{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:22:00Z","timestamp":1780633320442,"version":"3.54.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaapos.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of American Association for Pediatric Ophthalmology and Strabismus"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.jaapos.2011.05.020","type":"journal-article","created":{"date-parts":[[2011,11,22]],"date-time":"2011-11-22T10:24:51Z","timestamp":1321957491000},"page":"441-446","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"title":["Pediatric optic neuritis and risk of multiple sclerosis: Meta-analysis of observational studies"],"prefix":"10.1016","volume":"15","author":[{"given":"Amy T.","family":"Waldman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey B.","family":"Stull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Galetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Balcer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant T.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaapos.2011.05.020_bib1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1469-8749.1988.tb14560.x","article-title":"Optic neuritis in children and its relationship to multiple sclerosis: a clinical study of 21 children","volume":"30","author":"Riikonen","year":"1988","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.jaapos.2011.05.020_bib2","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1136\/jnnp.51.10.1253","article-title":"Recovery after optic neuritis in childhood","volume":"51","author":"Kriss","year":"1988","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jaapos.2011.05.020_bib3","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S1091-8531(99)70072-8","article-title":"Pediatric optic neuritis","volume":"3","author":"Cassidy","year":"1999","journal-title":"J AAPOS"},{"key":"10.1016\/j.jaapos.2011.05.020_bib4","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1212\/01.wnl.0000224757.69746.fb","article-title":"The clinical features, MRI findings, and outcome of optic neuritis in children","volume":"67","author":"Wilejto","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.jaapos.2011.05.020_bib5","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1212\/WNL.49.5.1413","article-title":"Risk factors for developing multiple sclerosis after childhood optic neuritis","volume":"49","author":"Lucchinetti","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.jaapos.2011.05.020_bib6","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: A proposal for reporting","volume":"283","author":"Stroup","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.jaapos.2011.05.020_bib7","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1212\/01.wnl.0000344163.65326.48","article-title":"Pediatric optic neuritis: Brain MRI abnormalities and risk of multiple sclerosis","volume":"72","author":"Bonhomme","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.jaapos.2011.05.020_bib8","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1590\/S0004-282X2001000300001","article-title":"The clinical profile of childhood optic neuritis","volume":"59","author":"Lana-Peixoto","year":"2001","journal-title":"Arq Neuropsiquiatr"},{"issue":"16 Suppl 2","key":"10.1016\/j.jaapos.2011.05.020_bib9","first-page":"S7","article-title":"Consensus definitions proposed for pediatric multiple sclerosis and related disorders","volume":"68","author":"Krupp","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.jaapos.2011.05.020_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1177\/0883073808321052","article-title":"Demyelinating optic neuritis in children","volume":"24","author":"Alper","year":"2009","journal-title":"J Child Neurol"},{"key":"10.1016\/j.jaapos.2011.05.020_bib11","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ejpn.2008.09.003","article-title":"Childhood optic neuritis: The pediatric neurologist's perspective","volume":"13","author":"Cakmakli","year":"2009","journal-title":"Eur J Paediatr Neurol"},{"key":"10.1016\/j.jaapos.2011.05.020_bib12","first-page":"559","article-title":"Clinical characteristics of multiple sclerosis and associated optic neuritis in Korean children","volume":"11","author":"Hwang","year":"2007","journal-title":"J\u00a0AAPOS"},{"key":"10.1016\/j.jaapos.2011.05.020_bib13","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.pediatrneurol.2003.11.011","article-title":"Clinical characteristics of Japanese children with optic neuritis","volume":"31","author":"Mizota","year":"2004","journal-title":"Pediatr Neurol"},{"key":"10.1016\/j.jaapos.2011.05.020_bib14","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1023\/B:DOOP.0000005335.28820.05","article-title":"Optic neuritis in children\u2014clinical and electrophysiological follow-up","volume":"107","author":"Tekav\u010di\u010d-Pompe","year":"2003","journal-title":"Doc