{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:36:55Z","timestamp":1793371015209,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013671","name":"Sun Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013671","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaad.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Academy of Dermatology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jaad.2026.08.051","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T15:59:12Z","timestamp":1787155152000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The effects of tildrakizumab in the epigenetic aging deviation of psoriasis: A 52-week open-label study"],"prefix":"10.1016","author":[{"given":"Betul","family":"Macit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsie E.","family":"Benca-Bachman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abrar","family":"Qureshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Paulo","family":"de Lima Camillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunyoung","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"McGeary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4636-4489","authenticated-orcid":false,"given":"Carlos G.","family":"Wambier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaad.2026.08.051_bib1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jaut.2016.12.002","article-title":"Epigenetics of psoriatic disease: a systematic review and critical appraisal","volume":"78","author":"Pollock","year":"2017","journal-title":"J Autoimmun"},{"key":"10.1016\/j.jaad.2026.08.051_bib2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jaad.2017.03.037","article-title":"Real-world burden of comorbidities in US patients with psoriasis","volume":"77","author":"Shah","year":"2017","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2026.08.051_bib3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jid.2017.07.841","article-title":"Objective measures of psoriasis severity predict mortality: a prospective population-based cohort study","volume":"138","author":"Noe","year":"2018","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jaad.2026.08.051_bib4","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.exger.2005.03.012","article-title":"The essential mechanisms of aging: irreparable damage accumulation of biochemical side-reactions","volume":"40","author":"Yin","year":"2005","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.jaad.2026.08.051_bib5","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1093\/gerona\/glz220","article-title":"Multi-omic biological age estimation and its correlation with wellness and disease phenotypes: a longitudinal study of 3,558 individuals","volume":"74","author":"Earls","year":"2019","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.jaad.2026.08.051_bib6","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41576-018-0004-3","article-title":"DNA methylation-based biomarkers and the epigenetic clock theory of ageing","volume":"19","author":"Horvath","year":"2018","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jaad.2026.08.051_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101348","article-title":"A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration","volume":"69","author":"Oblak","year":"2021","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jaad.2026.08.051_bib8","doi-asserted-by":"crossref","first-page":"573","DOI":"10.18632\/aging.101414","article-title":"An epigenetic biomarker of aging for lifespan and healthspan","volume":"10","author":"Levine","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jaad.2026.08.051_bib9","doi-asserted-by":"crossref","first-page":"303","DOI":"10.18632\/aging.101684","article-title":"DNA methylation GrimAge strongly predicts lifespan and healthspan","volume":"11","author":"Lu","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jaad.2026.08.051_bib10","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.73420","article-title":"DunedinPACE, a DNA methylation biomarker of the pace of aging","volume":"11","author":"Belsky","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.jaad.2026.08.051_bib11","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/s43587-022-00248-2","article-title":"A computational solution for bolstering reliability of epigenetic clocks: implications for clinical trials and longitudinal tracking","volume":"2","author":"Higgins-Chen","year":"2022","journal-title":"Nat Aging"},{"key":"10.1016\/j.jaad.2026.08.051_bib12","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41514-022-00085-y","article-title":"A pan-tissue DNA-methylation epigenetic clock based on deep learning","volume":"8","author":"de Lima Camillo","year":"2022","journal-title":"npj Aging"},{"key":"10.1016\/j.jaad.2026.08.051_bib13","first-page":"619766","article-title":"CpGPT: a foundation model for DNA methylation","volume":"2010","author":"de Lima Camillo","year":"2024","journal-title":"bioRxiv"},{"issue":"18","key":"10.1016\/j.jaad.2026.08.051_bib14","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.1016\/j.cell.2023.08.003","article-title":"Biomarkers of aging for the identification and evaluation of longevity interventions","volume":"186","author":"Moqri","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.jaad.2026.08.051_bib15","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s00403-024-03075-0","article-title":"A case-control study: epigenetic age acceleration in psoriasis","volume":"316","author":"Macit","year":"2024","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jaad.2026.08.051_bib16","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1093\/gerona\/glw240","article-title":"Chronic inflammation: accelerator of biological aging","volume":"72","author":"Fougere","year":"2017","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.jaad.2026.08.051_bib17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13059-015-0584-6","article-title":"DNA methylation age of blood predicts all-cause mortality in later life","volume":"16","author":"Marioni","year":"2015","journal-title":"Genome Biol"},{"key":"10.1016\/j.jaad.2026.08.051_bib18","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12979-025-00500-4","article-title":"The relationship between biological aging and psoriasis: evidence from three observational studies","volume":"22","author":"Lin","year":"2025","journal-title":"Immun Ageing"},{"key":"10.1016\/j.jaad.2026.08.051_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13028","article-title":"Reversal of epigenetic aging and immunosenescent trends in humans","volume":"18","author":"Fahy","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.jaad.2026.08.051_bib20","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1111\/dom.13262","article-title":"Epigenetic