2026.03.088_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.xjidi.2022.100104","article-title":"Topical calcipotriol plus 5-fluorouracil immunotherapy for actinic keratosis treatment","volume":"2","author":"Azin","year":"2022","journal-title":"JID Innov"},{"issue":"4","key":"10.1016\/j.jaad.2026.03.088_bib15","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.jaad.2020.07.010","article-title":"Cyclic calcipotriene 0.005% foam and 1% 5-fluorouracil cream after cryotherapy in treatment of hyperkeratotic actinic keratosis: a retrospective study","volume":"84","author":"Moore","year":"2021","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"10.1016\/j.jaad.2026.03.088_bib16","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1016\/j.jfo.2020.04.030","article-title":"Topical treatment with calcipotriol combined with 5-fluorouracil for premalignant periocular lesions","volume":"44","author":"Teresa Sarandeses Diez","year":"2021","journal-title":"J Fr Ophtalmol"},{"issue":"1","key":"10.1016\/j.jaad.2026.03.088_bib17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/ced\/llac011","article-title":"CorrespondenceShort shock or slow burn? Patient perspectives on treatment of actinic keratoses with 5-fluorouracil 5% cream monotherapy versus 5-fluorouracil plus calcipotriol combination therapy","volume":"48","author":"Junejo","year":"2023","journal-title":"Clin Exp Dermatol"},{"issue":"6","key":"10.1016\/j.jaad.2026.03.088_bib18","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.125476","article-title":"Skin cancer precursor immunotherapy for squamous cell carcinoma prevention","volume":"4","author":"Rosenberg","year":"2019","journal-title":"JCI Insight"},{"issue":"2","key":"10.1016\/j.jaad.2026.03.088_bib19","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1001\/jamadermatol.2022.5261","article-title":"Prevention of skin cancers with topical calcipotriol and fluorouracil in patients with xeroderma pigmentosum","volume":"159","author":"Kim","year":"2023","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jaad.2026.03.088_bib20","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.jaad.2024.10.074","article-title":"Combined topical 5-fluorouracil and calcipotriene effectively treats superficial keratinocyte carcinomas: a retrospective cohort study from 2 academic centers","volume":"92","author":"Loranger","year":"2025","journal-title":"J Am Acad Dermatol"},{"issue":"6","key":"10.1016\/j.jaad.2026.03.088_bib21","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.jaad.2024.08.039","article-title":"Combination topical 5-fluorouracil 5%\/calcipotriene 0.005% cream for the treatment of cutaneous in situ squamous cell carcinoma: a pilot study","volume":"91","author":"Patel","year":"2024","journal-title":"J Am Acad Dermatol"},{"issue":"8","key":"10.1016\/j.jaad.2026.03.088_bib22","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1111\/jdv.14267","article-title":"A proposed scoring system for assessing the severity of actinic keratosis on the head: actinic keratosis area and severity index","volume":"31","author":"Dirschka","year":"2017","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"9","key":"10.1016\/j.jaad.2026.03.088_bib23","doi-asserted-by":"crossref","first-page":"979","DOI":"10.2105\/AJPH.74.9.979","article-title":"Consensus methods: characteristics and guidelines for use","volume":"74","author":"Fink","year":"1984","journal-title":"Am J Public Health"},{"issue":"4","key":"10.1016\/j.jaad.2026.03.088_bib24","doi-asserted-by":"crossref","first-page":"116","DOI":"10.5662\/wjm.v11.i4.116","article-title":"Delphi methodology in healthcare research: how to decide its appropriateness","volume":"11","author":"Nasa","year":"2021","journal-title":"World J Methodol"},{"issue":"4","key":"10.1016\/j.jaad.2026.03.088_bib25","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1046\/j.1365-2648.2003.02537.x","article-title":"The Delphi technique: myths and realities","volume":"41","author":"Powell","year":"2003","journal-title":"J Adv Nurs"},{"issue":"3","key":"10.1016\/j.jaad.2026.03.088_bib27","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/IOP.0b013e3182467c68","article-title":"Topical 5-fluorouracil for the treatment of periocular actinic keratosis and low-grade squamous malignancy","volume":"28","author":"Couch","year":"2012","journal-title":"Ophthalmic Plast Reconstr Surg"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962226005037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962226005037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T05:44:26Z","timestamp":1793598266000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962226005037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0190962226005037"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2026.03.088","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Topical combined 5-fluorouracil and calcipotriene for actinic keratosis and superficial keratinocyte carcinoma: Modified Delphi expert panel recommendations from ITSCC","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2026.03.088","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 by the American Academy of Dermatology, Inc.","name":"copyright","label":"Copyright"}]}}