Ophthalmol"},{"key":"10.1016\/j.jaapos.2011.05.020_bib15","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1093\/brain\/123.12.2407","article-title":"Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children","volume":"123","author":"Dale","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.jaapos.2011.05.020_bib16","first-page":"254","article-title":"Optic neuritis in children","volume":"37","author":"Morales","year":"2000","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"10.1016\/j.jaapos.2011.05.020_bib17","first-page":"98","article-title":"Optic neuritis in children: clinical features and visual outcome","volume":"3","author":"Brady","year":"1999","journal-title":"J\u00a0AAPOS"},{"key":"10.1016\/j.jaapos.2011.05.020_bib18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1136\/jnnp.52.1.115","article-title":"Multiple sclerosis following optic neuritis in Chile","volume":"52","author":"Alvarez","year":"1989","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jaapos.2011.05.020_bib19","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1093\/brain\/107.3.951","article-title":"Bilateral optic neuritis: A long-term follow-up","volume":"107","author":"Parkin","year":"1984","journal-title":"Brain"},{"key":"10.1016\/j.jaapos.2011.05.020_bib20","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1212\/WNL.0b013e3181ce5db0","article-title":"Younger children with MS have a distinct CSF inflammatory profile at disease onset","volume":"74","author":"Chabas","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.jaapos.2011.05.020_bib21","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1542\/peds.28.3.377","article-title":"Relation of optic neuritis to multiple sclerosis in children","volume":"28","author":"Kennedy","year":"1961","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaapos.2011.05.020_bib22","series-title":"Epidemiology","author":"Gordis","year":"2004"},{"key":"10.1016\/j.jaapos.2011.05.020_bib23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jclinepi.2009.12.005","article-title":"Advantages of individual patient data analysis in systematic reviews","volume":"63","author":"Tugwell","year":"2010","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.jaapos.2011.05.020_bib24","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1136\/ebm.14.4.100","article-title":"The devil is in the details\u2026or not? A primer on individual patient data meta-analysis","volume":"14","author":"Sud","year":"2009","journal-title":"Evid Based Med"},{"key":"10.1016\/j.jaapos.2011.05.020_bib25","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0140-6736(97)08468-7","article-title":"Summing up the evidence: One answer is not always enough","volume":"351","author":"Lau","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.jaapos.2011.05.020_bib26","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/0140-6736(93)93004-K","article-title":"Meta-analysis of the literature of individual patient data: Is there a difference?","volume":"341","author":"Stewart","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.jaapos.2011.05.020_bib27","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1093\/oxfordjournals.aje.a009051","article-title":"Comparison of effect estimates from a meta-analysis of summary data from published studies and from a meta-analysis using individual patient data for ovarian cancer studies","volume":"145","author":"Steinberg","year":"1997","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jaapos.2011.05.020_bib28","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1001\/archopht.121.7.944","article-title":"High- and low-risk profiles for the development of multiple sclerosis within 10 years after optic neuritis","volume":"121","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.jaapos.2011.05.020_bib29","first-page":"727","article-title":"Multiple sclerosis risk after optic neuritis: Final optic neuritis treatment trial follow-up","volume":"65","year":"2008","journal-title":"Arch Neurol"}],"container-title":["Journal of American Association for Pediatric Ophthalmology and Strabismus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1091853111004757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1091853111004757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T20:17:50Z","timestamp":1761077870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1091853111004757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S1091853111004757"],"URL":"https:\/\/doi.org\/10.1016\/j.jaapos.2011.05.020","relation":{},"ISSN":["1091-8531"],"issn-type":[{"value":"1091-8531","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pediatric optic neuritis and risk of multiple sclerosis: Meta-analysis of observational studies","name":"articletitle","label":"Article Title"},{"value":"Journal of American Association for Pediatric Ophthalmology and Strabismus","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaapos.2011.05.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 American Association for Pediatric Ophthalmology and Strabismus. Published by Mosby, Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}