{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:04:55Z","timestamp":1789643095665,"version":"4.0.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jaad.2026.06.092","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T07:30:30Z","timestamp":1782372630000},"page":"1043-1052","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ivarmacitinib is associated with rapid clinical improvement and immune remodeling in palmoplantar pustulosis: A multicenter, single-arm clinical trial"],"prefix":"10.1016","volume":"95","author":[{"given":"Zhongrui","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biqing","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiankang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaad.2026.06.092_bib1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41572-025-00630-5","article-title":"Psoriasis","volume":"11","author":"Armstrong","year":"2025","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.jaad.2026.06.092_bib2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jaad.2023.08.110","article-title":"Prevalence of palmoplantar pustulosis in the United States using the all of Us Research database","volume":"90","author":"Kam","year":"2024","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2026.06.092_bib3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jaci.2024.05.015","article-title":"A genome-wide meta-analysis of palmoplantar pustulosis implicates T(H)2 responses and cigarette smoking in disease pathogenesis","volume":"154","author":"Hernandez-Cordero","year":"2024","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaad.2026.06.092_bib4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/bjd\/ljaf394","article-title":"Real-world evidence on palmoplantar pustulosis: patient characteristics, diagnostic challenges and predictive factors for treatment survival - a retrospective registry study","volume":"194","author":"Graier","year":"2026","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2026.06.092_bib5","article-title":"Health-related quality of life in patients with palmoplantar pustulosis - a Swedish register study","volume":"56","author":"Norlin","year":"2024","journal-title":"Ann Med"},{"key":"10.1016\/j.jaad.2026.06.092_bib6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1177\/24755303221146990","article-title":"Palmoplantar Pustulosis has a greater disease burden than plaque psoriasis: Real-World evidence from the CorEvitas psoriasis registry","volume":"8","author":"Lebwohl","year":"2023","journal-title":"J Psoriasis Psoriatic Arthritis"},{"key":"10.1016\/j.jaad.2026.06.092_bib7","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s13555-024-01109-z","article-title":"Treatment patterns and negative health outcomes in palmoplantar pustulosis patients in Germany and the US","volume":"14","author":"Cheng","year":"2024","journal-title":"Dermatol Ther (Heidelb)"},{"key":"10.1016\/j.jaad.2026.06.092_bib8","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jaci.2022.04.027","article-title":"Single-cell analysis implicates T(H)17-to-T(H)2 cell plasticity in the pathogenesis of palmoplantar pustulosis","volume":"150","author":"McCluskey","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaad.2026.06.092_bib9","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1111\/all.16019","article-title":"Efficacy of dupilumab in palmoplantar pustulosis treatment highlights the role of Th2 inflammation","volume":"79","author":"Zheng","year":"2024","journal-title":"Allergy"},{"issue":"5","key":"10.1016\/j.jaad.2026.06.092_bib10","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.jaci.2026.01.011","article-title":"Molecular profiling of inflammatory palmoplantar disorders for diagnosis and treatment optimization","volume":"157","author":"Seremet","year":"2026","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaad.2026.06.092_bib11","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1080\/1744666X.2023.2185775","article-title":"An update on therapeutic options for palmoplantar pustulosis: a narrative review and expert recommendations","volume":"19","author":"Xu","year":"2023","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.jaad.2026.06.092_bib12","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/bjd.17625","article-title":"Persistence and effectiveness of nonbiologic systemic therapies for moderate-to-severe psoriasis in adults: a systematic review","volume":"181","author":"Mason","year":"2019","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaad.2026.06.092_bib13","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.jaad.2019.01.066","article-title":"Secukinumab for moderate-to-severe palmoplantar pustular psoriasis: results of the 2PRECISE study","volume":"80","author":"Mrowietz","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2026.06.092_bib14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jdin.2024.09.001","article-title":"Efficacy and safety of guselkumab in European patients with palmoplantar pustulosis: a multi-center, single-arm clinical trial (GAP study)","volume":"18","author":"Wilsmann-Theis","year":"2025","journal-title":"JAAD Int"},{"key":"10.1016\/j.jaad.2026.06.092_bib15","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2025.2594352","article-title":"Targeting the JAK\/STAT pathway in palmoplantar pustulosis: a review","volume":"57","author":"Vimbai Chirindo","year":"2025","journal-title":"Ann Med"},{"key":"10.1016\/j.jaad.2026.06.092_bib16","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2025-106361","article-title":"Janus kinase inhibitors in palmoplantar pustulosis: a mixed-methods feasibility (JAKPPPOT) trial protocol","volume":"15","author":"Gleeson","year":"2025","journal-title":"BMJ Open"},{"key":"10.1016\/j.jaad.2026.06.092_bib17","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.jaci.2026.01.028","article-title":"Single-cell and spatial transcriptomics unveil myeloid-lymphoid cross talk and the dermal immune niche underlying palmoplantar pustulosis","volume":"157","author":"Lee","year":"2026","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaad.2026.06.092_bib18","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s40257-021-00627-2","article-title":"Efficacy and safety of SHR0302, a highly selective janus kinase 1 inhibitor, in patients with moderate to severe atopic dermatitis: a phase II randomized clinical trial","volume":"22","author":"Zhao","year":"2021","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.jaad.2026.06.092_bib19","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.jaad.2023.02.063","article-title":"A randomized, double-blind, placebo-controlled phase II study to evaluate the efficacy and safety of ivarmacitinib (SHR0302) in adult patients with moderate-to-severe alopecia areata","volume":"89","author":"Zhou","year":"2023","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2026.06.092_bib20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s40257-024-00849-0","article-title":"Small-Molecule inhibitors and biologics for palmoplantar psoriasis and palmoplantar pustulosis: a systematic review and network meta-analysis","volume":"25","author":"Huang","year":"2024","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.jaad.2026.06.092_bib21","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.jaad.2023.10.064","article-title":"Systemic therapy in treating palmoplantar and scalp psoriasis: a systematic review and network meta-analysis","volume":"90","author":"Zhang","year":"2024","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2026.06.092_bib22","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.7573\/dic.2025-7-10","article-title":"JAK inhibitors for the treatment of palmoplantar pustulosis: a narrative review","volume":"14","author":"Henriques Dos Santos","year":"2025","journal-title":"Drugs Context"},{"key":"10.1016\/j.jaad.2026.06.092_bib23","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s40257-025-00971-7","article-title":"Upadacitinib versus acitretin for the resolution of pustules in palmoplantar pustulosis during acute phase: a Single-Center, open-label prospective cohort Study","volume":"26","author":"Huang","year":"2025","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.jaad.2026.06.092_bib24","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.jaci.2024.07.017","article-title":"Disease heterogeneity and molecular classification of inflammatory palmoplantar diseases","volume":"154","author":"van Straalen","year":"2024","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaad.2026.06.092_bib25","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s13555-025-01382-6","article-title":"Palmoplantar Pustulosis as an immune-mediated inflammatory disease with a possible relevance of Th17 cell plasticity: a narrative review","volume":"15","author":"Terui","year":"2025","journal-title":"Dermatol Ther (Heidelb)"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962226029725?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962226029725?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:57:41Z","timestamp":1789642661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962226029725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0190962226029725"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2026.06.092","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ivarmacitinib is associated with rapid clinical improvement and immune remodeling in palmoplantar pustulosis: A multicenter, single-arm clinical trial","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2026.06.092","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of the American Academy of Dermatology, Inc.","name":"copyright","label":"Copyright"}]}}