effects of metformin: from molecular mechanisms to clinical implications","volume":"20","author":"Bridgeman","year":"2018","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.jaad.2026.08.051_bib21","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41580-019-0204-5","article-title":"The ageing epigenome and its rejuvenation","volume":"21","author":"Zhang","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jaad.2026.08.051_bib22","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.16351","article-title":"Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice","volume":"5","author":"Bitto","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.jaad.2026.08.051_bib23","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jaad.2020.08.032","article-title":"Reduced risk of mortality associated with systemic psoriasis treatment in the Psoriasis Longitudinal Assessment and Registry (PSOLAR): a nested case-control analysis","volume":"84","author":"Langley","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaad.2026.08.051_bib24","article-title":"Semaglutide slows epigenetic aging in people with HIV-associated lipohypertrophy: evidence from a randomized controlled trial","author":"Corley","year":"2025","journal-title":"medRxiv"},{"key":"10.1016\/j.jaad.2026.08.051_bib25","first-page":"9484","article-title":"DNA methylation GrimAge version 2","volume":"14","author":"Lu","year":"2022","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jaad.2026.08.051_bib26","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.molcel.2012.10.016","article-title":"Genome-wide methylation profiles reveal quantitative views of human aging rates","volume":"49","author":"Hannum","year":"2013","journal-title":"Mol Cell"},{"key":"10.1016\/j.jaad.2026.08.051_bib27","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13073-020-00752-3","article-title":"A comparison of epigenetic mitotic-like clocks for cancer risk prediction","volume":"12","author":"Teschendorff","year":"2020","journal-title":"Genome Med"},{"key":"10.1016\/j.jaad.2026.08.051_bib28","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging. An evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jaad.2026.08.051_bib29","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.tem.2019.07.015","article-title":"Metformin as anti-aging therapy: is it for everyone?","volume":"30","author":"Soukas","year":"2019","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.jaad.2026.08.051_bib30","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s43587-024-00642-y","article-title":"SGLT2 inhibition eliminates senescent cells and alleviates pathological aging","volume":"4","author":"Katsuumi","year":"2024","journal-title":"Nat Aging"},{"key":"10.1016\/j.jaad.2026.08.051_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101024","article-title":"Effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on ageing: molecular mechanisms","volume":"58","author":"Bahrami","year":"2020","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.jaad.2026.08.051_bib32","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1038\/ncomms3192","article-title":"Metformin improves healthspan and lifespan in mice","volume":"4","author":"Martin-Montalvo","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaad.2026.08.051_bib33","doi-asserted-by":"crossref","first-page":"e883","DOI":"10.1111\/jdv.19978","article-title":"Dysregulation of epigenetic, biological and mitotic age in the context of biologic drug treatment and phototherapy in plaque psoriasis patients","volume":"38","author":"Jeremian","year":"2024","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jaad.2026.08.051_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2024.1493406","article-title":"Assessing the utility of epigenetic clocks for health prediction in South Korean","volume":"5","author":"Kim","year":"2024","journal-title":"Front Aging"},{"key":"10.1016\/j.jaad.2026.08.051_bib35","doi-asserted-by":"crossref","first-page":"14604","DOI":"10.18632\/aging.203115","article-title":"Accelerated DNA methylation age and medication use among African Americans","volume":"13","author":"Kho","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jaad.2026.08.051_bib36","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.18632\/aging.101626","article-title":"Accelerated DNA methylation age and the use of antihypertensive medication among older adults","volume":"10","author":"Gao","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jaad.2026.08.051_bib37","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1001\/jamadermatol.2016.1984","article-title":"Association between changes in coronary artery disease progression and treatment with biologic agents for severe psoriasis","volume":"152","author":"Hjuler","year":"2016","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.jaad.2026.08.051_bib38","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jaad.2016.07.042","article-title":"Cardiovascular event risk assessment in psoriasis patients treated with tumor necrosis factor-alpha inhibitors versus methotrexate","volume":"76","author":"Wu","year":"2017","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"10.1016\/j.jaad.2026.08.051_bib39","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1038\/s41591-026-04239-3","article-title":"Effects of daily multivitamin-multimineral and cocoa extract supplementation on epigenetic aging clocks in the COSMOS randomized clinical trial","volume":"32","author":"Li","year":"2026","journal-title":"Nat Med"},{"issue":"6","key":"10.1016\/j.jaad.2026.08.051_bib40","doi-asserted-by":"crossref","first-page":"e560","DOI":"10.1093\/cid\/ciaf247","article-title":"Effect of pitavastatin on epigenetic aging biomarkers in people with HIV: pilot substudy of the REPRIEVE trial","volume":"81","author":"Corley","year":"2025","journal-title":"Clin Infect Dis"}],"container-title":["Journal of the American Academy of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962226033682?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0190962226033682?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:27:28Z","timestamp":1793370448000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0190962226033682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":40,"alternative-id":["S0190962226033682"],"URL":"https:\/\/doi.org\/10.1016\/j.jaad.2026.08.051","relation":{},"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of tildrakizumab in the epigenetic aging deviation of psoriasis: A 52-week open-label study","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Academy of Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaad.2026.08.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of American Academy of Dermatology, Inc.","name":"copyright","label":"Copyright"}]}}