{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T22:39:03Z","timestamp":1771540743340,"version":"3.50.1"},"reference-count":23,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaapos.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of American Association for Pediatric Ophthalmology and Strabismus"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.jaapos.2007.11.004","type":"journal-article","created":{"date-parts":[[2008,3,6]],"date-time":"2008-03-06T19:10:56Z","timestamp":1204830656000},"page":"239.e1-239.e11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Efficacy of brinzolamide and levobetaxolol in pediatric glaucomas: A randomized clinical trial"],"prefix":"10.1016","volume":"12","author":[{"given":"Jess T.","family":"Whitson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Roarty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingam","family":"Vijaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan L.","family":"Robin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Gross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa A.","family":"Landry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime E.","family":"Dickerson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally A.","family":"Scheib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haydn","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven Y.","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrienne M.","family":"Woodside","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael V.W.","family":"Bergamini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaapos.2007.11.004_bib1","series-title":"Congenital and Paediatric Glaucomas","author":"Shaffer","year":"1970"},{"key":"10.1016\/j.jaapos.2007.11.004_bib2","series-title":"Shields' Textbook of Glaucoma","author":"Allingham","year":"2005"},{"key":"10.1016\/j.jaapos.2007.11.004_bib3","series-title":"The Pediatric Glaucomas","author":"Mandal","year":"2006"},{"key":"10.1016\/j.jaapos.2007.11.004_bib4","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/00061198-199906000-00009","article-title":"Latanoprost in glaucoma associated with Sturge-Weber syndrome","volume":"8","author":"Altuna","year":"1999","journal-title":"J Glaucoma"},{"issue":"Suppl","key":"10.1016\/j.jaapos.2007.11.004_bib5","doi-asserted-by":"crossref","first-page":"S129","DOI":"10.1016\/S0039-6257(02)00303-X","article-title":"Latanoprost for the treatment of pediatric glaucoma","volume":"47","author":"Enyedi","year":"2002","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.jaapos.2007.11.004_bib6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/08820539709059808","article-title":"Dorzolamide: A review","volume":"12","author":"Donohue","year":"1997","journal-title":"Semin Ophthalmol"},{"key":"10.1016\/j.jaapos.2007.11.004_bib7","first-page":"33","article-title":"Topical versus oral carbonic anhydrase inhibitor therapy for pediatric glaucoma","volume":"3","author":"Portellos","year":"1999","journal-title":"J AAPOS"},{"key":"10.1016\/j.jaapos.2007.11.004_bib8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0161-6420(81)35055-6","article-title":"Timolol in uncontrolled childhood glaucomas","volume":"88","author":"Boger","year":"1981","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jaapos.2007.11.004_bib9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0161-6420(81)35043-X","article-title":"Timolol and pediatric glaucomas","volume":"88","author":"McMahon","year":"1981","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jaapos.2007.11.004_bib10","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1001\/archopht.1985.01050080075024","article-title":"Clinical experience with timolol in childhood glaucoma","volume":"103","author":"Hoskins","year":"1985","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jaapos.2007.11.004_bib11","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1001\/archopht.123.9.1177","article-title":"A randomized trial assessing dorzolamide in patients with glaucoma who are younger than 6 years","volume":"123","author":"Ott","year":"2005","journal-title":"Arch Ophthalmol"},{"issue":"S2","key":"10.1016\/j.jaapos.2007.11.004_bib12","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.1016\/S0039-6257(99)00108-3","article-title":"Preclinical overview of brinzolamide","volume":"44","author":"DeSantis","year":"2000","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.jaapos.2007.11.004_bib13","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0002-9394(98)00095-6","article-title":"Clinical efficacy and safety of brinzolamide (Azopt\u2122), a new topical carbonic anhydrase inhibitor for primary open-angle glaucoma and ocular hypertension","volume":"126","author":"Silver","year":"1998","journal-title":"Am J Ophthalmol"},{"issue":"Suppl 2","key":"10.1016\/j.jaapos.2007.11.004_bib14","doi-asserted-by":"crossref","first-page":"S163","DOI":"10.1016\/S0039-6257(99)00106-X","article-title":"Adjunctive therapy with brinzolamide 1% ophthalmic suspension (Azopt\u00ae) in patients with open-angle glaucoma or ocular hypertension maintained on timolol therapy","volume":"44","author":"Shin","year":"2000","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.jaapos.2007.11.004_bib15","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0002-9394(01)00974-6","article-title":"Comparison of topical brinzolamide 1% and dorzolamide 2% eye drops given twice daily in addition to timolol 0.5% in patients with primary open-angle glaucoma or ocular hypertension","volume":"132","author":"Michaud","year":"2001","journal-title":"Am J Ophthalmol"},{"issue":"S2","key":"10.1016\/j.jaapos.2007.11.004_bib16","doi-asserted-by":"crossref","first-page":"S155","DOI":"10.1016\/S0039-6257(99)00107-1","article-title":"The efficacy and safety of brinzolamide 1% ophthalmic suspension (Azopt) as a primary therapy in patients with open-angle glaucoma or ocular hypertension","volume":"44","author":"Sall","year":"2000","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.jaapos.2007.11.004_bib17","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1089\/108076801753162726","article-title":"Levobetaxolol (BETAXON\u2122) and other beta-adrenergic antagonists: Preclinical pharmacology. IOP-lowering activity and sites of action in human eyes","volume":"17","author":"Sharif","year":"2001","journal-title":"J Ocul Pharmacol Ther"},{"key":"10.1016\/j.jaapos.2007.11.004_bib18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2165\/00148581-200709020-00001","article-title":"Pharmacologic management of glaucoma in childhood","volume":"9","author":"Moore","year":"2007","journal-title":"Pediatr Drugs"},{"key":"10.1016\/j.jaapos.2007.11.004_bib19","first-page":"244","article-title":"Validity and reliability of the Observer's Assessment of Alertness\/Sedation Scale: Study with intravenous midazolam","volume":"10","author":"Chernik","year":"1990","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.jaapos.2007.11.004_bib20","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0749-0704(18)30040-X","article-title":"Methods for monitoring the level of sedation","volume":"11","author":"Avramov","year":"1995","journal-title":"Crit Care Clin"},{"key":"10.1016\/j.jaapos.2007.11.004_bib21","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/S0161-6420(88)33026-5","article-title":"The effects of withdrawal of timolol in chronically treated glaucoma patients","volume":"95","author":"Schlecht","year":"1988","journal-title":"Ophthalmology"},{"issue":"S2","key":"10.1016\/j.jaapos.2007.11.004_bib22","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1016\/S0039-6257(99)00110-1","article-title":"Dose response evaluation of the ocular hypotensive effect of brinzolamide ophthalmic suspension (Azopt)","volume":"44","author":"Silver","year":"2000","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.jaapos.2007.11.004_bib23","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S1091-8531(99)70093-5","article-title":"Glaucoma in Sturge-Weber syndrome","volume":"3","author":"Awad","year":"1999","journal-title":"J AAPOS"}],"container-title":["Journal of American Association for Pediatric Ophthalmology and Strabismus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1091853107005411?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1091853107005411?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T20:15:30Z","timestamp":1761077730000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1091853107005411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S1091853107005411"],"URL":"https:\/\/doi.org\/10.1016\/j.jaapos.2007.11.004","relation":{},"ISSN":["1091-8531"],"issn-type":[{"value":"1091-8531","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of brinzolamide and levobetaxolol in pediatric glaucomas: A randomized clinical trial","name":"articletitle","label":"Article Title"},{"value":"Journal of American Association for Pediatric Ophthalmology and Strabismus","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaapos.2007.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 American Association for Pediatric Ophthalmology and Strabismus. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}